Research graph
References from PHD3-VHL axis controls HIV-2 infection through oxygen-dependent hydroxylation and degradation of Vpx. Local targets link to admitted publications; unresolved targets remain external evidence.
Lower human immunodeficiency virus (HIV) type 2 viral load reflects the difference in pathogenicity of HIV-1 and HIV-2
10.1086/315010 · 1999 · External reference
Comparing HIV-1 and HIV-2 infection: Lessons for viral immunopathogenesis
10.1002/rmv.1739 · 2013 · External reference
Insight into HIV-2 latency may disclose strategies for a cure for HIV-1 infection
10.1016/s2055-6640(20)30300-9 · 2017 · External reference
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
10.1038/nature10117 · 2011 · External reference
Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
10.1038/nature10195 · 2011 · External reference
SAMHD1 restricts HIV-1 infection in resting CD4(+) T cells
10.1038/nm.2964 · 2012 · External reference
HIV/simian immunodeficiency virus (SIV) accessory virulence factor Vpx loads the host cell restriction factor SAMHD1 onto the E3 ubiquitin ligase complex CRL4DCAF1
10.1074/jbc.m112.340711 · 2012 · External reference
HIV-2/SIV Vpx targets a novel functional domain of STING to selectively inhibit cGAS-STING-mediated NF-κB signalling
10.1038/s41564-019-0585-4 · 2019 · External reference
HIV-2/SIV Vpx antagonises NF-κB activation by targeting p65
10.1186/s12977-021-00586-w · 2022 · External reference
HIV-2/SIV viral protein X counteracts HUSH repressor complex
10.1038/s41564-018-0179-6 · 2018 · External reference
Primate immunodeficiency virus proteins Vpx and Vpr counteract transcriptional repression of proviruses by the HUSH complex
10.1038/s41564-018-0256-x · 2018 · External reference
Protein posttranslational modifications in health and diseases: Functions, regulatory mechanisms, and therapeutic implications
2023 · External reference
PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
10.1038/s41467-019-09867-7 · 2019 · External reference
HIV-2 viral protein X (Vpx) ubiquitination is dispensable for ubiquitin ligase interaction and effects on macrophage infection
10.1016/j.virol.2012.02.002 · 2012 · External reference
Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex
10.1016/j.str.2014.12.014 · 2015 · External reference
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
10.1038/20459 · 1999 · External reference
Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
10.1093/emboj/19.16.4298 · 2000 · External reference
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
10.1126/science.1059796 · 2001 · External reference
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
10.1016/s0092-8674(01)00507-4 · 2001 · External reference
Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor
10.1073/pnas.192342099 · 2002 · External reference
Cleavable cross-linker for protein structure analysis: reliable identification of cross-linking products by tandem MS
10.1021/ac101241t · 2010 · External reference
Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions
10.4049/jimmunol.167.11.6140 · 2001 · External reference
Why is the partial oxygen pressure of human tissues a crucial parameter? Small molecules and hypoxia
10.1111/j.1582-4934.2011.01258.x · 2011 · External reference
Oxygen Sensing and Viral Replication: Implications for Tropism and Pathogenesis
10.3390/v12111213 · 2020 · External reference
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function
10.1126/science.284.5413.455 · 1999 · External reference
Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3
10.1074/jbc.m206955200 · 2002 · External reference
Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx
10.1128/jvi.01437-09 · 2010 · External reference
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation
10.1038/s41467-017-00954-1 · 2017 · External reference
Virological characterization of HIV-2 vpx gene mutants in various cell systems
10.1016/j.micinf.2014.06.004 · 2014 · External reference
ASK1 restores the antiviral activity of APOBEC3G by disrupting HIV-1 Vif-mediated counteraction
10.1038/ncomms7945 · 2015 · External reference
Hypoxia-inducible factor linked to differential kidney cancer risk seen with type 2A and type 2B VHL mutations
10.1128/mcb.00282-07 · 2007 · External reference
Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes
10.1002/ijc.2910410324 · 1988 · External reference
Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins
10.1038/s41467-022-28171-5 · 2022 · External reference
MAL Inhibits the Production of HIV-1 Particles by Sequestering Gag to Intracellular Endosomal Compartments
2022 · External reference
Protocol for micro-purification, enrichment, pre-fractionation and storage of peptides for proteomics using StageTips
10.1038/nprot.2007.261 · 2007 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
The ClusPro web server for protein-protein docking
10.1038/nprot.2016.169 · 2017 · External reference
Datamonkey 2.0: A Modern Web Application for Characterizing Selective and Other Evolutionary Processes
10.1093/molbev/msx335 · 2018 · External reference
Not so different after all: a comparison of methods for detecting amino acid sites under selection
10.1093/molbev/msi105 · 2005 · External reference
FUBAR: a fast, unconstrained bayesian approximation for inferring selection
10.1093/molbev/mst030 · 2013 · External reference
Full-length human immunodeficiency virus type 1 genomes from subtype C-infected seroconverters in India, with evidence of intersubtype recombination
10.1128/jvi.73.1.152-160.1999 · 1999 · External reference
MAFFT multiple sequence alignment software version 7: improvements in performance and usability
10.1093/molbev/mst010 · 2013 · External reference
IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era
10.1093/molbev/msaa015 · 2020 · External reference
