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References from Transcription factor activity divergence across muscle atrophy conditions: A comparative analysis of spaceflight, aging, and disuse using decoupleR. Local targets link to admitted publications; unresolved targets remain external evidence.
Skeletal muscle: a brief review of structure and function
10.1007/s00223-014-9915-y · 2015 · External reference
Signaling in muscle atrophy and hypertrophy
2008 · External reference
Cellular and molecular mechanisms of muscle atrophy
10.1242/dmm.010389 · 2013 · External reference
Sarcopenia: revised European consensus on definition and diagnosis
10.1093/ageing/afy169 · 2019 · External reference
Sarcopenia: origins and clinical relevance
10.1093/jn/127.5.990s · 1997 · External reference
Skeletal muscle atrophy during short-term disuse: implications for age-related sarcopenia
10.1016/j.arr.2013.07.003 · 2013 · External reference
Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways
10.3389/fphys.2014.00099 · 2014 · External reference
Functional and structural adaptations of skeletal muscle to microgravity
10.1242/jeb.204.18.3201 · 2001 · External reference
Myonuclear domain and myosin phenotype in human soleus after bed rest with or without loading
10.1152/jappl.1999.87.5.1776 · 1999 · External reference
Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy
10.1016/s0092-8674(04)00400-3 · 2004 · External reference
IKKbeta/NF-kappaB activation causes severe muscle wasting in mice
10.1016/j.cell.2004.09.027 · 2004 · External reference
Glucocorticoid-induced skeletal muscle atrophy
10.1016/j.biocel.2013.05.036 · 2013 · External reference
Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size
10.1152/ajpcell.00105.2009 · 2009 · External reference
Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo
10.1038/ncb1101-1014 · 2001 · External reference
Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases
10.1096/fj.06-6604com · 2007 · External reference
Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
10.1096/fj.03-0610com · 2004 · External reference
Global transcriptomic analysis suggests carbon dioxide as an environmental stressor in spaceflight: A systems biology GeneLab case study
10.1038/s41598-018-22613-1 · 2018 · External reference
Benchmark and integration of resources for the estimation of human transcription factor activities
10.1101/gr.240663.118 · 2019 · External reference
decoupleR: ensemble of computational methods to infer biological activities from omics data
2022 · External reference
Expanding the coverage of regulons from high-confidence prior knowledge for accurate estimation of transcription factor activities
10.1093/nar/gkad841 · 2023 · External reference
OmniPath: guidelines and gateway for literature-curated signaling pathway resources
10.1038/nmeth.4077 · 2016 · External reference
NASA GeneLab: interfaces for the exploration of space omics data
10.1093/nar/gkaa887 · 2021 · External reference
Spaceflight inhibits regenerative and structural responses to mechanical loading in mouse skeletal muscle
2021 · External reference
Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia
10.1038/s42003-021-01723-z · 2021 · External reference
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and remodelling during disuse
2024 · External reference
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
10.1093/nar/30.1.207 · 2002 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
PyDESeq2: a python package for bulk RNA-seq differential expression analysis
10.1093/bioinformatics/btad547 · 2023 · External reference
The molecular regulation of muscle stem cell function
10.1101/sqb.2008.73.064 · 2008 · External reference