Research graph
References from CD24-Fc resolves inflammation and enhances anti-HIV CD8 T cells with polyfunctionality during HIV-1 infection under cART. Local targets link to admitted publications; unresolved targets remain external evidence.
Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study
10.1016/s0140-6736(19)30418-0 · 2019 · External reference
Viral suppression and HIV transmission in serodiscordant male couples: an international, prospective, observational, cohort study
10.1016/s2352-3018(18)30132-2 · 2018 · External reference
Residual inflammation and viral reservoirs: alliance against an HIV cure
10.1097/coh.0000000000000230 · 2016 · External reference
Long-term increase in CD4+ T-cell counts during combination antiretroviral therapy for HIV-1 infection
10.1097/qad.0b013e32833adbcf · 2010 · External reference
Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment
10.1086/597093 · 2009 · External reference
CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression
10.1086/510746 · 2007 · External reference
Relationship between CD4+ T-cell counts/HIV-1 RNA plasma viral load and AIDS-defining events among persons followed in the ACTG longitudinal linked randomized trials study
10.1097/qai.0b013e3181e8c129 · 2010 · External reference
CD4+ count and risk of non-AIDS diseases following initial treatment for HIV infection
10.1097/qad.0b013e3282f7cb76 · 2008 · External reference
Immunologic failure despite suppressive antiretroviral therapy is related to activation and turnover of memory CD4 cells
10.1093/infdis/jir507 · 2011 · External reference
Immune Activation, Inflammation, and Non-AIDS Co-Morbidities in HIV-Infected Patients under Long-Term ART
10.3390/v11030200 · 2019 · External reference
Serious Non-AIDS Events: Therapeutic Targets of Immune Activation and Chronic Inflammation in HIV Infection
10.1007/s40265-016-0546-7 · 2016 · External reference
Serious Non-AIDS events: Immunopathogenesis and interventional strategies
10.1186/1742-6405-10-29 · 2013 · External reference
A Matter of Life or Death: Productively Infected and Bystander CD4 T Cells in Early HIV Infection
10.3389/fimmu.2020.626431 · 2021 · External reference
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
10.1038/nature12940 · 2014 · External reference
10.1186/1742-4690-1-12 · 2004 · Admitted local publication
Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes
10.1038/nm0295-129 · 1995 · External reference
HIV-1-mediated apoptosis of neuronal cells: Proximal molecular mechanisms of HIV-1-induced encephalopathy
10.1073/pnas.0304859101 · 2004 · External reference
Effects of antiretroviral drugs on human immunodeficiency virus type 1-induced CD4(+) T-cell death
10.1128/jvi.76.12.5966-5973.2002 · 2002 · External reference
NLRP3 inflammasome induces CD4+ T cell loss in chronically HIV-1-infected patients
10.1172/jci138861 · 2021 · External reference
Nonalcoholic Fatty Liver Disease Among Individuals with HIV Mono-infection: A Growing Concern?
10.1007/s10620-019-05861-7 · 2019 · External reference
Changing concepts of HIV infection and renal disease
10.1097/mnh.0000000000000400 · 2018 · External reference
Inflammatory responses and inflammation-associated diseases in organs
10.18632/oncotarget.23208 · 2017 · External reference
The inflammatory response to cell death
10.1146/annurev.pathmechdis.3.121806.151456 · 2008 · External reference
CD24 and Siglec-10 selectively repress tissue damage-induced immune responses
10.1126/science.1168988 · 2009 · External reference
Alarmin(g) news about danger: workshop on innate danger signals and HMGB1
10.1038/sj.embor.7400759 · 2006 · External reference
Release mechanisms of major DAMPs
10.1007/s10495-021-01663-3 · 2021 · External reference
Immunomodulatory and Anti-Inflammatory Strategies to Reduce Comorbidity Risk in People with HIV
10.1007/s11904-020-00509-y · 2020 · External reference
Targeting type I interferon-mediated activation restores immune function in chronic HIV infection
10.1172/jci89488 · 2017 · External reference
Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs
10.1172/jci90745 · 2017 · External reference
Type I interferons suppress viral replication but contribute to T cell depletion and dysfunction during chronic HIV-1 infection
10.1172/jci.insight.94366 · 2017 · External reference
Plasmacytoid dendritic cells suppress HIV-1 replication but contribute to HIV-1 induced immunopathogenesis in humanized mice
2014 · External reference
CD24Fc protects against viral pneumonia in simian immunodeficiency virus-infected Chinese rhesus monkeys
10.1038/s41423-020-0452-5 · 2020 · External reference
CD24 and Fc fusion protein protects SIVmac239-infected Chinese rhesus macaque against progression to AIDS
10.1016/j.antiviral.2018.07.004 · 2018 · External reference
A phase 2 trial of CD24Fc for prevention of graft-versus-host disease
10.1182/blood.2023020250 · 2024 · External reference
Treatment with soluble CD24 attenuates COVID-19-associated systemic immunopathology
10.1186/s13045-021-01222-y · 2022 · External reference
Identification of pathogenic TRAIL-expressing innate immune cells during HIV-1 infection in humanized mice by scRNA-Seq
2020 · External reference
Pathogenic Role of Type I Interferons in HIV-Induced Immune Impairments in Humanized Mice
10.1007/s11904-019-00444-7 · 2019 · External reference
Specific Activation In Vivo of HIV-1 by a Bromodomain Inhibitor from Monocytic Cells in Humanized Mice under Antiretroviral Therapy
2019 · External reference
Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway
10.1371/journal.ppat.1006819 · 2018 · External reference
TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs
10.1172/jci99005 · 2018 · External reference
