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References from Anticoagulant therapy and altered tissue factor expression protect against experimental placental and cerebral malaria. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
External reference
Pathogenesis of cerebral malaria--inflammation and cytoadherence
10.3389/fcimb.2014.00100 · 2014 · External reference
Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria
10.1016/s1471-4906(03)00229-1 · 2003 · External reference
Proteomic profiling of the plasma of Gambian children with cerebral malaria
10.1186/s12936-018-2487-y · 2018 · External reference
Dysregulation of coagulation in cerebral malaria
10.1016/j.molbiopara.2009.03.006 · 2009 · External reference
Emerging roles for hemostatic dysfunction in malaria pathogenesis
10.1182/blood-2015-11-636464 · 2016 · External reference
Severe malaria: what’s new on the pathogenesis front?
10.1016/j.ijpara.2016.08.002 · 2017 · External reference
Plasmodium falciparum-infected erythrocytes adhere both in the intervillous space and on the villous surface of human placenta by binding to the low-sulfated chondroitin sulfate proteoglycan receptor
10.1016/s0002-9440(10)63761-3 · 2004 · External reference
Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria
10.1046/j.1365-2958.2003.03570.x · 2003 · External reference
Evidence for the involvement of VAR2CSA in pregnancy-associated malaria
10.1084/jem.20041579 · 2004 · External reference
Polymorphic molecular signatures in variable regions of the Plasmodium falciparum var2csa DBL3x domain are associated with virulence in placental malaria
10.3390/pathogens11050520 · 2022 · External reference
Syncytiotrophoblast Functions and Fetal Growth Restriction during Placental Malaria: Updates and Implication for Future Interventions
10.1155/2015/451735 · 2015 · External reference
Immunologic activation of human syncytiotrophoblast by Plasmodium falciparum
10.1186/1475-2875-7-42 · 2008 · External reference
Immune escape strategies of malaria parasites
10.3389/fmicb.2016.01617 · 2016 · External reference
Massive chronic intervillositis of the placenta associated with malaria infection
10.1097/00000478-199808000-00011 · 1998 · External reference
Systemic Inflammatory Response to Malaria During Pregnancy Is Associated With Pregnancy Loss and Preterm Delivery
10.1093/cid/cix623 · 2017 · External reference
Placental pathology in malaria: a histological, immunohistochemical, and quantitative study
10.1016/s0046-8177(00)80203-8 · 2000 · External reference
Oxidative Stress: A Potential Therapeutic Target in Placental Malaria
10.4049/immunohorizons.1700002 · 2017 · External reference
Maternal malaria induces a procoagulant and antifibrinolytic state that is embryotoxic but responsive to anticoagulant therapy
10.1371/journal.pone.0031090 · 2012 · External reference
Haemozoin as a marker of placental parasitization
10.1016/s0035-9203(02)90339-1 · 2002 · External reference
Immunopathological effects of malaria pigment or hemozoin and other crystals
10.1002/biof.1119 · 2014 · External reference
Natural hemozoin stimulates syncytiotrophoblast to secrete chemokines and recruit peripheral blood mononuclear cells
10.1016/j.placenta.2011.05.003 · 2011 · External reference
Epidemiology and burden of malaria in pregnancy
10.1016/s1473-3099(07)70021-x · 2007 · External reference
The contribution of malaria in pregnancy to perinatal mortality
10.4269/ajtmh.2004.71.35 · 2004 · External reference
Malaria in pregnancy as an indirect cause of infant mortality in sub-Saharan Africa
10.1016/s0035-9203(01)90082-3 · 2001 · External reference
Estimated risk of placental infection and low birthweight attributable to Plasmodium falciparum malaria in Africa in 2010: a modelling study
2014 · External reference
Impact of Sulfadoxine-Pyrimethamine Resistance on Effectiveness of Intermittent Preventive Therapy for Malaria in Pregnancy at Clearing Infections and Preventing Low Birth Weight
10.1093/cid/civ881 · 2016 · External reference
Chloroquine and Sulfadoxine-Pyrimethamine Resistance in Sub-Saharan Africa - A Review
10.3389/fgene.2021.668574 · 2021 · External reference
Drugs for Intermittent Preventive Treatment of Malaria in Pregnancy: Current Knowledge and Way Forward
10.3390/tropicalmed7080152 · 2022 · External reference
The impact of malaria during pregnancy on low birth weight in East-Africa: a topical review
10.1186/s12936-021-03883-z · 2021 · External reference
Blantyre Malaria Project Epilepsy Study (BMPES) of neurological outcomes in retinopathy-positive paediatric cerebral malaria survivors: a prospective cohort study
10.1016/s1474-4422(10)70270-2 · 2010 · External reference
New Insights into Malaria Pathogenesis
10.1146/annurev-pathmechdis-012419-032640 · 2020 · External reference
Severe malaria is associated with parasite binding to endothelial protein C receptor
10.1038/nature12216 · 2013 · External reference
The role of EPCR in the pathogenesis of severe malaria
2016 · External reference
High-level cerebellar expression of cytokines and adhesion molecules in fatal, paediatric, cerebral malaria
10.1179/136485905x51508 · 2005 · External reference
Blood-brain barrier function in cerebral malaria in Malawian children
10.4269/ajtmh.2001.64.207 · 2001 · External reference
Endothelium-based biomarkers are associated with cerebral malaria in Malawian children: a retrospective case-control study
10.1371/journal.pone.0015291 · 2010 · External reference
A histological method for quantifying Plasmodium falciparum in the brain in fatal paediatric cerebral malaria
10.1186/1475-2875-12-191 · 2013 · External reference
The neuropathology of fatal cerebral malaria in malawian children
