Research graph
References from TIGIT blockade improves anti-Mycobacterium tuberculosis immunity. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2024 · External reference
The global prevalence of latent tuberculosis: a systematic review and meta-analysis
10.1183/13993003.00655-2019 · 2019 · External reference
Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection
10.1038/s41577-018-0025-3 · 2018 · External reference
How can immunology contribute to the control of tuberculosis?
10.1038/35095558 · 2001 · External reference
CD8 T cells and Mycobacterium tuberculosis infection
10.1007/s00281-015-0490-8 · 2015 · External reference
Tuberculosis and T cells: impact of T cell diversity in tuberculosis infection
10.1016/j.tube.2024.102567 · 2024 · External reference
CD8 lymphocytes are critical for early control of tuberculosis in macaques
10.1084/jem.20230707 · 2023 · External reference
Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control
10.1016/j.immuni.2022.04.004 · 2022 · External reference
Prevention of tuberculosis in macaques after intravenous BCG immunization
10.1038/s41586-019-1817-8 · 2020 · External reference
Molecular and cellular insights into T cell exhaustion
10.1038/nri3862 · 2015 · External reference
Inhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups
10.1038/s41590-019-0512-0 · 2019 · External reference
Immune checkpoint blockade in infectious diseases
10.1038/nri.2017.112 · 2018 · External reference
The paradox of immune checkpoint inhibition re-activating tuberculosis
10.1183/13993003.02512-2021 · 2022 · External reference
Mycobacterial infections due to PD-1 and PD-L1 checkpoint inhibitors
10.1136/esmoopen-2020-000866 · 2020 · External reference
TIGIT as an emerging immune checkpoint
10.1111/cei.13407 · 2020 · External reference
The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function
10.1016/j.ccell.2014.10.018 · 2014 · External reference
Memory re-differentiation and reduced lymphocyte activation in chronic HCV-infected patients receiving direct-acting antivirals
10.1111/jvh.12465 · 2015 · External reference
TIGIT marks exhausted T Cells, correlates with disease progression, and serves as a target for immune restoration in HIV and SIV infection
2016 · External reference
Immune exhaustion of T Cells in alveolar echinococcosis patients and its reversal by blocking checkpoint receptor TIGIT in a murine model
10.1002/hep.30896 · 2020 · External reference
Expression of TIGIT in splenic and circulatory T cells from mice acutely infected with Toxoplasma gondii
10.1051/parasite/2021010 · 2021 · External reference
TIGIT blockade: a multipronged approach to target the HIV reservoir
10.3389/fcimb.2020.00175 · 2020 · External reference
TIGIT in cancer immunotherapy
2020 · External reference
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
10.1038/ni1268 · 2005 · External reference
TIGIT-CD226-PVR axis: advancing immune checkpoint blockade for cancer immunotherapy
10.1136/jitc-2022-004711 · 2022 · External reference
TIGIT: An emerging immune checkpoint target for immunotherapy in autoimmune disease and cancer
10.1016/j.intimp.2023.110358 · 2023 · External reference
Progress in T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain-mediated T-cell exhaustion in chronic infection
2021 · External reference
Distinct human NK cell phenotypes and functional responses to mycobacterium tuberculosis in adults from TB endemic and non-endemic regions
10.3389/fcimb.2020.00120 · 2020 · External reference
Pre-existing simian immunodeficiency virus infection increases expression of T cell markers associated with activation during early mycobacterium tuberculosis coinfection and impairs TNF responses in granulomas
10.4049/jimmunol.2100073 · 2021 · External reference
Expression of immunosuppressive receptor T cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain on CD8 T cells in silicosis patients with Mycobacterium tuberculosis infection
2021 · External reference
The roles of coinhibitory receptors in pathogenesis of human retroviral infections
10.3389/fimmu.2018.02755 · 2018 · External reference
Immune checkpoint molecule TIGIT manipulates T cell dysfunction in septic patients
10.1016/j.intimp.2021.108205 · 2021 · External reference
TIGIT limits immune pathology during viral infections
10.1038/s41467-020-15025-1 · 2020 · External reference
PD-1 modulating Mycobacterium tuberculosis-specific polarized effector memory T cells response in tuberculosis pleurisy
10.1002/jlb.ma1118-450rr · 2019 · External reference
Tim-3-expressing CD4+ and CD8+ T cells in human tuberculosis (TB) exhibit polarized effector memory phenotypes and stronger anti-TB effector functions
2012 · External reference
Patterns of TIGIT expression in lymphatic tissue, inflammation, and cancer
10.1155/2019/5160565 · 2019 · External reference
Spontaneous control of SIV replication does not prevent T cell dysregulation and bacterial dissemination in animals co-infected with M. tuberculosis
10.1128/spectrum.01724-21 · 2022 · External reference
MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection
10.1371/journal.ppat.1008585 · 2020 · External reference
Study on role of TIGIT signal in Th1/Th2 balance in Schistosoma japonicum-infected mice
2018 · External reference
Involvement of TIGIT in natural killer cell exhaustion and immune escape in patients and mouse model with liver echinococcus multilocularis infection
10.1002/hep.32035 · 2021 · External reference
Th22 response induced by Mycobacterium tuberculosis strains is closely related to severity of pulmonary lesions and bacillary load in patients with multi-drug-resistant tuberculosis
10.1111/cei.13544 · 2021 · External reference
Elevated expression of Tim-3 on CD8 T cells correlates with disease severity of pulmonary tuberculosis
10.1016/j.jinf.2011.02.013 · 2011 · External reference
The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells
10.1038/ni.1674 · 2009 · External reference
CD8 T cell exhaustion during chronic viral infection and cancer
10.1146/annurev-immunol-041015-055318 · 2019 · External reference
Lag-3, Tim-3, and TIGIT: co-inhibitory receptors with specialized functions in immune regulation
10.1016/j.immuni.2016.05.001 · 2016 · External reference
Perturbed CD8+ T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals
10.1038/srep40354 · 2017 · External reference
Correlation between TIGIT expression on CD8+ T cells and higher cytotoxic capacity
10.1093/infdis/jiab155 · 2021 · External reference
KIR(+)CD8(+) and NKG2A(+)CD8(+) T cells are distinct innate-like populations in humans
2023 · External reference
Inhibition of hepatic natural killer cell function via the TIGIT receptor in schistosomiasis-induced liver fibrosis
2023 · External reference
Low levels of T cell exhaustion in tuberculous lung granulomas
2018 · External reference
Programmed death-1 (PD-1)-deficient mice are extraordinarily sensitive to tuberculosis
10.1073/pnas.1007394107 · 2010 · External reference
T cells from Programmed Death-1 deficient mice respond poorly to Mycobacterium tuberculosis infection
10.1371/journal.pone.0019864 · 2011 · External reference
CD4 T cells promote rather than control tuberculosis in the absence of PD-1-mediated inhibition
10.4049/jimmunol.1003304 · 2011 · External reference
PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques
10.1126/sciimmunol.abf3861 · 2021 · External reference
Tuberculosis following PD-1 blockade for cancer immunotherapy
10.1126/scitranslmed.aat2702 · 2019 · External reference
Assessing and screening for T-cell epitopes from Mycobacterium tuberculosis RD2 proteins for the diagnosis of active tuberculosis
10.1016/j.bjid.2018.10.280 · 2018 · External reference
IFN-γ-independent control of M. tuberculosis requires CD4 T cell-derived GM-CSF and activation of HIF-1α
10.1371/journal.ppat.1010721 · 2022 · External reference
