Research graph
References from LANA-dependent transcription-replication conflicts and R-loops at the terminal repeats (TR) correlate with KSHV episome maintenance. Local targets link to admitted publications; unresolved targets remain external evidence.
Telomeres and viruses: common themes of genome maintenance
10.3389/fonc.2012.00201 · 2012 · External reference
Regulation and function of R-loops at repetitive elements
10.1016/j.biochi.2023.08.013 · 2023 · External reference
Kaposi’s sarcoma herpesvirus genome persistence
10.3389/fmicb.2016.01149 · 2016 · External reference
KSHV LANA--the master regulator of KSHV latency
10.3390/v6124961 · 2014 · External reference
Kaposi sarcoma-associated herpesvirus latency-associated nuclear antigen: more than a key mediator of viral persistence
10.1016/j.coviro.2023.101336 · 2023 · External reference
An atlas of chromatin landscape in KSHV-infected cells during de novo infection and reactivation
10.1016/j.virol.2024.110146 · 2024 · External reference
Kaposi sarcoma
10.1038/s41572-019-0060-9 · 2019 · External reference
Twenty years of KSHV
10.3390/v6114258 · 2014 · External reference
Efficient persistence of extrachromosomal KSHV DNA mediated by latency-associated nuclear antigen
10.1126/science.284.5414.641 · 1999 · External reference
The size and conformation of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) DNA in infected cells and virions
10.1128/jvi.70.11.8151-8154.1996 · 1996 · External reference
ORC, MCM, and histone hyperacetylation at the Kaposi’s sarcoma-associated herpesvirus latent replication origin
10.1128/jvi.78.22.12566-12575.2004 · 2004 · External reference
Chromatin remodeling of the Kaposi’s sarcoma-associated herpesvirus ORF50 promoter correlates with reactivation from latency
10.1128/jvi.77.21.11425-11435.2003 · 2003 · External reference
KSHV LANA1 binds DNA as an oligomer and residues N-terminal to the oligomerization domain are essential for DNA binding, replication, and episome persistence
10.1016/j.virol.2003.11.002 · 2004 · External reference
The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNA
10.1073/pnas.1421804112 · 2015 · External reference
Characterization of the minimal replicator of Kaposi’s sarcoma-associated herpesvirus latent origin
10.1128/jvi.79.4.2637-2642.2005 · 2005 · External reference
The 222- to 234-kilodalton latent nuclear protein (LNA) of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus 8) is encoded by orf73 and is a component of the latency-associated nuclear antigen
10.1128/jvi.71.8.5915-5921.1997 · 1997 · External reference
Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation
10.1371/journal.ppat.1009231 · 2021 · External reference
Molecular basis for oligomeric-DNA binding and episome maintenance by KSHV LANA
10.1371/journal.ppat.1003672 · 2013 · External reference
Close but distinct regions of human herpesvirus 8 latency-associated nuclear antigen 1 are responsible for nuclear targeting and binding to human mitotic chromosomes
10.1128/jvi.75.8.3948-3959.2001 · 2001 · External reference
The latency-associated nuclear antigen tethers the Kaposi’s sarcoma-associated herpesvirus genome to host chromosomes in body cavity-based lymphoma cells
10.1006/viro.1999.9999 · 1999 · External reference
Identification of Kaposi’s sarcoma-associated herpesvirus LANA regions important for episome segregation, replication, and persistence
10.1128/jvi.01243-13 · 2013 · External reference
The nucleosomal surface as a docking station for Kaposi’s sarcoma herpesvirus LANA
10.1126/science.1120541 · 2006 · External reference
MLL1 is regulated by KSHV LANA and is important for virus latency
10.1093/nar/gkab1094 · 2021 · External reference
Bub1 in complex with LANA recruits PCNA to regulate Kaposi’s sarcoma-associated herpesvirus latent replication and DNA translesion synthesis
10.1128/jvi.01524-15 · 2015 · External reference
Kaposi’s sarcoma-associated herpesvirus terminal repeat regulates inducible lytic gene promoters
10.1128/jvi.01386-23 · 2024 · External reference
KSHV encoded LANA recruits nucleosome assembly protein NAP1L1 for regulating viral DNA replication and transcription
10.1038/srep32633 · 2016 · External reference
LANA oligomeric architecture is essential for KSHV nuclear body formation and viral genome maintenance during latency
10.1371/journal.ppat.1007489 · 2019 · External reference
BET-inhibitors disrupt Rad21-dependent conformational control of KSHV latency
2017 · External reference
KSHV topologically associating domains in latent and reactivated viral chromatin
10.1128/jvi.00565-22 · 2022 · External reference
The role of chromatin at transcription-replication conflicts as a genome safeguard
10.1042/bst20210691 · 2021 · External reference
Transcription-replication conflicts as a source of genome instability
10.1146/annurev-genet-080320-031523 · 2023 · External reference
Transcription as a threat to genome integrity
10.1146/annurev-biochem-060815-014908 · 2016 · External reference
The contribution of co-transcriptional RNA:DNA hybrid structures to DNA damage and genome instability
10.1016/j.dnarep.2014.03.023 · 2014 · External reference
R-loop-forming sequences analysis in thousands of viral genomes identify a new common element in herpesviruses
10.1038/s41598-020-63101-9 · 2020 · External reference
Global epigenomic analysis of KSHV-infected primary effusion lymphoma identifies functional MYC superenhancers and enhancer RNAs
