Research graph
References from IFN alpha inducible protein 27 (IFI27) acts as a positive regulator of PACT-dependent PKR activation after RNA virus infections. Local targets link to admitted publications; unresolved targets remain external evidence.
Detection of Viral Infections by Innate Immunity
10.1016/j.bcp.2020.114316 · 2021 · External reference
Pathogen recognition and innate immunity
10.1016/j.cell.2006.02.015 · 2006 · External reference
Viruses Seen by Our Cells: The Role of Viral RNA Sensors
2018 · External reference
Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA
10.1016/j.immuni.2005.06.008 · 2005 · External reference
Physiological functions of RIG-I-like receptors
10.1016/j.immuni.2024.03.003 · 2024 · External reference
SARS-CoV-2 NSP5 and N protein counteract the RIG-I signaling pathway by suppressing the formation of stress granules
10.1038/s41392-022-00878-3 · 2022 · External reference
Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children
2023 · External reference
Inhibition of the OAS/RNase L pathway by viruses
10.1016/j.coviro.2015.07.002 · 2015 · External reference
Elucidation of the Epitranscriptomic RNA Modification Landscape of Chikungunya Virus
10.3390/v16060945 · 2024 · External reference
Adenosine deaminase acting on RNA (ADAR1), a suppressor of double-stranded RNA-triggered innate immune responses
10.1074/jbc.tm118.004166 · 2019 · External reference
Multi-level regulation of cellular recognition of viral dsRNA
10.1007/s00018-012-1149-4 · 2013 · External reference
Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action
10.1128/mmbr.00027-06 · 2006 · External reference
PKR: A Kinase to Remember
10.3389/fnmol.2018.00480 · 2019 · External reference
Inhibition of PKR by Viruses
10.3389/fmicb.2021.757238 · 2021 · External reference
A tale of two proteins: PACT and PKR and their roles in inflammation
10.1111/febs.15691 · 2021 · External reference
The eIF2α kinases: their structures and functions
10.1007/s00018-012-1252-6 · 2013 · External reference
PKR activity modulation by phosphomimetic mutations of serine residues located three aminoacids upstream of double-stranded RNA binding motifs
10.1038/s41598-021-88610-z · 2021 · External reference
Activation of the double-stranded RNA-dependent protein kinase PKR by small ubiquitin-like modifier (SUMO)
10.1074/jbc.m114.560961 · 2014 · External reference
Viral subversion of the host protein synthesis machinery
10.1038/nrmicro2655 · 2011 · External reference
eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition
10.1128/mbio.00976-20 · 2020 · External reference
Activation of the Antiviral Kinase PKR and Viral Countermeasures
10.3390/v1030523 · 2009 · External reference
The search for a PKR code-differential regulation of protein kinase R activity by diverse RNA and protein regulators
10.1261/rna.070169.118 · 2019 · External reference
A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis
10.1016/j.virol.2007.01.038 · 2007 · External reference
SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b
10.1371/journal.ppat.1011582 · 2023 · External reference
SARS-CoV-2 nsp15 endoribonuclease antagonizes dsRNA-induced antiviral signaling
10.1073/pnas.2320194121 · 2024 · External reference
PACT, a protein activator of the interferon-induced protein kinase, PKR
10.1093/emboj/17.15.4379 · 1998 · External reference
TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR
10.1073/pnas.91.11.4713 · 1994 · External reference
Regulation of PKR activation and apoptosis during oxidative stress by TRBP phosphorylation
10.1016/j.biocel.2021.106030 · 2021 · External reference
Interaction of human tRNA-dihydrouridine synthase-2 with interferon-induced protein kinase PKR
10.1093/nar/gkm1129 · 2008 · External reference
NF90 exerts antiviral activity through regulation of PKR phosphorylation and stress granules in infected cells
10.4049/jimmunol.1302813 · 2014 · External reference
ADAR1 and PKR, interferon stimulated genes with clashing effects on HIV-1 replication
10.1016/j.cytogfr.2018.03.007 · 2018 · External reference
Dissecting the roles of TRBP and PACT in double-stranded RNA recognition and processing of noncoding RNAs
