Research graph
References from Mobilization of nuclear antiviral factors by exportin XPO1 via the actin network inhibits RNA virus replication. Local targets link to admitted publications; unresolved targets remain external evidence.
The dependence of viral RNA replication on co-opted host factors
10.1038/nrmicro2692 · 2011 · External reference
(+)RNA viruses rewire cellular pathways to build replication organelles
10.1016/j.coviro.2012.09.006 · 2012 · External reference
Dissecting the molecular network of virus-plant interactions: the complex roles of host factors
10.1146/annurev-phyto-080614-120001 · 2015 · External reference
Host factors in coronavirus replication
2018 · External reference
Plant translation factors and virus resistance
10.3390/v7072778 · 2015 · External reference
Positive-strand RNA viruses stimulate host phosphatidylcholine synthesis at viral replication sites
10.1073/pnas.1519730113 · 2016 · External reference
Host ESCRT proteins are required for bromovirus RNA replication compartment assembly and function
10.1371/journal.ppat.1004742 · 2015 · External reference
Hepatitis C virus: Enslavement of host factors
10.1002/iub.1702 · 2018 · External reference
Susceptibility genes to plant viruses
10.3390/v10090484 · 2018 · External reference
Hijacking of host cellular components as proviral factors by plant-infecting viruses
10.1016/bs.aivir.2020.04.002 · 2020 · External reference
Autophagy is an essential component of Drosophila immunity against vesicular stomatitis virus
10.1016/j.immuni.2009.02.009 · 2009 · External reference
The broad-spectrum antiviral functions of IFIT and IFITM proteins
10.1038/nri3344 · 2013 · External reference
Cell-based genomic screening: elucidating virus-host interactions
10.1016/j.coviro.2012.10.007 · 2012 · External reference
Tombusvirus-yeast interactions identify conserved cell-intrinsic viral restriction factors
10.3389/fpls.2014.00383 · 2014 · External reference
The roles of host factors in tombusvirus RNA recombination
10.1016/b978-0-12-385885-6.00008-0 · 2011 · External reference
Exploitation of a surrogate host, Saccharomyces cerevisiae, to identify cellular targets and develop novel antiviral approaches
10.1016/j.coviro.2017.07.031 · 2017 · External reference
Tombusviruses orchestrate the host endomembrane system to create elaborate membranous replication organelles
10.1016/j.coviro.2021.03.007 · 2021 · External reference
Co-opted membranes, lipids, and host proteins: what have we learned from tombusviruses?
10.1016/j.coviro.2022.101258 · 2022 · External reference
Interviral Recombination between Plant, Insect, and Fungal RNA Viruses: Role of the Intracellular Ca2+/Mn2+ Pump
10.1128/jvi.01015-19 · 2019 · External reference
Screening bacterial effectors and human virus proteins in yeast to identify host factors driving tombusvirus RNA recombination: a role for autophagy and membrane phospholipid content
10.1128/jvi.01661-24 · 2025 · External reference
Host protein chaperones, RNA helicases and the ubiquitin network highlight the arms race for resources between tombusviruses and their hosts
10.1016/bs.aivir.2020.06.006 · 2020 · External reference
Tombusvirus-host interactions: co-opted evolutionarily conserved host factors take center court
10.1146/annurev-virology-110615-042312 · 2016 · External reference
Co-opted Cellular Sac1 Lipid Phosphatase and PI(4)P phosphoinositide are key host factors during the biogenesis of the tombusvirus replication compartment
10.1128/jvi.01979-19 · 2020 · External reference
RNA virus replication depends on enrichment of phosphatidylethanolamine at replication sites in subcellular membranes
2015 · External reference
Recruitment of Vps34 PI3K and enrichment of PI3P phosphoinositide in the viral replication compartment is crucial for replication of a positive-strand RNA virus
10.1371/journal.ppat.1007530 · 2019 · External reference
The retromer is co-opted to deliver lipid enzymes for the biogenesis of lipid-enriched tombusviral replication organelles
10.1073/pnas.2016066118 · 2021 · External reference
Coordinated function of cellular DEAD-box helicases in suppression of viral RNA recombination and maintenance of viral genome integrity
10.1371/journal.ppat.1004680 · 2015 · External reference
Noncanonical role for the host Vps4 AAA+ ATPase ESCRT protein in the formation of Tomato bushy stunt virus replicase
