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References from Fexinidazole and Corallopyronin A target Wolbachia-infected sheath cells present in filarial nematodes. Local targets link to admitted publications; unresolved targets remain external evidence.
The long and winding road towards new treatments against lymphatic filariasis and onchocerciasis
10.1016/j.pt.2024.07.005 · 2024 · External reference
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017
10.1016/s0140-6736(18)32279-7 · 2018 · External reference
The Health and Economic Burdens of Lymphatic Filariasis Prior to Mass Drug Administration Programs
10.1093/cid/ciz671 · 2020 · External reference
Intracytoplasmic bacteria in Onchocerca volvulus
10.4269/ajtmh.1977.26.663 · 1977 · External reference
Transovarially-transmitted intracellular microorganisms in adult and larval stages of Brugia malayi
10.2307/3279832 · 1977 · External reference
Micro-organisms in filarial larvae (Nematoda)
10.1016/0035-9203(75)90110-8 · 1975 · External reference
Molecular evidence for a close relative of the arthropod endosymbiont Wolbachia in a filarial worm
10.1016/0166-6851(95)02494-8 · 1995 · External reference
The cellular lives of Wolbachia
10.1038/s41579-023-00918-x · 2023 · External reference
Effects of tetracycline on the filarial worms Brugia pahangi and Dirofilaria immitis and their bacterial endosymbionts Wolbachia
10.1016/s0020-7519(98)00200-8 · 1999 · External reference
Tetracycline therapy targets intracellular bacteria in the filarial nematode Litomosoides sigmodontis and results in filarial infertility
10.1172/jci4768 · 1999 · External reference
Anti-Wolbachia therapy for onchocerciasis & lymphatic filariasis: Current perspectives
10.4103/ijmr.ijmr_454_17 · 2019 · External reference
Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis
10.1017/s0031182013001108 · 2014 · External reference
Wolbachia endobacteria depletion by doxycycline as antifilarial therapy has macrofilaricidal activity in onchocerciasis: a randomized placebo-controlled study
10.1007/s00430-007-0072-z · 2008 · External reference
Onchocerciasis drug development: from preclinical models to humans
10.1007/s00436-021-07307-4 · 2021 · External reference
Lymphatic filariasis and onchocerciasis
10.1016/s0140-6736(10)60586-7 · 2010 · External reference
The endosymbiont Wolbachia rebounds following antibiotic treatment
10.1371/journal.ppat.1008623 · 2020 · External reference
Insect Bacteriocytes: Adaptation, Development, and Evolution
10.1146/annurev-ento-010323-124159 · 2024 · External reference
Efficient in vitro RNA interference and immunofluorescence-based phenotype analysis in a human parasitic nematode, Brugia malayi
10.1186/1756-3305-5-16 · 2012 · External reference
Regulation of Actin Dynamics in the C. elegans Somatic Gonad
10.3390/jdb7010006 · 2019 · External reference
Scratching the niche that controls Caenorhabditis elegans germline stem cells
10.1016/j.semcdb.2009.09.005 · 2009 · External reference
An overview of lymphatic filariasis lymphedema
2017 · External reference
Wolbachia Control Stem Cell Behavior and Stimulate Germline Proliferation in Filarial Nematodes
10.1016/j.devcel.2018.03.017 · 2018 · External reference
Population dynamics of Wolbachia bacterial endosymbionts in Brugia malayi
10.1016/j.molbiopara.2004.01.006 · 2004 · External reference
Tissue and stage-specific distribution of Wolbachia in Brugia malayi
10.1371/journal.pntd.0001174 · 2011 · External reference
Mechanisms of antibiotics inhibiting bacterial RNA polymerase
10.1042/bst20180499 · 2019 · External reference
Vol. 36 1153-1166
1975 · External reference
Pharmacokinetics of albendazole in sheep
10.2460/ajvr.1980.41.07.1126 · 1980 · External reference
A cell-based screen reveals that the albendazole metabolite, albendazole sulfone, targets Wolbachia
10.1371/journal.ppat.1002922 · 2012 · External reference
Corallopyronin A: antimicrobial discovery to preclinical development
10.1039/d2np00012a · 2022 · External reference
Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections
10.1371/journal.pntd.0008930 · 2020 · External reference
Fexinidazole: First Global Approval
10.1007/s40265-019-1051-6 · 2019 · External reference
Metronidazole: an update on metabolism, structure-cytotoxicity and resistance mechanisms
