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References from In vitro HIV DNA integration in STAT3 drives T cell persistence—A model of HIV-associated T cell lymphoma. Local targets link to admitted publications; unresolved targets remain external evidence.
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LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
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Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
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Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
10.1172/jci35700 · 2008 · External reference
Gene therapy for Wiskott-Aldrich syndrome--long-term efficacy and genotoxicity
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FDA investigating safety risks in CAR T-cell recipients
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Second primary malignancies after commercial CAR T-cell therapy: analysis of the FDA Adverse Events Reporting System
10.1182/blood.2024024166 · 2024 · External reference
Secondary cancers after chimeric antigen receptor T-cell therapy
10.1056/nejmp2400209 · 2024 · External reference
Unanswered questions following reports of secondary malignancies after CAR-T cell therapy
10.1038/s41591-023-02767-w · 2024 · External reference
Hematologic Cancer after Gene Therapy for Cerebral Adrenoleukodystrophy
10.1056/nejmoa2405541 · 2024 · External reference
CAR+ T-Cell Lymphoma after Cilta-cel Therapy for Relapsed or Refractory Myeloma
10.1056/nejmoa2309728 · 2025 · External reference
CD4 T-cell lymphoma harboring a chimeric antigen receptor integration in TP53
10.1056/nejmoa2411507 · 2025 · External reference
T cell malignancies after CAR T cell therapy in the DESCAR-T registry
2025 · External reference
Integration of HIV-1 caused STAT3-associated B cell lymphoma in an AIDS patient
10.1016/j.micinf.2007.09.008 · 2007 · External reference
Insertional activation of STAT3 and LCK by HIV-1 proviruses in T cell lymphomas
10.1126/sciadv.abi8795 · 2021 · External reference
Pathology of lymphoma in HIV
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Association of immunosuppression and HIV viraemia with non-Hodgkin lymphoma risk overall and by subtype in people living with HIV in Canada and the USA: a multicentre cohort study
10.1016/s2352-3018(18)30360-6 · 2019 · External reference
Risk of non-Hodgkin lymphoma subtypes in HIV-infected people during the HAART era: a population-based study
10.1097/qad.0000000000000428 · 2014 · External reference
HIV-associated immune dysfunction and viral infection: role in the pathogenesis of AIDS-related lymphoma
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Human Immunodeficiency Virus Tat Protein Aids V Region Somatic Hypermutation in Human B Cells
10.1128/mbio.02315-17 · 2018 · External reference
HIV-1 Tat Activates Akt/mTORC1 Pathway and AICDA Expression by Downregulating Its Transcriptional Inhibitors in B Cells
10.3390/ijms22041588 · 2021 · External reference
STAT3 Dysregulation in Mature T and NK Cell Lymphomas
10.3390/cancers11111711 · 2019 · External reference
STAT3 Target Genes Relevant to Human Cancers
10.3390/cancers6020897 · 2014 · External reference
STAT3 Activation and Oncogenesis in Lymphoma
2019 · External reference
STAT3 Role in T-Cell Memory Formation
10.3390/ijms23052878 · 2022 · External reference
Genome-wide Analysis of STAT3-Mediated Transcription during Early Human Th17 Cell Differentiation
10.1016/j.celrep.2017.05.013 · 2017 · External reference
Constitutively Activated STAT3 Promotes Cell Proliferation and Survival in the Activated B Cell Subtype of Diffuse Large B Cell Lymphomas
10.1182/blood.v110.11.1621.1621 · 2007 · External reference
Genetics of anaplastic large cell lymphoma
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ALK-Negative Anaplastic Large Cell Lymphoma: Current Concepts and Molecular Pathogenesis of a Heterogeneous Group of Large T-Cell Lymphomas
10.3390/cancers13184667 · 2021 · External reference
The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding
10.1074/jbc.m411681200 · 2005 · External reference
A role for LEDGF/p75 in targeting HIV DNA integration
10.1038/nm1329 · 2005 · External reference
The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication
10.1371/journal.ppat.1000046 · 2008 · External reference
HIV latency. Proliferation of cells with HIV integrated into cancer genes contributes to persistent infection
10.1126/science.1256304 · 2014 · External reference
HIV latency. Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
10.1126/science.1254194 · 2014 · External reference
HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells
10.1038/s41467-017-00609-1 · 2017 · External reference
Integration in oncogenes plays only a minor role in determining the in vivo distribution of HIV integration sites before or during suppressive antiretroviral therapy
10.1371/journal.ppat.1009141 · 2021 · External reference
What integration sites tell us about HIV persistence
10.1016/j.chom.2016.04.010 · 2016 · External reference
Antigen-driven clonal selection shapes the persistence of HIV-1-infected CD4 T cells in vivo
10.1172/jci145254 · 2021 · External reference
Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones
10.1016/j.immuni.2022.03.004 · 2022 · External reference
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence
10.1016/j.immuni.2023.10.002 · 2023 · External reference
HIV proviral DNA integration can drive T cell growth ex vivo
10.1073/pnas.2013194117 · 2020 · External reference
An analytical pipeline for identifying and mapping the integration sites of HIV and other retroviruses
10.1186/s12864-020-6647-4 · 2020 · External reference
