Research graph
References from A comprehensive phylogeny of mammalian PRNP gene reveals no influence of prion misfolding propensity on the evolution of this gene. Local targets link to admitted publications; unresolved targets remain external evidence.
Prions
10.1073/pnas.95.23.13363 · 1998 · External reference
Prion encephalopathies of animals and humans
1993 · External reference
Updated global epidemiology atlas of human prion diseases
10.3389/fpubh.2024.1411489 · 2024 · External reference
Prions on the move
10.1038/embor.2011.192 · 2011 · External reference
Prion strains in mammals: Different conformations leading to disease
10.1371/journal.ppat.1006323 · 2017 · External reference
Mouse-hamster chimeric prion protein (PrP) devoid of N-terminal residues 23-88 restores susceptibility to 22L prions, but not to RML prions in PrP-knockout mice
10.1371/journal.pone.0109737 · 2014 · External reference
Host-genotype and agent effects in scrapie incubation: change in allelic interaction with different strains of agent
10.1007/bf00266934 · 1971 · External reference
Experimental transmission of scrapie to rats
10.1016/s0140-6736(63)90820-1 · 1963 · External reference
Characteristics of a short incubation model of scrapie in the golden hamster
10.1099/0022-1317-34-2-295 · 1977 · External reference
The host range of chronic wasting disease is altered on passage in ferrets
10.1006/viro.1998.9427 · 1998 · External reference
Aggregates of scrapie-associated prion protein induce the cell-free conversion of protease-sensitive prion protein to the protease-resistant state
10.1016/1074-5521(95)90087-x · 1995 · External reference
Cell-free formation of protease-resistant prion protein
10.1038/370471a0 · 1994 · External reference
In vitro generation of infectious scrapie prions
10.1016/j.cell.2005.02.011 · 2005 · External reference
Formation of native prions from minimal components in vitro
10.1073/pnas.0702662104 · 2007 · External reference
De novo generation of infectious prions in vitro produces a new disease phenotype
10.1371/journal.ppat.1000421 · 2009 · External reference
Synthetic mammalian prions
10.1126/science.1100195 · 2004 · External reference
Mammalian prions generated from bacterially expressed prion protein in the absence of any mammalian cofactors
10.1074/jbc.c110.113464 · 2010 · External reference
Recombinant prion protein induces a new transmissible prion disease in wild-type animals
10.1007/s00401-009-0633-x · 2010 · External reference
Generating a prion with bacterially expressed recombinant prion protein
10.1126/science.1183748 · 2010 · External reference
De novo generation of infectious prions with bacterially expressed recombinant prion protein
10.1096/fj.13-233965 · 2013 · External reference
Understanding the key features of the spontaneous formation of bona fide prions through a novel methodology that enables their swift and consistent generation
10.1186/s40478-023-01640-8 · 2023 · External reference
Disparate Modes of Evolution Shaped Modern Prion (PRNP) and Prion-Related Doppel (PRND) Variation in Domestic Cattle
10.1371/journal.pone.0155924 · 2016 · External reference
Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein
10.1006/jmbi.1999.2831 · 1999 · External reference
A prion-like protein from chicken brain copurifies with an acetylcholine receptor-inducing activity
10.1073/pnas.88.17.7664 · 1991 · External reference
cDNA cloning of turtle prion protein
10.1016/s0014-5793(00)01232-1 · 2000 · External reference
Molecular cloning of the cDNA coding for Xenopus laevis prion protein
10.1016/s0014-5793(01)03027-7 · 2001 · External reference
An evolutionary basis for scrapie disease: identification of a fish prion mRNA
10.1016/s0168-9525(02)00032-x · 2003 · External reference
Rabbits are not resistant to prion infection
10.1073/pnas.1120076109 · 2012 · External reference
Transgenic Mouse Bioassay: Evidence That Rabbits Are Susceptible to a Variety of Prion Isolates
10.1371/journal.ppat.1004977 · 2015 · External reference
In Vitro Approach To Identify Key Amino Acids in Low Susceptibility of Rabbit Prion Protein to Misfolding
10.1128/jvi.01543-17 · 2017 · External reference
Unraveling the key to the resistance of canids to prion diseases
10.1371/journal.ppat.1006716 · 2017 · External reference
An Amino Acid Substitution Found in Animals with Low Susceptibility to Prion Diseases Confers a Protective Dominant-Negative Effect in Prion-Infected Transgenic Mice
10.1007/s12035-017-0832-8 · 2018 · External reference
A Single Amino Acid Substitution, Found in Mammals with Low Susceptibility to Prion Diseases, Delays Propagation of Two Prion Strains in Highly Susceptible Transgenic Mouse Models
10.1007/s12035-019-1535-0 · 2019 · External reference
Behind the potential evolution towards prion resistant species
10.1080/19336896.2018.1435935 · 2018 · External reference
Naturally prion resistant mammals: a utopia?
