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References from Adeno-Associated Virus 2 (AAV2) - Induced RPA exhaustion generates cellular DNA damage and restricts viral gene expression. Local targets link to admitted publications; unresolved targets remain external evidence.
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication
10.1371/journal.ppat.1001141 · 2010 · External reference
Parvovirus minute virus of mice interacts with sites of cellular DNA damage to establish and amplify its lytic infection
10.7554/elife.37750 · 2018 · External reference
Induction and utilization of an ATM signaling pathway by polyomavirus
10.1128/jvi.79.20.13007-13017.2005 · 2005 · External reference
SV40 utilizes ATM kinase activity to prevent non-homologous end joining of broken viral DNA replication products
2014 · External reference
Human papillomaviruses activate the ATM DNA damage pathway for viral genome amplification upon differentiation
10.1371/journal.ppat.1000605 · 2009 · External reference
Human papillomaviruses recruit cellular DNA repair and homologous recombination factors to viral replication centers
10.1128/jvi.00247-12 · 2012 · External reference
Relocalization of the Mre11-Rad50-Nbs1 complex by the adenovirus E4 ORF3 protein is required for viral replication
10.1128/jvi.79.10.6207-6215.2005 · 2005 · External reference
Mislocalization of the MRN complex prevents ATR signaling during adenovirus infection
10.1038/emboj.2009.15 · 2009 · External reference
Differential requirements of the C terminus of Nbs1 in suppressing adenovirus DNA replication and promoting concatemer formation
10.1128/jvi.00900-08 · 2008 · External reference
Viral and Cellular Genomes Activate Distinct DNA Damage Responses
10.1016/j.cell.2015.07.058 · 2015 · External reference
Adenovirus oncoproteins inactivate the Mre11-Rad50-NBS1 DNA repair complex
10.1038/nature00863 · 2002 · External reference
A viral E3 ligase targets RNF8 and RNF168 to control histone ubiquitination and DNA damage responses
10.1038/emboj.2009.400 · 2010 · External reference
An intrinsically disordered region of the DNA repair protein Nbs1 is a species-specific barrier to Herpes Simplex Virus 1 in primates
10.1016/j.chom.2016.07.003 · 2016 · External reference
DNA repair proteins affect the lifecycle of herpes simplex virus 1
10.1073/pnas.0501916102 · 2005 · External reference
Herpes simplex virus type I disrupts the ATR-dependent DNA-damage response during lytic infection
10.1242/jcs.02981 · 2006 · External reference
Adeno-associated virus replication induces a DNA damage response coordinated by DNA-dependent protein kinase
10.1128/jvi.00318-09 · 2009 · External reference
Take your PIKK: tumour viruses and DNA damage response pathways
10.1098/rstb.2016.0269 · 2017 · External reference
ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
10.1016/j.molcel.2017.05.015 · 2017 · External reference
The ATR signaling pathway is disabled during infection with the parvovirus minute virus of mice
10.1128/jvi.01412-14 · 2014 · External reference
Induction of DNA damage signaling upon Rift Valley fever virus infection results in cell cycle arrest and increased viral replication
10.1074/jbc.m111.296608 · 2012 · External reference
A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels and activates the DNA damage response
10.1128/mbio.00676-24 · 2024 · External reference
Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding
10.1128/jvi.01515-08 · 2009 · External reference
Genomes of the autonomous parvovirus minute virus of mice induce replication stress through RPA exhaustion
10.1371/journal.ppat.1011203 · 2023 · External reference
Parvovirus-induced depletion of cyclin B1 prevents mitotic entry of infected cells
10.1371/journal.ppat.1003891 · 2014 · External reference
Targeting human glioblastoma cells: comparison of nine viruses with oncolytic potential
10.1128/jvi.79.10.6005-6022.2005 · 2005 · External reference
Characterization of the temporal accumulation of minute virus of mice replicative intermediates
10.1099/0022-1317-75-7-1633 · 1994 · External reference
The adeno-associated virus 2 genome and Rep 68/78 proteins interact with cellular sites of DNA damage
