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References from Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease. Local targets link to admitted publications; unresolved targets remain external evidence.
A Review of Scrub Typhus (Orientia tsutsugamushi and Related Organisms): Then, Now, and Tomorrow
10.3390/tropicalmed3010008 · 2018 · External reference
Scrub typhus and tropical rickettsioses
10.1097/00001432-200310000-00009 · 2003 · External reference
A review of the global epidemiology of scrub typhus
2017 · External reference
Endemic Scrub Typhus in South America
10.1056/nejmoa1603657 · 2016 · External reference
Scrub Typhus in Continental Chile, 2016-20181
10.3201/eid2506.181860 · 2019 · External reference
Molecular Description of a Novel Orientia Species Causing Scrub Typhus in Chile
10.3201/eid2609.200918 · 2020 · External reference
Isolation of a novel Orientia species (O. chuto sp. nov.) from a patient infected in Dubai
10.1128/jcm.01526-10 · 2010 · External reference
The Orientia tsutsugamushi genome reveals massive proliferation of conjugative type IV secretion system and host-cell interaction genes
10.1073/pnas.0611553104 · 2007 · External reference
The Whole-genome sequencing of the obligate intracellular bacterium Orientia tsutsugamushi revealed massive gene amplification during reductive genome evolution
10.1093/dnares/dsn011 · 2008 · External reference
Long-read whole genome sequencing and comparative analysis of six strains of the human pathogen Orientia tsutsugamushi
2018 · External reference
Orientia tsutsugamushi: comprehensive analysis of the mobilome of a highly fragmented and repetitive genome reveals the capacity for ongoing lateral gene transfer in an obligate intracellular bacterium
10.1128/msphere.00268-23 · 2023 · External reference
Orientia tsutsugamushi ankyrin repeat-containing protein family members are Type 1 secretion system substrates that traffic to the host cell endoplasmic reticulum
10.3389/fcimb.2014.00186 · 2015 · External reference
Orientia tsutsugamushi Strain Ikeda Ankyrin Repeat-Containing Proteins Recruit SCF1 Ubiquitin Ligase Machinery via Poxvirus-Like F-Box Motifs
10.1128/jb.00276-15 · 2015 · External reference
Orientia tsutsugamushi Ank9 is a multifunctional effector that utilizes a novel GRIP-like Golgi localization domain for Golgi-to-endoplasmic reticulum trafficking and interacts with host COPB2
10.1111/cmi.12727 · 2017 · External reference
Orientia tsutsugamushi uses two Ank effectors to modulate NF-κB p65 nuclear transport and inhibit NF-κB transcriptional activation
10.1371/journal.ppat.1007023 · 2018 · External reference
Orientia tsutsugamushi Nucleomodulin Ank13 Exploits the RaDAR Nuclear Import Pathway To Modulate Host Cell Transcription
10.1128/mbio.01816-21 · 2021 · External reference
Orientia tsutsugamushi modulates cellular levels of NF-κB inhibitor p105
10.1371/journal.pntd.0009339 · 2021 · External reference
The obligate intracellular bacterium Orientia tsutsugamushi differentiates into a developmentally distinct extracellular state
10.1038/s41467-022-31176-9 · 2022 · External reference
Exploitation of the endocytic pathway by Orientia tsutsugamushi in nonprofessional phagocytes
10.1128/iai.01620-05 · 2006 · External reference
Microtubule- and dynein-mediated movement of Orientia tsutsugamushi to the microtubule organizing center
10.1128/iai.69.1.494-500.2001 · 2001 · External reference
The intracellular bacterium Orientia tsutsugamushi hijacks the adaptor protein BICD2 for dynein-based motility
2024 · External reference
Intracellular localization of Rickettsia tsutsugamushi in polymorphonuclear leukocytes
10.1084/jem.150.3.703 · 1979 · External reference
Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen
10.1038/s41467-020-17094-8 · 2020 · External reference
10.1371/journal.pone.0054570
10.1371/journal.pone.0054570 · 2013 · External reference
Comparative susceptibility to mouse interferons of Rickettsia tsutsugamushi strains with different virulence in mice and of Rickettsia rickettsii
10.1128/iai.59.11.4134-4141.1991 · 1991 · External reference
Differential cellular immune responses against Orientia tsutsugamushi Karp and Gilliam strains following acute infection in mice
10.1371/journal.pntd.0011445 · 2023 · External reference
Phylogenetic analysis of Orientia tsutsugamushi strains based on the sequence homologies of 56-kDa type-specific antigen genes
10.1111/j.1574-6968.1999.tb08791.x · 1999 · External reference