10.1073/pnas.1922216117 · 2020 · External reference
A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation
10.1128/mbio.03172-24 · 2025 · External reference
R loops are linked to histone H3 S10 phosphorylation and chromatin condensation
10.1016/j.molcel.2013.10.006 · 2013 · External reference
Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II)
2011 · External reference
Kaposi’s sarcoma-associated herpesvirus latency-associated nuclear antigen 1 mediates episome persistence through cis-acting terminal repeat (TR) sequence and specifically binds TR DNA
10.1128/jvi.75.7.3250-3258.2001 · 2001 · External reference
KSHV-encoded LANA bypasses transcriptional block through the stabilization of RNA Pol II in hypoxia
10.1128/mbio.02774-23 · 2024 · External reference
Kaposi’s sarcoma-associated herpesvirus hijacks RNA polymerase II to create a viral transcriptional factory
2017 · External reference
Kaposi’s sarcoma-associated herpesvirus Lana-1 is a major activator of the serum response element and mitogen-activated protein kinase pathways via interactions with the Mediator complex
10.1099/vir.0.017715-0 · 2010 · External reference
P-TEFb: the master regulator of transcription elongation
10.1016/j.molcel.2022.12.006 · 2023 · External reference
The super elongation complex (SEC) and MLL in development and disease
10.1101/gad.2015411 · 2011 · External reference
Defining R-loop classes and their contributions to genome instability
10.1016/j.dnarep.2021.103182 · 2021 · External reference
A cohesin traffic pattern genetically linked to gene regulation
10.1038/s41594-022-00890-9 · 2022 · External reference
Distinct properties and functions of CTCF revealed by a rapidly inducible degron system
10.1016/j.celrep.2021.108783 · 2021 · External reference
Transcription-replication conflict orientation modulates R-loop levels and activates distinct DNA damage responses
10.1016/j.cell.2017.07.043 · 2017 · External reference
R-loop generation during transcription: Formation, processing and cellular outcomes
10.1016/j.dnarep.2018.08.009 · 2018 · External reference
KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4
10.1016/j.celrep.2022.110788 · 2022 · External reference
Proximity labeling identifies a repertoire of site-specific R-loop modulators
10.1038/s41467-021-27722-6 · 2022 · External reference
Histone 3 s10 phosphorylation: “caught in the R loop!”
10.1016/j.molcel.2013.11.006 · 2013 · External reference
Rebelled epigenome: histone H3S10 phosphorylation and H3S10 kinases in cancer biology and therapy
10.1186/s13148-020-00941-2 · 2020 · External reference
Neuronal stress pathway mediating a histone methyl/phospho switch is required for herpes simplex virus reactivation
10.1016/j.chom.2015.11.007 · 2015 · External reference
Shugoshin 1 is dislocated by KSHV-encoded LANA inducing aneuploidy
10.1371/journal.ppat.1007253 · 2018 · External reference
Kaposi’s sarcoma-associated herpesvirus-encoded LANA can induce chromosomal instability through targeted degradation of the mitotic checkpoint kinase Bub1
10.1128/jvi.00554-14 · 2014 · External reference
Comprehensive analysis of LANA interacting proteins essential for viral genome tethering and persistence
10.1371/journal.pone.0074662 · 2013 · External reference
Bub1 and CENP-F can contribute to Kaposi’s sarcoma-associated herpesvirus genome persistence by targeting LANA to kinetochores
10.1128/jvi.00713-10 · 2010 · External reference
A novel mechanism inducing genome instability in Kaposi’s sarcoma-associated herpesvirus infected cells
10.1371/journal.ppat.1004098 · 2014 · External reference
DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks
10.1093/nar/gkad1141 · 2024 · External reference
A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins
10.1371/journal.ppat.1003640 · 2013 · External reference
Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi’s Sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1
10.1128/jvi.79.21.13618-13629.2005 · 2005 · External reference
Studies on gene enhancer with KSHV mini-chromatin
2025 · External reference
BRD4 prevents R-loop formation and transcription-replication conflicts by ensuring efficient transcription elongation
10.1016/j.celrep.2020.108166 · 2020 · External reference
The contribution of Kaposi’s sarcoma-associated herpesvirus ORF7 and its zinc-finger motif to viral genome cleavage and capsid formation
10.1128/jvi.00684-22 · 2022 · External reference
Acetylation of the latency-associated nuclear antigen regulates repression of Kaposi’s sarcoma-associated herpesvirus lytic transcription
10.1128/jvi.02541-05 · 2006 · External reference
Evidence for DNA hairpin recognition by Zta at the Epstein-Barr virus origin of lytic replication
10.1128/jvi.02666-09 · 2010 · External reference
ADAR1 RNA editing enzyme regulates R-loop formation and genome stability at telomeres in cancer cells
10.1038/s41467-021-21921-x · 2021 · External reference
Cell cycle control of Kaposi’s sarcoma-associated herpesvirus latency transcription by CTCF-cohesin interactions
10.1128/jvi.00052-09 · 2009 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
Minimap2: pairwise alignment for nucleotide sequences
10.1093/bioinformatics/bty191 · 2018 · External reference
Twelve years of SAMtools and BCFtools
10.1093/gigascience/giab008 · 2021 · External reference
