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References from Ticagrelor and gut microbiota: Absence of pharmacokinetic interaction in vitro and in vivo studies. Local targets link to admitted publications; unresolved targets remain external evidence.
Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation
10.1111/j.1538-7836.2009.03527.x · 2009 · External reference
Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1
10.1177/1074248413511693 · 2014 · External reference
2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: A report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
10.1016/j.jtcvs.2016.07.044 · 2016 · External reference
Ticagrelor versus clopidogrel in patients with acute coronary syndromes
10.1056/nejmoa0904327 · 2009 · External reference
Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3
10.1080/09537100903075324 · 2009 · External reference
Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: A genetic substudy of the PLATO trial
10.1016/s0140-6736(10)61274-3 · 2010 · External reference
An evidence-based framework for evaluating pharmacogenomics knowledge for personalized medicine
10.1002/cpt.2350 · 2021 · External reference
Drug-microbiota interactions: An emerging priority for precision medicine
10.1038/s41392-023-01619-w · 2023 · External reference
Gut microbiota-mediated drug-antibiotic interactions
10.1124/dmd.115.063867 · 2015 · External reference
Sulphasalazine in ulcerative colitis: In memoriam?
10.1136/gut.32.5.462 · 1991 · External reference
Botanical characteristics, pharmacological effects and medicinal components of Korean Panax ginseng C A Meyer
10.1111/j.1745-7254.2008.00869.x · 2008 · External reference
The anaerobic metabolism of metronidazole forms N-(2-hydroxyethyl)-oxamic acid
10.1016/s0022-3565(25)31588-0 · 1979 · External reference
Personalized mapping of drug metabolism by the human gut microbiome
10.1016/j.cell.2020.05.001 · 2020 · External reference
Bioaccumulation of therapeutic drugs by human gut bacteria
10.1038/s41586-021-03891-8 · 2021 · External reference
The gut microbiome influences the bioavailability of olanzapine in rats
10.1016/j.ebiom.2021.103307 · 2021 · External reference
Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment
2022 · External reference
A practical guide to amplicon and metagenomic analysis of microbiome data
10.1007/s13238-020-00724-8 · 2021 · External reference
Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice
10.1073/pnas.1102938108 · 2011 · External reference
In vivo pharmacodynamic and pharmacokinetic effects of metformin mediated by the gut microbiota in rats
10.1016/j.lfs.2019.04.009 · 2019 · External reference
Regulation of hepatic P-gp expression and activity by genistein in rats
10.1007/s00204-020-02708-3 · 2020 · External reference
RNA-Seq profiling of intestinal expression of xenobiotic processing genes in germ-free mice
10.1124/dmd.117.077313 · 2017 · External reference
The influence of the gut microbiota on the bioavailability of oral drugs
10.1016/j.apsb.2020.09.013 · 2021 · External reference
