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References from Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists. Local targets link to admitted publications; unresolved targets remain external evidence.
Evidence for MR1 antigen presentation to mucosal-associated invariant T cells
10.1074/jbc.m501087200 · 2005 · External reference
Selection of evolutionarily conserved mucosal-associated invariant T cells by MR1
10.1038/nature01433 · 2003 · External reference
MR1 presents microbial vitamin B metabolites to MAIT cells
10.1038/nature11605 · 2012 · External reference
T-cell activation by transitory neo-antigens derived from distinct microbial pathways
10.1038/nature13160 · 2014 · External reference
Mucosal-associated invariant T (MAIT) cells: an evolutionarily conserved T cell subset
10.1016/j.micinf.2004.12.013 · 2005 · External reference
High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells
10.1111/imm.12461 · 2015 · External reference
Human mucosal associated invariant T cells detect bacterially infected cells
2010 · External reference
Antimicrobial activity of mucosal-associated invariant T cells
10.1038/ni.1890 · 2010 · External reference
MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage
10.1126/sciimmunol.aao2556 · 2018 · External reference
Multiple isomers of photolumazine V bind MR1 and differentially activate MAIT cells
10.4049/jimmunol.2300609 · 2024 · External reference
Human TRAV1-2-negative MR1-restricted T cells detect S. pyogenes and alternatives to MAIT riboflavin-based antigens
10.1038/ncomms12506 · 2016 · External reference
Mucosal-associated invariant T-cell activation and accumulation after in vivo infection depends on microbial riboflavin synthesis and co-stimulatory signals
10.1038/mi.2016.39 · 2017 · External reference
Microbial metabolites control the thymic development of mucosal-associated invariant T cells
10.1126/science.aaw2719 · 2019 · External reference
In vitro and in vivo analysis of the gram-negative bacteria-derived riboflavin precursor derivatives activating mouse MAIT cells
10.4049/jimmunol.1403224 · 2015 · External reference
Riboflavin metabolism variation among clinical isolates of Streptococcus pneumoniae results in differential activation of mucosal-associated invariant T cells
10.1165/rcmb.2017-0290oc · 2018 · External reference
Type I interferons drive MAIT cell functions against bacterial pneumonia
10.1084/jem.20230037 · 2023 · External reference
Human MAIT cells are rapidly activated by Aspergillus spp. in an APC-dependent manner. Eur
2018 · External reference
Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease
10.1073/pnas.2007472117 · 2020 · External reference
Augmentation of the Riboflavin-biosynthetic pathway enhances mucosa-associated invariant T (MAIT) cell activation and diminishes Mycobacterium tuberculosis Virulence
2021 · External reference
Modulation of riboflavin biosynthesis and utilization in mycobacteria
10.1128/spectrum.03207-23 · 2024 · External reference
Functional organization of the riboflavin biosynthesis operon from Bacillus subtilis SHgw
10.1007/bf00391014 · 1994 · External reference
An mRNA structure that controls gene expression by binding FMN
10.1073/pnas.212628899 · 2002 · External reference
Cofactor F420: an expanded view of its distribution, biosynthesis and roles in bacteria and archaea
10.1093/femsre/fuab021 · 2021 · External reference
Flavogenomics--a genomic and structural view of flavin-dependent proteins
10.1111/j.1742-4658.2011.08202.x · 2011 · External reference
Unexpected abundance of coenzyme F(420)-dependent enzymes in Mycobacterium tuberculosis and other actinobacteria
10.1128/jb.00425-10 · 2010 · External reference
The chemical synthesis, stability, and activity of MAIT cell prodrug agonists that access MR1 in recycling endosomes
10.1021/acschembio.9b00902 · 2020 · External reference
Immunodominant tuberculosis CD8 antigens preferentially restricted by HLA-B
10.1371/journal.ppat.0030127 · 2007 · External reference
Recognition of Vitamin B precursors and byproducts by mucosal associated invariant T cells
10.1074/jbc.r115.685990 · 2015 · External reference
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
10.1038/ncomms1060 · 2010 · External reference
Critical role of methylglyoxal and AGE in mycobacteria-induced macrophage apoptosis and activation
10.1371/journal.pone.0000029 · 2006 · External reference
The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide
10.1126/science.1091176 · 2003 · External reference
Alternative splicing of MR1 regulates antigen presentation to MAIT cells
10.1038/s41598-020-72394-9 · 2020 · External reference
Targeted gene knockout and essentiality testing by homologous recombination
10.1007/978-1-4939-2450-9_8 · 2015 · External reference
ORBIT: a new paradigm for genetic engineering of mycobacterial chromosomes
10.1128/mbio.01467-18 · 2018 · External reference
Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis
10.1128/jcm.29.11.2578-2586.1991 · 1991 · External reference
Methods for proteomic analyses of mycobacteria.
10.1007/978-1-0716-1460-0_23 · 2021 · External reference
Analysis of DIA proteomics data using MSFragger-DIA and FragPipe computational platform
10.1038/s41467-023-39869-5 · 2023 · External reference
Skyline: an open source document editor for creating and analyzing targeted proteomics experiments
10.1093/bioinformatics/btq054 · 2010 · External reference
Second generation multiple reaction monitoring assays for enhanced detection of ultra-low abundance Mycobacterium tuberculosis peptides in human serum
10.1186/s12014-017-9156-y · 2017 · External reference
Targeted metabolomics data for dimethyl-ribityl lumazine (DMRL) and riboflavin in Mycobacterium tuberculosis and Mycolicibacterium smegmatis mutants of the riboflavin biosynthetic pathway
2025 · External reference
Whole genome sequence data of Mycobacterium tuberculosis and Mycolicibacterium smegmatis mutants of the riboflavin biosynthetic pathway
2025 · External reference
Whole genome sequence data of Mycobacterium tuberculosis and Mycolicibacterium smegmatis mutants of the riboflavin biosynthetic pathway, version two [Dataset]. 2 ed
2025 · External reference
HLA-E-dependent presentation of Mtb-derived antigen to human CD8+ T cells
10.1084/jem.20020609 · 2002 · External reference
