Research graph
References from The zinc metalloprotein MigC impacts cell wall biogenesis through interactions with an essential Mur ligase in Acinetobacter baumannii. Local targets link to admitted publications; unresolved targets remain external evidence.
Acinetobacter baumannii: emergence of a successful pathogen
10.1128/cmr.00058-07 · 2008 · External reference
Hospital Reservoirs of Multidrug Resistant Acinetobacter Species-The Elephant in the Room!
10.3389/bjbs.2023.11098 · 2023 · External reference
Acinetobacter: An emerging pathogen with a versatile secretome
10.1038/s41426-018-0030-4 · 2018 · External reference
Multidrug-resistant Acinetobacter baumannii as an emerging concern in hospitals
10.1007/s11033-021-06690-6 · 2021 · External reference
WHO publishes updated list of bacterial priority pathogens
2024 · External reference
β-Lactams and β-lactamase inhibitors: an overview
10.1101/cshperspect.a025247 · 2016 · External reference
Breaking down the cell wall: Still an attractive antibacterial strategy
10.3389/fmicb.2022.952633 · 2022 · External reference
A new class of cell wall-recycling L,D-carboxypeptidase determines β-lactam susceptibility and morphogenesis in Acinetobacter baumannii
2021 · External reference
Coordination of bacterial cell wall and outer membrane biosynthesis
10.1038/s41586-023-05750-0 · 2023 · External reference
An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration
10.1016/j.celrep.2019.01.089 · 2019 · External reference
Characterization of Acinetobacter baumannii core oligosaccharide synthesis reveals novel aspects of lipooligosaccharide assembly
10.1128/mbio.03013-23 · 2024 · External reference
A conserved zinc-binding site in Acinetobacter baumannii PBP2 required for elongasome-directed bacterial cell shape
10.1073/pnas.2215237120 · 2023 · External reference
Acinetobacter baumannii can survive with an outer membrane lacking lipooligosaccharide due to structural support from elongasome peptidoglycan synthesis
10.1128/mbio.03099-21 · 2021 · External reference
Role of peptidoglycan recycling enzymes AmpD and AnmK in Acinetobacter baumannii virulence features
10.3389/fcimb.2022.1064053 · 2023 · External reference
Structure and function of the first full-length murein peptide ligase (Mpl) cell wall recycling protein
2011 · External reference
Architecture and genomic arrangement of the MurE-MurF bacterial cell wall biosynthesis complex
10.1073/pnas.2219540120 · 2023 · External reference
Prioritization of Mur family drug targets against A. baumannii and identification of their homologous proteins through molecular phylogeny, primary sequence, and structural analysis
10.1186/s43141-020-00048-4 · 2020 · External reference
Identification of promising molecules against MurD ligase from Acinetobacter baumannii: insights from comparative protein modelling, virtual screening, molecular dynamics simulations and MM/PBSA analysis
10.1007/s00894-020-04557-4 · 2020 · External reference
Characterisation of ATP-dependent Mur ligases involved in the biogenesis of cell wall peptidoglycan in Mycobacterium tuberculosis
10.1371/journal.pone.0060143 · 2013 · External reference
Nutritional immunity: the battle for nutrient metals at the host-pathogen interface
10.1038/s41579-022-00745-6 · 2022 · External reference
Identification of an Acinetobacter baumannii zinc acquisition system that facilitates resistance to calprotectin-mediated zinc sequestration
2012 · External reference
The Acinetobacter baumannii Znu System Overcomes Host-Imposed Nutrient Zinc Limitation
10.1128/iai.00746-19 · 2019 · External reference
The Response of Acinetobacter baumannii to Zinc Starvation
10.1016/j.chom.2016.05.007 · 2016 · External reference
Zn-regulated GTPase metalloprotein activator 1 modulates vertebrate zinc homeostasis
10.1016/j.cell.2022.04.011 · 2022 · External reference
Effects of metal on the biochemical properties of Helicobacter pylori HypB, a maturation factor of [NiFe]-hydrogenase and urease
10.1128/jb.01333-10 · 2011 · External reference
Zng1 is a GTP-dependent zinc transferase needed for activation of methionine aminopeptidase
10.1016/j.celrep.2022.110834 · 2022 · External reference
A subset of the diverse COG0523 family of putative metal chaperones is linked to zinc homeostasis in all kingdoms of life
10.1186/1471-2164-10-470 · 2009 · External reference
The role of nucleoside triphosphate hydrolase metallochaperones in making metalloenzymes
10.1093/mtomcs/mfac030 · 2022 · External reference
Coupling of zinc and GTP binding drives G-domain folding in Acinetobacter baumannii ZigA
10.1016/j.bpj.2024.03.010 · 2024 · External reference
COG0523 proteins: A functionally diverse family of transition metal-regulated G3E P-loop GTP hydrolases from bacteria to man
10.1093/mtomcs/mfab046 · 2021 · External reference
The interplay between Acinetobacter baumannii ZigA and SltB promotes zinc homeostasis and cell envelope integrity
10.1128/iai.00422-24 · 2025 · External reference
Mechanistic Insights into the Metal-Dependent Activation of ZnII-Dependent Metallochaperones
10.1021/acs.inorgchem.9b01173 · 2019 · External reference
Bacillus subtilis FolE is sustained by the ZagA zinc metallochaperone and the alarmone ZTP under conditions of zinc deficiency
10.1111/mmi.14314 · 2019 · External reference
Substitution matrix based color schemes for sequence alignment visualization
10.1186/s12859-020-3526-6 · 2020 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Multi-metal Restriction by Calprotectin Impacts De Novo Flavin Biosynthesis in Acinetobacter baumannii
10.1016/j.chembiol.2019.02.011 · 2019 · External reference
Metallo-GTPase HypB from Helicobacter pylori and its interaction with nickel chaperone protein HypA