10.1002/wrna.1272 · 2015 · External reference
The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity
10.1016/s0042-6822(03)00589-0 · 2003 · External reference
Inhibition of the inflammatory response to stress by targeting interaction between PKR and its cellular activator PACT
10.1038/s41598-017-16089-8 · 2017 · External reference
Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein
10.1128/jvi.76.21.11054-11064.2002 · 2002 · External reference
Regulation of PACT-Mediated Protein Kinase Activation by the OV20.0 Protein of Orf Virus
10.1128/jvi.01739-15 · 2015 · External reference
The PKR activator, PACT, becomes a PKR inhibitor during HIV-1 replication
10.1186/1742-4690-10-96 · 2013 · External reference
HIV-1 translation and its regulation by cellular factors PKR and PACT
10.1016/j.virusres.2014.07.014 · 2014 · External reference
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation
10.1016/j.chom.2009.11.004 · 2009 · External reference
Cyclophilin inhibitors reduce phosphorylation of RNA-dependent protein kinase to restore expression of IFN-stimulated genes in HCV-infected cells
10.1053/j.gastro.2014.04.035 · 2014 · External reference
Zika virus non-coding RNAs antagonize antiviral responses by PKR-mediated translational arrest
10.1093/nar/gkae507 · 2024 · External reference
Emerging roles of FAM14 family members (G1P3/ISG 6-16 and ISG12/IFI27) in innate immunity and cancer
10.1089/jir.2010.0105 · 2011 · External reference
The IFN-stimulated gene IFI27 counteracts innate immune responses after viral infections by interfering with RIG-I signaling
10.3389/fmicb.2023.1176177 · 2023 · External reference
The IFN-induced protein IFI27 binds MDA5 and counteracts its activation after SARS-CoV-2 infection
10.3389/fcimb.2024.1470924 · 2024 · External reference
Ifi27 is indispensable for mitochondrial function and browning in adipocytes
10.1016/j.bbrc.2018.04.234 · 2018 · External reference
Integrative bulk and single-cell transcriptome profiling analysis reveals IFI27 as a novel interferon-stimulated gene in dengue
10.1002/jmv.28706 · 2023 · External reference
Structural basis of innate immune recognition of viral RNA
10.1111/cmi.12061 · 2013 · External reference
Double-Stranded RNA Sensors and Modulators in Innate Immunity
10.1146/annurev-immunol-042718-041356 · 2019 · External reference
RNA-binding proteins in regulating mRNA stability and translation: roles and mechanisms in cancer
10.1016/j.semcancer.2022.03.025 · 2022 · External reference
Dengue Virus Life Cycle and Host Protein Interactions: Focus on RNA Binding Proteins and Therapeutic Advances
10.1002/rmv.70025 · 2025 · External reference
Exponentially modified protein abundance index (emPAI) for estimation of absolute protein amount in proteomics by the number of sequenced peptides per protein
10.1074/mcp.m500061-mcp200 · 2005 · External reference
The gamma(1)34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1alpha to dephosphorylate the alpha subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase
10.1073/pnas.94.3.843 · 1997 · External reference
TARBP2 negatively regulates IFN-β production and innate antiviral response by targeting MAVS
10.1016/j.molimm.2018.10.017 · 2018 · External reference
The mechanism of eukaryotic translation initiation and principles of its regulation
10.1038/nrm2838 · 2010 · External reference
The role of RNA-binding and ribosomal proteins as specific RNA translation regulators in cellular differentiation and carcinogenesis
10.1016/j.bbadis.2020.166046 · 2021 · External reference
RNABindRPlus: a predictor that combines machine learning and sequence homology-based methods to improve the reliability of predicted RNA-binding residues in proteins
10.1371/journal.pone.0097725 · 2014 · External reference
PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs
2018 · External reference
PKR is activated by cellular dsRNAs during mitosis and acts as a mitotic regulator
10.1101/gad.242644.114 · 2014 · External reference
MicroRNA-29b regulates ethanol-induced neuronal apoptosis in the developing cerebellum through SP1/RAX/PKR cascade
10.1074/jbc.m113.535195 · 2014 · External reference
