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References from APOE protects against severe infection with Mycobacterium tuberculosis by restraining production of neutrophil extracellular traps. Local targets link to admitted publications; unresolved targets remain external evidence.
Apolipoprotein E: cholesterol transport protein with expanding role in cell biology
10.1126/science.3283935 · 1988 · External reference
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
10.1016/0092-8674(92)90362-g · 1992 · External reference
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
10.1126/science.1411543 · 1992 · External reference
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
10.1172/jci116663 · 1993 · External reference
ApoE attenuates unresolvable inflammation by complex formation with activated C1q
10.1038/s41591-018-0336-8 · 2019 · External reference
Apolipoprotein E polymorphisms and risk of malaria
10.1136/jmg.2003.014613 · 2004 · External reference
Apolipoprotein E and viral infection: risks and mechanisms
10.1016/j.omtn.2023.07.031 · 2023 · External reference
The role of full-length apoE in clearance of Gram-negative bacteria and their endotoxins
10.1016/j.jlr.2021.100086 · 2021 · External reference
The receptor-binding region of human apolipoprotein E has direct anti-infective activity
10.1086/499280 · 2006 · External reference
Apolipoprotein E-deficient mice have impaired innate immune responses to Listeria monocytogenes in vivo
10.1016/s0022-2275(20)32160-x · 1998 · External reference
Hypercholesterolemia and ApoE deficiency result in severe infection with Lyme disease and relapsing-fever Borrelia
10.1073/pnas.1502561112 · 2015 · External reference
Hypercholesterolemia impairs immunity to tuberculosis
10.1128/iai.00037-08 · 2008 · External reference
Hypercholesterolemic LDL receptor-deficient mice mount a neutrophilic response to tuberculosis despite the timely expression of protective immunity
10.1189/jlb.0311164 · 2012 · External reference
Neutrophils are the predominant infected phagocytic cells in the airways of patients with active pulmonary TB
10.1378/chest.09-0903 · 2010 · External reference
Granulocytes act as a niche for Mycobacterium tuberculosis growth
10.1038/s41385-020-0300-z · 2021 · External reference
Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis
10.1038/nmicrobiol.2017.72 · 2017 · External reference
Irg1 expression in myeloid cells prevents immunopathology during M. tuberculosis infection
10.1084/jem.20180118 · 2018 · External reference
Early cellular mechanisms of type I interferon-driven susceptibility to tuberculosis
10.1016/j.cell.2023.11.002 · 2023 · External reference
Type I IFN exacerbates disease in tuberculosis-susceptible mice by inducing neutrophil-mediated lung inflammation and NETosis
10.1038/s41467-020-19412-6 · 2020 · External reference
Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population
10.1172/jci40817 · 2010 · External reference
Type I interferons in tuberculosis: foe and occasionally friend
10.1084/jem.20180325 · 2018 · External reference
Type I IFN-mediated NET release promotes Mycobacterium tuberculosis replication and is associated with granuloma caseation
10.1016/j.chom.2024.11.008 · 2024 · External reference
Unresolved reference
2023 · External reference
Plasmacytoid dendritic cells in immunity
10.1038/ni1141 · 2004 · External reference
IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors
10.1146/annurev.immunol.23.021704.115633 · 2005 · External reference
Neutrophils activate plasmacytoid dendritic cells by releasing self-DNA-peptide complexes in systemic lupus erythematosus
10.1126/scitranslmed.3001180 · 2011 · External reference
Netting neutrophils are major inducers of type I IFN production in pediatric systemic lupus erythematosus
2011 · External reference
PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps
10.1084/jem.20100239 · 2010 · External reference
Diverse stimuli engage different neutrophil extracellular trap pathways
10.7554/elife.24437 · 2017 · External reference
Mycobacterium tuberculosis infection induces low-density granulocyte generation by promoting neutrophil extracellular trap formation via ROS pathway
10.3389/fmicb.2019.01468 · 2019 · External reference
Tumor-associated neutrophils display a distinct N1 profile following TGFβ modulation: a transcriptomics analysis of pro- vs. antitumor TANs
10.1080/2162402x.2016.1232221 · 2016 · External reference
Polarization of tumor-associated neutrophil phenotype by TGF-beta: “N1” versus “N2” TAN
10.1016/j.ccr.2009.06.017 · 2009 · External reference
Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils
10.1371/journal.pone.0031524 · 2012 · External reference
Neutrophils from tuberculosis patients are polarized toward pro-inflammatory and anti-inflammatory phenotypes according to the disease severity
2025 · External reference
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
10.1038/s41467-018-05322-1 · 2018 · External reference