10.1093/hmg/ddab300 · 2022 · External reference
Minute virus of mice NS1 interacts with the SMN protein, and they colocalize in novel nuclear bodies induced by parvovirus infection
10.1128/jvi.76.8.3892-3904.2002 · 2002 · External reference
Recruitment of DNA replication and damage response proteins to viral replication centers during infection with NS2 mutants of Minute Virus of Mice (MVM)
10.1016/j.virol.2010.12.009 · 2011 · External reference
Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damage-response proteins
10.1242/jcs.003632 · 2008 · External reference
A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping
10.1016/j.cell.2014.11.021 · 2014 · External reference
Chromosome fragile sites
10.1146/annurev.genet.41.042007.165900 · 2007 · External reference
Genome organization drives chromosome fragility
10.1016/j.cell.2017.06.034 · 2017 · External reference
Genome-wide mapping and profiling of γH2AX binding hotspots in response to different replication stress inducers
10.1186/s12864-019-5934-4 · 2019 · External reference
Common fragile sites: genomic hotspots of DNA damage and carcinogenesis
10.3390/ijms130911974 · 2012 · External reference
Papillomavirus genomes associate with BRD4 to replicate at fragile sites in the host genome
2014 · External reference
Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs
10.1038/s41525-021-00264-y · 2021 · External reference
Chromosomal fragile site breakage by EBV-encoded EBNA1 at clustered repeats
10.1038/s41586-023-05923-x · 2023 · External reference
The autonomous parvovirus minute virus of mice localizes to cellular sites of DNA damage using ATR signaling
10.3390/v15061243 · 2023 · External reference
Minute virus of mice NS1 redirects casein kinase 2 specificity to suppress the ATR DNA damage response pathway during infection
10.1128/jvi.00559-24 · 2024 · External reference
Viral transport of DNA damage that mimics a stalled replication fork
10.1128/jvi.79.1.569-580.2005 · 2005 · External reference
Chk1 instability is coupled to mitotic cell death of p53-deficient cells in response to virus-induced DNA damage signaling
10.1016/j.jmb.2007.06.077 · 2007 · External reference
Virus-mediated killing of cells that lack p53 activity
10.1038/35091082 · 2001 · External reference
Adeno-associated virus monoinfection induces a DNA damage response and DNA repair that contributes to viral DNA replication
10.1128/mbio.03528-22 · 2023 · External reference
The Mre11/Rad50/Nbs1 complex limits adeno-associated virus transduction and replication
10.1128/jvi.01523-07 · 2007 · External reference
Viral single-strand DNA induces p53-dependent apoptosis in human embryonic stem cells
10.1371/journal.pone.0027520 · 2011 · External reference
DNA polymerase delta in DNA replication and genome maintenance
10.1002/em.21745 · 2012 · External reference
The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA
10.1093/nar/gkm741 · 2007 · External reference
Bulk synthesis and beyond: the roles of eukaryotic replicative DNA polymerases
10.1016/j.dnarep.2024.103740 · 2024 · External reference
Freedom to err: The expanding cellular functions of translesion DNA polymerases
10.1016/j.molcel.2023.07.008 · 2023 · External reference
Human parvovirus B19 utilizes cellular DNA replication machinery for viral DNA replication
2018 · External reference
Replication of an autonomous human parvovirus in non-dividing human airway epithelium is facilitated through the DNA damage and repair pathways
10.1371/journal.ppat.1005399 · 2016 · External reference
Cellular proteins required for adeno-associated virus DNA replication in the absence of adenovirus coinfection
10.1128/jvi.72.4.2777-2787.1998 · 1998 · External reference
Helper functions required for wild type and recombinant adeno-associated virus growth
10.2174/1566523054064977 · 2005 · External reference
ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage
10.1083/jcb.201008076 · 2011 · External reference
DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation
10.1038/emboj.2013.148 · 2013 · External reference
The identification of translesion DNA synthesis regulators: Inhibitors in the spotlight
10.1016/j.dnarep.2015.04.027 · 2015 · External reference
DNA fiber analysis: mind the gap!
