Research graph
References from NK cell-macrophage interactions in granulomas correlate with limited tuberculosis pathology. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2024 · External reference
Drug Resistance Mechanisms in Mycobacterium tuberculosis
10.3390/antibiotics3030317 · 2014 · External reference
A perspective on the success and failure of BCG
10.3389/fimmu.2021.778028 · 2021 · External reference
Tuberculosis
10.1038/nrdp.2016.76 · 2016 · External reference
Sterilization of granulomas is common in active and latent tuberculosis despite within-host variability in bacterial killing
10.1038/nm.3412 · 2014 · External reference
Spatial and temporal localization of immune transcripts defines hallmarks and diversity in the tuberculosis granuloma
10.1038/s41467-019-09816-4 · 2019 · External reference
In the Thick of It: Formation of the Tuberculous Granuloma and Its Effects on Host and Therapeutic Responses
10.3389/fimmu.2022.820134 · 2022 · External reference
In vivo inhibition of tryptophan catabolism reorganizes the tuberculoma and augments immune-mediated control of Mycobacterium tuberculosis
10.1073/pnas.1711373114 · 2018 · External reference
Spatial organization and recruitment of non-specific T cells may limit T cell-macrophage interactions within mycobacterium tuberculosis granulomas
10.3389/fimmu.2020.613638 · 2021 · External reference
Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis
10.3389/fimmu.2016.00434 · 2016 · External reference
The immune landscape in tuberculosis reveals populations linked to disease and latency
10.1016/j.chom.2020.11.013 · 2021 · External reference
The single-cell pathology landscape of breast cancer
10.1038/s41586-019-1876-x · 2020 · External reference
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions
10.1016/j.immuni.2021.06.002 · 2021 · External reference
Identification of a disease-associated network of intestinal immune cells in treatment-naive inflammatory bowel disease
10.3389/fimmu.2022.893803 · 2022 · External reference
The immunoregulatory landscape of human tuberculosis granulomas
10.1038/s41590-021-01121-x · 2022 · External reference
Spatial mapping reveals granuloma diversity and histopathological superstructure in human tuberculosis
10.1084/jem.20221392 · 2023 · External reference
Modeling tuberculosis in nonhuman primates
10.1101/cshperspect.a018564 · 2014 · External reference
Disparate tuberculosis disease development in macaque species is associated with innate immunity
10.3389/fimmu.2019.02479 · 2019 · External reference
Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry
10.1038/nmeth.2869 · 2014 · External reference
An imaging mass cytometry immunophenotyping panel for non-human primate tissues
10.3389/fimmu.2022.915157 · 2022 · External reference
Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
10.1111/imr.12252 · 2015 · External reference
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
10.1016/j.immuni.2022.04.004 · 2022 · External reference
Inflammatory signaling in human tuberculosis granulomas is spatially organized
10.1038/nm.4073 · 2016 · External reference
Rhesus macaques are more susceptible to progressive tuberculosis than cynomolgus macaques: a quantitative comparison
10.1128/iai.00505-17 · 2018 · External reference
Differences in host immune populations between rhesus macaques and cynomolgus macaque subspecies in relation to susceptibility to Mycobacterium tuberculosis infection
10.1038/s41598-021-87872-x · 2021 · External reference
Patients with tuberculosis have a dysfunctional circulating B-cell compartment, which normalizes following successful treatment
2016 · External reference
A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes
10.1038/s41586-018-0439-x · 2018 · External reference
CXCR5+ T helper cells mediate protective immunity against tuberculosis
2013 · External reference
Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy
10.1172/jci.insight.163101 · 2023 · External reference
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization
10.1371/journal.ppat.1004603 · 2015 · External reference
Lung-resident CD3-NK1.1+CD69+CD103+ Cells Play an Important Role in Bacillus Calmette-Guérin Vaccine-Induced Protective Immunity against Mycobacterium tuberculosis Infection
10.4049/jimmunol.2200728 · 2024 · External reference
Airway T cells are a correlate of i.v. Bacille Calmette-Guerin-mediated protection against tuberculosis in rhesus macaques
10.1016/j.chom.2023.05.006 · 2023 · External reference
Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis
10.1016/j.ebiom.2020.102686 · 2020 · External reference
IL-21-dependent expansion of memory-like NK cells enhances protective immune responses against Mycobacterium tuberculosis
10.1038/mi.2016.105 · 2017 · External reference
Evaluating the diversity of circulating natural killer cells between active tuberculosis and latent tuberculosis infection
10.1016/j.tube.2022.102221 · 2022 · External reference
Functional characterization of human natural killer cells responding to Mycobacterium bovis bacille Calmette-Guérin
10.1111/j.1365-2567.2004.01858.x · 2004 · External reference
Human natural killer cells mediate killing of intracellular Mycobacterium tuberculosis H37Rv via granule-independent mechanisms
10.1128/iai.69.3.1755-1765.2001 · 2001 · External reference
IL-22 produced by human NK cells inhibits growth of Mycobacterium tuberculosis by enhancing phagolysosomal fusion
10.4049/jimmunol.0902587 · 2009 · External reference
NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen
10.4049/jimmunol.172.1.130 · 2004 · External reference
A 40-marker panel for high dimensional characterization of cancer immune microenvironments by imaging mass cytometry
10.3389/fimmu.2019.02534 · 2019 · External reference
ilastik: interactive machine learning for (bio)image analysis
10.1038/s41592-019-0582-9 · 2019 · External reference
Semi-automated background removal limits data loss and normalizes imaging mass cytometry data
10.1002/cyto.a.24480 · 2021 · External reference
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
10.1186/gb-2006-7-10-r100 · 2006 · External reference
Cytosplore: Interactive Immune Cell Phenotyping for Large Single‐Cell Datasets
10.1111/cgf.12893 · 2016 · External reference
ImaCytE: Visual Exploration of Cellular Micro-Environments for Imaging Mass Cytometry Data
10.1109/tvcg.2019.2931299 · 2021 · External reference
