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References from Targeting translation initiation yields fast-killing therapeutics against the zoonotic parasite Cryptosporidium parvum. Local targets link to admitted publications; unresolved targets remain external evidence.
Taxonomy and molecular epidemiology of Cryptosporidium and Giardia - a 50 year perspective (1971-2021
2021 · External reference
Cryptosporidium in humans and animals-a one health approach to prophylaxis
10.1111/pim.12350 · 2016 · External reference
A review of the global burden, novel diagnostics, therapeutics, and vaccine targets for cryptosporidium
10.1016/s1473-3099(14)70772-8 · 2015 · External reference
A one health approach to tackle Cryptosporidiosis
10.1016/j.pt.2019.12.016 · 2020 · External reference
Cryptosporidium and Giardia infections in children: a review
10.1016/j.pcl.2017.03.014 · 2017 · External reference
Long-term production effects of clinical cryptosporidiosis in neonatal calves
10.1016/j.ijpara.2020.03.002 · 2020 · External reference
Study of the economic impact of cryptosporidiosis in calves after implementing good practices to manage the disease on dairy farms in Belgium, France, and the Netherlands
10.1016/j.crpvbd.2023.100149 · 2023 · External reference
Cryptosporidium - An update with an emphasis on foodborne and waterborne transmission
10.1016/j.rvsc.2020.08.002 · 2020 · External reference
Farm fairs and petting zoos: a review of animal contact as a source of zoonotic enteric disease
10.1089/fpd.2016.2185 · 2017 · External reference
Current status and challenges in drug discovery against the globally important zoonotic cryptosporidiosis
2021 · External reference
Past, current, and potential treatments for cryptosporidiosis in humans and farm animals: a comprehensive review
10.3389/fcimb.2023.1115522 · 2023 · External reference
Current pharmacotherapy of cryptosporidiosis: an update of the state-of-the-art
10.1080/14656566.2021.1957097 · 2021 · External reference
A conditional protein degradation system to study essential gene function in Cryptosporidium parvum
10.1128/mbio.01231-20 · 2020 · External reference
Genetic modification of the diarrhoeal pathogen Cryptosporidium parvum
10.1038/nature14651 · 2015 · External reference
Complete genome sequence of the apicomplexan, Cryptosporidium parvum
10.1126/science.1094786 · 2004 · External reference
Cryptosporidium: genomic and biochemical features
10.1016/j.exppara.2008.12.014 · 2010 · External reference
Unlocking the mystery of the feeder organelle and versatile energy metabolism in Cryptosporidium parvum
10.1016/j.pt.2024.03.002 · 2024 · External reference
Multiple pathways for glucose phosphate transport and utilization support growth of Cryptosporidium parvum
10.1038/s41467-024-44696-3 · 2024 · External reference
Cryptosporidium lactate dehydrogenase is associated with the parasitophorous vacuole membrane and is a potential target for developing therapeutics
10.1371/journal.ppat.1005250 · 2015 · External reference
Current progress in the fatty acid metabolism in Cryptosporidium parvum
10.1111/j.1550-7408.2004.tb00384.x · 2004 · External reference
Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell
10.1073/pnas.1908239116 · 2019 · External reference
Bicyclic azetidines kill the diarrheal pathogen Cryptosporidium in mice by inhibiting parasite phenylalanyl-tRNA synthetase
10.1126/scitranslmed.aba8412 · 2020 · External reference
A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis
10.1038/nature22337 · 2017 · External reference
Treating cryptosporidiosis: a review on drug discovery strategies
10.1016/j.ijpddr.2024.100542 · 2024 · External reference
Amelioration of Cryptosporidium parvum infection in vitro and in vivo by targeting parasite fatty acyl-coenzyme A synthetases
10.1093/infdis/jit645 · 2014 · External reference
The existing drug vorinostat as a new lead against Cryptosporidiosis by targeting the parasite histone deacetylases
10.1093/infdis/jix689 · 2018 · External reference
Development of 5-Aminopyrazole-4-carboxamide-based bumped-kinase inhibitors for Cryptosporidiosis therapy
10.1021/acs.jmedchem.9b00069 · 2019 · External reference
Rocaglates convert DEAD-box protein eIF4A into a sequence-selective translational repressor
10.1038/nature17978 · 2016 · External reference
Quantitative RT-PCR assay for high-throughput screening (HTS) of drugs against the growth of Cryptosporidium parvum in vitro
