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References from HIV-1 Tat favors the multiplication of Mycobacterium tuberculosis and Toxoplasma by inhibiting clathrin-mediated endocytosis and autophagy. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2024 · External reference
The immune response to Mycobacterium tuberculosis in HIV-1-coinfected persons
10.1146/annurev-immunol-042617-053420 · 2018 · External reference
HIV infection functionally impairs mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses
10.1128/jvi.01728-18 · 2019 · External reference
Immune responses in lung granulomas during Mtb/HIV Co-infection: implications for pathogenesis and therapy
10.3390/pathogens12091120 · 2023 · External reference
Chronic immune activation in TB/HIV Co-infection
10.1016/j.tim.2020.03.015 · 2020 · External reference
Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection
10.1038/nrmicro.2017.128 · 2018 · External reference
Polyfunctional CD4(+) and CD8(+) T cell responses to tuberculosis antigens in HIV-1-infected patients before and after anti-retroviral treatment
10.4049/jimmunol.1000399 · 2010 · External reference
Effects of in vitro HIV-1 infection on mycobacterial growth in peripheral blood monocyte-derived macrophages
10.1128/iai.00106-10 · 2010 · External reference
CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes
10.1172/jci28796 · 2006 · External reference
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages
10.1016/j.cell.2004.11.038 · 2004 · External reference
Host cell autophagy activated by antibiotics is required for their effective antimycobacterial drug action
10.1016/j.chom.2012.03.008 · 2012 · External reference
Plasma membrane contributes to the formation of pre-autophagosomal structures
10.1038/ncb2078 · 2010 · External reference
The autophagosome: origins unknown, biogenesis complex
10.1038/nrm3696 · 2013 · External reference
Diverse autophagosome membrane sources coalesce in recycling endosomes
10.1016/j.cell.2013.08.044 · 2013 · External reference
Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase
10.1016/j.cmet.2011.03.023 · 2011 · External reference
Experimental models of foamy macrophages and approaches for dissecting the mechanisms of lipid accumulation and consumption during dormancy and reactivation of tuberculosis
10.3389/fcimb.2016.00122 · 2016 · External reference
Mitochondria restrict growth of the intracellular parasite toxoplasma gondii by limiting its uptake of fatty acids
10.1016/j.cmet.2018.02.018 · 2018 · External reference
Emerging roles for lipid droplets in immunity and host-pathogen interactions
10.1146/annurev-cellbio-092910-153958 · 2012 · External reference
Emerging role of lipid droplets in host/pathogen interactions
10.1074/jbc.r111.300202 · 2012 · External reference
HIV-1 antiretroviral drug therapy
2012 · External reference
Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA
10.1371/journal.pone.0191613 · 2018 · External reference
Induction of IL-17 and nonclassical T-cell activation by HIV-Tat protein
10.1073/pnas.1308673110 · 2013 · External reference
HIV-1 Tat is present in the serum of people living with HIV-1 despite viral suppression
10.1016/j.ijid.2024.106994 · 2024 · External reference
Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells
10.1038/emboj.2010.32 · 2010 · External reference
Presence of Tat and transactivation response element in spinal fluid despite antiretroviral therapy
2019 · External reference
HIV-1 Tat enters T cells using coated pits before translocating from acidified endosomes and eliciting biological responses
10.1091/mbc.e03-12-0921 · 2004 · External reference
Mechanism for HIV-1 Tat insertion into the endosome membrane
10.1074/jbc.m109.023705 · 2009 · External reference
Cyclophilin A enables specific HIV-1 Tat palmitoylation and accumulation in uninfected cells
10.1038/s41467-018-04674-y · 2018 · External reference
HIV-1 Tat protein inhibits neurosecretion by binding to phosphatidylinositol 4,5-bisphosphate
10.1242/jcs.111658 · 2013 · External reference
HIV-1 Tat inhibits phagocytosis by preventing the recruitment of Cdc42 to the phagocytic cup
10.1038/ncomms7211 · 2015 · External reference
Transient exposure to HIV-1 Tat protein results in cytokine production in macrophages and astrocytes. A hit and run phenomenon
10.1074/jbc.274.24.17098 · 1999 · External reference
The ability of chloroquine to prevent tat-induced cytokine secretion by monocytes is implicated in its in vivo anti-human immunodeficiency virus type 1 activity
10.1128/jvi.78.21.12054-12057.2004 · 2004 · External reference
HIV-1 Tat protein induces IL-10 production in monocytes by classical and alternative NF-kappaB pathways
10.1016/j.ejcb.2008.06.005 · 2008 · External reference
Role of innate cytokines in mycobacterial infection
10.1038/mi.2011.13 · 2011 · External reference
Differential cytokine regulation by NF-kappaB and AP-1 in Jurkat T-cells
10.1186/1471-2172-11-26 · 2010 · External reference
Polymeric nanobiotics as a novel treatment for mycobacterial infections
10.1016/j.jconrel.2019.10.009 · 2019 · External reference
Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis
10.1111/j.1462-5822.2008.01133.x · 2008 · External reference
Real-time visualization of mycobacterium-macrophage interactions leading to initiation of granuloma formation in zebrafish embryos
10.1016/s1074-7613(02)00475-2 · 2002 · External reference
