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References from Network toxicology, molecular docking and molecular dynamics simulations for bisphenol A neurotoxicity in depression pathogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
What do people need to know about endocrine disrupting chemicals and health? A mental models approach using focus groups of community-engaged research teams and a national survey
10.1186/s12889-025-25561-4 · 2025 · External reference
Endocrine-disrupting chemicals (EDCs) and cancer: New perspectives on an old relationship
10.1007/s40618-022-01983-4 · 2023 · External reference
Endocrine disrupting chemicals and male fertility: From physiological to molecular effects
10.3389/fpubh.2023.1232646 · 2023 · External reference
The effects of endocrine-disrupting chemicals on ovarian- and ovulation-related fertility outcomes
10.1002/mrd.23652 · 2022 · External reference
Endocrine disruptors and metabolic changes: Impact on puberty control
10.1016/j.eprac.2024.01.006 · 2024 · External reference
Impact of endocrine disrupting chemicals on neurodevelopment: The need for better testing strategies for endocrine disruption-induced developmental neurotoxicity
10.1080/17446651.2022.2044788 · 2022 · External reference
Exposure to endocrine-disrupting chemicals and implications for neurodevelopment
10.1111/dmcn.15551 · 2023 · External reference
Prenatal exposure to endocrine-disrupting chemicals in relation to autism spectrum disorder and intellectual disability
10.1097/ede.0000000000000983 · 2019 · External reference
Impact of endocrine-disrupting chemicals in breast milk on postpartum depression in Korean mothers
10.3390/ijerph18094444 · 2021 · External reference
Exposure to endocrine-disrupting compounds such as phthalates and bisphenol A is associated with an increased risk for obesity
10.1016/j.beem.2021.101546 · 2021 · External reference
Systematic review methodologies and endocrine disrupting chemicals: Improving evaluations of the plastic monomer bisphenol A
10.2174/1871530321666211005163614 · 2022 · External reference
Exposure of the U.S. population to bisphenol A and 4-tertiary-octylphenol: 2003-2004
10.1289/ehp.10753 · 2008 · External reference
Genotoxic potential of bisphenol A: A review
10.1016/j.envpol.2022.119346 · 2022 · External reference
Perinatal exposure to bisphenol A at the intersection of stress, anxiety, and depression
10.1016/j.ntt.2020.106884 · 2020 · External reference
Bisphenol A and its potential mechanism of action for reproductive toxicity
10.1016/j.tox.2024.154040 · 2025 · External reference
Bisphenol A and microglia: Could microglia be responsive to this environmental contaminant during neural development?
10.1152/ajpendo.00443.2017 · 2018 · External reference
Recent advances on bisphenol-A and endocrine disruptor effects on human prostate cancer
10.1016/j.mce.2017.02.045 · 2017 · External reference
Effects of Bisphenol A on the risk of developing obesity
10.3390/nu16213740 · 2024 · External reference
Ergosterol isolated from cloud ear mushroom (Auricularia polytricha) attenuates bisphenol A-induced BV2 microglial cell inflammation
10.1016/j.foodres.2022.111433 · 2022 · External reference
Bisphenol A exposure and symptoms of anxiety and depression among inner city children at 10-12 years of age
10.1016/j.envres.2016.07.028 · 2016 · External reference
Bisphenol A exposure and children’s behavior: A systematic review
10.1038/jes.2016.8 · 2017 · External reference
Bisphenol-A inhibits improvement of testosterone in anxiety- and depression-like behaviors in gonadectomied male mice
10.1016/j.yhbeh.2018.05.012 · 2018 · External reference
Major depression and its recurrences: Life course matters
10.1146/annurev-clinpsy-072220-021440 · 2022 · External reference
Depression
10.1016/s0095-4543(08)70003-4 · 1999 · External reference
Microglia in depression: An overview of microglia in the pathogenesis and treatment of depression
10.1186/s12974-022-02492-0 · 2022 · External reference
Long-term air pollution, genetic susceptibility, and the risk of depression and anxiety: A prospective study in the UK biobank cohort
10.1289/ehp10391 · 2023 · External reference
Long-term exposure to multiple ambient air pollutants and association with incident depression and anxiety
10.1001/jamapsychiatry.2022.4812 · 2023 · External reference
Environmental endocrine disruptors and depression in adolescence: A missing link?
10.1016/j.ecoenv.2025.119568 · 2026 · External reference
Network toxicology and its application to traditional Chinese medicine
2011 · External reference
Application and development trends of network toxicology in the safety assessment of traditional Chinese medicine
10.1016/j.jep.2025.119480 · 2025 · External reference
Network Toxicology and molecular docking strategy for analyzing the toxicity and mechanisms of bisphenol A in Alzheimer’s disease
2025 · External reference
Integrative systems toxicology to predict human biological systems affected by exposure to environmental chemicals
10.1016/j.taap.2020.115210 · 2020 · External reference
Use of molecular docking computational tools in drug discovery
10.1016/bs.pmch.2021.01.004 · 2021 · External reference
Exploring the molecular mechanism of action of Yinchen Wuling Powder for the treatment of hyperlipidemia, using network pharmacology, molecular docking, and molecular dynamics simulation
10.1155/2021/9965906 · 2021 · External reference
Expansion of the Gene Ontology knowledgebase and resources
2017 · External reference
Molecular docking: Shifting paradigms in drug discovery
10.3390/ijms20184331 · 2019 · External reference
Developmental myosins: Expression patterns and functional significance
10.1186/s13395-015-0046-6 · 2015 · External reference
Interaction of estrogen receptor β and negative life events in susceptibility to major depressive disorder in a Chinese Han female population
10.1016/j.jad.2016.08.083 · 2017 · External reference
Understanding insulin in the age of precision medicine and big data: Under-explored nature of genomics
10.3390/biom13020257 · 2023 · External reference
The expression of insulin in the central nervous system: What have we learned so far?