10.1371/journal.ppat.1004087 · 2014 · External reference
A Co-Opted DEAD-Box RNA helicase enhances tombusvirus plus-strand synthesis
10.1371/journal.ppat.1002537 · 2012 · External reference
A temperature sensitive mutant of heat shock protein 70 reveals an essential role during the early steps of tombusvirus replication
10.1016/j.virol.2009.08.003 · 2009 · External reference
A key role for heat shock protein 70 in the localization and insertion of tombusvirus replication proteins to intracellular membranes
10.1128/jvi.02313-08 · 2009 · External reference
In vitro assembly of the Tomato bushy stunt virus replicase requires the host Heat shock protein 70
10.1073/pnas.0810851105 · 2008 · External reference
Synergistic roles of eukaryotic translation elongation factors 1Bγ and 1A in stimulation of tombusvirus minus-strand synthesis
10.1371/journal.ppat.1002438 · 2011 · External reference
Role reversal of functional identity in host factors: Dissecting features affecting pro-viral versus antiviral functions of cellular DEAD-box helicases in tombusvirus replication
2020 · External reference
Global genomics and proteomics approaches to identify host factors as targets to induce resistance against Tomato bushy stunt virus
10.1016/s0065-3527(10)76004-8 · 2010 · External reference
Yeast as a model host to explore plant virus-host interactions
10.1146/annurev.phyto.121407.093958 · 2008 · External reference
Advances in the molecular biology of tombusviruses: gene expression, genome replication, and recombination
10.1016/s0079-6603(04)78005-8 · 2004 · External reference
Proteome-wide overexpression of host proteins for identification of factors affecting tombusvirus RNA replication: an inhibitory role of protein kinase C
10.1128/jvi.00019-12 · 2012 · External reference
Cpr1 cyclophilin and Ess1 parvulin prolyl isomerases interact with the tombusvirus replication protein and inhibit viral replication in yeast model host
10.1016/j.virol.2010.07.022 · 2010 · External reference
Translation elongation factor 1A is a component of the tombusvirus replicase complex and affects the stability of the p33 replication co-factor
10.1016/j.virol.2008.11.041 · 2009 · External reference
Cdc34p ubiquitin-conjugating enzyme is a component of the tombusvirus replicase complex and ubiquitinates p33 replication protein
10.1128/jvi.00702-08 · 2008 · External reference
Yeast genome-wide screen reveals dissimilar sets of host genes affecting replication of RNA viruses
10.1073/pnas.0502604102 · 2005 · External reference
The nuclear export protein XPO1 - from biology to targeted therapy
10.1038/s41571-020-00442-4 · 2021 · External reference
Mechanistic insights from the recent structures of the CRM1 nuclear export complex and its disassembly intermediate
10.2142/biophysics.8.145 · 2012 · External reference
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning
10.7554/elife.11466 · 2015 · External reference
CRM1-mediated nuclear export: to the pore and beyond
10.1016/j.tcb.2007.02.003 · 2007 · External reference
Ran-dependent nuclear export mediators: a structural perspective
10.1038/emboj.2011.287 · 2011 · External reference
Silencing of Nicotiana benthamiana Xrn4p exoribonuclease promotes tombusvirus RNA accumulation and recombination
10.1016/j.virol.2009.01.015 · 2009 · External reference
Inhibitors of nuclear transport
10.1016/j.ceb.2019.01.001 · 2019 · External reference
Yeast screens for host factors in positive-strand RNA virus replication based on a library of temperature-sensitive mutants
10.1016/j.ymeth.2012.11.001 · 2013 · External reference
Authentic replication and recombination of Tomato bushy stunt virus RNA in a cell-free extract from yeast
10.1128/jvi.02737-07 · 2008 · External reference
Template role of double-stranded RNA in tombusvirus replication
10.1128/jvi.03842-13 · 2014 · External reference
Specific binding of tombusvirus replication protein p33 to an internal replication element in the viral RNA is essential for replication
10.1128/jvi.79.8.4859-4869.2005 · 2005 · External reference
Viral replication protein inhibits cellular cofilin actin depolymerization factor to regulate the actin network and promote viral replicase assembly
2016 · External reference
Three-dimensional imaging of the intracellular assembly of a functional viral RNA replicase complex
