Research graph
References from IRF6 controls Epstein-Barr virus (EBV) lytic reactivation and differentiation in EBV-infected epithelial cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Epstein-Barr virus: biology and clinical disease
10.1016/j.cell.2022.08.026 · 2022 · External reference
Epstein-Barr virus infection in oral hairy leukoplakia: virus replication in the absence of a detectable latent phase
10.1099/0022-1317-72-12-3035 · 1991 · External reference
Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia
10.1128/jvi.65.6.2868-2874.1991 · 1991 · External reference
Efficient replication of Epstein-Barr virus in stratified epithelium in vitro
10.1073/pnas.1400818111 · 2014 · External reference
Air-liquid interface method to study Epstein-Barr virus pathogenesis in nasopharyngeal epithelial cells
10.1128/msphere.00152-18 · 2018 · External reference
A primary nasopharyngeal three-dimensional air-liquid interface cell culture model of the pseudostratified epithelium reveals differential donor- and cell type-specific susceptibility to Epstein-Barr virus infection
10.1371/journal.ppat.1009041 · 2021 · External reference
Differentiation-associated expression of the Epstein-Barr virus BZLF1 transactivator protein in oral hairy leukoplakia
10.1128/jvi.65.6.2868-2874.1991 · 1991 · External reference
Differentiation-dependent KLF4 expression promotes lytic Epstein-Barr virus infection in epithelial cells
10.1371/journal.ppat.1005195 · 2015 · External reference
Epstein-Barr virus infection promotes epithelial cell growth by attenuating differentiation-dependent exit from the cell cycle
10.1128/mbio.01332-19 · 2019 · External reference
Retinoblastoma protein is required for Epstein-Barr virus replication in differentiated epithelia
10.1128/jvi.01032-22 · 2023 · External reference
Epstein-Barr virus replication within differentiated epithelia requires pRb sequestration of activator E2F transcription factors
10.1128/jvi.00995-24 · 2024 · External reference
Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters
10.1128/jvi.02781-14 · 2015 · External reference
ΔNp63α promotes Epstein-Barr virus latency in undifferentiated epithelial cells
10.1371/journal.ppat.1010045 · 2021 · External reference
Inhibition of the integrated stress response by Epstein-Barr virus oncoprotein LMP1 attenuates epithelial cell differentiation and lytic viral reactivation
10.1371/journal.ppat.1012934 · 2025 · External reference
Lack of IRF6 disrupts human epithelial homeostasis by altering colony morphology, migration pattern, and differentiation potential of keratinocytes
10.3389/fcell.2021.718066 · 2021 · External reference
The RIPK4-IRF6 signalling axis safeguards epidermal differentiation and barrier function
10.1038/s41586-019-1615-3 · 2019 · External reference
Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)
10.1038/ng1903 · 2006 · External reference
Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate
10.1056/nejmoa032909 · 2004 · External reference
Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch
10.1038/ng1894 · 2006 · External reference
Developmental factor IRF6 exhibits tumor suppressor activity in squamous cell carcinomas
10.1073/pnas.1110931108 · 2011 · External reference
Interferon regulatory factor 6 promotes differentiation of the periderm by activating expression of Grainyhead-like 3
10.1038/jid.2012.269 · 2013 · External reference
Analysis of cell populations in fine needle aspiration biopsies from human renal allografts by separation on a preformed continuous Percoll density gradient
1989 · External reference
A regulatory feedback loop involving p63 and IRF6 links the pathogenesis of 2 genetically different human ectodermal dysplasias
10.1172/jci40267 · 2010 · External reference
Receptor-interacting protein kinase 4 and interferon regulatory factor 6 function as a signaling axis to regulate keratinocyte differentiation
10.1074/jbc.m114.589382 · 2014 · External reference
The developmental transcription factor IRF6 attenuates ABCG2 gene expression and distinctively reverses stemness phenotype in nasopharyngeal carcinoma
10.1016/j.canlet.2017.10.016 · 2018 · External reference
RIPK4 activity in keratinocytes is controlled by the SCFβ-TrCP ubiquitin ligase to maintain cortical actin organization
10.1007/s00018-018-2763-6 · 2018 · External reference
Consistent downregulation of the cleft lip/palate-associated genes IRF6 and GRHL3 in carcinomas
10.3389/fonc.2022.1023072 · 2022 · External reference
The NOTCH-RIPK4-IRF6-ELOVL4 axis suppresses squamous cell carcinoma
10.3390/cancers15030737 · 2023 · External reference
IRF6 is directly regulated by ZEB1 and ELF3, and predicts a favorable prognosis in gastric cancer
10.3389/fonc.2019.00220 · 2019 · External reference
Epstein-Barr virus LMP1 protein promotes proliferation and inhibits differentiation of epithelial cells via activation of YAP and TAZ
10.1073/pnas.2219755120 · 2023 · External reference
Type 1 and Type 2 Epstein-Barr viruses induce proliferation, and inhibit differentiation, in infected telomerase-immortalized normal oral keratinocytes
10.1371/journal.ppat.1010868 · 2022 · External reference
Terminal differentiation of epidermal keratinocytes
10.1016/s0955-0674(89)80058-4 · 1989 · External reference
Establishment and characterization of an Epstein-Barr virus-positive cell line from a non-keratinizing differentiated primary nasopharyngeal carcinoma
10.1158/2767-9764.crc-23-0341 · 2024 · External reference
Highly efficient CRISPR/Cas9-mediated cloning and functional characterization of gastric cancer-derived Epstein-Barr virus strains
10.1128/jvi.00060-16 · 2016 · External reference
Epigenomic landscape study reveals molecular subtypes and EBV-associated regulatory epigenome reprogramming in nasopharyngeal carcinoma
10.1016/j.ebiom.2022.104357 · 2022 · External reference
Change of preoptic opiate receptors after injection of 6-OHDA into sublocus coeruleus in the rabbit
1990 · External reference
Protein kinase C-delta mRNA is down-regulated transcriptionally and post-transcriptionally by 12-O-tetradecanoylphorbol-13-acetate
10.1074/jbc.271.27.16040 · 1996 · External reference
Clonal proliferations of cells infected with Epstein-Barr virus in preinvasive lesions related to nasopharyngeal carcinoma
10.1056/nejm199509143331103 · 1995 · External reference
Plasticity-induced repression of Irf6 underlies acquired resistance to cancer immunotherapy in pancreatic ductal adenocarcinoma
10.1038/s41467-024-46048-7 · 2024 · External reference
Potentially functional genetic variants in interferon regulatory factor family genes are associated with colorectal cancer survival
10.1002/mc.23752 · 2024 · External reference
Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β
10.1371/journal.ppat.1007158 · 2018 · External reference
Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma
10.1038/s41467-018-06889-5 · 2018 · External reference
A naturally derived gastric cancer cell line shows latency I Epstein-Barr virus infection closely resembling EBV-associated gastric cancer
10.1016/j.virol.2003.12.005 · 2004 · External reference
Epstein-barr virus immediate-early protein BZLF1 is SUMO-1 modified and disrupts promyelocytic leukemia bodies
10.1128/jvi.75.5.2388-2399.2001 · 2001 · External reference
