Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Privacy-aware community infrastructureResearch graph
References from A chaperonin complex regulates organelle proteostasis in malaria parasites. Local targets link to admitted publications; unresolved targets remain external evidence.
The 2023 WHO World malaria report
10.1016/s2666-5247(24)00016-8 · 2024 · External reference
Plastid in human parasites
10.1038/381482a0 · 1996 · External reference
A plastid of probable green algal origin in Apicomplexan parasites
10.1126/science.275.5305.1485 · 1997 · External reference
The algal past and parasite present of the apicoplast
10.1146/annurev-micro-092412-155741 · 2013 · External reference
Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplast
10.1038/nrmicro843 · 2004 · External reference
A plastid organelle as a drug target in apicomplexan parasites
10.1038/37132 · 1997 · External reference
Targeting the apicoplast in malaria
10.1042/bst20170563 · 2019 · External reference
Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway
10.1093/emboj/19.8.1794 · 2000 · External reference
Dissecting apicoplast targeting in the malaria parasite Plasmodium falciparum
10.1126/science.1078599 · 2003 · External reference
A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites
10.1371/journal.ppat.1008316 · 2020 · External reference
Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum
2011 · External reference
ATG8 Is Essential Specifically for an Autophagy-Independent Function in Apicoplast Biogenesis in Blood-Stage Malaria Parasites
10.1128/mbio.02021-17 · 2018 · External reference
Dephospho-CoA kinase, a nuclear-encoded apicoplast protein, remains active and essential after Plasmodium falciparum apicoplast disruption
10.15252/embj.2020107247 · 2021 · External reference
PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum
10.1016/j.celrep.2017.10.081 · 2017 · External reference
Plastid biogenesis in malaria parasites requires the interactions and catalytic activity of the Clp proteolytic system
10.1073/pnas.1919501117 · 2020 · External reference
HSP100/Clp proteins: a common mechanism explains diverse functions
10.1016/s0968-0004(96)10038-4 · 1996 · External reference
Organization, function and substrates of the essential Clp protease system in plastids
10.1016/j.bbabio.2014.11.012 · 2015 · External reference
Structure, Function and Substrates of Clp AAA+ protease systems in cyanobacteria, plastids and apicoplasts; a comparative analysis
10.1016/j.jbc.2021.100338 · 2021 · External reference
Subunit stoichiometry, evolution, and functional implications of an asymmetric plant plastid ClpP/R protease complex in Arabidopsis
10.1105/tpc.111.086454 · 2011 · External reference
Subunits of the plastid ClpPR protease complex have differential contributions to embryogenesis, plastid biogenesis, and plant development in Arabidopsis
10.1105/tpc.108.063784 · 2009 · External reference
Structural insights into the inactive subunit of the apicoplast-localized caseinolytic protease complex of Plasmodium falciparum
10.1074/jbc.m112.416560 · 2013 · External reference
The Clp chaperones and proteases of the human malaria parasite Plasmodium falciparum
10.1016/j.jmb.2010.09.051 · 2010 · External reference
Molecular Chaperonin HSP60: Current Understanding and Future Prospects
10.3390/ijms25105483 · 2024 · External reference
Entering deeper into the mysteries of the GroEL-GroES nanomachine
10.1016/j.mib.2024.102480 · 2024 · External reference
Mitochondrial Chaperone Code: Just warming up
10.1016/j.cstres.2024.05.002 · 2024 · External reference
A Plastid Protein That Evolved from Ubiquitin and Is Required for Apicoplast Protein Import in Toxoplasma gondii
10.1128/mbio.00950-17 · 2017 · External reference
Synthetic RNA-protein modules integrated with native translation mechanisms to control gene expression in malaria parasites
10.1038/ncomms10727 · 2016 · External reference
Apicoplast Dynamics During Plasmodium Cell Cycle
10.3389/fcimb.2022.864819 · 2022 · External reference
10.1101/2025.03.06.641809
10.1101/2025.03.06.641809 · 2025 · External reference
Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast
10.1128/aac.00527-07 · 2007 · External reference
The apicoplast link to fever-survival and artemisinin-resistance in the malaria parasite
10.1038/s41467-021-24814-1 · 2021 · External reference
Phenotypic Screens Identify Parasite Genetic Factors Associated with Malarial Fever Response in Plasmodium falciparum piggyBac Mutants
10.1128/msphere.00273-16 · 2016 · External reference
Crystal structure of P. falciparum Cpn60 bound to ATP reveals an open dynamic conformation before substrate binding
10.1038/s41598-021-85197-3 · 2021 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
A biochemical screen for GroEL/GroES inhibitors
10.1016/j.bmcl.2013.12.100 · 2014 · External reference
Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target
10.1021/jacs.4c05057 · 2024 · External reference
Rubisco Assembly in the Chloroplast
10.3389/fmolb.2018.00024 · 2018 · External reference
A systematic screen to discover and analyze apicoplast proteins identifies a conserved and essential protein import factor
10.1371/journal.ppat.1002392 · 2011 · External reference
Apicoplast dynamics during Plasmodium cell cycle
2022 · External reference
Antiapicoplast and gametocytocidal screening to identify the mechanisms of action of compounds within the malaria box
10.1128/aac.01500-13 · 2014 · External reference
Disruption of Apicoplast Biogenesis by Chemical Stabilization of an Imported Protein Evades the Delayed-Death Phenotype in Malaria Parasites
10.1128/msphere.00710-18 · 2019 · External reference
Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens
10.7554/elife.29865 · 2017 · External reference
Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites
10.1128/aac.01161-17 · 2017 · External reference
Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity
10.7554/elife.60246 · 2020 · External reference
Heat-shock responses: systemic and essential ways of malaria parasite survival
10.1016/j.mib.2023.102322 · 2023 · External reference
Malaria parasites do respond to heat
10.1016/j.pt.2022.02.009 · 2022 · External reference
Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design
10.1073/pnas.1216016110 · 2012 · External reference
The cryo-EM structure of the chloroplast ClpP complex
10.1038/s41477-021-01020-x · 2021 · External reference
GroEL/ES inhibitors as potential antibiotics
10.1016/j.bmcl.2016.04.089 · 2016 · External reference
Exploring the Role of Hsp60 in Alzheimer’s Disease and Type 2 Diabetes: Suggestion for Common Drug Targeting
10.3390/ijms241512456 · 2023 · External reference
Hsp60 Post-translational Modifications: Functional and Pathological Consequences
10.3389/fmolb.2020.00095 · 2020 · External reference
Dual-targeting GroEL/ES chaperonin and protein tyrosine phosphatase B (PtpB) inhibitors: A polypharmacology strategy for treating Mycobacterium tuberculosis infections
10.1016/j.bmcl.2019.04.034 · 2019 · External reference
Targeting the HSP60/10 chaperonin systems of Trypanosoma brucei as a strategy for treating African sleeping sickness
10.1016/j.bmcl.2016.09.051 · 2016 · External reference
The molecular architecture of the eukaryotic chaperonin TRiC/CCT
10.1016/j.str.2012.03.007 · 2012 · External reference
Plasmodium chaperonin TRiC/CCT identified as a target of the antihistamine clemastine using parallel chemoproteomic strategy
10.1073/pnas.1913525117 · 2020 · External reference
The chaperonin TRiC forms an oligomeric complex in the malaria parasite cytosol
10.1111/cmi.12719 · 2017 · External reference
New Export Pathway in Plasmodium falciparum-Infected Erythrocytes: Role of the Parasite Group II Chaperonin, PfTRiC
10.1111/tra.12266 · 2015 · External reference
Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag
10.1073/pnas.1018449108 · 2011 · External reference
CRISPR/Cas9 Gene Editing to Make Conditional Mutants of Human Malaria Parasite P. falciparum
2018 · External reference
Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers
10.1038/ncomms2306 · 2012 · External reference
Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy
10.7554/elife.88088.3 · 2023 · External reference
