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References from Reprogramming M2 macrophages via TLR7/8 agonist-loaded hollow MnO2 nanovehicles to suppress the progression of liver cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
Global burden of primary liver cancer in 2020 and predictions to 2040
10.1016/j.jhep.2022.08.021 · 2022 · External reference
Evolving global etiology of hepatocellular carcinoma (HCC): insights and trends for 2024
10.1016/j.jceh.2024.102406 · 2025 · External reference
Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition)
10.1159/000509424 · 2020 · External reference
Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives
10.1186/s13045-024-01549-2 · 2024 · External reference
The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma
10.1002/hep.32740 · 2023 · External reference
Tumor-associated macrophages in liver cancer: From mechanisms to therapy
10.1002/cac2.12345 · 2022 · External reference
Deciphering the possible reciprocal loop between hepatic stellate cells and cancer cells in the tumor microenvironment of the liver
10.1016/j.critrevonc.2022.103902 · 2023 · External reference
Advances of cancer-associated fibroblasts in liver cancer
10.1186/s40364-022-00406-z · 2022 · External reference
Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway
10.1155/2020/3126182 · 2020 · External reference
Role of tumor-associated macrophages in common digestive system malignant tumors
10.4251/wjgo.v15.i4.596 · 2023 · External reference
Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments
10.1038/s41392-025-02325-5 · 2025 · External reference
Antitumor therapy for breast cancer: Focus on tumor-associated macrophages and nanosized drug delivery systems
10.1002/cam4.5489 · 2023 · External reference
Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity
10.3390/ijms21218363 · 2020 · External reference
Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer
2022 · External reference
Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies
10.3389/fcell.2021.756315 · 2021 · External reference
Toll-Like Receptor-Based Strategies for Cancer Immunotherapy
10.1155/2021/9912188 · 2021 · External reference
Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy
10.3389/fimmu.2022.888713 · 2022 · External reference
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy
10.1038/s41551-018-0236-8 · 2018 · External reference
Directing toll-like receptor signaling in macrophages to enhance tumor immunotherapy
10.1016/j.copbio.2019.01.010 · 2019 · External reference
Imidazoquinolines with improved pharmacokinetic properties induce a high IFNα to TNFα ratio in vitro and in vivo
10.3389/fimmu.2023.1168252 · 2023 · External reference
Controlled PAH-mediated method with enhanced optical properties for simple, stable immunochromatographic assays
10.1016/j.bios.2022.114150 · 2022 · External reference
Manganese-based nanomaterials promote synergistic photo-immunotherapy: green synthesis, underlying mechanisms, and multiple applications
10.1039/d3tb02844e · 2024 · External reference
Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy
10.34133/bmr.0158 · 2025 · External reference
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
10.1038/s41422-020-00395-4 · 2020 · External reference
Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy
10.1038/s41565-021-00962-9 · 2021 · External reference
Multifunctional MnO2 nanoparticles for tumor microenvironment modulation and cancer therapy
10.1002/wnan.1720 · 2021 · External reference
Nanoparticle Delivery of MnO2 and Antiangiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma
10.1021/acsami.0c08473 · 2020 · External reference
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
10.3390/ani4010035 · 2014 · External reference
Unresolved reference
External reference
Manganese-based multifunctional nanoplatform for dual-modal imaging and synergistic therapy of breast cancer
10.1016/j.actbio.2022.01.019 · 2022 · External reference
NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
10.1016/j.celrep.2023.112185 · 2023 · External reference
cGAS-STING pathway in cancer biotherapy
10.1186/s12943-020-01247-w · 2020 · External reference
A Biomimetic Polymer Magnetic Nanocarrier Polarizing Tumor-Associated Macrophages for Potentiating Immunotherapy
2020 · External reference
Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity
10.1016/j.ebiom.2018.02.009 · 2018 · External reference
“Manganese Extraction” Strategy Enables Tumor-Sensitive Biodegradability and Theranostics of Nanoparticles
10.1021/jacs.6b04299 · 2016 · External reference
Gadolinium concentration dependent signal enhancement profiles using routine clinical sequences with gadopiclenol, gadoterate, gadobutrol, and gadoxetate at 1.5, 3 and 7 Tesla
10.1016/j.ejrad.2025.112322 · 2025 · External reference
High-Integrity Nanoformulation of Resiquimod (R848) for Dual Autophagy Activation and PD-L1 Modulation in Triple-Negative Breast Cancer
10.1002/mabi.202500388 · 2025 · External reference
Mouse Models of Hepatocellular Carcinoma: Classification, Advancement, and Application
10.3389/fonc.2022.902820 · 2022 · External reference
Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis
10.1038/s41467-022-30543-w · 2022 · External reference
Tumor-associated macrophages in liver cancer: From mechanisms to therapy
10.1002/cac2.12345 · ExternalCitation · doi-reference
