Research graph
References from Circovirus Rep evades immune restriction by disrupting cGAS oligomerization and phase separation. Local targets link to admitted publications; unresolved targets remain external evidence.
Cyclic GMP-AMP synthase is activated by double-stranded DNA-induced oligomerization
10.1016/j.immuni.2013.10.019 · 2013 · External reference
Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway
10.1126/science.1232458 · 2013 · External reference
Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA
10.1126/science.1229963 · 2013 · External reference
Cyclic [G(2’,5’)pA(3’,5’)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase
10.1016/j.cell.2013.04.046 · 2013 · External reference
cGAS produces a 2’-5’-linked cyclic dinucleotide second messenger that activates STING
10.1038/nature12306 · 2013 · External reference
Cellular functions of cGAS-STING signaling
10.1016/j.tcb.2022.11.001 · 2023 · External reference
Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein
10.1016/j.chom.2015.07.015 · 2015 · External reference
Cooperative DNA binding mediated by KicGAS/ORF52 oligomerization allows inhibition of DNA-induced phase separation and activation of cGAS
10.1093/nar/gkab689 · 2021 · External reference
Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion
2021 · External reference
Phase-separated nucleocapsid protein of SARS-CoV-2 suppresses cGAS-DNA recognition by disrupting cGAS-G3BP1 complex
10.1038/s41392-023-01420-9 · 2023 · External reference
Species-specific cleavage of cGAS by picornavirus protease 3C disrupts mitochondria DNA-mediated immune sensing
2023 · External reference
Viral protease binds to nucleosomal DNA and cleaves nuclear cGAS that attenuates type I interferon
2025 · External reference
Human Cytomegalovirus Protein UL31 Inhibits DNA Sensing of cGAS to Mediate Immune Evasion
2018 · External reference
African swine fever virus QP383R dampens type I interferon production by promoting cGAS palmitoylation
10.3389/fimmu.2023.1186916 · 2023 · External reference
Co-Infection of Swine with Porcine Circovirus Type 2 and Other Swine Viruses
10.3390/v11020185 · 2019 · External reference
Macrophage Polarization Modulated by Porcine Circovirus Type 2 Facilitates Bacterial Coinfection
10.3389/fimmu.2021.688294 · 2021 · External reference
Advances in Crosstalk between Porcine Circoviruses and Host
10.3390/v14071419 · 2022 · External reference
Synergistic Pathogenicity by Coinfection and Sequential Infection with NADC30-like PRRSV and PCV2 in Post-Weaned Pigs
10.3390/v14020193 · 2022 · External reference
Porcine circovirus type 2 and its associated diseases in China
10.1016/j.virusres.2011.10.005 · 2012 · External reference
Novel circovirus species identified in farmed pigs designated as Porcine circovirus 4, Hunan province, China
10.1111/tbed.13446 · 2020 · External reference
Recent Progress on Epidemiology and Pathobiology of Porcine Circovirus 3
10.3390/v13101944 · 2021 · External reference
Porcine circoviruses: current status, knowledge gaps and challenges
10.1016/j.virusres.2020.198044 · 2020 · External reference
Current understanding of genomic DNA of porcine circovirus type 2
10.1007/s11262-014-1099-z · 2014 · External reference
Porcine circovirus type 2 exploits cap to inhibit PKR activation through interaction with Hsp40
10.1016/j.vetmic.2020.108929 · 2021 · External reference
Porcine circovirus type 2 infection promotes the SUMOylation of nucleophosmin-1 to facilitate the viral circular single-stranded DNA replication
2024 · External reference
PCV2 targets cGAS to inhibit type I interferon induction to promote other DNA virus infection
10.1371/journal.ppat.1009940 · 2021 · External reference
Mechanism of DNA Interaction and Translocation by the Replicase of a Circular Rep-Encoding Single-Stranded DNA Virus
10.1128/mbio.00763-21 · 2021 · External reference
Crystal structure of the dimerized of porcine circovirus type II replication-related protein Rep’
10.1002/prot.26498 · 2023 · External reference
Crystal Structure of the Dimerized N Terminus of Porcine Circovirus Type 2 Replicase Protein Reveals a Novel Antiviral Interface
2018 · External reference
G3BP1 promotes DNA binding and activation of cGAS
10.1038/s41590-018-0262-4 · 2019 · External reference
Nucleic-acid-induced ZCCHC3 condensation promotes broad innate immune responses
2025 · External reference
AARS1 and AARS2 sense L-lactate to regulate cGAS as global lysine lactyltransferases
10.1038/s41586-024-07992-y · 2024 · External reference
cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing
10.1016/j.molcel.2021.01.024 · 2021 · External reference
DNA-induced liquid phase condensation of cGAS activates innate immune signaling
10.1126/science.aat1022 · 2018 · External reference
Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation
10.1073/pnas.1905013116 · 2019 · External reference
New frontiers in the cGAS-STING intracellular DNA-sensing pathway
10.1016/j.immuni.2024.02.019 · 2024 · External reference
Polyamine metabolism controls B-to-Z DNA transition to orchestrate DNA sensor cGAS activity
10.1016/j.immuni.2023.09.012 · 2023 · External reference
Coinfection with Porcine Circovirus Type 2 (PCV2) and Streptococcus suis Serotype 2 (SS2) Enhances the Survival of SS2 in Swine Tracheal Epithelial Cells by Decreasing Reactive Oxygen Species Production
10.1128/iai.00537-20 · 2020 · External reference
Tetraspanin CD81 serves as a functional entry factor for porcine circovirus type 2 infection
2024 · External reference
Porcine circovirus type 2 infection inhibits the activation of type I interferon signaling via capsid protein and host gC1qR
10.1016/j.vetmic.2022.109354 · 2022 · External reference
The molecular basis of tight nuclear tethering and inactivation of cGAS
10.1038/s41586-020-2749-z · 2020 · External reference
Porcine circovirus type 2 infection attenuates the K63-linked ubiquitination of STING to inhibit IFN-β induction via p38-MAPK pathway
10.1016/j.vetmic.2021.109098 · 2021 · External reference
Identification of poly(ADP-ribose) polymerase 9 (PARP9) as a noncanonical sensor for RNA virus in dendritic cells
10.1038/s41467-021-23003-4 · 2021 · External reference
Loss of TRIM29 mitigates viral myocarditis by attenuating PERK-driven ER stress response in male mice
10.1038/s41467-024-44745-x · 2024 · External reference
