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References from Metformin modulates survival, oxidative stress, and gene expression in a high-sucrose Drosophila diabetes model. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Melatonin increases AKT and SOD gene and protein expressions in diabetic rats
10.1016/j.heliyon.2024.e28639 · 2024 · External reference
Effects of Conocarpus lancifolius and crocin on superoxide dismutase and protein kinase B genes and protein expressions in diabetic rats
10.1371/journal.pone.0326676 · 2025 · External reference
Metabolic effects of fructose and the worldwide increase in obesity
10.1152/physrev.00019.2009 · 2010 · External reference
Lifetime risk for diabetes mellitus in the United States
10.1001/jama.290.14.1884 · 2003 · External reference
Chronic complications of diabetes mellitus: A mini review
10.2174/1573399812666151016101622 · 2017 · External reference
Biochemistry and molecular cell biology of diabetic complications
10.1038/414813a · 2001 · External reference
Drosophila as a model to study obesity and metabolic disease
10.1242/jeb.163881 · 2018 · External reference
Remote control of insulin secretion by fat cells in Drosophila
10.1016/j.cmet.2009.08.002 · 2009 · External reference
Insulin/IGF signaling in Drosophila and other insects: Factors that regulate production, release and post-release action of the insulin-like peptides
10.1007/s00018-015-2063-3 · 2016 · External reference
A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila
10.1242/dmm.007948 · 2011 · External reference
A Drosophila model of high sugar diet-induced cardiomyopathy
2013 · External reference
High sugar-induced insulin resistance in Drosophila relies on the lipocalin Neural Lazarillo
10.1371/journal.pone.0036583 · 2012 · External reference
Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion
10.1016/j.cell.2012.08.019 · 2012 · External reference
Drosophila melanogaster diabetes models and its usage in the research of anti-diabetes management with traditional Chinese medicines
10.3389/fmed.2022.953490 · 2022 · External reference
Reduction of DILP2 in Drosophila triages a metabolic phenotype from lifespan revealing redundancy and compensation among DILPs
10.1371/journal.pone.0003721 · 2008 · External reference
Understanding diabetes and its complications through the lens of Drosophila
10.1016/j.yexmp.2025.105017 · 2026 · External reference
Quantification of food intake in Drosophila
10.1371/journal.pone.0006063 · 2009 · External reference
Drosophila gains traction as a repurposed tool to investigate metabolism
10.1016/j.tem.2014.03.011 · 2014 · External reference
Modeling metabolic homeostasis and nutrient sensing in Drosophila: Implications for aging and metabolic diseases
10.1242/dmm.012989 · 2014 · External reference
The mechanisms of action of metformin
10.1007/s00125-017-4342-z · 2017 · External reference
Role of AMP-activated protein kinase in mechanism of metformin action
10.1172/jci13505 · 2001 · External reference
AMPK: a nutrient and energy sensor that maintains energy homeostasis
10.1038/nrm3311 · 2012 · External reference
Cellular and molecular mechanisms of metformin: An overview
10.1042/cs20110386 · 2012 · External reference
mTOR signaling in growth, metabolism, and disease
10.1016/j.cell.2017.02.004 · 2017 · External reference
The energy sensor AMP-activated protein kinase directly regulates the mammalian FOXO3 transcription factor
10.1074/jbc.m705325200 · 2007 · External reference
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
10.1111/j.1474-9726.2006.00267.x · 2007 · External reference
Metformin alleviates oxidative stress and enhances autophagy in diabetic kidney disease via AMPK/SIRT1-FoxO1 pathway
10.1016/j.mce.2019.110628 · 2020 · External reference
Obligatory role of AMPK activation and antioxidant defense pathway in the regulatory effects of metformin on cellular protection and prevention of lens opacity
10.3390/cells11193021 · 2022 · External reference
Nutraceutical interventions for promoting healthy aging in invertebrate models
10.1155/2012/718491 · 2012 · External reference
10.1371/journal.pone.0047699
10.1371/journal.pone.0047699 · External reference
