Research graph
References from Disease-first public-data integration with local virtual knockout prioritizes shared proteins linking osteoarthritis and osteoporosis. Local targets link to admitted publications; unresolved targets remain external evidence.
The relationship between osteoarthritis and osteoporosis in the general population: the Chingford Study
10.1136/ard.53.3.158 · 1994 · External reference
The interplay between osteoarthritis and osteoporosis: Mechanisms, implications, and treatment considerations - A narrative review
10.1016/j.exger.2024.112614 · 2024 · External reference
Osteoarthritis
10.1016/s0140-6736(19)30417-9 · 2019 · External reference
10.1038/s41572-025-00594-6
10.1038/s41572-025-00594-6 · 2025 · External reference
Inflammation in osteoarthritis: Our view on its presence and involvement in disease development over the years
10.1016/j.joca.2023.12.005 · 2024 · External reference
Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis
10.1038/s41413-024-00375-z · 2024 · External reference
Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols
10.1016/j.biopha.2020.110452 · 2020 · External reference
Oxidative Stress and Inflammation in Osteoporosis: Molecular Mechanisms Involved and the Relationship with microRNAs
10.3390/ijms24043772 · 2023 · External reference
Oxidative stress and inflammation: roles in osteoporosis
10.3389/fimmu.2025.1611932 · 2025 · External reference
Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation
10.1186/ar4526 · 2014 · External reference
Functional Tissue Analysis Reveals Successful Cryopreservation of Human Osteoarthritic Synovium
2016 · External reference
Distinct degenerative phenotype of articular cartilage from knees with meniscus tear compared to knees with osteoarthritis
10.1016/j.joca.2019.02.792 · 2019 · External reference
Attenuated monocyte apoptosis, a new mechanism for osteoporosis suggested by a transcriptome-wide expression study of monocytes
2015 · External reference
The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors
10.1371/journal.pone.0045142 · 2012 · External reference
Comparisons of gene expression between peripheral blood mononuclear cells and bone tissue in osteoporosis
2023 · External reference
Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology
10.1126/scitranslmed.adf4590 · 2024 · External reference
Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis
10.1038/s41598-020-67730-y · 2020 · External reference
Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells
10.7150/ijbs.61950 · 2021 · External reference
CZ CELLxGENE Discover: a single-cell data platform for scalable exploration, analysis and modeling of aggregated data
10.1093/nar/gkae1142 · 2025 · External reference
The STRING database in 2025: protein networks with directionality of regulation
10.1093/nar/gkae1113 · 2025 · External reference
OmniPath: integrated knowledgebase for multi-omics analysis
10.1093/nar/gkaf1126 · 2026 · External reference
UniProt: the Universal Protein Knowledgebase in 2025
10.1093/nar/gkae1010 · 2025 · External reference
Tissue-based map of the human proteome
10.1126/science.1260419 · 2015 · External reference
Open Targets Platform: Facilitating Therapeutic Hypotheses Building in Drug Discovery
10.1093/nar/gkae1128 · 2025 · External reference
The DisGeNET knowledge platform for disease genomics: 2019 update
2020 · External reference
The NHGRI-EBI GWAS Catalog: standards for reusability, sustainability and diversity
10.1093/nar/gkae1070 · 2025 · External reference
From expression footprints to causal pathways: contextualizing large signaling networks with CARNIVAL
10.1038/s41540-019-0118-z · 2019 · External reference
HLA-Class II Artificial Antigen Presenting Cells in CD4 T Cell-Based Immunotherapy
10.3389/fimmu.2019.01081 · 2019 · External reference
Cathepsin K inhibitors for osteoporosis: biology, potential clinical utility, and lessons learned
10.1210/er.2015-1114 · 2017 · External reference
Differential expression patterns of matrix metalloproteinases and their inhibitors during development of osteoarthritis in a transgenic mouse model
10.1136/ard.61.7.591 · 2002 · External reference
Proteoglycan 4 expression protects against the development of osteoarthritis
2013 · External reference
A potential role for tetranectin in mineralization during osteogenesis
10.1083/jcb.127.6.1767 · 1994 · External reference
Osteopontin, a bridge links osteoarthritis and osteoporosis
10.3389/fendo.2022.1012508 · 2022 · External reference
Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection
10.1172/jci46262 · 2011 · External reference
HSP90 at the hub of protein homeostasis: emerging mechanistic insights
10.1038/nrm2918 · 2010 · External reference
HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma
10.1186/s13046-018-0880-6 · 2018 · External reference
Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis
10.3389/fphys.2018.00706 · 2018 · External reference
Role of the heat shock protein family in bone metabolism
10.1007/s12192-018-0932-z · 2018 · External reference
Robust rank aggregation for gene list integration and meta-analysis
10.1093/bioinformatics/btr709 · 2012 · External reference
The Gene Ontology resource: enriching a GOld mine
2021 · External reference
A general framework for weighted gene co-expression network analysis
10.2202/1544-6115.1128 · 2005 · External reference
scTenifoldKnk: An efficient virtual knockout tool for gene function predictions via single-cell gene regulatory network perturbation
10.1016/j.patter.2022.100434 · 2022 · External reference
Doublet identification in single-cell sequencing data using scDblFinder
10.12688/f1000research.73600.1 · 2021 · External reference
