Research graph
References from EPHA5 regulates antifungal innate immunity by phosphorylating EPHB2 and Dectin-1. Local targets link to admitted publications; unresolved targets remain external evidence.
Immune defence to invasive fungal infections: a comprehensive review
10.1016/j.biopha.2020.110550 · 2020 · External reference
Global incidence and mortality of severe fungal disease
10.1016/s1473-3099(23)00692-8 · 2024 · External reference
Hidden killers: human fungal infections
10.1126/scitranslmed.3004404 · 2012 · External reference
A synthetic peptide mimic kills Candida albicans and synergistically prevents infection
10.1038/s41467-024-50491-x · 2024 · External reference
Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival
10.3390/jof7080667 · 2021 · External reference
Candida auris: a rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally
10.1371/journal.ppat.1006290 · 2017 · External reference
Antimicrobials and resistance part II: antifungals, antivirals, and antiparasitics
10.1016/j.jaad.2021.11.065 · 2022 · External reference
C-type lectin receptors in anti-fungal immunity
10.1016/j.mib.2017.11.004 · 2017 · External reference
Antifungal immunity: advances in PRR recognition, adaptive responses, and immune-based therapies
2025 · External reference
Dectin-1 is required for beta-glucan recognition and control of fungal infection
10.1038/ni1408 · 2007 · External reference
Syk kinase-coupled C-type lectin receptors engage protein kinase C-δ to elicit Card9 adaptor-mediated innate immunity
10.1016/j.immuni.2011.11.015 · 2012 · External reference
The nucleotide receptor STING translocates to the phagosomes to negatively regulate anti-fungal immunity
10.1016/j.immuni.2023.06.002 · 2023 · External reference
TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity
10.1038/s41392-021-00711-3 · 2021 · External reference
Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses
10.1038/ni.3155 · 2015 · External reference
DOCK2 regulates antifungal immunity by regulating RAC GTPase activity
10.1038/s41423-021-00835-0 · 2022 · External reference
MYO1F regulates antifungal immunity by regulating acetylation of microtubules
2021 · External reference
TAGAP instructs Th17 differentiation by bridging Dectin activation to EPHB2 signaling in innate antifungal response
10.1038/s41467-020-15564-7 · 2020 · External reference
Cutting edge: EPHB2 is a coreceptor for fungal recognition and phosphorylation of Syk in the Dectin-1 signaling pathway
10.4049/jimmunol.2001373 · 2021 · External reference
Ephs and ephrins
10.1016/j.cub.2017.01.003 · 2017 · External reference
EphA5 and EphA6: regulation of neuronal and spine morphology
10.1186/s13578-016-0115-5 · 2016 · External reference
EPHA5 mutations predict survival after immunotherapy in lung adenocarcinoma
10.18632/aging.202169 · 2020 · External reference
Innate immune responses against the fungal pathogen Candida auris
10.1038/s41467-022-31201-x · 2022 · External reference
Th17-associated cytokines IL-17 and IL-23 in inflamed skin of Darier disease patients as potential therapeutic targets
10.1038/s41467-023-43210-5 · 2023 · External reference
Receptor tyrosine kinase activation: From the ligand perspective
10.1016/j.ceb.2020.01.016 · 2020 · External reference
Eph receptor signaling and ephrins
10.1101/cshperspect.a009159 · 2013 · External reference
EphA2 is an epithelial cell pattern recognition receptor for fungal β-glucans
10.1038/s41564-017-0059-5 · 2018 · External reference
EphA2 is a neutrophil receptor for Candida albicans that stimulates antifungal activity during oropharyngeal infection
10.1016/j.celrep.2019.06.020 · 2019 · External reference
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins
10.1016/j.immuni.2005.03.004 · 2005 · External reference
Dectin-1 activation controls maturation of β-1,3-glucan-containing phagosomes
10.1074/jbc.m113.473223 · 2013 · External reference
PD-L1 negatively regulates antifungal immunity by inhibiting neutrophil release from bone marrow
10.1038/s41467-022-34722-7 · 2022 · External reference
JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression
10.1038/nm.4260 · 2017 · External reference
C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection
10.1016/j.immuni.2013.05.017 · 2013 · External reference
E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-κB activation
2021 · External reference
C-type lectins in immunity and homeostasis
10.1038/s41577-018-0004-8 · 2018 · External reference