Diet modification and metformin have a beneficial effect in a fly model of obesity and mucormycosis
10.1371/journal.pone.0108635 · 2014 · External reference
High-sucrose diet induces diabetic-like phenotypes and oxidative stress in Drosophila melanogaster: Protective role of Syzygium cumini and Bauhinia forficata
10.1016/j.biopha.2017.02.076 · 2017 · External reference
A Drosophila model of diabetic neuropathy reveals a role of proteasome activity in the glia
10.1016/j.isci.2023.106997 · 2023 · External reference
Drosophila melanogaster larvae control amylase secretion according to the hardness of food
10.3389/fphys.2013.00200 · 2013 · External reference
Neuroprotective effects of ferulic acid and thymoquinone against deltamethrin-induced neurotoxicity in Drosophila melanogaster
10.62940/als.v10i2.1799 · 2023 · External reference
10.1371/journal.pone.0303115 · 2024 · Admitted local publication
Chlorpyrifos-induced dopaminergic damage in Drosophila melanogaster assessed by gene expression, AChE assay, and negative geotaxis using a new feeding device
10.4238/gmr19056 · 2022 · External reference
Flies without trehalose
10.1074/jbc.m114.619411 · 2015 · External reference
A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster
10.1242/dev.201769 · 2023 · External reference
Assessment of antioxidant activity of eugenol in vitro and in vivo.
2009 · External reference
Superoxide dismutase (SOD) and catalase (CAT) activity assay protocols for Caenorhabditis elegans
10.21769/bioprotoc.2505 · 2017 · External reference
Drosophila as a model for diabetes and diseases of insulin resistance
10.1016/bs.ctdb.2016.07.011 · 2017 · External reference
Regulation of carbohydrate energy metabolism in Drosophila melanogaster
2017 · External reference
Reactive oxygen species prime Drosophila haematopoietic progenitors for differentiation
10.1038/nature08313 · 2009 · External reference
The pathobiology of diabetic complications: A unifying mechanism
10.2337/diabetes.54.6.1615 · 2005 · External reference
Metformin and trehalose-modulated autophagy exerts a neurotherapeutic effect on Parkinson’s Disease
10.1007/s12035-023-03530-5 · 2023 · External reference
Molecular mechanisms underlying the lifespan and healthspan benefits of dietary restriction across species
10.3389/fgene.2026.1771707 · 2026 · External reference
Biological assay of superoxide dismutase (SOD) activity in Drosophila melanogaster
2009 · External reference
Octopamine drives endurance exercise adaptations in Drosophila
10.1016/j.celrep.2017.10.065 · 2017 · External reference
Oxidative stress and glycemic regulation
10.1016/s0026-0495(00)80082-7 · 2000 · External reference
Reactive oxygen species have a causal role in multiple forms of insulin resistance
10.1038/nature04634 · 2006 · External reference
Oxidative stress and stress-activated signaling pathways: A unifying hypothesis of type 2 diabetes
10.1210/er.2001-0039 · 2002 · External reference
Hyperglycemia increases mitochondrial superoxide in retina and retinal cells
10.1016/j.freeradbiomed.2003.08.018 · 2003 · External reference
Metformin: from mechanisms of action to therapies
10.1016/j.cmet.2014.09.018 · 2014 · External reference
Metformin prolongs lifespan through remodeling the energy distribution strategy in silkworm, Bombyx mori
10.18632/aging.101746 · 2019 · External reference
The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth
10.1111/bcp.13780 · 2019 · External reference
Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation
10.1111/acel.12075 · 2013 · External reference
Knockout of Hsp70 genes modulates age-related transcriptomic changes in leg muscles and reduces the locomotion speed and lifespan of Drosophila melanogaster
10.1134/s0026893324020109 · 2024 · External reference
Metformin attenuates ER stress-induced mitochondrial dysfunction
10.1016/j.trsl.2017.09.003 · 2017 · External reference
Heat Shock proteins as a potential therapeutic target in the treatment of gestational diabetes mellitus: What we know so far
10.3390/ijms19103205 · 2018 · External reference
Role of a heat shock transcription factor and the major heat shock protein Hsp70 in memory formation and neuroprotection
10.3390/cells10071638 · 2021 · External reference
