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References from Interleukin-17A signaling promotes CD8+ T cell cytotoxicity against West Nile virus infection through enhancing PI3K-mTOR-mediated metabolism. Local targets link to admitted publications; unresolved targets remain external evidence.
Current understanding of West Nile virus clinical manifestations, immune responses, neuroinvasion, and immunotherapeutic implications
2019 · External reference
West Nile virus. The
10.1016/s1473-3099(02)00368-7 · 2002 · External reference
West nile virus: an historical overview
2003 · External reference
Neurologic manifestations and outcome of West Nile virus infection
10.1001/jama.290.4.511 · 2003 · External reference
Concurrent West Nile virus infection in pneumococcal meningitis: clinical and MRI features
10.1111/jon.12125 · 2015 · External reference
West Nile virus: a growing concern?
10.1172/jci21623 · 2004 · External reference
Outcome of West Nile fever in older adults
10.1046/j.1532-5415.2002.505402.x · 2002 · External reference
A Neurotropic Virus Isolated from the Blood of a Native of Uganda
10.4269/ajtmh.1940.s1-20.471 · 1940 · External reference
Unresolved reference
2024 · External reference
Unresolved reference
External reference
The long-term outcomes of human West Nile virus infection
10.1086/518281 · 2007 · External reference
Twenty years of West Nile virus spread and evolution in the Americas visualized by Nextstrain
10.1371/journal.ppat.1008042 · 2019 · External reference
Introduction to West Nile Virus
2022 · External reference
Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus
10.1093/infdis/jir048 · 2011 · External reference
Mechanistic rationales for targeting interleukin-17A in spondyloarthritis
10.1186/s13075-017-1249-5 · 2017 · External reference
Interleukin-17-A multifaceted cytokine in viral infections
10.1002/jcp.30471 · 2021 · External reference
The IL-23-IL-17 axis in inflammatory arthritis
10.1038/nrrheum.2015.53 · 2015 · External reference
Role of IL-17 in psoriasis and psoriatic arthritis
10.1007/s12016-012-8307-1 · 2013 · External reference
IL-17 and IL-17-producing cells in protection versus pathology
2022 · External reference
Cutting edge: interleukin 17 signals through a heteromeric receptor complex
10.4049/jimmunol.177.1.36 · 2006 · External reference
Basic biology and role of interleukin-17 in immunity and inflammation
10.1111/prd.12083 · 2015 · External reference
IL-17: prototype member of an emerging cytokine family
10.1189/jlb.71.1.1 · 2002 · External reference
Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer
2023 · External reference
Multiple sclerosis: a complicated picture of autoimmunity
10.1038/ni1507 · 2007 · External reference
IL-17 receptor signaling and T helper 17-mediated autoimmune demyelinating disease
10.1016/j.it.2011.02.007 · 2011 · External reference
EBV and vitamin D status in relapsing-remitting multiple sclerosis patients with a unique cytokine signature
2015 · External reference
Microglia Induce Neurotoxic IL-17+ γδ T Cells Dependent on TLR2, TLR4, and TLR9 Activation
10.1371/journal.pone.0135898 · 2015 · External reference
Interleukin-17 in systemic lupus erythematosus: A comprehensive review
10.3109/08916934.2015.1037441 · 2015 · External reference
IL-17 as a future therapeutic target for rheumatoid arthritis
10.1038/nrrheum.2009.179 · 2009 · External reference
Th17 Cytokines Regulate Osteoclastogenesis in Rheumatoid Arthritis
2015 · External reference
The paradoxical role of IL-17 in atherosclerosis
10.1016/j.cellimm.2015.05.007 · 2015 · External reference
The IL-23-IL-17 axis in inflammatory arthritis
10.1038/nrrheum.2015.53 · 2015 · External reference
Basic biology and role of interleukin-17 in immunity and inflammation
10.1111/prd.12083 · 2015 · External reference
Role of IL-17 in psoriasis and psoriatic arthritis
10.1007/s12016-012-8307-1 · 2013 · External reference
Clinical efficacy and safety of anti-IL-17 agents for the treatment of patients with psoriasis
2015 · External reference
Defect of IL17 Signaling, but Not Centrinone, Inhibits the Development of Psoriasis and Skin Papilloma in Mouse Models
10.3390/biomedicines10081976 · 2022 · External reference
Th17-mediated inflammation in asthma
10.1016/j.coi.2013.08.002 · 2013 · External reference
IL-17 in severe asthma. Where do we stand?
