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References from Membrane-wide screening identifies potential tissue-specific determinants of SARS-CoV-2 tropism. Local targets link to admitted publications; unresolved targets remain external evidence.
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Unresolved reference
External reference
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Genome-wide CRISPR screens reveal host factors critical for SARS-CoV-2 infection
2021 · External reference
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion
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Soluble ACE2-mediated cell entry of SARS-CoV-2 via interaction with proteins related to the renin-angiotensin system
10.1016/j.cell.2021.02.053 · 2021 · External reference
Genome-wide CRISPR screening identifies TMEM106B as a proviral host factor for SARS-CoV-2
10.1038/s41588-021-00805-2 · 2021 · External reference
Identification of required host factors for SARS-CoV-2 infection in human cells
10.1016/j.cell.2020.10.030 · 2021 · External reference
TMEM41B is a pan-flavivirus host factor
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Genome-scale identification of SARS-CoV-2 and Pan-coronavirus host factor networks
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A Crisp(r) new perspective on SARS-CoV-2 biology
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Neuropilin-1 is a host factor for SARS-CoV-2 infection
10.1126/science.abd3072 · 2020 · External reference
Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity
10.1126/science.abd2985 · 2020 · External reference
Surfaceome CRISPR screen identifies OLFML3 as a rhinovirus-inducible IFN antagonist
10.1186/s13059-021-02513-w · 2021 · External reference
REGN-COV2, a neutralizing antibody cocktail, in outpatients with Covid-19
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Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine through 6 months
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SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodies
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Antibody evasion by the P.1 strain of SARS-CoV-2
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Antibody resistance of SARS-CoV-2 variants B.1.351 and B.1.1.7
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Effectiveness of the BNT162b2 Covid-19 vaccine against the B.1.1.7 and B.1.351 variants
10.1056/nejmc2104974 · 2021 · External reference
Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination
10.1016/s0140-6736(21)01290-3 · 2021 · External reference
Oral antiviral treatments for COVID-19: opportunities and challenges
10.1007/s43440-022-00388-7 · 2022 · External reference
Design of potent membrane fusion inhibitors against SARS-CoV-2, an emerging coronavirus with high fusogenic activity
2020 · External reference
Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion
10.1038/s41422-020-0305-x · 2020 · External reference
Intranasal fusion inhibitory lipopeptide prevents direct-contact SARS-CoV-2 transmission in ferrets
10.1126/science.abf4896 · 2021 · External reference
Unresolved reference
External reference
Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19
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10.1126/science.1260419 · 2015 · External reference
The GTEx consortium atlas of genetic regulatory effects across human tissues
10.1126/science.aaz1776 · 2020 · External reference
Multiorgan and renal tropism of SARS-CoV-2
10.1056/nejmc2011400 · 2020 · External reference
Association of cardiac infection with SARS-CoV-2 in confirmed COVID-19 autopsy cases
10.1001/jamacardio.2020.3551 · 2020 · External reference
COVID-19-related anosmia is associated with viral persistence and inflammation in human olfactory epithelium and brain infection in hamsters
10.1126/scitranslmed.abf8396 · 2021 · External reference
Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike
10.1073/pnas.2100425118 · 2021 · External reference
A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures
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2017 · External reference
Voltage-gated potassium channels as therapeutic targets
10.1038/nrd2983 · 2009 · External reference
Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer’s disease
10.1038/nm.3700 · 2014 · External reference
A public genome-scale lentiviral expression library of human ORFs
10.1038/nmeth.1638 · 2011 · External reference
SARS-CoV-2 productively infects human gut enterocytes
10.1126/science.abc1669 · 2020 · External reference
Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process
External reference
SARS-CoV-2 renal tropism associates with acute kidney injury
10.1016/s0140-6736(20)31759-1 · 2020 · External reference
Cross-validation of SARS-CoV-2 responses in kidney organoids and clinical populations
10.1172/jci.insight.154882 · 2021 · External reference
Structure and function of legumain in health and disease
10.1016/j.biochi.2015.09.022 · 2016 · External reference
Role of LGMN in tumor development and its progression and connection with the tumor microenvironment
10.3389/fmolb.2023.1121964 · 2023 · External reference
Autocrine pro-legumain promotes breast cancer metastasis via binding to integrin αvβ3
10.1038/s41388-022-02409-4 · 2022 · External reference
SARS-CoV-2 infection and replication kinetics in different human cell types: The role of autophagy, cellular metabolism and ACE2 expression
10.1016/j.lfs.2022.120930 · 2022 · External reference
SARS-CoV-2 infection triggers profibrotic macrophage responses and lung fibrosis
10.1016/j.cell.2021.11.033 · 2021 · External reference
The human olfactory transcriptome
10.1186/s12864-016-2960-3 · 2016 · External reference
Transcriptome analysis reveals distinct gene expression profiles in eosinophilic and noneosinophilic chronic rhinosinusitis with nasal polyps
10.1038/srep26604 · 2016 · External reference
Single-cell analysis of olfactory neurogenesis and differentiation in adult humans
10.1038/s41593-020-0587-9 · 2020 · External reference
SARS-CoV-2 receptor ACE2 and TMPRSS2 are primarily expressed in bronchial transient secretory cells
10.15252/embj.20105114 · 2020 · External reference
Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
10.1183/13993003.01123-2020 · 2020 · External reference
The protein expression profile of ACE2 in human tissues
10.15252/msb.20209610 · 2020 · External reference
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19
10.1038/s41593-020-00758-5 · 2021 · External reference
Neurological associations of COVID-19
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ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALF
2022 · External reference
Neuroinvasion of SARS-CoV-2 in human and mouse brain
10.1084/jem.20202135 · 2021 · External reference
SARS-CoV-2 targets neurons of 3D human brain organoids
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Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection
10.1038/s41588-022-01131-x · 2022 · External reference
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs
10.1038/s41588-022-01110-2 · 2022 · External reference
Genome-wide CRISPR activation screen identifies candidate receptors for SARS-CoV-2 entry
10.1007/s11427-021-1990-5 · 2022 · External reference
A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection
2022 · External reference
Pooled extracellular receptor-ligand interaction screening using CRISPR activation
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A replication-competent vesicular stomatitis virus for studies of SARS-CoV-2 spike-mediated cell entry and its inhibition
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