Antitumor therapy for breast cancer: Focus on tumor-associated macrophages and nanosized drug delivery systems
10.1002/cam4.5489 · ExternalCitation · doi-reference
The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma
10.1002/hep.32740 · ExternalCitation · doi-reference
High-Integrity Nanoformulation of Resiquimod (R848) for Dual Autophagy Activation and PD-L1 Modulation in Triple-Negative Breast Cancer
10.1002/mabi.202500388 · ExternalCitation · doi-reference
Multifunctional MnO2 nanoparticles for tumor microenvironment modulation and cancer therapy
10.1002/wnan.1720 · ExternalCitation · doi-reference
Manganese-based multifunctional nanoplatform for dual-modal imaging and synergistic therapy of breast cancer
10.1016/j.actbio.2022.01.019 · ExternalCitation · doi-reference
Controlled PAH-mediated method with enhanced optical properties for simple, stable immunochromatographic assays
10.1016/j.bios.2022.114150 · ExternalCitation · doi-reference
NF-κB activation enhances STING signaling by altering microtubule-mediated STING trafficking
10.1016/j.celrep.2023.112185 · ExternalCitation · doi-reference
Directing toll-like receptor signaling in macrophages to enhance tumor immunotherapy
10.1016/j.copbio.2019.01.010 · ExternalCitation · doi-reference
Deciphering the possible reciprocal loop between hepatic stellate cells and cancer cells in the tumor microenvironment of the liver
10.1016/j.critrevonc.2022.103902 · ExternalCitation · doi-reference
Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity
10.1016/j.ebiom.2018.02.009 · ExternalCitation · doi-reference
Gadolinium concentration dependent signal enhancement profiles using routine clinical sequences with gadopiclenol, gadoterate, gadobutrol, and gadoxetate at 1.5, 3 and 7 Tesla
10.1016/j.ejrad.2025.112322 · ExternalCitation · doi-reference
Evolving global etiology of hepatocellular carcinoma (HCC): insights and trends for 2024
10.1016/j.jceh.2024.102406 · ExternalCitation · doi-reference
Global burden of primary liver cancer in 2020 and predictions to 2040
10.1016/j.jhep.2022.08.021 · ExternalCitation · doi-reference
Nanoparticle Delivery of MnO2 and Antiangiogenic Therapy to Overcome Hypoxia-Driven Tumor Escape and Suppress Hepatocellular Carcinoma
10.1021/acsami.0c08473 · ExternalCitation · doi-reference
“Manganese Extraction” Strategy Enables Tumor-Sensitive Biodegradability and Theranostics of Nanoparticles
10.1021/jacs.6b04299 · ExternalCitation · doi-reference
Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments
10.1038/s41392-025-02325-5 · ExternalCitation · doi-reference
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
10.1038/s41422-020-00395-4 · ExternalCitation · doi-reference
Nanoparticle-enhanced radiotherapy synergizes with PD-L1 blockade to limit post-surgical cancer recurrence and metastasis
10.1038/s41467-022-30543-w · ExternalCitation · doi-reference
TLR7/8-agonist-loaded nanoparticles promote the polarization of tumour-associated macrophages to enhance cancer immunotherapy
10.1038/s41551-018-0236-8 · ExternalCitation · doi-reference
Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy
10.1038/s41565-021-00962-9 · ExternalCitation · doi-reference
Manganese-based nanomaterials promote synergistic photo-immunotherapy: green synthesis, underlying mechanisms, and multiple applications
10.1039/d3tb02844e · ExternalCitation · doi-reference
Apatinib Inhibits the Invasion and Metastasis of Liver Cancer Cells by Downregulating MMP-Related Proteins via Regulation of the NF-κB Signaling Pathway
10.1155/2020/3126182 · ExternalCitation · doi-reference
Toll-Like Receptor-Based Strategies for Cancer Immunotherapy
10.1155/2021/9912188 · ExternalCitation · doi-reference
Guidelines for the Diagnosis and Treatment of Hepatocellular Carcinoma (2019 Edition)
10.1159/000509424 · ExternalCitation · doi-reference
cGAS-STING pathway in cancer biotherapy
10.1186/s12943-020-01247-w · ExternalCitation · doi-reference
Immunosuppressive tumor microenvironment and immunotherapy of hepatocellular carcinoma: current status and prospectives
10.1186/s13045-024-01549-2 · ExternalCitation · doi-reference
Advances of cancer-associated fibroblasts in liver cancer
10.1186/s40364-022-00406-z · ExternalCitation · doi-reference
Toll-Like Receptors as a Therapeutic Target in the Era of Immunotherapies
10.3389/fcell.2021.756315 · ExternalCitation · doi-reference
Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy
10.3389/fimmu.2022.888713 · ExternalCitation · doi-reference
Imidazoquinolines with improved pharmacokinetic properties induce a high IFNα to TNFα ratio in vitro and in vivo
10.3389/fimmu.2023.1168252 · ExternalCitation · doi-reference
Mouse Models of Hepatocellular Carcinoma: Classification, Advancement, and Application
10.3389/fonc.2022.902820 · ExternalCitation · doi-reference
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research
10.3390/ani4010035 · ExternalCitation · doi-reference
Lactic Acid and an Acidic Tumor Microenvironment suppress Anticancer Immunity
10.3390/ijms21218363 · ExternalCitation · doi-reference
Mechanisms and Applications of Manganese-Based Nanomaterials in Tumor Diagnosis and Therapy
10.34133/bmr.0158 · ExternalCitation · doi-reference
Role of tumor-associated macrophages in common digestive system malignant tumors
10.4251/wjgo.v15.i4.596 · ExternalCitation · doi-reference
