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References from Lipopolysaccharide-induced alterations in barrier integrity and inflammatory signaling in porcine small intestinal organoids. Local targets link to admitted publications; unresolved targets remain external evidence.
Weaning stress and intestinal health of piglets: A review
10.3389/fimmu.2022.1042778 · 2022 · External reference
Stress, Nutrition, and Intestinal Immune Responses in Pigs - A Review
10.5713/ajas.16.0118 · 2016 · External reference
Clinical, Pathological and Virological Outcomes of Tissue-Homogenate-Derived and Cell-Adapted Strains of Porcine Epidemic Diarrhea Virus (PEDV) in a Neonatal Pig Model
10.3390/v16010044 · 2023 · External reference
Enterotoxigenic Escherichia coli infection of weaned pigs: Intestinal challenges and nutritional intervention to enhance disease resistance
10.3389/fimmu.2022.885253 · 2022 · External reference
Maintenance of gut microbiome stability for optimum intestinal health in pigs - a review
10.1186/s40104-022-00790-4 · 2022 · External reference
Organogenesis of Ileal Peyer’s Patches Is Initiated Prenatally and Accelerated Postnatally With Comprehensive Proliferation of B Cells in Pigs
10.3389/fimmu.2020.604674 · 2020 · External reference
Porcine small intestinal organoids as a model to explore ETEC-host interactions in the gut
10.1186/s13567-021-00961-7 · 2021 · External reference
Long-Term Expansion of Porcine Intestinal Organoids Serves as an in vitro Model for Swine Enteric Coronavirus Infection
10.3389/fmicb.2022.865336 · 2022 · External reference
Development and characterization of segment-specific enteroids from the pig small intestine in Matrigel and transwell inserts: insights into susceptibility to porcine epidemic diarrhea Virus
10.3389/fimmu.2024.1451154 · 2024 · External reference
LPS challenge increased intestinal permeability, disrupted mitochondrial function and triggered mitophagy of piglets
10.1177/1753425918769372 · 2018 · External reference
Recent Advances in Lipopolysaccharide Recognition Systems
10.3390/ijms21020379 · 2020 · External reference
Capsaicin Attenuates Lipopolysaccharide-Induced Inflammation and Barrier Dysfunction in Intestinal Porcine Epithelial Cell Line-J2
10.3389/fphys.2021.715469 · 2021 · External reference
Thymol Improves Barrier Function and Attenuates Inflammatory Responses in Porcine Intestinal Epithelial Cells during Lipopolysaccharide (LPS)-Induced Inflammation
10.1021/acs.jafc.8b05480 · 2019 · External reference
Ethyl pyruvate inhibits LPS induced IPEC-J2 inflammation and apoptosis through p38 and ERK1/2 pathways
10.1080/15384101.2019.1653106 · 2019 · External reference
Lactoferrin attenuates lipopolysaccharide-stimulated inflammatory responses and barrier impairment through the modulation of NF-κB/MAPK/Nrf2 pathways in IPEC-J2 cells
10.1039/d0fo01570a · 2020 · External reference
The protective effect of Eleutheroside E against the mechanical barrier dysfunction triggered by lipopolysaccharide in IPEC-J2 cells
10.1016/j.rvsc.2022.11.002 · 2023 · External reference
Dietary Fiber Ameliorates Lipopolysaccharide-Induced Intestinal Barrier Function Damage in Piglets by Modulation of Intestinal Microbiome
2021 · External reference
Yeast hydrolysate attenuates lipopolysaccharide-induced inflammatory responses and intestinal barrier damage in weaned piglets
10.1186/s40104-023-00835-2 · 2023 · External reference
Pectin supplementation ameliorates intestinal epithelial barrier function damage by modulating intestinal microbiota in lipopolysaccharide-challenged piglets