Humanized Mice Engrafted With Human HSC Only or HSC and Thymus Support Comparable HIV-1 Replication, Immunopathology, and Responses to ART and Immune Therapy
10.3389/fimmu.2018.00817 · 2018 · External reference
HIV-1 infection depletes human CD34+CD38- hematopoietic progenitor cells via pDC-dependent mechanisms
2017 · External reference
Regulatory T Cells Contribute to HIV-1 Reservoir Persistence in CD4+ T Cells Through Cyclic Adenosine Monophosphate-Dependent Mechanisms in Humanized Mice In Vivo
10.1093/infdis/jix547 · 2017 · External reference
Human innate responses and adjuvant activity of TLR ligands in vivo in mice reconstituted with a human immune system
10.1016/j.vaccine.2017.09.052 · 2017 · External reference
Adaptive mutations in the V3 loop of gp120 enhance fusogenicity of human immunodeficiency virus type 1 and enable use of a CCR5 coreceptor that lacks the amino-terminal sulfated region
10.1128/jvi.75.24.12266-12278.2001 · 2001 · External reference
Dissecting How CD4 T Cells Are Lost During HIV Infection
10.1016/j.chom.2016.02.012 · 2016 · External reference
Failure to reconstitute CD4+ T-cells despite suppression of HIV replication under HAART
2006 · External reference
The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options
10.1086/695852 · 2009 · External reference
Programmed death-1 is a marker for abnormal distribution of naive/memory T cell subsets in HIV-1 infection
10.4049/jimmunol.1200646 · 2013 · External reference
Follicular CXCR5- expressing CD8(+) T cells curtail chronic viral infection
10.1038/nature19317 · 2016 · External reference
HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
10.1073/pnas.0611244104 · 2007 · External reference
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T cells
10.1182/blood-2005-12-4818 · 2006 · External reference
CXCR5(+) follicular cytotoxic T cells control viral infection in B cell follicles
10.1038/ni.3543 · 2016 · External reference
HIV-1 immunopathogenesis in humanized mouse models
10.1038/cmi.2012.7 · 2012 · External reference
Efficient infection, activation, and impairment of pDCs in the BM and peripheral lymphoid organs during early HIV-1 infection in humanized rag2⁻/⁻γ C⁻/⁻ mice in vivo
10.1182/blood-2011-01-331173 · 2011 · External reference
FoxP3+CD4+ regulatory T cells play an important role in acute HIV-1 infection in humanized Rag2-/-gammaC-/- mice in vivo
10.1182/blood-2008-03-145946 · 2008 · External reference
Humanized immune system mouse models: progress, challenges and opportunities
10.1038/s41590-019-0416-z · 2019 · External reference
Regulatory T cells prevent liver fibrosis during HIV type 1 infection in a humanized mouse model
10.1093/infdis/jit548 · 2014 · External reference
Type I interferons and TGF-β cooperate to induce liver fibrosis during HIV-1 infection under antiretroviral therapy
10.1172/jci.insight.152738 · 2022 · External reference
CD24-Siglec interactions in inflammatory diseases
10.3389/fimmu.2023.1174789 · 2023 · External reference
Efficacy and safety of CD24Fc in hospitalised patients with COVID-19: a randomised, double-blind, placebo-controlled, phase 3 study
10.1016/s1473-3099(22)00058-5 · 2022 · External reference
CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy
10.1038/s41586-019-1456-0 · 2019 · External reference
CD24Fc ameliorates immune-related adverse events while preserving anti-tumor therapeutic effect
10.1038/s41392-022-01030-x · 2022 · External reference
Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue
10.1016/j.cell.2010.11.001 · 2010 · External reference
Mechanisms of apoptosis induction by the HIV-1 envelope
10.1038/sj.cdd.4401584 · 2005 · External reference
Necroptosis takes place in human immunodeficiency virus type-1 (HIV-1)-infected CD4+ T lymphocytes
2014 · External reference
Human immunodeficiency virus-1 (HIV-1)-mediated apoptosis: new therapeutic targets
10.3390/v6083181 · 2014 · External reference
Activation-associated necrosis in human immunodeficiency virus infection
10.1086/314594 · 1999 · External reference
Host and Viral Factors in HIV-Mediated Bystander Apoptosis
10.3390/v9080237 · 2017 · External reference
Potential effects of HMGB1 on viral replication and virus infection-induced inflammatory responses: A promising therapeutic target for virus infection-induced inflammatory diseases
10.1016/j.cytogfr.2021.08.003 · 2021 · External reference
HMGB1 Is Involved in IFN-α Production and TRAIL Expression by HIV-1-Exposed Plasmacytoid Dendritic Cells: Impact of the Crosstalk with NK Cells
10.1371/journal.ppat.1005407 · 2016 · External reference
Circulating levels of HMGB1 are correlated strongly with MD2 in HIV-infection: possible implication for TLR4-signalling and chronic immune activation
10.1177/1753425912461042 · 2013 · External reference
HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells
10.1158/0008-5472.can-13-2347 · 2014 · External reference
Functions and therapeutic targets of Siglec-mediated infections, inflammations and cancers
10.1016/j.jfma.2019.10.019 · 2021 · External reference
Siglec-10 expression is up-regulated in activated human CD4+ T cells
10.1016/j.humimm.2020.01.009 · 2020 · External reference
Relationship between T cell activation and CD4+ T cell count in HIV-seropositive individuals with undetectable plasma HIV RNA levels in the absence of therapy
10.1086/524143 · 2008 · External reference
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells
10.1371/journal.pbio.0020198 · 2004 · External reference
HIV-1 infection and pathogenesis in a novel humanized mouse model
10.1182/blood-2006-07-033159 · 2007 · External reference
Broadly neutralizing antibodies and viral inducers decrease rebound from HIV-1 latent reservoirs in humanized mice
10.1016/j.cell.2014.07.043 · 2014 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
