Research graph
References from PPARγ-dependent and -independent regulation of genes involved in hepatic methionine cycle in fasted or diet-induced obese mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Methionine metabolism in mammals
10.1016/0955-2863(90)90070-2 · 1990 · External reference
Methionine cycle in nonalcoholic fatty liver disease and its potential applications
10.1016/j.bcp.2022.115033 · 2022 · External reference
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma
10.1016/s0168-8278(00)80122-1 · 2000 · External reference
Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver
10.1073/pnas.91.1.210 · 1994 · External reference
Phosphatidylethanolamine N-methyltransferase from liver
10.1016/s0005-2760(97)00108-2 · 1997 · External reference
S-Adenosylmethionine: a control switch that regulates liver function
10.1096/fj.01-0401rev · 2002 · External reference
Rosiglitazone requires hepatocyte PPARγ expression to promote steatosis in male mice with diet-induced obesity
2021 · External reference
Dysregulated hepatic methionine metabolism drives homocysteine elevation in diet-induced nonalcoholic fatty liver disease
10.1371/journal.pone.0136822 · 2015 · External reference
Loss of glycine N-methyltransferase associates with angiopoietin-like protein 8 expression in high fat-diet-fed mice
10.3390/ijms20174223 · 2019 · External reference
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
10.1002/hep.22159 · 2008 · External reference
Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline
10.1042/bj20021523 · 2003 · External reference
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas
10.1074/jbc.m111.265348 · 2011 · External reference
Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice
10.1530/joe-16-0447 · 2017 · External reference
Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice
10.1016/j.bbrc.2005.08.070 · 2005 · External reference
Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction
10.1210/jc.2010-2129 · 2011 · External reference
Hepatocyte PPARγ contributes to the progression of non-alcoholic steatohepatitis in male and female obese mice
10.1007/s00018-022-04629-z · 2023 · External reference
Dual outcomes of rosiglitazone treatment on fatty liver
10.1208/s12248-016-9919-9 · 2016 · External reference
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
10.1074/jbc.m300043200 · 2003 · External reference
Diet modifies Pioglitazone’s influence on hepatic PPARγ-regulated mitochondrial gene expression
10.1155/2020/3817573 · 2020 · External reference
Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts
10.1096/fj.10-173716 · 2011 · External reference
Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression
10.1074/jbc.m210062200 · 2003 · External reference
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
10.1172/jci200317223 · 2003 · External reference
Role of hepatic peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease
2023 · External reference
Hepatocyte-specific loss of PPARγ protects mice from NASH and increases the therapeutic effects of rosiglitazone in the liver
10.1016/j.jcmgh.2021.01.003 · 2021 · External reference
Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications--a review
10.1186/1475-2891-13-17 · 2014 · External reference
PPARs in liver physiology
10.1016/j.bbadis.2021.166097 · 2021 · External reference
Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
10.1016/j.cmet.2023.07.002 · 2023 · External reference
Effect of fasting on methionine adenosyltransferase expression and the methionine cycle in the mouse liver
10.3177/jnsv.51.118 · 2005 · External reference
Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha
2009 · External reference
Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice
10.1152/ajpendo.00420.2014 · 2014 · External reference
Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice
10.1152/ajpendo.00514.2010 · 2011 · External reference
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
10.1186/gb-2002-3-7-research0034 · 2002 · External reference
HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
10.1038/s41467-020-17818-w · 2020 · External reference
S-adenosylmethionine in liver health, injury, and cancer
10.1152/physrev.00047.2011 · 2012 · External reference
S-adenosylmethionine metabolism and liver disease
10.1016/s1665-2681(19)31355-9 · 2013 · External reference
S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver
10.1096/fj.00-0121com · 2000 · External reference
Methionine as a regulator of bone remodeling with fasting
10.1172/jci.insight.177997 · 2024 · External reference
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways
10.1172/jci11596 · 2001 · External reference
AMPK-PPARγ-Cidec axis drives the fasting-induced lipid droplet aggregation in the liver of obese mice
10.3389/fnut.2022.917801 · 2022 · External reference
Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention
10.1152/physiolgenomics.00179.2010 · 2011 · External reference
Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism
10.1371/journal.pone.0057387 · 2013 · External reference
Hepatocyte-specific PPARγ deletion uncovers role of an antagonistic PPARγ-HNF4α transcriptional axis in metabolic dysfunction-associated steatotic liver disease progression
10.1016/j.ajpath.2026.04.015 · 2026 · External reference
Association between homocysteine and non-alcoholic fatty liver disease in Chinese adults: a cross-sectional study
10.1186/s12937-016-0221-6 · 2016 · External reference
Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease
10.1111/j.1440-1746.2005.03891.x · 2005 · External reference
Association of hepatic global DNA methylation and serum one-carbon metabolites with histological severity in patients with NAFLD
10.1002/oby.22667 · 2020 · External reference
Association between serum homocysteine levels and advanced hepatic fibrosis in alcohol-related liver disease: a cross-sectional study of NHANES
2025 · External reference
Elevated homocysteine is associated with liver fibrosis in metabolic dysfunction-associated steatotic liver disease in a sex- and menopause-specific manner
10.1016/j.gastha.2025.100800 · 2025 · External reference
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice
10.1002/hep.22159 · ExternalCitation · doi-reference