Single-cell transcriptional landscapes reveal HIV-1-driven aberrant host gene transcription as a potential therapeutic target
2020 · External reference
CRISPR/Cas9-Mediated Insertion of HIV Long Terminal Repeat within BACH2 Promotes Expansion of T Regulatory-like Cells
10.4049/jimmunol.2100491 · 2022 · External reference
HIV reproducibly establishes a latent infection after acute infection of T cells in vitro
10.1093/emboj/cdg188 · 2003 · External reference
The Vif and Vpr accessory proteins independently cause HIV-1-induced T cell cytopathicity and cell cycle arrest
10.1073/pnas.0509417103 · 2006 · External reference
Cellular GFP Toxicity and Immunogenicity: Potential Confounders in in Vivo Cell Tracking Experiments
10.1007/s12015-016-9670-8 · 2016 · External reference
Epigenetic silencing of human immunodeficiency virus (HIV) transcription by formation of restrictive chromatin structures at the viral long terminal repeat drives the progressive entry of HIV into latency
10.1128/jvi.01383-08 · 2008 · External reference
Monokine regulation of human immunodeficiency virus-1 expression in a chronically infected human T cell clone
10.4049/jimmunol.142.2.431 · 1989 · External reference
Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone
10.1073/pnas.86.7.2365 · 1989 · External reference
HIV integration sites in latently infected cell lines: evidence of ongoing replication
10.1186/s12977-016-0325-2 · 2017 · External reference
Tracking HIV-1-Infected Cell Clones Using Integration Site-Specific qPCR
10.3390/v13071235 · 2021 · External reference
INSPIIRED: A Pipeline for Quantitative Analysis of Sites of New DNA Integration in Cellular Genomes
10.1016/j.omtm.2016.11.002 · 2016 · External reference
An inhibitory role for the transcription factor Stat3 in controlling IL-4 and Bcl6 expression in follicular helper T cells
10.4049/jimmunol.1500335 · 2015 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
SOCS3, a Major Regulator of Infection and Inflammation
10.3389/fimmu.2014.00058 · 2014 · External reference
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory
10.1016/j.immuni.2011.09.016 · 2011 · External reference
Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling
10.1016/j.yexcr.2022.113079 · 2022 · External reference
SGK1 in Human Cancer: Emerging Roles and Mechanisms
10.3389/fonc.2020.608722 · 2021 · External reference
Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis
10.1038/nm1269 · 2005 · External reference
Anti-apoptotic effects of suppressor of cytokine signaling 3 and 1 in psoriasis
10.1038/cddis.2012.69 · 2012 · External reference
Effect of SOCS3 on apoptosis of human trophoblasts via adjustment of the JAK2/STAT3 signaling pathway in preterm birth
10.21037/tp-21-39 · 2021 · External reference
Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes
10.1186/s40425-019-0635-8 · 2019 · External reference
STAT3 gain-of-function mutations connect leukemia with autoimmune disease by pathological NKG2D(hi) CD8(+) T cell dysregulation and accumulation
10.1016/j.immuni.2022.11.001 · 2022 · External reference
STAT3 governs hyporesponsiveness and granzyme B-dependent suppressive capacity in human CD4+ T cells
10.1096/fj.14-257584 · 2015 · External reference
Viral manipulation of STAT3: Evade, exploit, and injure
10.1371/journal.ppat.1006839 · 2018 · External reference
TCR signaling induces STAT3 phosphorylation to promote TH17 cell differentiation
2024 · External reference
A model of Th2 differentiation based on polarizing cytokine repression
10.1016/j.it.2023.04.004 · 2023 · External reference
Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype
10.3389/fimmu.2018.02832 · 2018 · External reference
Stem cell-like memory T cells: The generation and application
10.1002/jlb.5mr0321-145r · 2021 · External reference
CARD8 is an inflammasome sensor for HIV-1 protease activity
10.1126/science.abe1707 · 2021 · External reference
A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection
10.7554/elife.84108 · 2023 · External reference
The CARD8 inflammasome dictates HIV/SIV pathogenesis and disease progression
10.1016/j.cell.2024.01.048 · 2024 · External reference
Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects
10.3960/jslrt.17023 · 2017 · External reference
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A pan-cancer analysis reveals role of clusterin (CLU) in carcinogenesis and prognosis of human tumors
10.3389/fgene.2022.1056184 · 2023 · External reference
HIV-1 integration in the human genome favors active genes and local hotspots
10.1016/s0092-8674(02)00864-4 · 2002 · External reference
CKAP2L, a crucial target of miR-326, promotes prostate cancer progression
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Cytopathic killing of peripheral blood CD4(+) T lymphocytes by human immunodeficiency virus type 1 appears necrotic rather than apoptotic and does not require env
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HIV immune evasin Nef enhances allogeneic CAR T cell potency
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Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat
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An analog of the natural steroidal alkaloid cortistatin A potently suppresses Tat-dependent HIV transcription
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The Tat inhibitor didehydro-cortistatin A prevents HIV-1 reactivation from latency
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External reference
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Cutadapt removes adapter sequences from high-throughput sequencing reads
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