2017 · External reference
Tomato bushy stunt virus co-opts the RNA-binding function of a host metabolic enzyme for viral genomic RNA synthesis
10.1016/j.chom.2008.02.005 · 2008 · External reference
Localization of the tomato bushy stunt virus replication protein p33 reveals a peroxisome-to-endoplasmic reticulum sorting pathway
10.1105/tpc.105.036350 · 2005 · External reference
Posttranscriptional gene silencing in nuclei
10.1073/pnas.1009805108 · 2011 · External reference
Nuclear gene silencing directs reception of long-distance mRNA silencing in Arabidopsis
10.1073/pnas.0706701104 · 2007 · External reference
Characterization of a DCL2-Insensitive Tomato Bushy Stunt Virus Isolate Infecting Arabidopsis thaliana
10.3390/v12101121 · 2020 · External reference
Identification of an ARGONAUTE for antiviral RNA silencing in Nicotiana benthamiana
10.1104/pp.111.178764 · 2011 · External reference
Crispr/Cas9 mediated inactivation of Argonaute 2 reveals its differential involvement in antiviral responses
10.1038/s41598-017-01050-6 · 2017 · External reference
The centromeric histone CenH3 is recruited into the tombusvirus replication organelles
10.1371/journal.ppat.1010653 · 2022 · External reference
Nucleolin/Nsr1p binds to the 3’ noncoding region of the tombusvirus RNA and inhibits replication
10.1016/j.virol.2009.10.007 · 2010 · External reference
Co-opted cytosolic proteins form condensate substructures within membranous replication organelles of a positive-strand RNA virus
10.1111/nph.19691 · 2024 · External reference
A novel viral strategy for host factor recruitment: The co-opted proteasomal Rpn11 protein interaction hub in cooperation with subverted actin filaments are targeted to deliver cytosolic host factors for viral replication
10.1371/journal.ppat.1009680 · 2021 · External reference
Race against Time between the Virus and Host: Actin-Assisted Rapid Biogenesis of Replication Organelles is Used by TBSV to Limit the Recruitment of Cellular Restriction Factors
10.1128/jvi.00168-21 · 2022 · External reference
Screening Legionella effectors for antiviral effects reveals Rab1 GTPase as a proviral factor coopted for tombusvirus replication
10.1073/pnas.1911108116 · 2019 · External reference
A Legionella Effector Disrupts Host Cytoskeletal Structure by Cleaving Actin
2017 · External reference
The Legionella pneumophila effector VipA is an actin nucleator that alters host cell organelle trafficking
10.1371/journal.ppat.1002546 · 2012 · External reference
Nicotiana benthamiana RanBP1-1 Is Involved in the Induction of Disease Resistance via Regulation of Nuclear-Cytoplasmic Transport of Small GTPase Ran
10.3389/fpls.2019.00222 · 2019 · External reference
Subversion of selective autophagy for the biogenesis of tombusvirus replication organelles inhibits autophagy
10.1371/journal.ppat.1012085 · 2024 · External reference
Novel exploitation of autophagy by tombusviruses
10.1016/j.virol.2024.110363 · 2025 · External reference
Co-opted SUMO machinery promotes condensate formation associated with membranous replication organelles of a positive-strand RNA virus
2025 · External reference
The role of the p33:p33/p92 interaction domain in RNA replication and intracellular localization of p33 and p92 proteins of Cucumber necrosis tombusvirus
10.1016/j.virol.2005.04.025 · 2005 · External reference
Tombusvirus polymerase: Structure and function
10.1016/j.virusres.2017.01.012 · 2017 · External reference
Characterization of the RNA-binding domains in the replicase proteins of tomato bushy stunt virus
10.1128/jvi.77.17.9244-9258.2003 · 2003 · External reference
Genome-wide screen identifies host genes affecting viral RNA recombination
10.1073/pnas.0504844102 · 2005 · External reference
Nuclear transport proteins: structure, function, and disease relevance
10.1038/s41392-023-01649-4 · 2023 · External reference
Proviral role of ATG2 autophagy related protein in tomato bushy stunt virus replication through bulk phospholipid transfer into the viral replication organelle
10.1091/mbc.e24-05-0236 · 2024 · External reference
Nuclear localization of dengue virus nonstructural protein 5 through its importin alpha/beta-recognized nuclear localization sequences is integral to viral infection
10.1111/j.1600-0854.2007.00579.x · 2007 · External reference
CRM1-dependent nuclear export of dengue virus type 2 NS5
