Research graph
References from Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2013 · External reference
Comparative analysis of the genomes.
10.1017/cbo9780511545313.003 · 2007 · External reference
Liquid-crystalline, phage-like packing of encapsidated DNA in herpes simplex virus
10.1016/0092-8674(91)90324-r · 1991 · External reference
Solid-to-fluid DNA transition inside HSV-1 capsid close to the temperature of infection
10.1038/nchembio.1628 · 2014 · External reference
Visualization of tegument-capsid interactions and DNA in intact herpes simplex virus type 1 virions
10.1128/jvi.73.4.3210-3218.1999 · 1999 · External reference
Structure of the herpes simplex virus portal-vertex
10.1371/journal.pbio.2006191 · 2018 · External reference
Cryo-EM structures of herpes simplex virus type 1 portal vertex and packaged genome
10.1038/s41586-019-1248-6 · 2019 · External reference
Comparative virion structures of human herpesviruses.
10.1017/cbo9780511545313.004 · 2007 · External reference
Compartmentalization of spermine and spermidine in the herpes simplex virion
10.1073/pnas.68.11.2818 · 1971 · External reference
Temporal association of the herpes simplex virus genome with histone proteins during a lytic infection
10.1128/jvi.00586-07 · 2008 · External reference
Herpes virus genome, the pressure is on
10.1021/ja404008r · 2013 · External reference
Microtubule-mediated transport of incoming herpes simplex virus 1 capsids to the nucleus
10.1083/jcb.136.5.1007 · 1997 · External reference
Herpes simplex virus type 1 entry into host cells: reconstitution of capsid binding and uncoating at the nuclear pore complex in vitro
10.1128/mcb.20.13.4922-4931.2000 · 2000 · External reference
The genome of HSV-1 translocates through the nuclear pore as a condensed rod-like structure
10.1242/jcs.02705 · 2006 · External reference
DNA virus uncoating
10.1016/j.virol.2015.01.024 · 2015 · External reference
Distinct temporal roles for the promyelocytic leukaemia (PML) protein in the sequential regulation of intracellular host immunity to HSV-1 infection
10.1371/journal.ppat.1006769 · 2018 · External reference
Spatiotemporal dynamics of HSV genome nuclear entry and compaction state transitions using bioorthogonal chemistry and super-resolution microscopy
10.1371/journal.ppat.1006721 · 2017 · External reference
Histone chaperone networks shaping chromatin function
10.1038/nrm.2016.159 · 2017 · External reference
The histone chaperoning pathway: from ribosome to nucleosome
10.1042/ebc20180055 · 2019 · External reference
Structural diversity of the nucleosome
10.1093/jb/mvx081 · 2018 · External reference
Molecular Complexes at Euchromatin, Heterochromatin and Centromeric Chromatin
10.3390/ijms22136922 · 2021 · External reference
Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail
10.1038/nrg2438 · 2008 · External reference
Dynamic modulation of HSV chromatin drives initiation of infection and provides targets for epigenetic therapies
10.1016/j.virol.2015.01.026 · 2015 · External reference
Snapshots: chromatin control of viral infection
10.1016/j.virol.2012.09.023 · 2013 · External reference
Strength in diversity: Understanding the pathways to herpes simplex virus reactivation
10.1016/j.virol.2018.07.011 · 2018 · External reference
Epigenetic and epitranscriptomic regulation of viral replication
10.1038/s41579-020-0382-3 · 2020 · External reference
Single-genome analysis reveals a heterogeneous association of the herpes simplex virus genome with H3K27me2 and the reader PHF20L1 following infection of human fibroblasts
10.1128/mbio.03278-23 · 2024 · External reference
ATRX promotes maintenance of herpes simplex virus heterochromatin during chromatin stress
10.7554/elife.40228 · 2018 · External reference
Temporal Viral Genome-Protein Interactions Define Distinct Stages of Productive Herpesviral Infection
10.1128/mbio.01182-18 · 2018 · External reference
The HSV-1 ubiquitin ligase ICP0: Modifying the cellular proteome to promote infection
10.1016/j.virusres.2020.198015 · 2020 · External reference
Regulation of alphaherpesvirus infections by the ICP0 family of proteins
10.1099/vir.0.048900-0 · 2013 · External reference
Host Intrinsic and Innate Intracellular Immunity During Herpes Simplex Virus Type 1 (HSV-1) Infection
10.3389/fmicb.2019.02611 · 2019 · External reference
PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1
10.1083/jcb.147.2.221 · 1999 · External reference
Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus
10.1093/emboj/17.1.61 · 1998 · External reference
The disruption of ND10 during herpes simplex virus infection correlates with the Vmw110- and proteasome-dependent loss of several PML isoforms
10.1128/jvi.72.8.6581-6591.1998 · 1998 · External reference
Herpes virus induced proteasome-dependent degradation of the nuclear bodies-associated PML and Sp100 proteins
10.1038/sj.onc.1202366 · 1999 · External reference