10.1016/bs.mie.2017.03.019 · 2017 · External reference
Adeno-associated virus vector as a platform for gene therapy delivery
10.1038/s41573-019-0012-9 · 2019 · External reference
Recombinant adeno-associated viral vectors are deficient in provoking a DNA damage response
10.1128/jvi.00358-08 · 2008 · External reference
Purification of proteins on newly synthesized DNA using iPOND
10.1007/978-1-4939-1680-1_10 · 2015 · External reference
Casein kinase 2 activity is a host restriction factor for AAV transduction
10.1016/j.ymthe.2023.11.010 · 2024 · External reference
Replication protein A: single-stranded DNA’s first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair
10.1002/bies.201400107 · 2014 · External reference
Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
10.1093/nar/gks849 · 2012 · External reference
Targeted inhibition of Replication Protein A reveals cytotoxic activity, synergy with chemotherapeutic DNA-damaging agents, and insight into cellular function
10.1158/0008-5472.can-09-3422 · 2010 · External reference
A PRMT5-ZNF326 axis mediates innate immune activation upon replication stress
10.1126/sciadv.adm9589 · 2024 · External reference
Minute virus of mice inhibits transcription of the cyclin B1 gene during infection
10.1128/jvi.00428-17 · 2017 · External reference
Bocavirus infection induces mitochondrion-mediated apoptosis and cell cycle arrest at G2/M phase
10.1128/jvi.02094-09 · 2010 · External reference
Proteome profiling of polyomavirus nuclear replication centers using iPOND
10.1128/jvi.00790-24 · 2024 · External reference
Identifying host factors associated with DNA replicated during virus infection
10.1074/mcp.m117.067116 · 2017 · External reference
Replication-coupled recruitment of viral and cellular factors to Herpes Simplex Virus Type 1 replication forks for the maintenance and expression of viral genomes
10.1371/journal.ppat.1006166 · 2017 · External reference
The herpes simplex virus alkaline nuclease is required to maintain replication fork progression
10.1128/jvi.01836-24 · 2024 · External reference
Adenovirus remodeling of the host proteome and host factors associated with viral genomes
10.1128/msystems.00468-21 · 2021 · External reference
Identification of rep-associated factors in herpes simplex virus type 1-induced adeno-associated virus type 2 replication compartments
10.1128/jvi.00725-10 · 2010 · External reference
Tyrosine-phosphorylation of AAV2 vectors and its consequences on viral intracellular trafficking and transgene expression
10.1016/j.virol.2008.08.027 · 2008 · External reference
Adeno-associated virus type 2 (AAV2) uncoating is a stepwise process and is linked to structural reorganization of the nucleolus
10.1371/journal.ppat.1010187 · 2022 · External reference
AAV2 can replicate its DNA by a rolling hairpin or rolling circle mechanism, depending on the helper virus
10.1128/jvi.01282-24 · 2024 · External reference
Replication protein A interactions with DNA. 2. Characterization of double-stranded DNA-binding/helix-destabilization activities and the role of the zinc-finger domain in DNA interactions
10.1021/bi982371m · 1999 · External reference
G9a coordinates with the RPA complex to promote DNA damage repair and cell survival
10.1073/pnas.1700694114 · 2017 · External reference
Functional role of G9a histone methyltransferase in cancer
10.3389/fimmu.2015.00487 · 2015 · External reference
Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome
10.1073/pnas.1721883115 · 2018 · External reference
ATR prohibits replication catastrophe by preventing global exhaustion of RPA
10.1016/j.cell.2013.10.043 · 2013 · External reference
Viral Chromosome Conformation Capture (V3C) Assays for Identifying Trans-interaction Sites between Lytic Viruses and the Cellular Genome
10.21769/bioprotoc.3198 · 2019 · External reference
Improved enzymatic labeling of fluorescent in situ hybridization probes applied to the visualization of retained introns in cells
10.1261/rna.079591.123 · 2023 · External reference
