Research graph
References from Structural and functional studies of rabbit SAMD9 reveal a distinct tRNase module that underlies the antiviral activity. Local targets link to admitted publications; unresolved targets remain external evidence.
The complex domain architecture of SAMD9 family proteins, predicted STAND-like NTPases, suggests new links to inflammation and apoptosis
10.1186/s13062-017-0185-2 · 2017 · External reference
A paralogous pair of mammalian host restriction factors form a critical host barrier against poxvirus infection
10.1371/journal.ppat.1006884 · 2018 · External reference
Identification of restriction factors by human genome-wide RNA interference screening of viral host range mutants exemplified by discovery of SAMD9 and WDR6 as inhibitors of the vaccinia virus K1L-C7L- mutant
10.1128/mbio.01122-15 · 2015 · External reference
M062 is a host range factor essential for myxoma virus pathogenesis and functions as an antagonist of host SAMD9 in human cells
10.1128/jvi.02243-10 · 2011 · External reference
Structure and function of an effector domain in antiviral factors and tumor suppressors SAMD9 and SAMD9L
10.1073/pnas.2116550119 · 2022 · External reference
Germline SAMD9L truncation variants trigger global translational repression
10.1084/jem.20201195 · 2021 · External reference
An interaction domain in human SAMD9 is essential for myxoma virus host-range determinant M062 antagonism of host anti-viral function
10.1016/j.virol.2017.01.004 · 2017 · External reference
Identification of CP77 as the third orthopoxvirus SAMD9 and SAMD9L inhibitor with unique specificity for a rodent SAMD9L
10.1128/jvi.00225-19 · 2019 · External reference
The cowpox virus host range gene, CP77, affects phosphorylation of eIF2 alpha and vaccinia viral translation in apoptotic HeLa cells
10.1016/j.virol.2004.07.032 · 2004 · External reference
Host range deletion mutant of vaccinia virus defective in human cells
10.1016/0042-6822(81)90351-2 · 1981 · External reference
Identification from diverse mammalian poxviruses of host-range regulatory genes functioning equivalently to vaccinia virus C7L
10.1016/j.virol.2007.10.023 · 2008 · External reference
SAMD9 mutations cause a novel multisystem disorder, MIRAGE syndrome, and are associated with loss of chromosome 7
10.1038/ng.3569 · 2016 · External reference
A landscape of germ line mutations in a cohort of inherited bone marrow failure patients
10.1182/blood-2017-09-806489 · 2018 · External reference
The genomic landscape of pediatric myelodysplastic syndromes
10.1038/s41467-017-01590-5 · 2017 · External reference
Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes
10.1038/s41591-021-01511-6 · 2021 · External reference
Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes
2018 · External reference
Ataxia-Pancytopenia Syndrome Is Caused by Missense Mutations in SAMD9L
10.1016/j.ajhg.2016.04.009 · 2016 · External reference
Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms
10.1182/blood-2016-10-743302 · 2017 · External reference
STAND, a class of P-loop NTPases including animal and plant regulators of programmed cell death: multiple, complex domain architectures, unusual phyletic patterns, and evolution by horizontal gene transfer
10.1016/j.jmb.2004.08.023 · 2004 · External reference
Intracellular innate immune surveillance devices in plants and animals
2016 · External reference
Human SAMD9 is a poxvirus-activatable anticodon nuclease inhibiting codon-specific protein synthesis
2023 · External reference
Human host range restriction of the vaccinia virus C7/K1 double deletion mutant is mediated by an atypical mode of translation inhibition
10.1128/jvi.01329-18 · 2018 · External reference
Poxvirus host-range determinants: SAMD9/9L and beyond
2025 · External reference
Evolution and divergence of the mammalian SAMD9/SAMD9L gene family
10.1186/1471-2148-13-121 · 2013 · External reference
Investigating the impact of host factors on vaccinia virus infection through single-cell analysis via flow cytometry
10.1007/978-1-0716-4160-6_14 · 2025 · External reference
An improved protocol for rapid freezing of protein samples for long-term storage
10.1107/s0907444903024491 · 2004 · External reference
Solving structures of protein complexes by molecular replacement withPhaser
10.1107/s0907444906045975 · 2006 · External reference
PHENIX: a comprehensive Python-based system for macromolecular structure solution
10.1107/s0907444909052925 · 2010 · External reference
Coot: model-building tools for molecular graphics
10.1107/s0907444904019158 · 2004 · External reference
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion
10.1107/s0907444906005270 · 2006 · External reference
Unresolved reference
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