Association of hepatic global DNA methylation and serum one-carbon metabolites with histological severity in patients with NAFLD
10.1002/oby.22667 · ExternalCitation · doi-reference
Hepatocyte PPARγ contributes to the progression of non-alcoholic steatohepatitis in male and female obese mice
10.1007/s00018-022-04629-z · ExternalCitation · doi-reference
Methionine metabolism in mammals
10.1016/0955-2863(90)90070-2 · ExternalCitation · doi-reference
Hepatocyte-specific PPARγ deletion uncovers role of an antagonistic PPARγ-HNF4α transcriptional axis in metabolic dysfunction-associated steatotic liver disease progression
10.1016/j.ajpath.2026.04.015 · ExternalCitation · doi-reference
PPARs in liver physiology
10.1016/j.bbadis.2021.166097 · ExternalCitation · doi-reference
Increased expression of PPARgamma in high fat diet-induced liver steatosis in mice
10.1016/j.bbrc.2005.08.070 · ExternalCitation · doi-reference
Methionine cycle in nonalcoholic fatty liver disease and its potential applications
10.1016/j.bcp.2022.115033 · ExternalCitation · doi-reference
Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
10.1016/j.cmet.2023.07.002 · ExternalCitation · doi-reference
Elevated homocysteine is associated with liver fibrosis in metabolic dysfunction-associated steatotic liver disease in a sex- and menopause-specific manner
10.1016/j.gastha.2025.100800 · ExternalCitation · doi-reference
Hepatocyte-specific loss of PPARγ protects mice from NASH and increases the therapeutic effects of rosiglitazone in the liver
10.1016/j.jcmgh.2021.01.003 · ExternalCitation · doi-reference
Phosphatidylethanolamine N-methyltransferase from liver
10.1016/s0005-2760(97)00108-2 · ExternalCitation · doi-reference
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma
10.1016/s0168-8278(00)80122-1 · ExternalCitation · doi-reference
S-adenosylmethionine metabolism and liver disease
10.1016/s1665-2681(19)31355-9 · ExternalCitation · doi-reference
HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer
10.1038/s41467-020-17818-w · ExternalCitation · doi-reference
Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline
10.1042/bj20021523 · ExternalCitation · doi-reference
Tissue distribution of glycine N-methyltransferase, a major folate-binding protein of liver
10.1073/pnas.91.1.210 · ExternalCitation · doi-reference
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas
10.1074/jbc.m111.265348 · ExternalCitation · doi-reference
Adipocyte-specific gene expression and adipogenic steatosis in the mouse liver due to peroxisome proliferator-activated receptor gamma1 (PPARgamma1) overexpression
10.1074/jbc.m210062200 · ExternalCitation · doi-reference
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
10.1074/jbc.m300043200 · ExternalCitation · doi-reference
S-adenosylmethionine regulates MAT1A and MAT2A gene expression in cultured rat hepatocytes: a new role for S-adenosylmethionine in the maintenance of the differentiated status of the liver
10.1096/fj.00-0121com · ExternalCitation · doi-reference
S-Adenosylmethionine: a control switch that regulates liver function
10.1096/fj.01-0401rev · ExternalCitation · doi-reference
Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts
10.1096/fj.10-173716 · ExternalCitation · doi-reference
Elevated plasma homocysteine concentrations as a predictor of steatohepatitis in patients with non-alcoholic fatty liver disease
10.1111/j.1440-1746.2005.03891.x · ExternalCitation · doi-reference
Differential impact of selective GH deficiency and endogenous GH excess on insulin-mediated actions in muscle and liver of male mice
10.1152/ajpendo.00420.2014 · ExternalCitation · doi-reference
Somatostatin and its receptors contribute in a tissue-specific manner to the sex-dependent metabolic (fed/fasting) control of growth hormone axis in mice
10.1152/ajpendo.00514.2010 · ExternalCitation · doi-reference
Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention
10.1152/physiolgenomics.00179.2010 · ExternalCitation · doi-reference
S-adenosylmethionine in liver health, injury, and cancer
10.1152/physrev.00047.2011 · ExternalCitation · doi-reference
Diet modifies Pioglitazone’s influence on hepatic PPARγ-regulated mitochondrial gene expression
10.1155/2020/3817573 · ExternalCitation · doi-reference
Methionine as a regulator of bone remodeling with fasting
10.1172/jci.insight.177997 · ExternalCitation · doi-reference
Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways
10.1172/jci11596 · ExternalCitation · doi-reference
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
10.1172/jci200317223 · ExternalCitation · doi-reference
Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications--a review
10.1186/1475-2891-13-17 · ExternalCitation · doi-reference
Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes
10.1186/gb-2002-3-7-research0034 · ExternalCitation · doi-reference
Association between homocysteine and non-alcoholic fatty liver disease in Chinese adults: a cross-sectional study
10.1186/s12937-016-0221-6 · ExternalCitation · doi-reference
Dual outcomes of rosiglitazone treatment on fatty liver
10.1208/s12248-016-9919-9 · ExternalCitation · doi-reference
Up-regulation of PPAR-gamma mRNA expression in the liver of obese patients: an additional reinforcing lipogenic mechanism to SREBP-1c induction
10.1210/jc.2010-2129 · ExternalCitation · doi-reference
Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism
10.1371/journal.pone.0057387 · ExternalCitation · doi-reference
Dysregulated hepatic methionine metabolism drives homocysteine elevation in diet-induced nonalcoholic fatty liver disease
10.1371/journal.pone.0136822 · ExternalCitation · doi-reference
Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice
10.1530/joe-16-0447 · ExternalCitation · doi-reference
Effect of fasting on methionine adenosyltransferase expression and the methionine cycle in the mouse liver
10.3177/jnsv.51.118 · ExternalCitation · doi-reference
AMPK-PPARγ-Cidec axis drives the fasting-induced lipid droplet aggregation in the liver of obese mice
10.3389/fnut.2022.917801 · ExternalCitation · doi-reference
Loss of glycine N-methyltransferase associates with angiopoietin-like protein 8 expression in high fat-diet-fed mice
10.3390/ijms20174223 · ExternalCitation · doi-reference
