References

Causes of severe pneumonia requiring hospital admission in children without HIV infection from Africa and Asia: the PERCH multi-country case-control study

10.1016/s0140-6736(19)30721-4 · 2019 · External reference

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

10.1016/s0140-6736(22)00478-0 · 2022 · External reference

Respiratory syncytial virus infection and novel interventions

10.1038/s41579-023-00919-w · 2023 · External reference

Vaccine and therapeutic agents against the respiratory syncytial virus: resolved and unresolved issue

2024 · External reference

Role of Type I Interferon (IFN) in the Respiratory Syncytial Virus (RSV) Immune Response and Disease Severity

10.3389/fimmu.2019.00566 · 2019 · External reference

ICTV Virus Taxonomy Profile: Pneumoviridae

10.1099/jgv.0.000959 · 2017 · External reference

Respiratory syncytial virus mechanisms to interfere with type 1 interferons

2013 · External reference

How RSV Proteins Join Forces to Overcome the Host Innate Immune Response

10.3390/v14020419 · 2022 · External reference

Pathogenicity and virulence of human respiratory syncytial virus: multifunctional nonstructural proteins NS1 and NS2

2023 · External reference

Respiratory Syncytial Virus’s Non-structural Proteins: Masters of Interference

10.3389/fcimb.2020.00225 · 2020 · External reference

Respiratory syncytial virus nonstructural proteins 1 and 2: Exceptional disrupters of innate immune responses

10.1371/journal.ppat.1007984 · 2019 · External reference

Human Respiratory Syncytial Virus NS 1 Targets TRIM25 to Suppress RIG-I Ubiquitination and Subsequent RIG-I-Mediated Antiviral Signaling

10.3390/v10120716 · 2018 · External reference

Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase

10.1128/jvi.02303-06 · 2007 · External reference

Respiratory syncytial virus nonstructural proteins decrease levels of multiple members of the cellular interferon pathways

10.1128/jvi.00715-09 · 2009 · External reference

Multiple functional domains and complexes of the two nonstructural proteins of human respiratory syncytial virus contribute to interferon suppression and cellular location

10.1128/jvi.00413-11 · 2011 · External reference

Antagonism of BST2/Tetherin, a new restriction factor of respiratory syncytial virus, requires the viral NS1 protein

10.1371/journal.ppat.1012687 · 2024 · External reference

Nonstructural proteins of respiratory syncytial virus suppress premature apoptosis by an NF-kappaB-dependent, interferon-independent mechanism and facilitate virus growth

10.1128/jvi.01420-06 · 2007 · External reference

Respiratory syncytial virus (RSV) nonstructural (NS) proteins as host range determinants: a chimeric bovine RSV with NS genes from human RSV is attenuated in interferon-competent bovine cells

10.1128/jvi.76.9.4287-4293.2002 · 2002 · External reference

The interactome of the human respiratory syncytial virus NS1 protein highlights multiple effects on host cell biology

10.1128/jvi.00460-12 · 2012 · External reference

Nonstructural protein-1 of respiratory syncytial virus regulates HOX gene expression through interacting with histone

2012 · External reference

Nuclear-localized human respiratory syncytial virus NS1 protein modulates host gene transcription

10.1016/j.celrep.2021.109803 · 2021 · External reference

The Mediator complex and transcription regulation

10.3109/10409238.2013.840259 · 2013 · External reference

The Mediator complex as a master regulator of transcription by RNA polymerase II

10.1038/s41580-022-00498-3 · 2022 · External reference

Transcription regulation by the Mediator complex

10.1038/nrm.2017.115 · 2018 · External reference

Exploitation of the Mediator complex by viruses

10.1371/journal.ppat.1010422 · 2022 · External reference

Respiratory Syncytial Virus NS1 Protein Targets the Transactivator Binding Domain of MED25

10.1016/j.jmb.2022.167763 · 2022 · External reference

An Unexpected Encounter: Respiratory Syncytial Virus Nonstructural Protein 1 Interacts with Mediator Subunit MED25

10.1128/jvi.01297-22 · 2022 · External reference

Assessment of machine-learning predictions for the Mediator complex subunit MED25 ACID domain interactions with transactivation domains