Contribution of dsRBD2 to PKR Activation
10.1021/acsomega.1c00343 · 2021 · External reference
The Nucleocapsid Proteins of SARS-CoV-2 and Its Close Relative Bat Coronavirus RaTG13 Are Capable of Inhibiting PKR- and RNase L-Mediated Antiviral Pathways
10.1128/spectrum.00994-23 · 2023 · External reference
Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication
2021 · External reference
SARS-CoV-2 induces double-stranded RNA-mediated innate immune responses in respiratory epithelial-derived cells and cardiomyocytes
2021 · External reference
The murine double-stranded RNA-dependent protein kinase PKR is required for resistance to vesicular stomatitis virus
10.1128/jvi.74.20.9580-9585.2000 · 2000 · External reference
LincRNA-EPS impairs host antiviral immunity by antagonizing viral RNA-PKR interaction
2022 · External reference
The role of protein kinase R in placental inflammation, mtUPR and apoptosis
10.1016/j.placenta.2023.07.007 · 2023 · External reference
ADAR1p110 promotes Enterovirus D68 replication through its deaminase domain and inhibition of PKR pathway
10.1186/s12985-022-01952-6 · 2022 · External reference
Ebola virus VP35 induces high-level production of recombinant TPL-2-ABIN-2-NF-κB1 p105 complex in co-transfected HEK-293 cells
10.1042/bj20121873 · 2013 · External reference
Modular structure of PACT: distinct domains for binding and activating PKR
10.1128/mcb.21.6.1908-1920.2001 · 2001 · External reference
PACT-mediated PKR activation acts as a hyperosmotic stress intensity sensor weakening osmoadaptation and enhancing inflammation
10.7554/elife.52241 · 2020 · External reference
Molecular basis for PKR activation by PACT or dsRNA
10.1073/pnas.0602317103 · 2006 · External reference
PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration
2024 · External reference
Cooperative Role of PACT and ADAR1 in Preventing Aberrant PKR Activation by Self-Derived Double-Stranded RNA
2024 · External reference
The Leader Protein of Theiler’s Virus Prevents the Activation of PKR
10.1128/jvi.01010-19 · 2019 · External reference
Dance with the Devil: Stress Granules and Signaling in Antiviral Responses
10.3390/v12090984 · 2020 · External reference
Viral evasion of PKR restriction by reprogramming cellular stress granules
2022 · External reference
Stress granules, RNA-binding proteins and polyglutamine diseases: too much aggregation?
10.1038/s41419-021-03873-8 · 2021 · External reference
Translation inhibition and stress granules in the antiviral immune response
10.1038/nri.2017.63 · 2017 · External reference
Stress granules regulate double-stranded RNA-dependent protein kinase activation through a complex containing G3BP1 and Caprin1
10.1128/mbio.02486-14 · 2015 · External reference
Hepatitis C virus reveals a novel early control in acute immune response
10.1371/journal.ppat.1002289 · 2011 · External reference
PKR Transduces MDA5-Dependent Signals for Type I IFN Induction
2016 · External reference
IPS-1 plays an essential role in dsRNA-induced stress granule formation by interacting with PKR and promoting its activation
2014 · External reference
PKR-dependent cytosolic cGAS foci are necessary for intracellular DNA sensing
2019 · External reference
Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B
10.1073/pnas.91.14.6288 · 1994 · External reference
Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways
10.1093/emboj/16.6.1291 · 1997 · External reference
Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3
10.1093/emboj/20.10.2487 · 2001 · External reference
Membraneless Organelles and Condensates Orchestrate Innate Immunity Against Viruses
10.1016/j.jmb.2023.167976 · 2023 · External reference
Initiation factor eIF2 alpha phosphorylation in stress responses and apoptosis
10.1007/978-3-662-09889-9_3 · 2001 · External reference
A Retrospective on eIF2A-and Not the Alpha Subunit of eIF2
10.3390/ijms21062054 · 2020 · External reference
PACT and PKR: turning on NF-kappa B in the absence of virus
2001 · External reference
Upper airway gene expression reveals suppressed immune responses to SARS-CoV-2 compared with other respiratory viruses
10.1038/s41467-020-19587-y · 2020 · External reference