10.3390/ijms24076586 · 2023 · External reference
Insulin resistance, an unmasked culprit in depressive disorders: Promises for interventions
10.1016/j.neuropharm.2017.11.038 · 2018 · External reference
Insulin resistance in depression: A large meta-analysis of metabolic parameters and variation
10.1016/j.neubiorev.2022.104758 · 2022 · External reference
Biological basis of depression in adults with diabetes
10.1007/s11892-010-0148-9 · 2010 · External reference
Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats
10.1016/j.bbr.2013.10.011 · 2014 · External reference
Brain injury with diabetes mellitus: Evidence, mechanisms and treatment implications
10.1080/17512433.2017.1293521 · 2017 · External reference
A review of estrogen receptor alpha gene (ESR1) polymorphisms, mood, and cognition
10.1097/gme.0b013e3181df4a19 · 2010 · External reference
Estrogen levels, emotion regulation, and emotional symptoms of women with premenstrual dysphoric disorder: The moderating effect of estrogen receptor 1α polymorphism
10.1016/j.pnpbp.2017.11.013 · 2018 · External reference
Sex-specific association between polymorphisms in estrogen receptor alpha gene (ESR1) and depression: A genome-wide association study of all of Us and UK Biobank data
2025 · External reference
Alteration in estrogen receptor alpha mRNA levels in frontal cortex and hippocampus of patients with major mental illness
10.1016/j.biopsych.2005.04.047 · 2005 · External reference
Polymorphisms of estrogen receptors and risk of depression: Therapeutic implications
10.2165/11635960-000000000-00000 · 2012 · External reference
Estrogen receptor alpha gene variants and major depressive episodes
10.1016/j.jad.2011.10.010 · 2012 · External reference
Linkage mapping of serotonin transporter protein gene SLC6A4 on chromosome 17
10.1007/bf00209486 · 1995 · External reference
Organization of the human serotonin transporter gene
10.1007/bf01276434 · 1994 · External reference
Epigenetic variation at the SLC6A4 gene promoter in mother-child pairs with major depressive disorder
10.1016/j.jad.2018.10.369 · 2019 · External reference
The potential of SLC6A4 gene methylation analysis for the diagnosis and treatment of major depression
10.1016/j.jpsychires.2014.02.002 · 2014 · External reference
Factors related to age at depression onset: The role of SLC6A4 methylation, sex, exposure to stressful life events and personality in a sample of inpatients suffering from major depression
10.1186/s12888-021-03166-6 · 2021 · External reference
Evidence of biologic epistasis between BDNF and SLC6A4 and implications for depression
10.1038/mp.2008.32 · 2008 · External reference
Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory
10.1016/s0092-8674(03)00122-3 · 2003 · External reference
Mechanisms of ketamine action as an antidepressant
10.1038/mp.2017.255 · 2018 · External reference
Elevated GRIA1 mRNA expression in Layer II/III and V pyramidal cells of the DLPFC in schizophrenia
10.1016/j.schres.2007.09.022 · 2007 · External reference
Microglial-derived nitric oxide regulates amygdala synaptic plasticity to drive chronic pain and depression induced by lumbar disc herniation
10.1016/j.neuropharm.2025.110662 · 2025 · External reference
Advances in neurotransmitter-mediated prefrontal circuitry in depression
10.1016/j.pnpbp.2025.111475 · 2025 · External reference
Association of NTRK2 gene with suicidality: A meta-analysis
10.1097/ypg.0000000000000373 · 2024 · External reference
The role of BDNF, NTRK2 gene and their interaction in development of treatment-resistant depression: Data from multicenter, prospective, longitudinal clinic practice
10.1016/j.jpsychires.2012.10.003 · 2013 · External reference
Association between NTRK2 polymorphisms, hippocampal volumes and treatment resistance in major depressive disorder
10.3390/genes14112037 · 2023 · External reference
The CREB1-BDNF-NTRK2 pathway in depression: Multiple gene-cognition-environment interactions
10.1016/j.biopsych.2010.11.019 · 2011 · External reference
Synaptic dysfunction in depression: Potential therapeutic targets
10.1126/science.1222939 · 2012 · External reference
Altered synaptic homeostasis: A key factor in the pathophysiology of depression
10.1186/s13578-025-01369-y · 2025 · External reference
Eucommia ulmoides Oliver-Tribulus terrestris L. Drug Pair Regulates Ferroptosis by Mediating the Neurovascular-Related Ligand-Receptor Interaction Pathway- A Potential Drug Pair for Treatment Hypertension and Prevention Ischemic Stroke
10.3389/fneur.2022.833922 · 2022 · External reference