Multiple mechanisms compensate to enhance tumor-protective CD8( ) T cell response in the long-term despite poor CD8( ) T cell priming initially: comparison between an acute versus a chronic intracellular bacterium expressing a model antigen
10.4049/jimmunol.168.11.5737 · 2002 · External reference
Delayed protection by ESAT-6-specific effector CD4+ T cells after airborne M. tuberculosis infection
10.1084/jem.20080353 · 2008 · External reference
Contained Mycobacterium tuberculosis infection induces concomitant and heterologous protection
10.1371/journal.ppat.1008655 · 2020 · External reference
Type I interferon-driven susceptibility to Mycobacterium tuberculosis is mediated by IL-1Ra
10.1038/s41564-019-0578-3 · 2019 · External reference
Role of the transcriptional regulator SP140 in resistance to bacterial infections via repression of type I interferons
2021 · External reference
Immunosuppression is a conserved driver of tuberculosis susceptibility
2023 · External reference
Bone marrow stromal cell antigen 2: tumor biology, signaling pathway and therapeutic targeting (Review)
10.3892/or.2024.8704 · 2024 · External reference
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation
10.1038/nchembio.1735 · 2015 · External reference
GSK484, an inhibitor of peptidyl arginine deiminase 4, increases the radiosensitivity of colorectal cancer and inhibits neutrophil extracellular traps
10.1002/jgm.3530 · 2023 · External reference
Zinc-dependent histone deacetylases drive neutrophil extracellular trap formation and potentiate local and systemic inflammation
10.1016/j.isci.2021.103256 · 2021 · External reference
PAD4 controls tumor immunity via restraining the MHC class II machinery in macrophages
10.1016/j.celrep.2024.113942 · 2024 · External reference
CD4-mediated immunity shapes neutrophil-driven tuberculous pathology
2024 · External reference
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
10.1016/j.ccell.2023.02.004 · 2023 · External reference
Post-tuberculosis lung disease: clinical review of an under-recognised global challenge
10.1159/000512531 · 2021 · External reference
Increasing number and volume of cavitary lesions on chest computed tomography are associated with prolonged time to culture conversion in pulmonary tuberculosis
10.1093/ofid/ofz232 · 2019 · External reference
Rifapentine and isoniazid once a week versus rifampicin and isoniazid twice a week for treatment of drug-susceptible pulmonary tuberculosis in HIV-negative patients: a randomised clinical trial
10.1016/s0140-6736(02)09742-8 · 2002 · External reference
PAD4-mediated neutrophil extracellular trap formation is not required for immunity against influenza infection
10.1371/journal.pone.0022043 · 2011 · External reference
Alleviation of arthritis through prevention of neutrophil extracellular traps by an orally available inhibitor of protein arginine deiminase 4
10.1038/s41598-023-30246-2 · 2023 · External reference
PAD4 deficiency leads to decreased organ dysfunction and improved survival in a dual insult model of hemorrhagic shock and sepsis
2018 · External reference
A blood RNA signature for tuberculosis disease risk: a prospective cohort study
10.1016/s0140-6736(15)01316-1 · 2016 · External reference
Host blood RNA signatures predict the outcome of tuberculosis treatment
10.1016/j.tube.2017.08.004 · 2017 · External reference
Coagulation induced by C3aR-dependent NETosis drives protumorigenic neutrophils during small intestinal tumorigenesis
10.1038/ncomms11037 · 2016 · External reference
Sulindac. A potentially renal-sparing nonsteroidal anti-inflammatory drug
10.1001/jama.1982.03330210046033 · 1982 · External reference
Neutrophil extracellular traps formed during chemotherapy confer treatment resistance via TGF-β activation
10.1016/j.ccell.2023.03.008 · 2023 · External reference
Targeted delivery of protein arginine deiminase-4 inhibitors to limit arterial intimal NETosis and preserve endothelial integrity
2021 · External reference
The PAD4 inhibitor GSK484 enhances the radiosensitivity of triple-negative breast cancer
10.1177/0960327120979028 · 2021 · External reference
A novel peptidylarginine deiminase 4 (PAD4) inhibitor BMS-P5 blocks formation of neutrophil extracellular traps and delays progression of multiple myeloma
10.1158/1535-7163.mct-19-1020 · 2020 · External reference
Flow cytometry analysis and fluorescence-activated cell sorting of myeloid cells from lung and bronchoalveolar lavage samples from Mycobacterium tuberculosis-infected mice
10.21769/bioprotoc.3630 · 2020 · External reference
Fast and SNP-tolerant detection of complex variants and splicing in short reads
2010 · External reference
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2014 · External reference
edgeR: a Bioconductor package for differential expression analysis of digital gene expression data
10.1093/bioinformatics/btp616 · 2010 · External reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · 2019 · External reference
The Immunological Genome Project: networks of gene expression in immune cells
10.1038/ni1008-1091 · 2008 · External reference
Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage
10.1038/s41590-018-0276-y · 2019 · External reference
