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References from Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal loss. Local targets link to admitted publications; unresolved targets remain external evidence.
Microglial NF-kappaB drives tau spreading and toxicity in a mouse model of tauopathy
10.1038/s41467-022-29552-6 · 2022 · External reference
Microglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis
10.1016/j.neuron.2014.01.013 · 2014 · External reference
Microglia-specific knock-out of NF-kappaB/IKK2 increases the accumulation of misfolded alpha-synuclein through the inhibition of p62/sequestosome-1-dependent autophagy in the rotenone model of Parkinson’s disease
2023 · External reference
Prion infection of mouse brain reveals multiple new upregulated genes involved in neuroinflammation or signal transduction
10.1128/jvi.02952-14 · 2015 · External reference
Complement 3( )-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia
10.1186/s40478-019-0735-1 · 2019 · External reference
Comparative study of microglia activation induced by amyloid-beta and prion peptides: role in neurodegeneration
10.1002/jnr.20870 · 2006 · External reference
Non-cell autonomous astrocyte-mediated neuronal toxicity in prion diseases
10.1186/s40478-021-01123-8 · 2021 · External reference
Prion strain differences in accumulation of PrPSc on neurons and glia are associated with similar expression profiles of neuroinflammatory genes: comparison of three prion strains
10.1371/journal.ppat.1005551 · 2016 · External reference
Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice
10.1016/s0169-328x(99)00229-6 · 1999 · External reference
Core transcriptional regulatory circuits in prion diseases
10.1186/s13041-020-0551-3 · 2020 · External reference
Alterations in neuronal metabolism contribute to the pathogenesis of prion disease
10.1038/s41418-018-0148-x · 2018 · External reference
Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein
10.1111/j.1462-5822.2007.00950.x · 2007 · External reference
Prion propagation in mice lacking central nervous system NF-kappaB signalling
10.1099/vir.0.83622-0 · 2008 · External reference
Neurotoxic reactive astrocytes are induced by activated microglia
10.1038/nature21029 · 2017 · External reference
Complement and microglia mediate early synapse loss in Alzheimer mouse models
10.1126/science.aad8373 · 2016 · External reference
Neurotoxic reactive astrocytes induce cell death via saturated lipids
10.1038/s41586-021-03960-y · 2021 · External reference
Microglial regulation of immunological and neuroprotective functions of astroglia
10.1002/glia.22738 · 2015 · External reference
Inflammatory response of microglia to prions is controlled by sialylation of PrP(Sc)
10.1038/s41598-018-29720-z · 2018 · External reference
Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways
10.1042/bst20150014 · 2015 · External reference
NF-kappaB signaling in inflammation
10.1038/sigtrans.2017.23 · 2017 · External reference
Prion pathogenesis in the absence of NLRP3/ASC inflammasomes
10.1371/journal.pone.0117208 · 2015 · External reference
Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation
10.1002/glia.21070 · 2010 · External reference
Prion peptide uptake in microglial cells--the effect of naturally occurring autoantibodies against prion protein
10.1371/journal.pone.0067743 · 2013 · External reference
Phagocytic activities of reactive microglia and astrocytes associated with prion diseases are dysregulated in opposite directions
10.3390/cells10071728 · 2021 · External reference
Microglia have limited influence on early prion pathogenesis, clearance, or replication
10.1371/journal.pone.0276850 · 2022 · External reference
IKK beta is required for peripheral B cell survival and proliferation
10.4049/jimmunol.170.9.4630 · 2003 · External reference
Adipose-derived mesenchymal stromal cells decrease prion-induced glial inflammation in vitro
10.1038/s41598-022-26628-7 · 2022 · External reference
Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity
10.1186/s12974-017-0871-0 · 2017 · External reference
Roles of nuclear factor kappaB in neuronal survival and plasticity
10.1046/j.1471-4159.2000.740443.x · 2000 · External reference
Crosstalk in NF-κB signaling pathways
10.1038/ni.2065 · 2011 · External reference
CSF1R ligands IL-34 and CSF1 are differentially required for microglia development and maintenance in white and gray matter brain regions
10.3389/fimmu.2019.02199 · 2019 · External reference
A PrP EGFR signaling axis controls neural stem cell senescence through modulating cellular energy pathways
10.1016/j.jbc.2023.105319 · 2023 · External reference
Neuroinflammation, microglia, and cell-association during prion disease
10.3390/v11010065 · 2019 · External reference
Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected mice
10.1371/journal.ppat.1003002 · 2012 · External reference
Sustained translational repression by eIF2α-P mediates prion neurodegeneration
10.1038/nature11058 · 2012 · External reference
Intranasally delivered mesenchymal stromal cells decrease glial inflammation early in prion disease
10.3389/fnins.2023.1158408 · 2023 · External reference
Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked
10.1038/ncomms5347 · 2014 · External reference
Loss of homeostatic microglia signature in prion diseases
10.3390/cells11192948 · 2022 · External reference
Microglia are critical in host defense against prion disease
10.1128/jvi.00549-18 · 2018 · External reference
The role of glial cells in neurobiology and prion neuropathology
10.3390/cells13100832 · 2024 · External reference
Regulation of microglial proliferation during chronic neurodegeneration
10.1523/jneurosci.4440-12.2013 · 2013 · External reference
Interaction of microglia and astrocytes in the neurovascular unit
10.3389/fimmu.2020.01024 · 2020 · External reference
Ribosomal profiling during prion disease uncovers progressive translational derangement in glia but not in neurons
10.7554/elife.62911 · 2020 · External reference
Markers of A1 astrocytes stratify to molecular sub-types in sporadic Creutzfeldt-Jakob disease brain
10.1093/braincomms/fcaa029 · 2020 · External reference
Molecular mechanisms of prion pathogenesis
10.1146/annurev.pathmechdis.3.121806.154326 · 2008 · External reference
Loss of PIKfyve drives the spongiform degeneration in prion diseases
2021 · External reference
Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis
10.1126/science.1090187 · 2003 · External reference
Glial activation in prion diseases is selectively triggered by neuronal PrP(Sc)
2022 · External reference
Mice devoid of PrP are resistant to scrapie
10.1016/0092-8674(93)90360-3 · 1993 · External reference
Genome-wide transcriptomics identifies an early preclinical signature of prion infection
10.1371/journal.ppat.1008653 · 2020 · External reference
RNA-seq and network analysis reveal unique glial gene expression signatures during prion infection
10.1186/s13041-020-00610-8 · 2020 · External reference
Developmental expression of the prion protein gene in glial cells
10.1016/0896-6273(95)90307-0 · 1995 · External reference
Astrocyte-to-neuron intercellular prion transfer is mediated by cell-cell contact
10.1038/srep20762 · 2016 · External reference
The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation
2012 · External reference
Reactive astrocytes in prion diseases: Friend or foe?