IFI27 transcription is an early predictor for COVID-19 outcomes, a multi-cohort observational study
10.3389/fimmu.2022.1060438 · 2023 · External reference
Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study
10.1016/s2666-5247(21)00146-4 · 2021 · External reference
Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures
10.1183/13993003.01881-2021 · 2022 · External reference
Dynamic blood single-cell immune responses in patients with COVID-19
10.1038/s41392-021-00526-2 · 2021 · External reference
ADAR1 and PACT contribute to efficient translation of transcripts containing HIV-1 trans-activating response (TAR) element
10.1042/bcj20160964 · 2017 · External reference
The RNA-editing enzyme ADAR1: a regulatory hub that tunes multiple dsRNA-sensing pathways
10.1093/intimm/dxac056 · 2023 · External reference
The Role of RNA Editing in the Immune Response
10.1007/978-1-0716-0787-9_17 · 2021 · External reference
RNase L Reprograms Translation by Widespread mRNA Turnover Escaped by Antiviral mRNAs
10.1016/j.molcel.2019.07.029 · 2019 · External reference
Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown
10.1016/j.cell.2017.12.038 · 2018 · External reference
Mitochondrial localization and pro-apoptotic effects of the interferon-inducible protein ISG12a
10.1007/s10495-008-0190-0 · 2008 · External reference
miR-942 decreases TRAIL-induced apoptosis through ISG12a downregulation and is regulated by AKT
10.18632/oncotarget.2067 · 2014 · External reference
MDA5 localizes to stress granules, but this localization is not required for the induction of type I interferon
10.1128/jvi.03213-12 · 2013 · External reference
The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2
10.1128/jvi.66.4.1943-1950.1992 · 1992 · External reference
The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms
10.1128/jvi.67.3.1688-1692.1993 · 1993 · External reference
Viral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-kappaB activation, when the K1 protein is absent or mutated
10.1074/jbc.m110.194704 · 2011 · External reference
The gamma134.5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high molecular weight complex with the enzyme in infected cells
10.1074/jbc.273.33.20737 · 1998 · External reference
Inhibition of PKR activation by the proline-rich RNA binding domain of the herpes simplex virus type 1 Us11 protein
10.1128/jvi.74.23.11215-11221.2000 · 2000 · External reference
Double-stranded RNA binding of influenza B virus nonstructural NS1 protein inhibits protein kinase R but is not essential to antagonize production of alpha/beta interferon
10.1128/jvi.01142-06 · 2006 · External reference
Zika Virus Hijacks Stress Granule Proteins and Modulates the Host Stress Response
2017 · External reference
VSV strains with defects in their ability to shutdown innate immunity are potent systemic anti-cancer agents
10.1016/s1535-6108(03)00241-1 · 2003 · External reference
Cell type dependent stability and virulence of a recombinant SARS-CoV-2, and engineering of a propagation deficient RNA replicon to analyze virus RNA synthesis
10.3389/fcimb.2023.1268227 · 2023 · External reference
NS1 Protein Mutation I64T Affects Interferon Responses and Virulence of Circulating H3N2 Human Influenza A Viruses
10.1128/jvi.01039-16 · 2016 · External reference
Epigenetic targeting of the ACE2 and NRP1 viral receptors limits SARS-CoV-2 infectivity
10.1186/s13148-021-01168-5 · 2021 · External reference
Inhibition of retinoic acid-inducible gene I-mediated induction of beta interferon by the NS1 protein of influenza A virus
10.1128/jvi.01265-06 · 2007 · External reference
Interactions between the double-stranded RNA-binding proteins TRBP and PACT define the Medipal domain that mediates protein-protein interactions
10.4161/rna.5.2.6069 · 2008 · External reference
Quantitative proteomic analysis of serum-purified exosomes identifies putative pre-eclampsia-associated biomarkers
10.1186/s12014-022-09342-4 · 2022 · External reference
The Renilla luciferase gene as a reference gene for normalization of gene expression in transiently transfected cells
10.1186/1471-2199-11-103 · 2010 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
