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References from ERK-METTL3 axis acts as a novel regulator of antiviral innate immunity combating pseudorabies virus infection. Local targets link to admitted publications; unresolved targets remain external evidence.
The structural basis of herpesvirus entry
10.1038/s41579-020-00448-w · 2021 · External reference
Epigenetic and epitranscriptomic regulation of viral replication
10.1038/s41579-020-0382-3 · 2020 · External reference
Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers
10.1016/j.molcel.2019.04.025 · 2019 · External reference
Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation
10.1016/j.molcel.2020.10.026 · 2020 · External reference
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
10.1038/nchembio.1432 · 2014 · External reference
N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
10.1038/nchembio.687 · 2011 · External reference
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
10.1016/j.molcel.2012.10.015 · 2013 · External reference
RIG-I-like receptors: their regulation and roles in RNA sensing
10.1038/s41577-020-0288-3 · 2020 · External reference
Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine
10.1016/j.celrep.2021.108798 · 2021 · External reference
RNA m6 A modification enzymes shape innate responses to DNA by regulating interferon β
10.1101/gad.319475.118 · 2018 · External reference
m6A modification controls the innate immune response to infection by targeting type I interferons
10.1038/s41590-018-0275-z · 2019 · External reference
N6-methyladenosine RNA modification suppresses antiviral innate sensing pathways via reshaping double-stranded RNA
10.1038/s41467-021-21904-y · 2021 · External reference
TBK1-METTL3 axis facilitates antiviral immunity
10.1016/j.celrep.2022.110373 · 2022 · External reference
ERK signalling: a master regulator of cell behaviour, life and fate
10.1038/s41580-020-0255-7 · 2020 · External reference
Human DNA Virus Exploitation of the MAPK-ERK Cascade
10.3390/ijms20143427 · 2019 · External reference
A Novel Human Acute Encephalitis Caused by Pseudorabies Virus Variant Strain
2021 · External reference
Molecular biology of pseudorabies virus: impact on neurovirology and veterinary medicine
10.1128/mmbr.69.3.462-500.2005 · 2005 · External reference
Structural Basis for Cooperative Function of Mettl3 and Mettl14 Methyltransferases
10.1016/j.molcel.2016.05.041 · 2016 · External reference
The type I interferonopathies: 10 years on
10.1038/s41577-021-00633-9 · 2022 · External reference
m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype
10.1038/s41556-021-00656-3 · 2021 · External reference
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3
10.1016/j.cell.2005.08.012 · 2005 · External reference
NF-κB, inflammation, and metabolic disease
10.1016/j.cmet.2010.12.008 · 2011 · External reference
N6-methyladenosine RNA modification-mediated cellular metabolism rewiring inhibits viral replication
10.1126/science.aax4468 · 2019 · External reference
Alphaherpesvirus US3 protein-mediated inhibition of the m6A mRNA methyltransferase complex
10.1016/j.celrep.2022.111107 · 2022 · External reference
ERK1/2-HNF4α axis is involved in epigallocatechin-3-gallate inhibition of HBV replication
10.1038/s41401-019-0302-0 · 2020 · External reference
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
10.1038/s41586-021-03536-w · 2021 · External reference
PD98059, a specific MAP kinase inhibitor, attenuates multiple organ dysfunction syndrome/failure (MODS) induced by zymosan in mice
10.1016/j.phrs.2009.09.008 · 2010 · External reference
Targeting METTL3 enhances the chemosensitivity of non-small cell lung cancer cells by decreasing ABCC2 expression in an m6A-YTHDF1-dependent manner
10.7150/ijbs.97425 · 2024 · External reference
Interpreting the protein language using proteomics
10.1038/nrm1939 · 2006 · External reference
PTMD 2.0: an updated database of disease-associated post-translational modifications