10.1002/1873-3468.14837 · 2024 · External reference

Structure and VP16 binding of the Mediator Med25 activator interaction domain

10.1038/nsmb.1997 · 2011 · External reference

Structure of the VP16 transactivator target in the Mediator

10.1038/nsmb.1999 · 2011 · External reference

Solution NMR structure of MED25(391-543) comprising the activator-interacting domain (ACID) of human mediator subunit 25

10.1007/s10969-011-9115-1 · 2011 · External reference

NMR structure of the human Mediator MED25 ACID domain

10.1016/j.jsb.2010.10.011 · 2011 · External reference

Characterization of ERM transactivation domain binding to the ACID/PTOV domain of the Mediator subunit MED25

10.1093/nar/gkv650 · 2015 · External reference

ETV4 and AP1 Transcription Factors Form Multivalent Interactions with three Sites on the MED25 Activator-Interacting Domain

10.1016/j.jmb.2017.06.024 · 2017 · External reference

Endoplasmic reticulum stress-responsive transcription factor ATF6α directs recruitment of the Mediator of RNA polymerase II transcription and multiple histone acetyltransferase complexes

10.1074/jbc.m112.369504 · 2012 · External reference

Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators

10.1073/pnas.1806202115 · 2018 · External reference

Structural basis for the interaction between p53 transactivation domain and the mediator subunit MED25

2018 · External reference

Structural basis for human respiratory syncytial virus NS1-mediated modulation of host responses

10.1038/nmicrobiol.2017.101 · 2017 · External reference

ATF6 Is a Transcription Factor Specializing in the Regulation of Quality Control Proteins in the Endoplasmic Reticulum

10.1247/csf.07044 · 2008 · External reference

Human virus transcriptional regulators

10.1016/j.cell.2020.06.023 · 2020 · External reference

Highly accurate protein structure prediction with AlphaFold

10.1038/s41586-021-03819-2 · 2021 · External reference

Accurate structure prediction of biomolecular interactions with AlphaFold 3

10.1038/s41586-024-07487-w · 2024 · External reference

UCSF ChimeraX: Structure visualization for researchers, educators, and developers

10.1002/pro.3943 · 2021 · External reference

Unexpected specificity within dynamic transcriptional protein-protein complexes

10.1073/pnas.2013244117 · 2020 · External reference

Molecular basis for human respiratory syncytial virus transcriptional regulator NS1 interactions with MED25

10.1038/s41467-025-58216-4 · 2025 · External reference

The non-structural NS1 protein unique to respiratory syncytial virus: a two-state folding monomer in quasi-equilibrium with a stable spherical oligomer

10.1371/journal.pone.0074338 · 2013 · External reference

NanoLuc Complementation Reporter Optimized for Accurate Measurement of Protein Interactions in Cells

10.1021/acschembio.5b00753 · 2016 · External reference

Differential Responses by Human Respiratory Epithelial Cell Lines to Respiratory Syncytial Virus Reflect Distinct Patterns of Infection Control

10.1128/jvi.02202-17 · 2018 · External reference

Respiratory Syncytial Virus: Virology, Reverse Genetics, and Pathogenesis of Disease

10.1007/978-3-642-38919-1_1 · 2013 · External reference

A stabilized respiratory syncytial virus reverse genetics system amenable to recombination-mediated mutagenesis

10.1016/j.virol.2012.09.022 · 2012 · External reference

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members

10.1093/nar/gkt199 · 2013 · External reference

Role for human mediator subunit MED25 in recruitment of mediator to promoters by endoplasmic reticulum stress-responsive transcription factor ATF6α

10.1074/jbc.m113.496968 · 2013 · External reference

Analysis of the varicella-zoster virus IE62 N-terminal acidic transactivating domain and its interaction with the human mediator complex

10.1128/jvi.00054-09 · 2009 · External reference

Kaposi’s sarcoma-associated herpesvirus Lana-1 is a major activator of the serum response element and mitogen-activated protein kinase pathways via interactions with the Mediator complex