10.1016/j.jnutbio.2022.109107 · 2022 · External reference
Intestinal organoids in farm animals
10.1186/s13567-021-00909-x · 2021 · External reference
Development of an intestinal epithelial cell line and organoids derived from the same swine and characterization of their antiviral responses
10.12938/bmfh.2024-0046 · 2024 · External reference
Comparative evaluation of the modulatory role of 1,25-dihydroxy-vitamin D3 on endoplasmic reticulum stress-induced effects in 2D and 3D cultures of the intestinal porcine epithelial cell line IPEC-J2
10.1186/s40104-024-01112-6 · 2024 · External reference
Porcine Intestinal Organoids: Overview of the State of the Art
10.3390/v14051110 · 2022 · External reference
Chromosomal instability and its effect on cell lines
2023 · External reference
Detailed molecular and epigenetic characterization of the pig IPEC-J2 and chicken SL-29 cell lines
10.1016/j.isci.2023.106252 · 2023 · External reference
Variability in in vivo studies: Defining the upper limit of performance for predictions of systemic effect levels
2020 · External reference
In vitro and ex vivo systems at the forefront of infection modeling and drug discovery
10.1016/j.biomaterials.2018.10.030 · 2019 · External reference
Poor Translatability of Biomedical Research Using Animals - A Narrative Review
10.1177/02611929231157756 · 2023 · External reference
A review of animal models utilized in preclinical studies of approved gene therapy products: trends and insights
10.1186/s42826-024-00195-6 · 2024 · External reference
Intestinal organoid-based 2D monolayers mimic physiological and pathophysiological properties of the pig intestine
10.1371/journal.pone.0256143 · 2021 · External reference
Acute exposure to deoxynivalenol inhibits porcine enteroid activity via suppression of the Wnt/β-catenin pathway
10.1016/j.toxlet.2019.01.008 · 2019 · External reference
Research Progress, Challenges, and Breakthroughs of Organoids as Disease Models
10.3389/fcell.2021.740574 · 2021 · External reference
Organoids: a promising new in vitro platform in livestock and veterinary research
10.1186/s13567-021-00904-2 · 2021 · External reference
Evaluation of porcine intestinal organoids as an in vitro model for mammalian orthoreovirus 3 infection
2023 · External reference
Organoids as host models for infection biology - a review of methods
10.1038/s12276-021-00629-4 · 2021 · External reference
Recent progress on the organoids: Techniques, advantages and applications
10.1016/j.biopha.2025.117942 · 2025 · External reference
Intestinal organoids: A novel and ideal in vitro platform for swine enteric coronavirus investigations
10.1016/j.virol.2025.110595 · 2025 · External reference
Organoids: The current status and biomedical applications
2023 · External reference
Next-Generation Porcine Intestinal Organoids: an Apical-Out Organoid Model for Swine Enteric Virus Infection and Immune Response Investigations
2020 · External reference
Intestinal organoid as a research platform for the virus-host interaction
10.4167/jbv.2023.53.1.051 · 2023 · External reference
Recent progress in organoid culture to model intestinal epithelial barrier functions
10.1093/intimm/dxy065 · 2019 · External reference
A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine
10.3389/fcimb.2020.00272 · 2020 · External reference
Optimized procedures for generating an enhanced, near physiological 2D culture system from porcine intestinal organoids
10.1016/j.scr.2018.02.013 · 2018 · External reference
Establishing porcine jejunum-derived intestinal organoids to study the function of intestinal epithelium as an alternative for animal testing