Studies on scrib typhus; tsutsugamushi disease; heterogenicity of strains of R. tsutsugamushi as demonstrated by cross-vaccination studies
1948 · External reference
Genetic typing of the 56-kDa type-specific antigen gene of contemporary Orientia tsutsugamushi isolates causing human scrub typhus at two sites in north-eastern and western Thailand
10.1111/j.1574-695x.2007.00375.x · 2008 · External reference
Isolation of Rickettsia tsutsugamushi antigenically different from Kato, Karp, and Gilliam strains from patients
10.1111/j.1348-0421.1984.tb00743.x · 1984 · External reference
Clinical response of silvered leaf monkeys (Presbytis cristatus) to infection with strains of Rickettsia tsutsugamushi virulent and avirulent for mice
10.1093/infdis/134.2.193 · 1976 · External reference
Genomic bacterial load associated with bacterial genotypes and clinical characteristics in patients with scrub typhus in Hainan Island, Southern China
10.1371/journal.pntd.0011243 · 2023 · External reference
Differences in clinical features according to Boryoung and Karp genotypes of Orientia tsutsugamushi
2011 · External reference
Subversion of host cell signaling by Orientia tsutsugamushi
10.1016/j.micinf.2011.03.003 · 2011 · External reference
Scrub Typhus Pathogenesis: Innate Immune Response and Lung Injury During Orientia tsutsugamushi Infection
10.3389/fmicb.2019.02065 · 2019 · External reference
Multiple Orientia clusters and Th1-skewed chemokine profile: a cross-sectional study in patients with scrub typhus from Nepal
10.1016/j.ijid.2022.12.022 · 2023 · External reference
Cytokine network in scrub typhus: high levels of interleukin-8 are associated with disease severity and mortality
10.1371/journal.pntd.0002648 · 2014 · External reference
Increased level and interferon-γ production of circulating natural killer cells in patients with scrub typhus
2017 · External reference
Increased levels of macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha in sera of patients with Orientia tsutsugamushi infection
10.1128/jcm.35.12.3320-3322.1997 · 1997 · External reference
Differential expression of interferon-gamma and interferon-gamma-inducing cytokines in Thai patients with scrub typhus or leptospirosis
10.1016/j.clim.2004.08.006 · 2004 · External reference
Significant Growth by Rickettsia Species within Human Macrophage-Like Cells Is a Phenotype Correlated with the Ability to Cause Disease in Mammals
10.3390/pathogens10020228 · 2021 · External reference
Differences in Intracellular Fate of Two Spotted Fever Group Rickettsia in Macrophage-Like Cells
10.3389/fcimb.2016.00080 · 2016 · External reference
Lack of the IFN-γ signal leads to lethal Orientia tsutsugamushi infection in mice with skin eschar lesions
10.1371/journal.ppat.1012020 · 2024 · External reference
Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis
10.1038/s41564-020-0673-5 · 2020 · External reference
Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis
10.7554/elife.67029 · 2021 · External reference
Prevalence and Phylogenetic Analysis of Orientia tsutsugamushi in Small Mammals in Hanoi, Vietnam
10.1089/vbz.2015.1831 · 2016 · External reference
Detection of Orientia sp. DNA in rodents from Asia, West Africa and Europe
10.1186/s13071-015-0784-7 · 2015 · External reference
Epidemiological survey of Orientia tsutsugamushi distribution in field rodents in Saitama Prefecture, Japan, and discovery of a new type
10.1111/j.1348-0421.2001.tb02643.x · 2001 · External reference
Attempts to infect and demonstrate transovarial transmission of R. tsutsugamushi in three species of Leptotrombidium mites
10.1111/j.1749-6632.1975.tb35090.x · 1975 · External reference
The evolutionary origin of host association in the Rickettsiales
10.1038/s41564-022-01169-x · 2022 · External reference
Metagenome diversity illuminates origins of pathogen effectors
2023 · External reference
Targeted capture and sequencing of Orientia tsutsugamushi genomes from chiggers and humans
10.1016/j.meegid.2021.104818 · 2021 · External reference
Detection of Orientia spp. Bacteria in Field-Collected Free-Living Eutrombicula Chigger Mites, United States
10.3201/eid2908.230528 · 2023 · External reference
Orientia tsutsugamushi: analysis of the mobilome of a highly fragmented and repetitive genome reveals ongoing lateral gene transfer in an obligate intracellular bacterium
2023 · External reference
Improved Quantification, Propagation, Purification and Storage of the Obligate Intracellular Human Pathogen Orientia tsutsugamushi
10.1371/journal.pntd.0004009 · 2015 · External reference
Unresolved reference
2025 · External reference