10.1099/vir.0.017715-0 · 2010 · External reference

Decoding type I and III interferon signalling during viral infection

10.1038/s41564-019-0421-x · 2019 · External reference

Effects of nonstructural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NF-kappaB, and proinflammatory cytokines

10.1128/jvi.79.9.5353-5362.2005 · 2005 · External reference

A novel mechanism for the inhibition of interferon regulatory factor-3-dependent gene expression by human respiratory syncytial virus NS1 protein

10.1099/vir.0.032987-0 · 2011 · External reference

IFIT1: A dual sensor and effector molecule that detects non-2’-O methylated viral RNA and inhibits its translation

10.1016/j.cytogfr.2014.05.002 · 2014 · External reference

Interferon-induced Ifit proteins: their role in viral pathogenesis

10.1128/jvi.02744-14 · 2015 · External reference

IFITM-Family Proteins: The Cell’s First Line of Antiviral Defense

10.1146/annurev-virology-031413-085537 · 2014 · External reference

ISG15 in antiviral immunity and beyond

10.1038/s41579-018-0020-5 · 2018 · External reference

Type 1 IFN-independent activation of a subset of interferon stimulated genes in West Nile virus Eg101-infected mouse cells

10.1016/j.virol.2012.01.006 · 2012 · External reference

The nonstructural proteins of pneumoviruses are remarkably distinct in substrate diversity and specificity

10.1186/s12985-017-0881-7 · 2017 · External reference

Structural basis for IFN antagonism by human respiratory syncytial virus nonstructural protein 2

2021 · External reference

A novel docking site on Mediator is critical for activation by VP16 in mammalian cells

10.1093/emboj/cdg619 · 2003 · External reference

A Pliable Mediator Acts as a Functional Rather Than an Architectural Bridge between Promoters and Enhancers

10.1016/j.cell.2019.07.011 · 2019 · External reference

The H1 and H2 regions of the activation domain of herpes simplex virion protein 16 stimulate transcription through distinct molecular mechanisms

10.1046/j.1356-9597.2001.00492.x · 2002 · External reference

Pattern of aromatic and hydrophobic amino acids critical for one of two subdomains of the VP16 transcriptional activator

10.1073/pnas.90.3.883 · 1993 · External reference

Mutational analysis of varicella-zoster virus (VZV) immediate early protein (IE62) subdomains and their importance in viral replication

10.1016/j.virol.2016.02.012 · 2016 · External reference

Inositol-requiring enzyme 1 inhibits respiratory syncytial virus replication

10.1074/jbc.m113.510594 · 2014 · External reference

A Lipopeptidomimetic of Transcriptional Activation Domains Selectively Disrupts the Coactivator Med25 Protein-Protein Interactions

10.1002/anie.202400781 · 2024 · External reference

Suppression of p53 response by targeting p53-Mediator binding with a stapled peptide

10.1016/j.celrep.2022.110630 · 2022 · External reference

Med25 is required for RNA polymerase II recruitment to specific promoters, thus regulating xenobiotic and lipid metabolism in human liver

10.1128/mcb.00847-10 · 2011 · External reference

Nucleotide sequence of classical swine fever virus strain Alfort/187 and transcription of infectious RNA from stably cloned full-length cDNA

10.1128/jvi.70.6.3478-3487.1996 · 1996 · External reference

Visualizing the replication of respiratory syncytial virus in cells and in living mice

10.1038/ncomms6104 · 2014 · External reference

Genotypic and phenotypic characterisation of respiratory syncytial virus after nirsevimab breakthrough infections: a large, multicentre, observational, real-world study

10.1016/s1473-3099(24)00570-x · 2025 · External reference

ColabFold: making protein folding accessible to all

10.1038/s41592-022-01488-1 · 2022 · External reference

PAE viewer: a webserver for the interactive visualization of the predicted aligned error for multimer structure predictions and crosslinks

10.1093/nar/gkad350 · 2023 · External reference

Unresolved reference

2010 · External reference

CcpNmr AnalysisAssign: a flexible platform for integrated NMR analysis

10.1007/s10858-016-0060-y · 2016 · External reference