10.1093/nar/gkae850 · 2025 · External reference
Viral evasion of intracellular DNA and RNA sensing
10.1038/nrmicro.2016.45 · 2016 · External reference
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complex
10.1038/nature18298 · 2016 · External reference
Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex
10.1261/rna.064063.117 · 2018 · External reference
Pseudorabies Virus Infection Results in a Broad Inhibition of Host Gene Transcription
10.1128/jvi.00714-22 · 2022 · External reference
Pseudorabies virus VHS protein abrogates interferon responses by blocking NF-κB and IRF3 nuclear translocation
10.1016/j.virs.2024.05.009 · 2024 · External reference
Pseudorabies Virus EP0 Antagonizes the Type I Interferon Response via Inhibiting IRF9 Transcription
10.1128/jvi.02171-21 · 2022 · External reference
Pseudorabies Virus Infection Triggers NF-κB Activation via the DNA Damage Response but Actively Inhibits NF-κB-Dependent Gene Expression
10.1128/jvi.01666-21 · 2021 · External reference
BUB1 potentiates gastric cancer proliferation and metastasis by activating TRAF6/NF-κB/FGF18 through m6A modification
10.1016/j.lfs.2024.122916 · 2024 · External reference
Porcine deltacoronavirus nucleocapsid protein interacts with the Grb2 through its proline-rich motifs to induce activation of the Raf-MEK-ERK signal pathway and promote virus replication
2024 · External reference
m6 A RNA methylation: from mechanisms to therapeutic potential
2021 · External reference
Epitranscriptomic Enhancement of Influenza A Virus Gene Expression and Replication
10.1016/j.chom.2017.08.004 · 2017 · External reference
N6-methyladenosine modification of hepatitis B virus RNA differentially regulates the viral life cycle
10.1073/pnas.1808319115 · 2018 · External reference
The dual methyltransferase METTL13 targets N terminus and Lys55 of eEF1A and modulates codon-specific translation rates
10.1038/s41467-018-05646-y · 2018 · External reference
Reconstitution reveals the functional core of mammalian eIF3
10.1038/sj.emboj.7601765 · 2007 · External reference
Site-directed spectroscopy of cardiac myosin-binding protein C reveals effects of phosphorylation on protein structural dynamics
10.1073/pnas.1521281113 · 2016 · External reference
The roles of N6-methyladenosine and its target regulatory noncoding RNAs in tumors: classification, mechanisms, and potential therapeutic implications
10.1038/s12276-023-00944-y · 2023 · External reference
A novel peptide encoded by N6-methyladenosine modified circMAP3K4 prevents apoptosis in hepatocellular carcinoma
10.1186/s12943-022-01537-5 · 2022 · External reference
M6A RNA methylation-mediated RMRP stability renders proliferation and progression of non-small cell lung cancer through regulating TGFBR1/SMAD2/SMAD3 pathway
10.1038/s41418-021-00888-8 · 2023 · External reference
MicroRNAs as mediators of viral evasion of the immune system
10.1038/ni.2537 · 2013 · External reference
METTL14 and FTO mediated m6A modification regulate PCV2 replication by affecting miR-30a-5p maturity
10.1080/21505594.2023.2232910 · 2023 · External reference
Methyltransferase-like 3 Modulates Severe Acute Respiratory Syndrome Coronavirus-2 RNA N6-Methyladenosine Modification and Replication
10.1128/mbio.01067-21 · 2021 · External reference
METTL3 regulates viral m6A RNA modification and host cell innate immune responses during SARS-CoV-2 infection
10.1016/j.celrep.2021.109091 · 2021 · External reference
Extracellular signal-regulated kinase (ERK) activation is required for porcine epidemic diarrhea virus replication
10.1016/j.virol.2015.06.007 · 2015 · External reference
Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication
10.1101/gad.348320.121 · 2021 · External reference
Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants
10.1038/sj.cdd.4401054 · 2002 · External reference
Discovery of Small Molecules that Activate RNA Methylation through Cooperative Binding to the METTL3-14-WTAP Complex Active Site
10.1016/j.celrep.2019.02.100 · 2019 · External reference