10.3389/fmicb.2015.00991 · 2015 · External reference
High-throughput screening of drugs against the growth of Cryptosporidium parvum in vitro by qRT-PCR
10.1007/978-1-4939-9748-0_18 · 2020 · External reference
On-target inhibition of Cryptosporidium parvum by nitazoxanide (NTZ) and paclitaxel (PTX) validated using a novel MDR1-transgenic host cell model and algorithms to quantify the effect on the parasite target
10.1371/journal.pntd.0011217 · 2023 · External reference
Host cells with transient overexpression of MDR1 as a novel in vitro model for evaluating on-target effect for activity against the epicellular Cryptosporidium parasite
10.1093/jac/dkab369 · 2021 · External reference
eIF4F: a retrospective
10.1074/jbc.r115.675280 · 2015 · External reference
A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay
10.1073/pnas.0400933101 · 2004 · External reference
eIF4A3 is a novel component of the exon junction complex
10.1261/rna.5230104 · 2004 · External reference
The translation inhibitor rocaglamide targets a bimolecular cavity between eIF4A and polypurine RNA
10.1016/j.molcel.2018.11.026 · 2019 · External reference
Dual targeting of DDX3 and eIF4A by the translation inhibitor rocaglamide A
10.1016/j.chembiol.2020.11.008 · 2021 · External reference
The natural anticancer compounds rocaglamides inhibit the Raf-MEK-ERK pathway by targeting prohibitin 1 and 2
10.1016/j.chembiol.2012.07.012 · 2012 · External reference
Characterization of Plasmodium falciparum prohibitins as novel targets to block infection in humans by impairing the growth and transmission of the parasite
10.1016/j.bcp.2023.115567 · 2023 · External reference
PfeIF4E and PfeIF4A colocalize and their double-stranded RNA inhibits Plasmodium falciparum proliferation
10.4161/cib.3.6.13396 · 2010 · External reference
Identification of mRNA 5’ cap-associated proteins in the human malaria parasite Plasmodium falciparum
10.1016/j.molbiopara.2021.111443 · 2022 · External reference
Distinct modes of interaction within eIF4F-like complexes and susceptibility to the RocA inhibitor for the Trypanosoma brucei EIF4AI translation initiation factor
2025 · External reference
Trypanosoma cruzi eIF4E3- and eIF4E4-containing complexes bind different mRNAs and may sequester inactive mRNAs during nutritional stress
10.1093/nar/gkae1181 · 2025 · External reference
Enzymatic and molecular characterization of anti-Leishmania molecules that differently target Leishmania and Mammalian eIF4A Proteins, LieIF4A and eIF4AMus
10.3390/molecules27185890 · 2022 · External reference
Broad anti-pathogen potential of DEAD box RNA helicase eIF4A-targeting rocaglates
10.1038/s41598-023-35765-6 · 2023 · External reference
Rocaglates as dual-targeting agents for experimental cerebral malaria
10.1073/pnas.1713000115 · 2018 · External reference
A parasitic fungus employs mutated eIF4A to survive on rocaglate-synthesizing Aglaia plants
2023 · External reference
Cryptosporidium uses multiple distinct secretory organelles to interact with and modify its host cell
10.1016/j.chom.2023.03.001 · 2023 · External reference
Cryptosporidium oocyst purification using discontinuous gradient centrifugation
10.1007/978-1-4939-9748-0_4 · 2020 · External reference
Improved purification methods for calf-derived Cryptosporidium parvum oocysts using discontinuous sucrose and cesium chloride gradients
10.1111/j.1550-7408.1996.tb05015.x · 1996 · External reference
A clinical frailty index in aging mice: comparisons with frailty index data in humans
10.1093/gerona/glt136 · 2014 · External reference
A robust scoring system to evaluate sepsis severity in an animal model
10.1186/1756-0500-7-233 · 2014 · External reference
Thermal shift assay (TSA)-based drug screening strategy for rapid discovery of inhibitors against the Nsp13 helicase of SARS-CoV-2
10.1016/j.azn.2024.06.001 · 2025 · External reference
A new spectral shift-based method to characterize molecular interactions
10.1089/adt.2021.133 · 2022 · External reference
Analysis of protein stability and ligand interactions by thermal shift assay
10.1002/0471140864.ps2809s79 · 2015 · External reference
Unique tubulin-based structures in the zoonotic Apicomplexan Parasite Cryptosporidium parvum
10.3390/microorganisms9091921 · 2021 · External reference
Affinity purification of autoantibodies from an antigen strip excised from a nitrocellulose protein blot
10.1007/978-1-59745-542-8_22 · 2009 · External reference