10.1371/journal.ppat.1012286 · 2024 · External reference
Microglia regulate hippocampal neurogenesis during chronic neurodegeneration
10.1016/j.bbi.2015.11.001 · 2016 · External reference
A neuroprotective role for microglia in prion diseases
10.1084/jem.20151000 · 2016 · External reference
Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain
10.1002/glia.24244 · 2022 · External reference
Therapeutic effect of autologous compact bone-derived mesenchymal stem cell transplantation on prion disease
10.1099/jgv.0.000907 · 2017 · External reference
Effect of transplantation of bone marrow-derived mesenchymal stem cells on mice infected with prions
10.1128/jvi.00165-09 · 2009 · External reference
The role of microglia in prion diseases and possible therapeutic targets: a literature review
10.1080/19336896.2021.1991771 · 2021 · External reference
Inhibition of phagocytosis reduced the classical activation of BV2 microglia induced by amyloidogenic fragments of beta-amyloid and prion proteins
10.1093/abbs/gmt101 · 2013 · External reference
The origin and cell lineage of microglia: new concepts
10.1016/j.brainresrev.2006.11.002 · 2007 · External reference
Microglial cells in astroglial cultures: a cautionary note
10.1186/1742-2094-4-26 · 2007 · External reference
BCL2A1: the underdog in the BCL2 family
10.1038/cdd.2011.158 · 2012 · External reference
Innate immune responses after stimulation with Toll-like receptor agonists in ex vivo microglial cultures and an in vivo model using mice with reduced microglia
10.1186/s12974-021-02240-w · 2021 · External reference
TLR signaling tailors innate immune responses in human microglia and astrocytes
10.4049/jimmunol.175.7.4320 · 2005 · External reference
Microglia are required for astroglial Toll-like receptor 4 response and for optimal TLR2 and TLR3 response
10.1002/glia.22296 · 2012 · External reference
Toll-like receptor 2 confers partial neuroprotection during prion disease
10.1371/journal.pone.0208559 · 2018 · External reference
Accelerated prion disease pathogenesis in Toll-like receptor 4 signaling-mutant mice
10.1128/jvi.00522-08 · 2008 · External reference
Targeting neuroinflammation by pharmacologic downregulation of inflammatory pathways is neuroprotective in protein misfolding disorders
10.1021/acschemneuro.3c00846 · 2024 · External reference
Astrocyte-derived CCL2 is associated with m1 activation and recruitment of cultured microglial cells
10.1159/000443040 · 2016 · External reference
Glial-neuronal signaling mechanisms underlying the neuroinflammatory effects of manganese
10.1186/s12974-018-1349-4 · 2018 · External reference
Reactive astrocytes: production, function, and therapeutic potential
10.1016/j.immuni.2017.06.006 · 2017 · External reference
Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro
10.1016/j.bbi.2013.02.005 · 2013 · External reference
Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia
10.1016/j.jneuroim.2013.04.016 · 2013 · External reference
Cellular and molecular mechanisms of prion disease
10.1146/annurev-pathmechdis-012418-013109 · 2019 · External reference
Reactive microglia partially envelop viable neurons in prion diseases
10.1172/jci181169 · 2024 · External reference
Rapamycin delays disease onset and prevents PrP plaque deposition in a mouse model of Gerstmann-Straussler-Scheinker disease
10.1523/jneurosci.6189-11.2012 · 2012 · External reference
Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy-lysosome-dependent way
10.1007/s00430-013-0316-z · 2014 · External reference
Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells
10.1038/srep21658 · 2016 · External reference
SQSTM1/p62: a potential target for neurodegenerative disease
10.1021/acschemneuro.8b00516 · 2019 · External reference
p62/SQSTM1, a central but unexploited target: advances in its physiological/pathogenic functions and small molecular modulators
10.1021/acs.jmedchem.9b02038 · 2020 · External reference
The IKK complex contributes to the induction of autophagy
10.1038/emboj.2009.364 · 2010 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
10.1006/meth.2001.1262 · 2001 · External reference
Cell-based quantification of chronic wasting disease prions
10.1128/jvi.00633-10 · 2010 · External reference