PML contributes to a cellular mechanism of repression of herpes simplex virus type 1 infection that is inactivated by ICP0
10.1128/jvi.00734-06 · 2006 · External reference
The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection
10.1371/journal.ppat.1007667 · 2019 · External reference
Dynamic Response of IFI16 and Promyelocytic Leukemia Nuclear Body Components to Herpes Simplex Virus 1 Infection
10.1128/jvi.02249-15 · 2015 · External reference
The histone variant H3.3 regulates gene expression during lytic infection with herpes simplex virus type 1
10.1128/jvi.01276-08 · 2009 · External reference
Regulation of ICP0-null mutant herpes simplex virus type 1 infection by ND10 components ATRX and hDaxx
10.1128/jvi.02597-09 · 2010 · External reference
Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity
10.1093/nar/gkx771 · 2017 · External reference
Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis
10.1371/journal.ppat.1007313 · 2018 · External reference
PML-NB-dependent type I interferon memory results in a restricted form of HSV latency
10.15252/embr.202152547 · 2021 · External reference
VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection
10.1128/jvi.78.18.9689-9696.2004 · 2004 · External reference
Regulation of histone deposition on the herpes simplex virus type 1 genome during lytic infection
10.1128/jvi.00219-09 · 2009 · External reference
Herpes simplex virus ICP0 promotes both histone removal and acetylation on viral DNA during lytic infection
10.1128/jvi.01575-08 · 2008 · External reference
The nucleosome: from genomic organization to genomic regulation
10.1016/s0092-8674(04)00044-3 · 2004 · External reference
DAXX-dependent supply of soluble (H3.3-H4) dimers to PML bodies pending deposition into chromatin
10.1101/gr.142703.112 · 2013 · External reference
Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization
10.4161/cc.26988 · 2014 · External reference
The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3
10.1101/gad.566910 · 2010 · External reference
Heterochromatin and ND10 are cell-cycle regulated and phosphorylation-dependent alternate nuclear sites of the transcription repressor Daxx and SWI/SNF protein ATRX
10.1242/jcs.01230 · 2004 · External reference
The ATRX syndrome protein forms a chromatin-remodeling complex with Daxx and localizes in promyelocytic leukemia nuclear bodies
10.1073/pnas.1937626100 · 2003 · External reference
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition
10.1038/nature11608 · 2012 · External reference
Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line
10.1083/jcb.106.3.761 · 1988 · External reference
Comparative proteomics identifies Schlafen 5 (SLFN5) as a herpes simplex virus restriction factor that suppresses viral transcription
10.1038/s41564-020-00826-3 · 2021 · External reference
Replication of ICP0-null mutant herpes simplex virus type 1 is restricted by both PML and Sp100
10.1128/jvi.02308-07 · 2008 · External reference
A novel transcription regulatory complex containing death domain-associated protein and the ATR-X syndrome protein
10.1074/jbc.m401321200 · 2004 · External reference
Uncoating the herpes simplex virus genome
10.1016/j.jmb.2007.05.023 · 2007 · External reference
Rapid visualization at high resolution of pathogens by atomic force microscopy: structural studies of herpes simplex virus-1
10.1016/s0002-9440(10)61145-5 · 2002 · External reference
Exceptional mechanical and structural stability of HSV-1 unveiled with fluid atomic force microscopy
10.1242/jcs.032284 · 2008 · External reference
During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription
10.1128/jvi.78.18.10178-10186.2004 · 2004 · External reference
Random cleavage of intranuclear herpes simplex virus DNA by micrococcal nuclease
10.1016/0014-5793(79)81141-2 · 1979 · External reference
The structure of herpes simplex virus type 1 DNA as probed by micrococcal nuclease digestion
10.1099/0022-1317-51-1-45 · 1980 · External reference
Intracellular organization of herpes simplex virus type 1 DNA assayed by staphylococcal nuclease sensitivity
10.1016/0168-1702(90)90053-e · 1990 · External reference
During lytic infections, herpes simplex virus type 1 DNA is in complexes with the properties of unstable nucleosomes
10.1128/jvi.01934-09 · 2010 · External reference
Herpes simplex viral nucleoprotein creates a competitive transcriptional environment facilitating robust viral transcription and host shut off
10.7554/elife.51109 · 2019 · External reference
ATRX limits the accessibility of histone H3-occupied HSV genomes during lytic infection
10.1371/journal.ppat.1009567 · 2021 · External reference
Single Cell Assay for Molecular Diagnostics and Medicine: Monitoring Intracellular Concentrations of Macromolecules by Two-photon Fluorescence Lifetime Imaging
10.7150/thno.11863 · 2015 · External reference
Osmotic pressure: resisting or promoting DNA ejection from phage?
