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References from Integrated multi-omic analysis characterizes an IFNγ-responsive-to-myeloid-suppressive immune continuum in immune-active hepatocellular carcinoma. Local targets link to admitted publications; unresolved targets remain external evidence.
Global burden of primary liver cancer in 2020 and predictions to 2040
10.1016/j.jhep.2022.08.021 · 2022 · External reference
Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma
10.1056/nejmoa1915745 · 2020 · External reference
Nivolumab plus ipilimumab versus lenvatinib or sorafenib as first-line treatment for unresectable hepatocellular carcinoma (CheckMate 9DW): An open-label, randomised, phase 3 trial
10.1016/s0140-6736(25)00403-9 · 2025 · External reference
Hepatocellular carcinoma
10.1038/s41572-020-00240-3 · 2021 · External reference
Identification of an immune-specific class of hepatocellular carcinoma, based on molecular features
10.1053/j.gastro.2017.06.007 · 2017 · External reference
Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
10.1038/s41586-022-05400-x · 2022 · External reference
A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma
10.1038/s41467-022-32283-3 · 2022 · External reference
Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma
10.1016/j.cell.2017.05.046 · 2017 · External reference
A unique metastasis gene signature enables prediction of tumor relapse in early-stage hepatocellular carcinoma patients
10.1158/0008-5472.can-10-2607 · 2010 · External reference
Integrated analysis of whole genome and transcriptome sequencing reveals diverse transcriptomic aberrations driven by somatic genomic changes in liver cancers
10.1371/journal.pone.0114263 · 2014 · External reference
THBS1+ myeloid cells expand in SLD hepatocellular carcinoma and contribute to immunosuppression and unfavorable prognosis through TREM1
10.1016/j.celrep.2024.113773 · 2024 · External reference
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma
10.1016/j.cell.2019.08.052 · 2019 · External reference
Intratumoral dendritic cell-CD4+ T helper cell niches enable CD8+ T cell differentiation following PD-1 blockade in hepatocellular carcinoma
10.1038/s41591-023-02345-0 · 2023 · External reference
Exploring markers of exhausted CD8 T cells to predict response to immune checkpoint inhibitor therapy for hepatocellular carcinoma
10.1159/000515305 · 2021 · External reference
Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma
10.1038/s41467-024-45215-0 · 2024 · External reference
ACE2 enhances sensitivity to PD-L1 blockade by inhibiting macrophage-induced immunosuppression and angiogenesis
10.1158/0008-5472.can-24-0954 · 2025 · External reference
Multiomics identifies metabolic subtypes based on fatty acid degradation allocating personalized treatment in hepatocellular carcinoma
10.1097/hep.0000000000000553 · 2024 · External reference
The efficacy of atezolizumab plus bevacizumab for advanced hepatocellular carcinoma in relation to tumor-infiltrating lymphocytes
10.1016/j.jhepr.2025.101614 · 2025 · External reference
Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
10.1016/j.cell.2016.02.065 · 2016 · External reference
Defining T cell states associated with response to checkpoint immunotherapy in melanoma
10.1016/j.cell.2018.10.038 · 2018 · External reference
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
10.1038/nature25501 · 2018 · External reference
Integrated genomic and molecular characterization of cervical cancer
10.1038/nature21386 · 2017 · External reference
An integrated TCGA pan-cancer clinical data resource to drive high-quality survival outcome analytics
2018 · External reference
Biomarkers for immunotherapy of hepatocellular carcinoma
10.1038/s41571-023-00816-4 · 2023 · External reference
Molecular markers of response to Anti-PD1 therapy in advanced hepatocellular carcinoma
10.1053/j.gastro.2022.09.005 · 2023 · External reference
Integrated single-cell transcriptome and TCR profiles of hepatocellular carcinoma highlight the convergence on interferon signaling during immunotherapy
2024 · External reference
Single-cell and spatial analyses revealed the co-location of cancer stem cells and SPP1+ macrophage in hypoxic region that determines the poor prognosis in hepatocellular carcinoma
10.1038/s41698-024-00564-3 · 2024 · External reference
Crosstalk between SPP1+ macrophages and ITGA5+ fibroblasts promotes hepatocellular carcinoma metastasis
10.1097/hc9.0000000000000907 · 2026 · External reference
