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References from Structural exposure of different microtubule binding domains determines the propagation and toxicity of pathogenic tau conformers in Alzheimer’s disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Genome-wide association studies identify novel loci in rapidly progressive Alzheimer’s disease
10.1002/alz.13655 · 2024 · External reference
Molecular mechanisms encoding strains of prions and prion-like misfolded proteins.
10.1007/978-3-031-20565-1_7 · 2023 · External reference
Distinct populations of highly potent TAU seed conformers in rapidly progressing Alzheimer’s disease
2022 · External reference
Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β
10.1093/brain/awv006 · 2015 · External reference
Pre-progression rates in Alzheimer’s disease revisited
10.3233/jad-130074 · 2013 · External reference
Rapidly progressive Alzheimer disease
10.1001/archneurol.2011.189 · 2011 · External reference
Rapidly progressive dementias - aetiologies, diagnosis and management
10.1038/s41582-022-00659-0 · 2022 · External reference
Alzheimer’s disease: genetic polymorphisms and rate of decline
10.1159/000336790 · 2012 · External reference
Clinical features of rapidly progressive Alzheimer’s disease
10.1159/000278692 · 2010 · External reference
Rapidly progressive Alzheimer’s disease: a multicenter update
10.3233/jad-2012-120007 · 2012 · External reference
Rapidly Progressive Alzheimer’s Disease in Two Distinct Autopsy Cohorts
10.3233/jad-180155 · 2018 · External reference
Distinct conformers of amyloid beta accumulate in the neocortex of patients with rapidly progressive Alzheimer’s disease
10.1016/j.jbc.2021.101267 · 2021 · External reference
Phosphorylated tau interactome in the human Alzheimer’s disease brain
10.1093/brain/awaa223 · 2020 · External reference
Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer’s disease
10.1007/s00401-017-1691-0 · 2017 · External reference
The basis of cellular and regional vulnerability in Alzheimer’s disease
10.1007/s00401-019-02054-4 · 2019 · External reference
The genetics and neuropathology of Alzheimer’s disease
10.1007/s00401-012-0996-2 · 2012 · External reference
Alzheimer’s disease
10.1101/cshperspect.a004457 · 2011 · External reference
The genetic landscape of Alzheimer disease: clinical implications and perspectives
10.1038/gim.2015.117 · 2016 · External reference
Cryo-EM structures of Tau filaments from Alzheimer’s disease brain
10.1038/nature23002 · 2017 · External reference
Fibril structure of amyloid-β(1-42) by cryo-electron microscopy
10.1126/science.aao2825 · 2017 · External reference
Heparin-induced tau filaments are polymorphic and differ from those in Alzheimer’s and Pick’s diseases
2019 · External reference
Ordered Assembly of Tau Protein and Neurodegeneration
10.1007/978-981-32-9358-8_1 · 2019 · External reference
Prion-like strain effects in tauopathies
2022 · External reference
Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT-P301L mutation
10.1007/s00401-020-02148-4 · 2020 · External reference
Disease-specific tau filaments assemble via polymorphic intermediates
10.1038/s41586-023-06788-w · 2024 · External reference
All the Tau We Cannot See
10.1146/annurev-med-042921-023749 · 2023 · External reference
Evolving prion-like tau conformers differentially alter postsynaptic proteins in neurons inoculated with distinct isolates of Alzheimer’s disease tau
10.1186/s13578-023-01133-0 · 2023 · External reference
Quantitative protein topography analysis and high-resolution structure prediction using hydroxyl radical labeling and tandem-ion mass spectrometry (MS)
10.1074/mcp.o114.044362 · 2015 · External reference
A synchrotron-based hydroxyl radical footprinting analysis of amyloid fibrils and prefibrillar intermediates with residue-specific resolution
10.1021/bi5010409 · 2014 · External reference
Structural analysis of proinsulin hexamer assembly by hydroxyl radical footprinting and computational modeling
10.1074/jbc.m111.297853 · 2011 · External reference
Future directions of structural mass spectrometry using hydroxyl radical footprinting
10.1002/jms.1808 · 2010 · External reference
Early clinical PET imaging results with the novel PHF-tau radioligandF18-T808
10.3233/jad-130098 · 2014 · External reference
Highly elevated cerebrospinal fluid total tau level reflects higher likelihood of non-amnestic subtype of Alzheimer’s Disease
2019 · External reference
O5-04-02: Altered Protein Expression in Amyloid Plaques in Rapidly Progressive Alzheimer’s Disease
10.1016/j.jalz.2016.06.723 · 2016 · External reference
Structural determinants of phenotypic diversity and replication rate of human prions
10.1371/journal.ppat.1004832 · 2015 · External reference
Prion infectivity plateaus and conversion to symptomatic disease originate from falling precursor levels and increased levels of oligomeric PrPSc species
10.1128/jvi.02142-15 · 2015 · External reference
Prion disease tempo determined by host-dependent substrate reduction
10.1172/jci72241 · 2014 · External reference
Unresolved reference
External reference
Small protease sensitive oligomers of PrPSc determine replication rate in distinct prion strains
2012 · External reference
Protease-sensitive conformers in broad spectrum of distinct PrPSc structures in sporadic Creutzfeldt-Jakob disease are indicator of progression rate
2011 · External reference
Some strategies and methods for the study of prions.