10.1164/rccm.201405-0859pp · 2014 · External reference
Proinflammatory cytokines underlying the inflammation of Crohn’s disease
10.1097/mog.0b013e328339d099 · 2010 · External reference
Role of the IL-23/IL-17 axis in Crohn’s disease
2012 · External reference
Interleukin-17 Promotes Migration and Invasion of Human Cancer Cells Through Upregulation of MTA1 Expression
10.3389/fonc.2019.00546 · 2019 · External reference
Genetic alterations of interleukin-17 and related genes in human prostate cancer
2019 · External reference
Inflammatory cytokines IL-17 and TNF-α up-regulate PD-L1 expression in human prostate and colon cancer cells
10.1016/j.imlet.2017.02.006 · 2017 · External reference
Critical role of IL-17RA in immunopathology of influenza infection
10.4049/jimmunol.0900995 · 2009 · External reference
IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease
10.1016/j.ajpath.2011.03.003 · 2011 · External reference
Th17 cells enhance viral persistence and inhibit T cell cytotoxicity in a model of chronic virus infection
10.1084/jem.20082030 · 2009 · External reference
Hepatitis B virus induces IL-23 production in antigen presenting cells and causes liver damage via the IL-23/IL-17 axis
10.1371/journal.ppat.1003410 · 2013 · External reference
Interleukin-17A Facilitates Chikungunya Virus Infection by Inhibiting IFN-alpha2 Expression
10.3389/fimmu.2020.588382 · 2020 · External reference
Intrahepatic innate lymphoid cells secrete IL-17A and IL-17F that are crucial for T cell priming in viral infection
10.4049/jimmunol.1303281 · 2014 · External reference
Interleukin-17A Promotes CD8+ T Cell Cytotoxicity To Facilitate West Nile Virus Clearance
10.1128/jvi.01529-16 · 2016 · External reference
IL-17RA-Signaling Modulates CD8+ T Cell Survival and Exhaustion During Trypanosoma cruzi Infection
10.3389/fimmu.2018.02347 · 2018 · External reference
IL-17A Is Critical for CD8+ T Effector Response in Airway Epithelial Injury After Transplantation
10.1097/tp.0000000000002452 · 2018 · External reference
Early IL-17 production by intrahepatic T cells is important for adaptive immune responses in viral hepatitis
10.4049/jimmunol.1201970 · 2013 · External reference
IL-23 enhances host defense against vaccinia virus infection via a mechanism partly involving IL-17
10.4049/jimmunol.179.6.3917 · 2007 · External reference
Interleukin-17 and prostaglandin E2 are involved in formation of an M2 macrophage-dominant microenvironment in lung cancer
10.1097/jto.0b013e3182542752 · 2012 · External reference
A Mouse Model of West Nile Virus Infection
10.1002/cpmo.33 · 2017 · External reference
Osteopontin facilitates West Nile virus neuroinvasion via neutrophil “Trojan horse” transport
10.1038/s41598-017-04839-7 · 2017 · External reference
TLR8 Couples SOCS-1 and Restrains TLR7-Mediated Antiviral Immunity, Exacerbating West Nile Virus Infection in Mice
10.4049/jimmunol.1600902 · 2016 · External reference
Splenic macrophages are required for protective innate immunity against West Nile virus
10.1371/journal.pone.0191690 · 2018 · External reference
Interactions between neutrophils and T-helper 17 cells
10.3389/fimmu.2023.1279837 · 2023 · External reference
Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin
10.4049/jimmunol.176.5.2730 · 2006 · External reference
Unresolved reference
2025 · External reference
Exploring the specificity of the PI3K family inhibitor LY294002
10.1042/bj20061489 · 2007 · External reference
LY294002 and rapamycin co-operate to inhibit T-cell proliferation
10.1038/sj.bjp.0706061 · 2005 · External reference
p70 S6 kinase as a therapeutic target in cancers: More than just an mTOR effector
10.1016/j.canlet.2022.215593 · 2022 · External reference
Regulation and function of mTOR signalling in T cell fate decisions
10.1038/nri3198 · 2012 · External reference
Role of PI3K/Akt signaling in memory CD8 T cell differentiation
2013 · External reference
Metabolic dynamics instruct CD8+ T-cell differentiation and functions
10.1002/eji.202149486 · 2022 · External reference
10.1101/sqb.2011.76.010942
10.1101/sqb.2011.76.010942 · 2011 · External reference
Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism
10.1186/2049-3002-1-8 · 2013 · External reference
Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate
10.1042/bj20130153 · 2013 · External reference
Metabolites related to purine catabolism and risk of type 2 diabetes incidence; modifying effects of the TCF7L2-rs7903146 polymorphism
10.1038/s41598-019-39441-6 · 2019 · External reference
Pyrimidine homeostasis is accomplished by directed overflow metabolism
10.1038/nature12445 · 2013 · External reference
Targeting Pyrimidine Metabolism in the Era of Precision Cancer Medicine
10.3389/fonc.2021.684961 · 2021 · External reference
Inborn Errors of Purine Salvage and Catabolism
10.3390/metabo13070787 · 2023 · External reference
Oxidative Stress: Love and Hate History in Central Nervous System
10.1016/bs.apcsb.2017.01.003 · 2017 · External reference