10.1016/j.jmb.2008.05.081 · 2008 · External reference
Phenotype of a herpes simplex virus type 1 mutant that fails to express immediate-early regulatory protein ICP0
10.1128/jvi.78.4.1763-1774.2004 · 2004 · External reference
Dynamic Proteomics of Herpes Simplex Virus Infection
10.1128/mbio.01612-17 · 2017 · External reference
HSV-1 single-cell analysis reveals the activation of anti-viral and developmental programs in distinct sub-populations
10.7554/elife.46339 · 2019 · External reference
Selective recruitment of nuclear factors to productively replicating herpes simplex virus genomes
10.1371/journal.ppat.1004939 · 2015 · External reference
Replication-Coupled Recruitment of Viral and Cellular Factors to Herpes Simplex Virus Type 1 Replication Forks for the Maintenance and Expression of Viral Genomes
10.1371/journal.ppat.1006166 · 2017 · External reference
Genomic Profiling by ALaP-Seq Reveals Transcriptional Regulation by PML Bodies through DNMT3A Exclusion
10.1016/j.molcel.2020.04.004 · 2020 · External reference
Chromatin contributes to structural integrity of promyelocytic leukemia bodies through a SUMO-1-independent mechanism
10.1074/jbc.m312580200 · 2004 · External reference
Cytomegalovirus immediate-early 1 proteins form a structurally distinct protein class with adaptations determining cross-species barriers
10.1371/journal.ppat.1009863 · 2021 · External reference
The Role of ND10 Nuclear Bodies in Herpesvirus Infection: A Frenemy for the Virus?
10.3390/v13020239 · 2021 · External reference
A Herpesviral Lytic Protein Regulates the Structure of Latent Viral Chromatin
10.1128/mbio.00633-16 · 2016 · External reference
HSV-1 genome subnuclear positioning and associations with host-cell PML-NBs and centromeres regulate LAT locus transcription during latency in neurons
10.1371/journal.ppat.1002852 · 2012 · External reference
Latency Entry of Herpes Simplex Virus 1 Is Determined by the Interaction of Its Genome with the Nuclear Environment
10.1371/journal.ppat.1005834 · 2016 · External reference
Herpes simplex virus 1 DNA is in unstable nucleosomes throughout the lytic infection cycle, and the instability of the nucleosomes is independent of DNA replication
10.1128/jvi.01468-12 · 2012 · External reference
Chromatin dynamics and the transcriptional competence of HSV-1 genomes during lytic infections
2019 · External reference
New players in heterochromatin silencing: histone variant H3.3 and the ATRX/DAXX chaperone
10.1093/nar/gkw012 · 2016 · External reference
Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication
10.1128/jvi.00057-18 · 2018 · External reference
HistoneDB 2.0: a histone database with variants--an integrated resource to explore histones and their variants
10.1093/database/baw014 · 2016 · External reference
Virion factors that target Daxx to overcome intrinsic immunity
10.1128/jvi.00425-13 · 2013 · External reference
Novel Role for Protein Inhibitor of Activated STAT 4 (PIAS4) in the Restriction of Herpes Simplex Virus 1 by the Cellular Intrinsic Antiviral Immune Response
10.1128/jvi.03055-15 · 2016 · External reference
Host and viral determinants of Mx2 antiretroviral activity
10.1128/jvi.00214-14 · 2014 · External reference
PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication
10.1242/jcs.075390 · 2011 · External reference
Improved vectors and genome-wide libraries for CRISPR screening
10.1038/nmeth.3047 · 2014 · External reference
Isolation and characterization of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide Vmw110
10.1099/0022-1317-67-12-2571 · 1986 · External reference
Recruitment of herpes simplex virus type 1 transcriptional regulatory protein ICP4 into foci juxtaposed to ND10 in live, infected cells
10.1128/jvi.77.6.3680-3689.2003 · 2003 · External reference
pH reduction as a trigger for dissociation of herpes simplex virus type 1 scaffolds
10.1128/jvi.76.15.7407-7417.2002 · 2002 · External reference
A truncated form of herpes simplex virus type 1 immediate-early protein Vmw110 is expressed in a cell type dependent manner
10.1006/viro.1993.1651 · 1993 · External reference
Monoclonal antibodies to herpes simplex virus type 1 proteins, including the immediate-early protein ICP 4
10.1128/iai.34.3.684-692.1981 · 1981 · External reference