10.4161/pri.22057 · 2012 · External reference
Prion-resistant or prion-susceptible species, this is the question
10.4161/viru.24456 · 2013 · External reference
Mutational effects and the evolution of new protein functions
10.1038/nrg2808 · 2010 · External reference
Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiological stress
10.1111/1348-0421.12162 · 2014 · External reference
Genetic Factors in Mammalian Prion Diseases
10.1146/annurev-genet-120213-092352 · 2019 · External reference
A species-level timeline of mammal evolution integrating phylogenomic data
10.1038/s41586-021-04341-1 · 2022 · External reference
A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions
10.1038/s41467-024-46360-2 · 2024 · External reference
Phylogenetic Tree Rooting
10.1016/b978-0-12-809633-8.20258-6 · 2019 · External reference
Molecules consolidate the placental mammal tree
10.1016/j.tree.2004.05.006 · 2004 · External reference
Molecular evidence for multiple origins of Insectivora and for a new order of endemic African insectivore mammals
10.1073/pnas.95.17.9967 · 1998 · External reference
Diversity dynamics: molecular phylogenies need the fossil record
10.1016/j.tree.2010.05.002 · 2010 · External reference
Investigating Difficult Nodes in the Placental Mammal Tree with Expanded Taxon Sampling and Thousands of Ultraconserved Elements
10.1093/gbe/evx168 · 2017 · External reference
The inference of gene trees with species trees
10.1093/sysbio/syu048 · 2015 · External reference
Balancing selection at the prion protein gene consistent with prehistoric kurulike epidemics
10.1126/science.1083320 · 2003 · External reference
Inferring the mammal tree: Species-level sets of phylogenies for questions in ecology, evolution, and conservation
10.1371/journal.pbio.3000494 · 2019 · External reference
Comparison of phylogenetic trees
10.1016/0025-5564(81)90043-2 · 1981 · External reference
Afrotheria
10.1016/j.cub.2022.02.001 · 2022 · External reference
Gene Trees in Species Trees
10.1093/sysbio/46.3.523 · 1997 · External reference
Discordance of species trees with their most likely gene trees
10.1371/journal.pgen.0020068 · 2006 · External reference
The genetic causes of convergent evolution
10.1038/nrg3483 · 2013 · External reference
Evolution of Transmissible Spongiform Encephalopathies and the Prion Protein Gene (PRNP) in Mammals
10.1007/s10914-021-09557-6 · 2021 · External reference
Molecular estimation of eulipotyphlan divergence times and the evolution of “Insectivora”
10.1016/s1055-7903(03)00119-2 · 2003 · External reference
Mesozoic origin for West Indian insectivores
10.1038/nature02597 · 2004 · External reference
Cetartiodactyla
10.1016/b978-0-12-804327-1.00090-x · 2018 · External reference
Genomic analysis reveals hidden biodiversity within colugos, the sister group to primates
10.1126/sciadv.1600633 · 2016 · External reference
A genomic timescale for placental mammal evolution
10.1126/science.abl8189 · 2023 · External reference
Mammalian phylogeny: shaking the tree
10.1038/356121a0 · 1992 · External reference
Molecular phylogenetics and the origins of placental mammals
10.1038/35054550 · 2001 · External reference
The Interrelationships of Placental Mammals and the Limits of Phylogenetic Inference
10.1093/gbe/evv261 · 2016 · External reference
Incomplete Lineage Sorting in Mammalian Phylogenomics
2017 · External reference
Selectivity in mammalian extinction risk and threat types: a new measure of phylogenetic signal strength in binary traits
10.1111/j.1523-1739.2010.01455.x · 2010 · External reference
A novel protective prion protein variant that colocalizes with kuru exposure