10.1093/jac/dkx351 · 2018 · External reference
Analysis of gene expression from the Wolbachia genome of a filarial nematode supports both metabolic and defensive roles within the symbiosis
10.1101/gr.138420.112 · 2012 · External reference
The Wolbachia genome of Brugia malayi: endosymbiont evolution within a human pathogenic nematode
10.1371/journal.pbio.0030121 · 2005 · External reference
Complete Genome Sequence of wBp, the Wolbachia Endosymbiont of Brugia pahangi FR3
10.1128/mra.00480-20 · 2020 · External reference
Draft genome sequence of the Wolbachia endosymbiont of Wuchereria bancrofti wWb
10.1093/femspd/ftx115 · 2017 · External reference
The genome of Onchocerca volvulus, agent of river blindness
10.1038/nmicrobiol.2016.216 · 2016 · External reference
Dual RNAseq analyses at soma and germline levels reveal evolutionary innovations in the elephantiasis-agent Brugia malayi, and adaptation of its Wolbachia endosymbionts
10.1371/journal.pntd.0008935 · 2021 · External reference
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae
10.1371/journal.pntd.0007636 · 2019 · External reference
Evolution and ontogeny of bacteriocytes in insects
10.3389/fphys.2022.1034066 · 2022 · External reference
Unresolved reference
1965 · External reference
Insects recycle endosymbionts when the benefit is over
10.1016/j.cub.2014.07.065 · 2014 · External reference
Asymmetric Wolbachia segregation during early Brugia malayi embryogenesis determines its distribution in adult host tissues
10.1371/journal.pntd.0000758 · 2010 · External reference
Both asymmetric mitotic segregation and cell-to-cell invasion are required for stable germline transmission of Wolbachia in filarial nematodes
10.1242/bio.2012737 · 2012 · External reference
A cellular basis for Wolbachia recruitment to the host germline
10.1371/journal.ppat.0030190 · 2007 · External reference
A feedback loop between Wolbachia and the Drosophila gurken mRNP complex influences Wolbachia titer
10.1242/jcs.092510 · 2011 · External reference
Wolbachia utilizes host microtubules and Dynein for anterior localization in the Drosophila oocyte
10.1371/journal.ppat.0010014 · 2005 · External reference
Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis
10.1073/pnas.1710845114 · 2017 · External reference
Ultrastructural features of the adult hermaphrodite gonad of Caenorhabditis elegans: relations between the germ line and soma
10.1006/dbio.1999.9356 · 1999 · External reference
Soma-germ cell interactions in Caenorhabditis elegans: multiple events of hermaphrodite germline development require the somatic sheath and spermathecal lineages
10.1006/dbio.1996.8429 · 1997 · External reference
On the control of oocyte meiotic maturation and ovulation in Caenorhabditis elegans
10.1006/dbio.1998.9109 · 1999 · External reference
Doxycycline reduces plasma VEGF-C/sVEGFR-3 and improves pathology in lymphatic filariasis
10.1371/journal.ppat.0020092 · 2006 · External reference
A randomized, double-blind clinical trial of a 3-week course of doxycycline plus albendazole and ivermectin for the treatment of Wuchereria bancrofti infection
10.1086/501351 · 2006 · External reference
Effective inhibition of rifampicin-resistant Chlamydia trachomatis by the novel DNA-dependent RNA polymerase inhibitor corallopyronin A
10.1016/j.ijantimicag.2018.07.025 · 2018 · External reference
Tackling Sleeping Sickness: Current and Promising Therapeutics and Treatment Strategies
10.3390/ijms241512529 · 2023 · External reference
From Magic Bullet to Magic Bomb: Reductive Bioactivation of Antiparasitic Agents
10.1021/acsinfecdis.1c00118 · 2021 · External reference
The Eagle effect in the Wolbachia-worm symbiosis
10.1186/s13071-020-04545-w · 2021 · External reference
A Paradoxical Zone Phenomenon in the Bactericidal Action of Penicillin in Vitro
10.1126/science.107.2767.44 · 1948 · External reference
10.1371/journal.ppat.1013301 · 2025 · Admitted local publication
Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections
10.1126/scitranslmed.aav3523 · 2019 · External reference
New strategies to improve minimap2 alignment accuracy
10.1093/bioinformatics/btab705 · 2021 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2014 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