10.12750/jarb.39.1.2 · 2024 · External reference
Functional characteristics of a pig 2D intestinal organoid model as an in vitro platform for nutritional studies
10.5187/jast.2024.e116 · 2026 · External reference
A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease
10.1096/fj.202300223r · 2023 · External reference
Dietary Copper Improves Intestinal Morphology via Modulating Intestinal Stem Cell Activity in Pigs
10.3390/ani11092513 · 2021 · External reference
Recombinant Porcine R-Spondin 1 Facilitates Intestinal Stem Cell Expansion along the Crypt-Villus Axis through Potentiating Wnt/β-Catenin Signaling in Homeostasis and Deoxynivalenol Injury
10.1021/acs.jafc.2c02013 · 2022 · External reference
Initial pig developmental stage influences intestinal organoid growth but not phenotype
2024 · External reference
Porcine Intestinal Enteroids: a New Model for Studying Enteric Coronavirus Porcine Epidemic Diarrhea Virus Infection and the Host Innate Response
2019 · External reference
Protective Effects of Tea Tree Oil on Inflammatory Injury of Porcine Intestinal Epithelial Cells Induced by Lipopolysaccharide In Vitro
10.3390/ani14172577 · 2024 · External reference
Lipopolysaccharide induced intestinal epithelial injury: a novel organoids-based model for sepsis in vitro
10.1097/cm9.0000000000002348 · 2022 · External reference
A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide
2013 · External reference
EphrinA1/EphA2 Promotes Epithelial Hyperpermeability Involving in Lipopolysaccharide-induced Intestinal Barrier Dysfunction
10.5056/jnm19095 · 2020 · External reference
Gut Barrier Dysfunction and Bacterial Lipopolysaccharides in Colorectal Cancer
10.1007/s11605-023-05654-4 · 2023 · External reference
Oxyberberine alleviates lipopolysaccharide-induced intestinal barrier disruption and inflammation in human colonic Caco-2 cells in vitro
10.3389/fphar.2024.1496874 · 2025 · External reference
Calcitonin gene-related peptide ameliorates sepsis-induced intestinal injury by suppressing NLRP3 inflammasome activation
10.1016/j.intimp.2023.109747 · 2023 · External reference
Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway
10.1016/j.chemosphere.2022.135662 · 2022 · External reference
L-theanine attenuates porcine intestinal tight junction damage induced by LPS via p38 MAPK/NLRP3 signaling in IPEC-J2 cells
10.1016/j.fct.2023.113870 · 2023 · External reference
Downregulation of MUC6 improves esophageal epithelial barrier dysfunction and inhibits epithelial-mesenchymal transition in reflux esophagitis
10.1186/s12876-025-04336-6 · 2026 · External reference
Dual role of E-cadherin in cancer cells
10.1080/21688370.2021.2005420 · 2022 · External reference
Tight junction proteins occludin and ZO-1 as regulators of epithelial proliferation and survival
10.1111/nyas.14798 · 2022 · External reference
Lipopolysaccharide-Induced Increase in Intestinal Epithelial Tight Permeability Is Mediated by Toll-Like Receptor 4/Myeloid Differentiation Primary Response 88 (MyD88) Activation of Myosin Light Chain Kinase Expression
10.1016/j.ajpath.2017.08.005 · 2017 · External reference
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
10.1007/s00018-020-03656-y · 2021 · External reference
Recognition of lipopolysaccharide pattern by TLR4 complexes
2013 · External reference
LPS-Binding Hydrogel for TLR4-Mediated Microbiota-Immune Modulation
2026 · External reference
The immune system in tissue environments regaining homeostasis after injury: is “inflammation” always inflammation?
