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References from The non-structural protein of SFTSV activates NLRP1 and CARD8 inflammasome through disrupting the DPP9-mediated ternary complex. Local targets link to admitted publications; unresolved targets remain external evidence.
Inflammasomes: mechanism of assembly, regulation and signalling
10.1038/nri.2016.58 · 2016 · External reference
Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity
10.1074/jbc.m112.378323 · 2012 · External reference
Human NLRP1 is a sensor for double-stranded RNA
10.1126/science.abd0811 · 2021 · External reference
The NLRP1 and CARD8 inflammasomes
10.1111/imr.12884 · 2020 · External reference
CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain
2011 · External reference
The N-end rule ubiquitin ligase UBR2 mediates NLRP1B inflammasome activation by anthrax lethal toxin
2019 · External reference
Human DPP9 represses NLRP1 inflammasome and protects against autoinflammatory diseases via both peptidase activity and FIIND domain binding
10.1074/jbc.ra118.004350 · 2018 · External reference
Structural and biochemical mechanisms of NLRP1 inhibition by DPP9
10.1038/s41586-021-03320-w · 2021 · External reference
Dipeptidyl peptidase 9 sets a threshold for CARD8 inflammasome formation by sequestering its active C-terminal fragment
10.1016/j.immuni.2021.04.024 · 2021 · External reference
DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation
10.1038/s41586-021-03350-4 · 2021 · External reference
Enteroviral 3C protease activates the human NLRP1 inflammasome in airway epithelia
10.1126/science.aay2002 · 2020 · External reference
The NLRP1 and CARD8 inflammasomes detect reductive stress
10.1016/j.celrep.2022.111966 · 2023 · External reference
Functional degradation: A mechanism of NLRP1 inflammasome activation by diverse pathogen enzymes
10.1126/science.aau1330 · 2019 · External reference
CARD8 is an inflammasome sensor for HIV-1 protease activity
10.1126/science.abe1707 · 2021 · External reference
Host-specific sensing of coronaviruses and picornaviruses by the CARD8 inflammasome
2023 · External reference
Viral proteases activate the CARD8 inflammasome in the human cardiovascular system
10.1084/jem.20212117 · 2022 · External reference
Severe fever with thrombocytopenia syndrome, South Korea, 2012
2013 · External reference
The first identification and retrospective study of Severe Fever with Thrombocytopenia Syndrome in Japan
10.1093/infdis/jit603 · 2014 · External reference
Fever with thrombocytopenia associated with a novel bunyavirus in China
10.1056/nejmoa1010095 · 2011 · External reference
Detection of viral RNA in diverse body fluids in an SFTS patient with encephalopathy, gastrointestinal bleeding and pneumonia: a case report and literature review
10.1186/s12879-020-05012-8 · 2020 · External reference
Immune modulation and immune-mediated pathogenesis of emerging Tickborne Banyangviruses
10.3390/vaccines7040125 · 2019 · External reference
Exploration of immunological responses underpinning severe fever with thrombocytopenia syndrome virus infection reveals IL-6 as a therapeutic target in an immunocompromised mouse model
10.1093/pnasnexus/pgac024 · 2022 · External reference
Epidemiology, clinical characteristics, and treatment of severe fever with thrombocytopenia syndrome
10.1016/j.imj.2021.10.001 · 2022 · External reference
Risk factors for death in severe fever with thrombocytopenia syndrome
10.1016/s1473-3099(18)30312-8 · 2018 · External reference
Host cytokine storm is associated with disease severity of severe fever with thrombocytopenia syndrome
10.1093/infdis/jis452 · 2012 · External reference
Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome
10.1186/s12985-016-0677-1 · 2017 · External reference
A coding polymorphism in NALP1 confers risk for autoimmune Addison’s disease and type 1 diabetes
10.1038/gene.2008.85 · 2009 · External reference
Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform
10.1093/jmcb/mju015 · 2014 · External reference
Functional and evolutionary analyses identify proteolysis as a general mechanism for NLRP1 inflammasome activation
10.1371/journal.ppat.1006052 · 2016 · External reference
P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection
2023 · External reference
ZAKα-driven ribotoxic stress response activates the human NLRP1 inflammasome
10.1126/science.abl6324 · 2022 · External reference
SFTSV infection induces BAK/BAX-dependent mitochondrial DNA release to trigger NLRP3 inflammasome activation
10.1016/j.celrep.2020.02.105 · 2020 · External reference
M24B aminopeptidase inhibitors selectively activate the CARD8 inflammasome
10.1038/s41589-021-00964-7 · 2022 · External reference
SFTSV infection induced interleukin-1β secretion through NLRP3 inflammasome activation
10.3389/fimmu.2021.595140 · 2021 · External reference
Recognition of 5’ triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus
10.1016/j.immuni.2009.05.008 · 2009 · External reference
A RIG-I-like receptor directs antiviral responses to a bunyavirus and is antagonized by virus-induced blockade of TRIM25-mediated ubiquitination
10.1074/jbc.ra120.013973 · 2020 · External reference
Hijacking of RIG-I signaling proteins into virus-induced cytoplasmic structures correlates with the inhibition of type I interferon responses
10.1128/jvi.03021-13 · 2014 · External reference
Roles of viroplasm-like structures formed by nonstructural protein NSs in infection with severe fever with thrombocytopenia syndrome virus
10.1096/fj.13-243857 · 2014 · External reference
The role of non-structural protein nss in the pathogenesis of severe fever with thrombocytopenia syndrome
10.3390/v13050876 · 2021 · External reference
Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis
10.1038/s41564-018-0329-x · 2019 · External reference
Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
10.1016/j.celrep.2022.111965 · 2023 · External reference
NLRP1: a jack of all trades, or a master of one?
10.1016/j.molcel.2021.01.001 · 2021 · External reference
DPP9 deficiency: an inflammasomopathy that can be rescued by lowering NLRP1/IL-1 signaling
10.1126/sciimmunol.abi4611 · 2022 · External reference
Germline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation
10.1016/j.cell.2016.09.001 · 2016 · External reference
Bunyavirus SFTSV NSs utilizes autophagy to escape the antiviral innate immune response
10.1080/15548627.2024.2356505 · 2024 · External reference
The SFTSV nonstructural proteins induce autophagy to promote viral replication via interaction with Vimentin
2023 · External reference
Nonstructural protein NSs activates inflammasome and pyroptosis through interaction with NLRP3 in human microglial cells infected with severe fever with thrombocytopenia syndrome Bandavirus
2022 · External reference
Caspase-1 interdomain linker cleavage is required for pyroptosis
2020 · External reference