10.1016/j.ajpath.2011.01.016 · 2011 · External reference
Activation of the host response in human Plasmodium falciparum malaria: relation of parasitemia to tumor necrosis factor/cachectin, thrombin-antithrombin III, and protein C levels
10.1016/0002-9343(91)90071-5 · 1991 · External reference
Low levels of fibrin-stabilizing factor (factor XIII) in human Plasmodium falciparum malaria: correlation with clinical severity
10.4269/ajtmh.1999.60.99 · 1999 · External reference
Cerebral malaria induced by plasmodium falciparum: clinical features, pathogenesis, diagnosis, and treatment
10.3389/fcimb.2022.939532 · 2022 · External reference
Human cerebral malaria: 2019 mini review
10.1016/j.neurol.2019.07.008 · 2019 · External reference
Artemisinin derivatives versus quinine for cerebral malaria in African children: a systematic review
10.2471/blt.08.060327 · 2009 · External reference
Neurological Complications of Malaria
10.1007/s11910-022-01214-6 · 2022 · External reference
Cerebral Malaria: Current Clinical and Immunological Aspects
10.3389/fimmu.2022.863568 · 2022 · External reference
Disseminated intravascular coagulation in malaria: A case report
10.4103/0300-1652.129665 · 2014 · External reference
Laboratory evidence of disseminated intravascular coagulation is associated with a fatal outcome in children with cerebral malaria despite an absence of clinically evident thrombosis or bleeding
10.1111/jth.13060 · 2015 · External reference
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African children
10.1182/blood-2013-03-490219 · 2013 · External reference
Hemostatic and protein C pathway dysfunction in the pathogenesis of experimental cerebral malaria
10.3324/haematol.2021.280450 · 2022 · External reference
Placental malaria. I. Pathological classification
10.1111/j.1365-2559.1993.tb00110.x · 1993 · External reference
Placental malaria. II. A semi-quantitative investigation of the pathological features
10.1111/j.1365-2559.1993.tb00111.x · 1993 · External reference
Pregnancy outcome and placenta pathology in Plasmodium berghei ANKA infected mice reproduce the pathogenesis of severe malaria in pregnant women
10.1371/journal.pone.0001608 · 2008 · External reference
Malaria-induced murine pregnancy failure: distinct roles for IFN-gamma and TNF
10.4049/jimmunol.0901669 · 2009 · External reference
Tissue Factor: An Essential Mediator of Hemostasis and Trigger of Thrombosis
10.1161/atvbaha.117.309846 · 2018 · External reference
Blood coagulation, inflammation, and malaria
10.1080/10739680701451516 · 2008 · External reference
Plasmodium falciparum-infected erythrocytes induce tissue factor expression in endothelial cells and support the assembly of multimolecular coagulation complexes
10.1111/j.1538-7836.2006.02232.x · 2007 · External reference
Expression of tissue factor, the clotting initiator, on macrophages in Plasmodium falciparum-infected placentas
10.1086/341507 · 2002 · External reference
Immunopathogenesis of cerebral malaria
10.1016/j.ijpara.2006.02.016 · 2006 · External reference
Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria
10.1186/s12974-018-1207-4 · 2018 · External reference
The contribution of the Tie2+ lineage to primitive and definitive hematopoietic cells
10.1002/dvg.20654 · 2010 · External reference
Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice
10.1182/blood-2009-12-259267 · 2010 · External reference
Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development
10.1016/s0002-9440(10)65089-4 · 2000 · External reference
The Angiopoietin-Tie2 axis contributes to placental vascular disruption and adverse birth outcomes in malaria in pregnancy
10.1016/j.ebiom.2021.103683 · 2021 · External reference
Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis
10.1172/jci116573 · 1993 · External reference
Protective and detrimental effects of neuroectodermal cell-derived tissue factor in mouse models of stroke
10.1172/jci.insight.86663 · 2016 · External reference
Dynamic intravital imaging reveals reactive vessel-associated microglia play a protective role in cerebral malaria coagulopathy
10.1038/s41598-023-43208-5 · 2023 · External reference
CD8+ T cells and human cerebral malaria: a shifting episteme
10.1172/jci135510 · 2020 · External reference
CD8+ and CD4+ T Cells Infiltrate into the Brain during Plasmodium berghei ANKA Infection and Form Long-Term Resident Memory
10.4049/jimmunol.2000773 · 2021 · External reference
Treatment Reducing Endothelial Activation Protects against Experimental Cerebral Malaria
10.3390/pathogens11060643 · 2022 · External reference
Role of cardiac myocyte tissue factor in heart hemostasis
10.1111/j.1538-7836.2007.02649.x · 2007 · External reference
Conditional gene targeting in macrophages and granulocytes using LysMcre mice
10.1023/a:1008942828960 · 1999 · External reference
Low levels of tissue factor are compatible with development and hemostasis in mice
10.1172/jci814 · 1998 · External reference
Tissue factor is required for uterine hemostasis and maintenance of the placental labyrinth during gestation
10.1073/pnas.96.14.8138 · 1999 · External reference
Murine malaria infection induces fetal loss associated with accumulation of Plasmodium chabaudi AS-infected erythrocytes in the placenta
10.1128/iai.74.5.2839-2848.2006 · 2006 · External reference
Quantitative measurement of Plasmodium-infected erythrocytes in murine models of malaria by flow cytometry using bidimensional assessment of SYTO-16 fluorescence
10.1002/cyto.a.20647 · 2009 · External reference
Measurement of Lung Vessel and Epithelial Permeability In Vivo with Evans Blue
10.1007/7651_2020_345 · 2021 · External reference