10.1155/2016/2856213 · 2016 · External reference
TGF-β stimulation in human and murine cells reveals commonly affected biological processes and pathways at transcription level
10.1186/1752-0509-8-55 · 2014 · External reference
Human intestinal epithelial cells express interleukin-10 through Toll-like receptor 4-mediated epithelial-macrophage crosstalk
10.1159/000365417 · 2015 · External reference
Inflammation and the Intestinal Barrier: Leukocyte-Epithelial Cell Interactions, Cell Junction Remodeling, and Mucosal Repair
10.1053/j.gastro.2016.07.008 · 2016 · External reference
Differential Transcriptomic Profiles Following Stimulation with Lipopolysaccharide in Intestinal Organoids from Dogs with Inflammatory Bowel Disease and Intestinal Mast Cell Tumor
10.3390/cancers14143525 · 2022 · External reference
Innate immune signaling in defense against intestinal microbes
10.1111/j.1600-065x.2011.01081.x · 2012 · External reference
Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion
10.2337/db11-1029 · 2012 · External reference
Transcriptional and functional regulation of the intestinal peptide transporter PEPT1
10.1113/jphysiol.2013.258889 · 2014 · External reference
Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation
10.1097/01.mib.0000443336.71488.08 · 2014 · External reference
TNFα regulates sugar transporters in the human intestinal epithelial cell line Caco-2
10.1016/j.cyto.2013.07.004 · 2013 · External reference
Gut Immunity and Microbiota Dysbiosis Are Associated with Altered Bile Acid Metabolism in LPS-Challenged Piglets
10.1155/2021/6634821 · 2021 · External reference
Galacto-Oligosaccharides Alleviate LPS-Induced Immune Imbalance in Small Intestine through Regulating Gut Microbe Composition and Bile Acid Pool
10.1021/acs.jafc.3c00419 · 2023 · External reference
The functions of gut microbiota-mediated bile acid metabolism in intestinal immunity
10.1016/j.jare.2025.05.015 · 2026 · External reference
Bile acids affect intestinal barrier function through FXR and TGR5
10.3389/fmed.2025.1607899 · 2025 · External reference
The Gut Microbiota-Bile Acids-TGR5 Axis Mediates Eucommia ulmoides Leaf Extract Alleviation of Injury to Colonic Epithelium Integrity
10.3389/fmicb.2021.727681 · 2021 · External reference
Proline rich-39 (PR-39) antimicrobial protein alleviated lipopolysaccharide-induced intestinal barrier dysfunction in piglets by altering intestinal flora associated bile acid metabolism and in turn regulating TGR-5/NF-κB/MLCK/MLC pathway
10.1016/j.ijbiomac.2025.141930 · 2025 · External reference
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration
10.1053/j.gastro.2020.05.067 · 2020 · External reference
Epidermal growth factor activates EGFR/AMPK signalling to up-regulate the expression of SGLT1 and GLUT2 to promote intestinal glucose absorption in lipopolysaccharide challenged IPEC-J2 cells and piglets
10.1080/1828051x.2022.2073832 · 2022 · External reference
Glucose transporters in the small intestine in health and disease
10.1007/s00424-020-02439-5 · 2020 · External reference
Intestinal invalidation of the glucose transporter GLUT2 delays tissue distribution of glucose and reveals an unexpected role in gut homeostasis
10.1016/j.molmet.2016.10.008 · 2016 · External reference
L-Tryptophan Differentially Regulated Glucose and Amino Acid Transporters in the Small Intestine of Rat Challenged with Lipopolysaccharide
10.3390/ani12213045 · 2022 · External reference
Generation of L cells in mouse and human small intestine organoids
10.2337/db13-0991 · 2014 · External reference
Enteroendocrine cell differentiation and function in the intestine
10.1097/med.0000000000000709 · 2022 · External reference
GLP-1 and GLP-2 Orchestrate Intestine Integrity, Gut Microbiota, and Immune System Crosstalk
10.3390/microorganisms10102061 · 2022 · External reference
The alleviating effect and mechanism of GLP-1 on ulcerative colitis
10.18632/aging.204953 · 2023 · External reference
Glucagon-like peptide-1: a multi-faceted anti-inflammatory agent
10.3389/fimmu.2023.1148209 · 2023 · External reference
Anti-Inflammatory Effects of GLP-1-Based Therapies beyond Glucose Control
2016 · External reference
GLP-1 receptor agonists in IBD: exploring the crossroads of metabolism and inflammation
10.3389/fimmu.2025.1610368 · 2025 · External reference
Intestine-selective reduction of Gcg expression reveals the importance of the distal gut for GLP-1 secretion
10.1016/j.molmet.2020.100990 · 2020 · External reference
Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion
10.1016/j.celrep.2017.10.008 · 2017 · External reference
Glucagon-like peptide-1 (GLP-1) receptor agonists in inflammatory bowel disease: mechanisms, clinical implications, and therapeutic potential
10.1093/ecco-jcc/jjaf167 · 2025 · External reference
Inflammation Meets Metabolic Disease: Gut Feeling Mediated by GLP-1
10.3389/fimmu.2016.00154 · 2016 · External reference