10.1002/0470058005.ch11 · 2006 · External reference
Exportin-1-Dependent Nuclear Export of DEAD-box Helicase DDX3X is Central to its Role in Antiviral Immunity
10.3390/cells8101181 · 2019 · External reference
Effect of Exportin 1/XPO1 Nuclear Export Pathway Inhibition on Coronavirus Replication
10.3390/v17020284 · 2025 · External reference
Therapeutic Effects of XPO1 Inhibition in Thymic Epithelial Tumors
10.1158/0008-5472.can-17-1323 · 2017 · External reference
XPO1, therapeutic … and prognostic target in sarcomas
10.18632/oncoscience.304 · 2016 · External reference
CRM1 Inhibitors for Antiviral Therapy
10.3389/fmicb.2017.01171 · 2017 · External reference
Region of Nipah virus C protein responsible for shuttling between the cytoplasm and nucleus
10.1016/j.virol.2016.07.013 · 2016 · External reference
NXT1, a Novel Influenza A NP Binding Protein, Promotes the Nuclear Export of NP via a CRM1-Dependent Pathway
10.3390/v8080209 · 2016 · External reference
Differential Disruption of Nucleocytoplasmic Trafficking Pathways by Rhinovirus 2A Proteases
10.1128/jvi.02472-16 · 2017 · External reference
Nuclear exportin 1 facilitates turnip mosaic virus infection by exporting the sumoylated viral replicase and by repressing plant immunity
10.1111/nph.17657 · 2021 · External reference
Nuclear Exportin 1 (XPO1) Binds to the Nuclear Localization/Export Signal of the Turnip Mosaic Virus NIb to Promote Viral Infection
10.3389/fmicb.2021.780724 · 2022 · External reference
Virus-induced gene silencing
10.1385/1-59259-413-1:287 · 2003 · External reference
Nicotiana benthamiana exportin 1 is required for elicitor-induced phytoalexin production, cell death induction, and resistance against potato late blight pathogen Phytophthora infestans
10.1007/s10327-019-00855-9 · 2019 · External reference
Targeting conserved co-opted host factors to block virus replication: Using allosteric inhibitors of the cytosolic Hsp70s to interfere with tomato bushy stunt virus replication
10.1016/j.virol.2021.08.002 · 2021 · External reference
Multifunctional role of the co-opted Cdc48 AAA+ ATPase in tombusvirus replication
10.1016/j.virol.2022.08.004 · 2022 · External reference
Lifeact: a versatile marker to visualize F-actin
10.1038/nmeth.1220 · 2008 · External reference
The Legionella pneumophila effector VipA is an actin nucleator that alters host cell organelle trafficking
10.1371/journal.ppat.1002546 · 2012 · External reference
Pathogen effector protein screening in yeast identifies Legionella factors that interfere with membrane trafficking
10.1073/pnas.0501315102 · 2005 · External reference
A novel viral strategy for host factor recruitment: The co-opted proteasomal Rpn11 protein interaction hub in cooperation with subverted actin filaments are targeted to deliver cytosolic host factors for viral replication
10.1371/journal.ppat.1009680 · 2021 · External reference
Co‐opted cytosolic proteins form condensate substructures within membranous replication organelles of a positive‐strand RNA virus
10.1111/nph.19691 · 2024 · External reference
In vitro assembly of the Tomato bushy stunt virus replicase requires the host Heat shock protein 70
10.1073/pnas.0810851105 · 2008 · External reference
Authentic replication and recombination of Tomato bushy stunt virus RNA in a cell-free extract from yeast
10.1128/jvi.02737-07 · 2008 · External reference
Systematic exploration of essential yeast gene function with temperature-sensitive mutants
10.1038/nbt.1832 · 2011 · External reference
Purification of the cucumber necrosis virus replicase from yeast cells: role of coexpressed viral RNA in stimulation of replicase activity
10.1128/jvi.78.15.8254-8263.2004 · 2004 · External reference
A unique role for the host ESCRT proteins in replication of Tomato bushy stunt virus
10.1371/journal.ppat.1000705 · 2009 · External reference
Enrichment of Phosphatidylethanolamine in Viral Replication Compartments via Co-opting the Endosomal Rab5 Small GTPase by a Positive-Strand RNA Virus
2016 · External reference
The hop-like stress-induced protein 1 cochaperone is a novel cell-intrinsic restriction factor for mitochondrial tombusvirus replication
10.1128/jvi.00561-14 · 2014 · External reference
The centromeric histone CenH3 is recruited into the tombusvirus replication organelles
10.1371/journal.ppat.1010653 · 2022 · External reference