10.1056/nejmoa0809716 · 2009 · External reference
Evidence suggesting a non-random character to nucleotide replacements in naturally occurring mutations
10.1016/0022-2836(67)90317-8 · 1967 · External reference
A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes
1985 · External reference
Higher frequencies of transitions among point mutations
10.1007/bf01732746 · 1977 · External reference
Loss of Octarepeats in two processed prion pseudogenes in the red squirrel, Sciurus vulgaris
10.1007/s00239-010-9390-7 · 2010 · External reference
Disparate evolution of prion protein domains and the distinct origin of Doppel- and prion-related loci revealed by fish-to-mammal comparisons
10.1096/fj.05-4279fje · 2006 · External reference
Trinucleotide repeat expansion and human disease
10.1146/annurev.ge.29.120195.003415 · 1995 · External reference
Evolution and differentiation of the prion protein gene (PRNP) among species
10.1093/jhered/esn073 · 2008 · External reference
Polymorphism of the prion protein in mammals: a phylogenetic approach
10.2174/187221509787236156 · 2009 · External reference
Prion protein gene variation among primates
10.1006/jmbi.1994.0030 · 1995 · External reference
PrP(Sc) accumulation in placentas of ewes exposed to natural scrapie: influence of foetal PrP genotype and effect on ewe-to-lamb transmission
10.1099/0022-1317-83-10-2607 · 2002 · External reference
Evidence of scrapie transmission via milk
10.1186/1746-6148-4-14 · 2008 · External reference
Evidence in sheep for pre-natal transmission of scrapie to lambs from infected mothers
10.1371/journal.pone.0079433 · 2013 · External reference
Excessive replacement changes drive evolution of global sheep prion protein (PRNP) sequences
10.1038/s41437-022-00520-6 · 2022 · External reference
Genetic predisposition to iatrogenic Creutzfeldt-Jakob disease
10.1016/0140-6736(91)93128-v · 1991 · External reference
Homozygous prion protein genotype predisposes to sporadic Creutzfeldt-Jakob disease
10.1038/352340a0 · 1991 · External reference
Dating genomic variants and shared ancestry in population-scale sequencing data
10.1371/journal.pbio.3000586 · 2020 · External reference
Is the prevalent human prion protein 129M/V mutation a living fossil from a Paleolithic panzootic superprion pandemic?
10.4161/pri.27601 · 2014 · External reference
Linkage of the Indiana kindred of Gerstmann-Sträussler-Scheinker disease to the prion protein gene
10.1038/ng0492-64 · 1992 · External reference
Cannibalism and burial in the late Upper Palaeolithic: Combining archaeological and genetic evidence
10.1016/j.quascirev.2023.108309 · 2023 · External reference
Biochemical evidence of cannibalism at a prehistoric Puebloan site in southwestern Colorado
10.1038/35024064 · 2000 · External reference
Human prion protein (PrP) 219K is converted to PrPSc but shows heterozygous inhibition in variant Creutzfeldt-Jakob disease infection
10.1074/jbc.m809254200 · 2009 · External reference
History of prion protein gene (PRNP) polymorphism in sheep and scientific findings
10.15666/aeer/1804_51495173 · 2020 · External reference
MEGA11: Molecular Evolutionary Genetics Analysis Version 11
10.1093/molbev/msab120 · 2021 · External reference
Some probabilistic and statistical problems in the analysis of DNA sequences
1986 · External reference
Maximum likelihood estimation of the heterogeneity of substitution rate among nucleotide sites
1995 · External reference
BEAST 2.5: An advanced software platform for Bayesian evolutionary analysis
10.1371/journal.pcbi.1006650 · 2019 · External reference
BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT
1999 · External reference