2004 · External reference
Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice
10.1038/nbt748 · 2002 · External reference
Quantitative traits of prion strains are enciphered in the conformation of the prion protein
2000 · External reference
Some strategies and methods for the study of prions.
1999 · External reference
Eight prion strains have PrP(Sc) molecules with different conformations
10.1038/2654 · 1998 · External reference
Structurally distinct external solvent-exposed domains drive replication of major human prions
10.1371/journal.ppat.1009642 · 2021 · External reference
Protein surface mapping by chemical oxidation: structural analysis by mass spectrometry
10.1016/s0003-2697(02)00612-7 · 2003 · External reference
The natively unfolded character of tau and its aggregation to Alzheimer-like paired helical filaments
10.1021/bi800783d · 2008 · External reference
Multiplex Chemical Labeling of Amino Acids for Protein Footprinting Structure Assessment
10.1021/acs.analchem.2c01640 · 2022 · External reference
Structural attributes of mammalian prion infectivity: Insights from studies with synthetic prions
10.1074/jbc.ra118.005622 · 2018 · External reference
Characterizing monoclonal antibody structure by carboxyl group footprinting
10.1080/19420862.2015.1023683 · 2015 · External reference
Visualizing Arp2/3 complex activation mediated by binding of ATP and WASp using structural mass spectrometry
10.1073/pnas.0605380104 · 2007 · External reference
Structural analysis of gelsolin using synchrotron protein footprinting
10.1074/mcp.m300068-mcp200 · 2003 · External reference
Hydroxyl radical probe of protein surfaces using synchrotron X-ray radiolysis and mass spectrometry
10.1080/09553000110094805 · 2002 · External reference
Brain-derived neurotrophic factor (BDNF) promotes molecular polarization and differentiation of immature neuroblastoma cells into definitive neurons
10.1016/j.bbamcr.2020.118737 · 2020 · External reference
Structural identification of individual helical amyloid filaments by integration of cryo-electron microscopy-derived maps in comparative morphometric atomic force microscopy image analysis
10.1016/j.jmb.2022.167466 · 2022 · External reference
Correction to: Diverse, evolving conformer populations drive distinct phenotypes in frontotemporal lobar degeneration caused by the same MAPT‑P301L mutation
10.1007/s00401-021-02262-x · 2021 · External reference
Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease
10.1038/s41591-020-0938-9 · 2020 · External reference
Rapidly progressive dementia
10.1002/ana.21430 · 2008 · External reference
Artificial strain of human prions created in vitro
10.1038/s41467-018-04584-z · 2018 · External reference
Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC
10.1186/s40478-018-0508-2 · 2018 · External reference
Diagnostic and prognostic value of human prion detection in cerebrospinal fluid
10.1002/ana.24833 · 2017 · External reference
β-Sheet core of tau paired helical filaments revealed by solid-state NMR
10.1021/ja305470p · 2012 · External reference
A cell culture model for investigation of synapse influenceability: epigenetics, expression and function of gene targets important for synapse formation and preservation in SH-SY5Y neuroblastoma cells differentiated by retinoic acid
10.1007/s00702-017-1769-9 · 2017 · External reference
Extracellular low-n oligomers of tau cause selective synaptotoxicity without affecting cell viability
10.1016/j.jalz.2017.04.002 · 2017 · External reference
Mechanisms of tau and Aβ-induced excitotoxicity
10.1016/j.brainres.2015.12.048 · 2016 · External reference
Tau filaments in neurodegenerative diseases
10.1002/1873-3468.13108 · 2018 · External reference
Tau filaments from multiple cases of sporadic and inherited Alzheimer’s disease adopt a common fold
10.1007/s00401-018-1914-z · 2018 · External reference
Extracellular tau is toxic to neuronal cells
10.1016/j.febslet.2006.07.078 · 2006 · External reference
Characteristics and consequences of muscarinic receptor activation by tau protein
10.1016/j.euroneuro.2009.04.006 · 2009 · External reference
Extracellular tau promotes intracellular calcium increase through M1 and M3 muscarinic receptors in neuronal cells
10.1016/j.mcn.2007.12.010 · 2008 · External reference
Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death
10.1016/j.ceca.2019.102150 · 2020 · External reference
Tau localises within mitochondrial sub-compartments and its caspase cleavage affects ER-mitochondria interactions and cellular Ca2+ handling
10.1016/j.bbadis.2018.07.011 · 2018 · External reference
Hyperphosphorylated Tau Inflicts Intracellular Stress Responses that Are Mitigated by Apomorphine
10.1007/s12035-023-03689-x · 2024 · External reference
Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage-gated calcium channels and NADPH oxidase
10.1111/febs.15340 · 2021 · External reference
Tau PTM profiles identify patient heterogeneity and stages of Alzheimer’s Disease
10.1016/j.cell.2020.10.029 · 2020 · External reference
2.7 Å cryo-EM structure of ex vivo RML prion fibrils
10.1038/s41467-022-30457-7 · 2022 · External reference
Sporadic human prion diseases: molecular insights and diagnosis
10.1016/s1474-4422(12)70063-7 · 2012 · External reference
Modeling the heterogeneity in risk of progression to Alzheimer’s disease across cognitive profiles in mild cognitive impairment
10.1186/alzrt168 · 2013 · External reference
The diagnosis of dementia due to Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer’s disease
10.1016/j.jalz.2011.03.005 · 2011 · External reference
National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
10.1007/s00401-011-0910-3 · 2012 · External reference
National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease
10.1016/j.jalz.2011.10.007 · 2012 · External reference
The National Alzheimer’s Coordinating Center (NACC) database: the Uniform Data Set
10.1097/wad.0b013e318142774e · 2007 · External reference
Genetic influence on the structural variations of the abnormal prion protein
10.1073/pnas.97.18.10168 · 2000 · External reference
Diagnosis of human prion disease
10.1073/pnas.0409651102 · 2005 · External reference
DNA sequencing with chain-terminating inhibitors
10.1073/pnas.74.12.5463 · 1977 · External reference
Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia
10.1093/brain/awr179 · 2011 · External reference
Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C)
2012 · External reference
Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule-binding repeat domains as demonstrated by new specific monoclonal antibodies
10.1046/j.1365-2990.2003.00463.x · 2003 · External reference
Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
10.1073/pnas.0908005106 · 2009 · External reference
Variations in filament conformation dictate seeding barrier between three- and four-repeat tau
10.1021/bi2004685 · 2011 · External reference
Selective precipitation of prions by polyoxometalate complexes
10.1021/ja055219y · 2005 · External reference
Aβ and tau prion-like activities decline with longevity in the Alzheimer’s disease human brain
10.1126/scitranslmed.aat8462 · 2019 · External reference
Human prions and plasma lipoproteins
10.1073/pnas.0604021103 · 2006 · External reference
Measuring prions causing bovine spongiform encephalopathy or chronic wasting disease by immunoassays and transgenic mice
10.1038/nbt748 · 2002 · External reference
Thermal stability and conformational transitions of scrapie amyloid (prion) protein correlate with infectivity
10.1002/pro.5560021220 · 1993 · External reference
Phosphomimetic substitutions in TDP-43’s transiently α-helical region suppress phase separation
10.1016/j.bpj.2024.01.001 · 2024 · External reference
Secondary reactions and strategies to improve quantitative protein footprinting
10.1021/ac048282z · 2005 · External reference
Hydroxyl radical-mediated modification of proteins as probes for structural proteomics
10.1021/cr0682047 · 2007 · External reference
Structural analysis of a therapeutic monoclonal antibody dimer by hydroxyl radical footprinting
10.4161/mabs.22964 · 2013 · External reference
Centering, scaling, and transformations: improving the biological information content of metabolomics data
10.1186/1471-2164-7-142 · 2006 · External reference
Seeding selectivity and ultrasensitive detection of tau aggregate conformers of Alzheimer disease
2018 · External reference
Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels
10.1186/s13195-017-0279-1 · 2017 · External reference