10.1074/jbc.m111.287581 · 2012 · External reference
Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens
10.1073/pnas.1220341110 · 2013 · External reference
Calprotectin: from biomarker to biological function
10.1136/gutjnl-2021-324855 · 2021 · External reference
Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus
10.1016/j.chom.2011.07.004 · 2011 · External reference
Tug of war between Acinetobacter baumannii and host immune responses
2018 · External reference
Synthesis of fluorescent D-amino acids (FDAAs) and their use for probing peptidoglycan synthesis and bacterial growth in situ
10.1038/nprot.2014.197 · 2015 · External reference
Yeast two-hybrid, a powerful tool for systems biology
10.3390/ijms10062763 · 2009 · External reference
Comparison of the D-glutamate-adding enzymes from selected gram-positive and gram-negative bacteria
10.1128/jb.181.17.5395-5401.1999 · 1999 · External reference
A perspective on the discovery of enzyme activators
10.1016/j.slasd.2022.09.001 · 2022 · External reference
Essential Gene Analysis in Acinetobacter baumannii by High-Density Transposon Mutagenesis and CRISPR Interference
2021 · External reference
Mini-Tn7 vectors as genetic tools for single copy gene cloning in Acinetobacter baumannii
10.1016/j.mimet.2010.07.002 · 2010 · External reference
Analysis and nucleotide sequence of an origin of DNA replication in Acinetobacter calcoaceticus and its use for Escherichia coli shuttle plasmids
10.1016/0378-1119(90)90494-c · 1990 · External reference
Zinc is an important inter-kingdom signal between the host and microbe
10.1186/s13567-021-00913-1 · 2021 · External reference
Structures of gram-negative cell walls and their derived membrane vesicles
10.1128/jb.181.16.4725-4733.1999 · 1999 · External reference
Possible functions of CobW domain-containing (CBWD) genes in dinoflagellates using Karlodinium veneficum as a representative
10.1016/j.hal.2022.102274 · 2022 · External reference
A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria
10.1016/j.cell.2016.05.003 · 2016 · External reference
CRISPRi-Seq for the identification and characterisation of essential mycobacterial genes and transcriptional units
2018 · External reference
The Tol-Pal system of Acinetobacter baumannii is important for cell morphology, antibiotic resistance and virulence
10.1007/s10123-022-00319-9 · 2023 · External reference
Antibiotic susceptibility signatures identify potential antimicrobial targets in the Acinetobacter baumannii cell envelope
2020 · External reference
Elongation factor P modulates Acinetobacter baumannii physiology and virulence as a cyclic dimeric guanosine monophosphate effector
2022 · External reference
Acinetobacter baumannii utilizes a type VI secretion system for bacterial competition
10.1371/journal.pone.0059388 · 2013 · External reference
A CRISPR interference system for efficient and rapid gene knockdown in Caulobacter crescentus
10.1128/mbio.02415-19 · 2020 · External reference
The nutritional requirements of isolates of Labyrinthula spp
10.1099/00221287-12-3-455 · 1955 · External reference
Transcriptional activation by tetracyclines in mammalian cells
10.1126/science.7792603 · 1995 · External reference
A new metabolic cell-wall labelling method reveals peptidoglycan in Chlamydia trachomatis
10.1038/nature12892 · 2014 · External reference
MicrobeJ, a tool for high throughput bacterial cell detection and quantitative analysis
10.1038/nmicrobiol.2016.77 · 2016 · External reference
Metal chelation and inhibition of bacterial growth in tissue abscesses
10.1126/science.1152449 · 2008 · External reference
Overcoming expression and purification problems of RhoGDI using a family of “parallel” expression vectors
10.1006/prep.1998.1003 · 1999 · External reference
Program DYNAFIT for the analysis of enzyme kinetic data: application to HIV proteinase
10.1006/abio.1996.0238 · 1996 · External reference
Measurement of free Zn2+ ion concentration with the fluorescent probe mag-fura-2 (furaptra)
10.1016/0165-022x(93)90065-v · 1993 · External reference
X-ray absorption spectroscopy
2007 · External reference
Unresolved reference
External reference
Metalloprotein active site structure determination: synergy between X-ray absorption spectroscopy and X-ray crystallography
10.1016/j.jinorgbio.2012.06.019 · 2012 · External reference
XAFS of dinuclear metal sites in proteins and model compounds
10.1016/0010-8545(95)01144-e · 1995 · External reference
A method for the enzymatic synthesis and HPLC purification of the peptidoglycan precursor UDP-N-acetylmuramic acid
10.1016/s0378-1097(03)00793-6 · 2003 · External reference
Automatic Calculation of the Kinetic Parameters of Enzymatic Reactions with Their Standard Errors Using Microsoft Excel
10.5458/jag.jag.jag-2022_0012 · 2023 · External reference
Statistical analysis of radioligand assay data
10.1016/s0076-6879(75)37003-1 · 1975 · External reference
Identification of Two Variants of Acinetobacter baumannii Strain ATCC 17978 with Distinct Genotypes and Phenotypes
2021 · External reference
Nonpolar mutagenesis of the ipa genes defines IpaB, IpaC, and IpaD as effectors of Shigella flexneri entry into epithelial cells
10.1128/jb.175.18.5899-5906.1993 · 1993 · External reference
A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants
10.1016/s0378-1119(98)00130-9 · 1998 · External reference
Replication of an origin-containing derivative of plasmid RK2 dependent on a plasmid function provided in trans
10.1073/pnas.76.4.1648 · 1979 · External reference
A Tn7-based broad-range bacterial cloning and expression system
10.1038/nmeth765 · 2005 · External reference
