Research graph
References from The conserved poxvirus membrane entry-fusion apparatus component OPG147 targets MITA/STING for immune evasion. Local targets link to admitted publications; unresolved targets remain external evidence.
The monkeypox virus-host interplays
10.1016/j.cellin.2024.100185 · 2024 · External reference
The 2023 - 2024 multi-source mpox outbreaks of Clade I MPXV in sub-Saharan Africa: Alarm bell for Africa and the World
10.1016/j.ijregi.2024.100397 · 2024 · External reference
Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: A rapid review
10.1016/j.ijbiomac.2023.125515 · 2023 · External reference
Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
10.1016/j.chom.2022.01.014 · 2022 · External reference
Expression profiling of the intermediate and late stages of poxvirus replication
10.1128/jvi.05446-11 · 2011 · External reference
Monkeypox virus and insights into its immunomodulatory proteins
10.1111/j.1600-065x.2008.00691.x · 2008 · External reference
Structural and functional insights into the modulation of T cell costimulation by monkeypox virus protein M2
10.1038/s41467-023-40748-2 · 2023 · External reference
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling
10.1038/s41586-019-0928-6 · 2019 · External reference
Vaccinia, cowpox, and camelpox viruses encode soluble gamma interferon receptors with novel broad species specificity
10.1128/jvi.69.8.4633-4639.1995 · 1995 · External reference
The vaccinia virus soluble interferon-gamma receptor is a homodimer
10.1099/0022-1317-83-3-545 · 2002 · External reference
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS
10.1038/s41467-023-38514-5 · 2023 · External reference
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
10.1126/science.1232458 · 2013 · External reference
Cyclic [G(2’,5’)pA(3’,5’)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
10.1016/j.cell.2013.04.046 · 2013 · External reference
cGAS produces a 2’-5’-linked cyclic dinucleotide second messenger that activates STING
10.1038/nature12306 · 2013 · External reference
USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity
10.1038/s41422-020-0341-6 · 2020 · External reference
The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation
10.1016/j.immuni.2008.09.003 · 2008 · External reference
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
10.1038/nature07317 · 2008 · External reference
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
10.1073/pnas.0900850106 · 2009 · External reference
MPYS, a novel membrane tetraspanner, is associated with major histocompatibility complex class II and mediates transduction of apoptotic signals
10.1128/mcb.00640-08 · 2008 · External reference
The Ca(2 ) sensor STIM1 regulates the type I interferon response by retaining the signaling adaptor STING at the endoplasmic reticulum
10.1038/s41590-018-0287-8 · 2019 · External reference
STIM1 moonlights as an anchor for STING
10.1038/s41590-018-0300-2 · 2019 · External reference
Structure-function analysis of STING activation by c[G(2’,5’)pA(3’,5’)p] and targeting by antiviral DMXAA
10.1016/j.cell.2013.07.023 · 2013 · External reference
Cyclic GMP-AMP containing mixed phosphodiester linkages is an endogenous high-affinity ligand for STING
10.1016/j.molcel.2013.05.022 · 2013 · External reference
Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
10.1016/j.immuni.2012.03.019 · 2012 · External reference
MITA/STING: a central and multifaceted mediator in innate immune response
10.1016/j.cytogfr.2014.05.003 · 2014 · External reference
Regulation of STING activity in DNA sensing by ISG15 modification
10.1016/j.celrep.2023.113277 · 2023 · External reference
ISGylation by HERCs facilitates STING activation
10.1016/j.celrep.2024.114135 · 2024 · External reference
STING Signaling the enERGIC Way
10.1016/j.chom.2015.07.014 · 2015 · External reference
STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease
10.1016/j.chom.2015.07.001 · 2015 · External reference
iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING
10.1038/ni.3510 · 2016 · External reference
PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response
10.1073/pnas.1906431116 · 2019 · External reference
Herpes simplex virus protein UL56 inhibits cGAS-Mediated DNA sensing to evade antiviral immunity
10.1016/j.cellin.2022.100014 · 2022 · External reference
Vaccinia virus A21 virion membrane protein is required for cell entry and fusion
10.1128/jvi.79.15.9458-9469.2005 · 2005 · External reference
Poxvirus multiprotein entry-fusion complex
10.1073/pnas.0509239102 · 2005 · External reference
STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway
10.1126/scisignal.2002521 · 2012 · External reference
The STING in the tail for cytosolic DNA-dependent activation of IRF3
10.1126/scisignal.2002919 · 2012 · External reference
Virulence differences of mpox (monkeypox) virus clades I, IIa, and IIb.1 in a small animal model
10.1073/pnas.2220415120 · 2023 · External reference
Resistance to ectromelia virus infection requires cGAS in bone marrow-derived cells which can be bypassed with cGAMP therapy
2019 · External reference
VISA is an adapter protein required for virus-triggered IFN-beta signaling
10.1016/j.molcel.2005.08.014 · 2005 · External reference
ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
10.1038/s41467-018-05559-w · 2018 · External reference
Glycogen synthase kinase 3β regulates IRF3 transcription factor-mediated antiviral response via activation of the kinase TBK1
10.1016/j.immuni.2010.11.021 · 2010 · External reference
LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus
10.1038/s41422-023-00917-w · 2024 · External reference
Genome-scale CRISPR-Cas9 knockout screening in human cells
10.1126/science.1247005 · 2014 · External reference
Reciprocal regulation of IL-33 receptor-mediated inflammatory response and pulmonary fibrosis by TRAF6 and USP38
2022 · External reference
PCDH10 is a neuronal receptor for western equine encephalitis virus
10.1038/s41422-024-01031-1 · 2024 · External reference
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity
10.1016/j.chom.2017.01.001 · 2017 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Protein complex prediction with AlphaFold-Multimer
2021 · External reference
The mechanism of STING autoinhibition and activation
2023 · External reference