Prevalence and burden of Toxoplasma gondii infection in HIV-infected people: a systematic review and meta-analysis
2017 · External reference
The pathogenicity and virulence of Toxoplasma gondii
10.1080/21505594.2021.2012346 · 2021 · External reference
Toxoplasmosis in HIV infection: an overview
10.4103/2229-5070.190817 · 2016 · External reference
Invasion of Toxoplasma gondii occurs by active penetration of the host cell
10.1242/jcs.108.6.2457 · 1995 · External reference
Export of a Toxoplasma gondii rhoptry neck protein complex at the host cell membrane to form the moving junction during invasion
10.1371/journal.ppat.1000309 · 2009 · External reference
Lytic cycle of Toxoplasma gondii
10.1128/mmbr.64.3.607-623.2000 · 2000 · External reference
Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens
10.1016/j.chom.2008.10.003 · 2008 · External reference
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3
10.4161/auto.4451 · 2007 · External reference
Delivery of cytosolic components by autophagic adaptor protein p62 endows autophagosomes with unique antimicrobial properties
10.1016/j.immuni.2010.02.009 · 2010 · External reference
Measuring autophagy in stressed cells
10.1007/978-1-4939-2522-3_10 · 2015 · External reference
HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3
10.1371/journal.pone.0011733 · 2010 · External reference
HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction
10.1097/qad.0b013e328340fd61 · 2011 · External reference
Bafilomycin A1 disrupts autophagic flux by inhibiting both V-ATPase-dependent acidification and Ca-P60A/SERCA-dependent autophagosome-lysosome fusion
10.1080/15548627.2015.1066957 · 2015 · External reference
Autophagy and formation of tubulovesicular autophagosomes provide a barrier against nonviral gene delivery
10.4161/auto.23877 · 2013 · External reference
Isolation and preliminary characterization of the major membrane boundaries of the endocytic pathway in lymphocytes
10.1083/jcb.111.5.1811 · 1990 · External reference
Clathrin-mediated endocytosis in AP-2-depleted cells
10.1083/jcb.200305145 · 2003 · External reference
A large-scale conformational change couples membrane recruitment to cargo binding in the AP2 clathrin adaptor complex
10.1016/j.cell.2010.05.006 · 2010 · External reference
Phosphoinositides in control of membrane dynamics
10.1146/annurev-cellbio-111315-125349 · 2016 · External reference
A high precision survey of the molecular dynamics of mammalian clathrin-mediated endocytosis
10.1371/journal.pbio.1000604 · 2011 · External reference
Phosphoinositide conversion in endocytosis and the endolysosomal system
10.1074/jbc.r117.000629 · 2018 · External reference
Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition
10.1016/j.cell.2011.06.025 · 2011 · External reference
Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis
10.1111/tra.12119 · 2013 · External reference
Regulation of clathrin-mediated endocytosis
10.1146/annurev-biochem-062917-012644 · 2018 · External reference
The assembly of lipid droplets and their roles in challenged cells
10.15252/embj.201898947 · 2018 · External reference
Fluorescent detection of lipid droplets and associated proteins
2007 · External reference
Immune responses of HIV-1 Tat transgenic mice to mycobacterium tuberculosis W-Beijing SA161
10.2174/1874613601105010086 · 2011 · External reference
Autophagy during viral infection - a double-edged sword
10.1038/s41579-018-0003-6 · 2018 · External reference
Lipid droplets and the host-pathogen dynamic: FATal attraction?
10.1083/jcb.202104005 · 2021 · External reference
Macrophage phagocytosis of virulent but not attenuated strains of Mycobacterium tuberculosis is mediated by mannose receptors in addition to complement receptors
10.4049/jimmunol.150.7.2920 · 1993 · External reference
The cytoskeleton in phagocytosis and macropinocytosis
10.1016/j.cub.2021.01.036 · 2021 · External reference
M. tuberculosis-initiated human mannose receptor signaling regulates macrophage recognition and vesicle trafficking by FcRgamma-chain, Grb2, and SHP-1
10.1016/j.celrep.2017.09.034 · 2017 · External reference
Clade C HIV-1 isolates circulating in Southern Africa exhibit a greater frequency of dicysteine motif-containing Tat variants than those in Southeast Asia and cause increased neurovirulence
10.1186/1742-4690-10-61 · 2013 · External reference
Clade-specific differences in neurotoxicity of human immunodeficiency virus-1 B and C Tat of human neurons: significance of dicysteine C30C31 motif
10.1002/ana.21292 · 2008 · External reference
Functional impact of HIV-1 Tat on cells of the CNS and its role in HAND
10.1007/s00018-020-03561-4 · 2020 · External reference
Inflammatory cardiac valvulitis in TAX1BP1-deficient mice through selective NF-kappaB activation
10.1038/emboj.2008.5 · 2008 · External reference
Autophagy protein Atg3 is essential for maintaining mitochondrial integrity and for normal intracellular development of Toxoplasma gondii tachyzoites
10.1371/journal.ppat.1002416 · 2011 · External reference
Characterization of microneme proteins of Toxoplasma gondii
10.1016/0166-6851(91)90182-6 · 1991 · External reference
Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16(+) monocyte population via the IL-10/STAT3 axis
10.1038/cr.2015.123 · 2015 · External reference
Deciphering and imaging pathogenesis and cording of Mycobacterium abscessus in Zebrafish embryos
2015 · External reference