Glutathione Metabolism and the Novel Role of Mitochondrial GSH in Retinal Degeneration
10.3390/antiox10050661 · 2021 · External reference
Unresolved reference
2019 · External reference
Role of CD8+ T cells in control of West Nile virus infection
10.1128/jvi.78.15.8312-8321.2004 · 2004 · External reference
Fas ligand interactions contribute to CD8+ T-cell-mediated control of West Nile virus infection in the central nervous system
10.1128/jvi.01136-07 · 2007 · External reference
CD8 T cells use TRAIL to restrict West Nile virus pathogenesis by controlling infection in neurons
10.1128/jvi.00673-12 · 2012 · External reference
CD8+ T cells require perforin to clear West Nile virus from infected neurons
10.1128/jvi.80.1.119-129.2006 · 2006 · External reference
Antibody prophylaxis and therapy against West Nile virus infection in wild-type and immunodeficient mice
2023 · External reference
Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases
10.1016/s0166-2236(02)02154-9 · 2002 · External reference
Activation of CD8 T lymphocytes during viral infections
10.1016/b978-0-12-374279-7.14009-3 · 2016 · External reference
Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications
10.1101/cshperspect.a028522 · 2018 · External reference
The neuroimmune response to West Nile virus
10.1007/s13365-013-0180-z · 2014 · External reference
Ly6c+ “inflammatory monocytes” are microglial precursors recruited in a pathogenic manner in West Nile virus encephalitis
10.1084/jem.20080421 · 2008 · External reference
A paradoxical role for neutrophils in the pathogenesis of West Nile virus
10.1086/657416 · 2010 · External reference
Unresolved reference
2011 · External reference
Fas-Fas Ligand: Checkpoint of T Cell Functions in Multiple Sclerosis
10.3389/fimmu.2016.00382 · 2016 · External reference
Fas modulation of apoptosis during negative selection of thymocytes
10.1016/s1074-7613(00)80275-7 · 1996 · External reference
IL-10 signaling blockade controls murine West Nile virus infection
2009 · External reference
Perforin deficiency impairs a critical immunoregulatory loop involving murine CD8( ) T cells and dendritic cells
10.1182/blood-2013-04-495309 · 2013 · External reference
Perforin and IL-2 upregulation define qualitative differences among highly functional virus-specific human CD8 T cells
10.1371/journal.ppat.1000798 · 2010 · External reference
IL-2 regulates perforin and granzyme gene expression in CD8+ T cells independently of its effects on survival and proliferation
10.4049/jimmunol.175.12.8003 · 2005 · External reference
Abundant expression of granzyme A, but not perforin, in granules of CD8+ T cells in GALT: implications for immune control of HIV-1 infection
10.4049/jimmunol.173.1.641 · 2004 · External reference
mTOR Modulates CD8+ T Cell Differentiation in Mice with Invasive Pulmonary Aspergillosis
10.1515/biol-2018-0018 · 2018 · External reference
A comprehensive network map of IL-17A signaling pathway
10.1007/s12079-022-00686-y · 2023 · External reference
Effects of altered glycolysis levels on CD8( ) T cell activation and function
2023 · External reference
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
10.4049/jimmunol.1003613 · 2011 · External reference
Understanding the Warburg effect: the metabolic requirements of cell proliferation
10.1126/science.1160809 · 2009 · External reference
Mtorc1 links cellular metabolism and immune functions in Mycobacterium tuberculosis infection and BCG vaccination
10.1016/b978-0-12-814603-3.00010-0 · 2018 · External reference
Control of T-Cell Activation and Signaling by Amino-Acid Catabolizing Enzymes
10.3389/fcell.2020.613416 · 2020 · External reference
Amino Acids and Their Transporters in T Cell Immunity and Cancer Therapy
10.1016/j.molcel.2020.09.006 · 2020 · External reference
Differential control of cell cycle, proliferation, and survival of primary T lymphocytes by purine and pyrimidine nucleotides
10.4049/jimmunol.170.10.4986 · 2003 · External reference
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway
10.1038/s41467-022-30362-z · 2022 · External reference
Isolation of West Nile virus from mosquitoes, crows, and a Cooper’s hawk in Connecticut
10.1126/science.286.5448.2331 · 1999 · External reference
Use of RNA interference to prevent lethal murine west nile virus infection
10.1086/428507 · 2005 · External reference
Quantification of West Nile Virus by Plaque-Forming Assay
2022 · External reference
A novel nanocomposite drug delivery system for SARS-CoV-2 infections
2024 · External reference
An effective live-attenuated Zika vaccine candidate with a modified 5’ untranslated region
10.1038/s41541-023-00650-w · 2023 · External reference
Intestinal Interleukin-17 Receptor Signaling Mediates Reciprocal Control of the Gut Microbiota and Autoimmune Inflammation
10.1016/j.immuni.2016.02.007 · 2016 · External reference
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
10.1038/ni.1649 · 2008 · External reference
Full-length RNA-seq from single cells using Smart-seq2
10.1038/nprot.2014.006 · 2014 · External reference
