Research graph
References from Polysaccharide synthesis operon modulates Rickettsia-endothelial cell interactions. Local targets link to admitted publications; unresolved targets remain external evidence.
Rickettsia phylogenomics: unwinding the intricacies of obligate intracellular life
10.1371/journal.pone.0002018 · 2008 · External reference
Diagnosis and Management of Tickborne Rickettsial Diseases: Rocky Mountain Spotted Fever and Other Spotted Fever Group Rickettsioses, Ehrlichioses, and Anaplasmosis - United States
10.15585/mmwr.rr6502a1 · 2016 · External reference
Rickettsial genomics and the paradigm of genome reduction associated with increased virulence
10.1016/j.micinf.2017.11.009 · 2018 · External reference
Pathogenicity and virulence of Rickettsia
10.1080/21505594.2022.2132047 · 2022 · External reference
Correlation of the distribution of Rickettsia conorii, microscopic lesions, and clinical features in South African tick bite fever
10.4269/ajtmh.1985.34.361 · 1985 · External reference
The pathology of fatal Mediterranean spotted fever
10.1093/ajcp/87.5.669 · 1987 · External reference
Histopathology and immunohistologic demonstration of the distribution of Rickettsia typhi in fatal murine typhus
10.1093/ajcp/91.6.720 · 1989 · External reference
Severe and Fatal Rocky Mountain Spotted Fever After Exposure in Tecate, Mexico - California, July 2023-January 2024
10.15585/mmwr.mm7347a1 · 2024 · External reference
Spotted Fever Group Rickettsioses in Israel, 2010-2019
10.3201/eid2708.203661 · 2021 · External reference
Immunomodulation by endothelial cells - partnering up with the immune system?
10.1038/s41577-022-00694-4 · 2022 · External reference
Pathogen interactions with endothelial cells and the induction of innate and adaptive immunity
10.1002/eji.201646789 · 2018 · External reference
Rickettsia disrupts and reduces endothelial tight junction protein zonula occludens-1 in association with inflammasome activation
2024 · External reference
Endothelial exosome plays a functional role during rickettsial infection
2021 · External reference
Rickettsia rickettsii virulence determinants RARP2 and RapL mitigate IFN-β signaling in primary human dermal microvascular endothelial cells
10.1128/mbio.03450-23 · 2024 · External reference
Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence
10.1038/s41564-019-0583-6 · 2019 · External reference
Function and biogenesis of lipopolysaccharides
10.1128/ecosalplus.esp-0001-2018 · 2018 · External reference
Bacterial lipopolysaccharide-induced endothelial activation and dysfunction: a new predictive and therapeutic paradigm for sepsis
10.1186/s40001-023-01301-5 · 2023 · External reference
A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide
10.1016/j.molcel.2014.03.012 · 2014 · External reference
Innate immunity to intracellular LPS
10.1038/s41590-019-0368-3 · 2019 · External reference
Pushing the envelope: LPS modifications and their consequences
10.1038/s41579-019-0201-x · 2019 · External reference
Orientia and Rickettsia: different flowers from the same garden
10.1016/j.mib.2023.102318 · 2023 · External reference
Wholly Rickettsia! Reconstructed Metabolic Profile of the Quintessential Bacterial Parasite of Eukaryotic Cells
10.1128/mbio.00859-17 · 2017 · External reference
Lipid A Structural Divergence in Rickettsia Pathogens
10.1128/msphere.00184-21 · 2021 · External reference
Structural determination of Rickettsia lipid A without chemical extraction confirms shorter acyl chains in later-evolving spotted fever group pathogens
10.1128/msphere.00609-23 · 2024 · External reference
Rickettsia conorii O antigen is the target of bactericidal Weil-Felix antibodies
10.1073/pnas.1911922116 · 2019 · External reference
Chemical properties of lipopolysaccharides from spotted fever group rickettsiae and their common antigenicity with lipopolysaccharides from Proteus species
10.1128/iai.61.10.4350-4355.1993 · 1993 · External reference
Structural properties of lipopolysaccharides from Rickettsia typhi and Rickettsia prowazekii and their chemical similarity to the lipopolysaccharide from Proteus vulgaris OX19 used in the Weil-Felix test
10.1128/iai.66.3.923-926.1998 · 1998 · External reference
Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis
10.1038/s41564-020-0673-5 · 2020 · External reference
Activation of ASC Inflammasome Driven by Toll-Like Receptor 4 Contributes to Host Immunity against Rickettsial Infection
10.1128/iai.00886-19 · 2020 · External reference
Rickettsiae stimulate dendritic cells through toll-like receptor 4, leading to enhanced NK cell activation in vivo
10.1086/595833 · 2009 · External reference
10.1038/s41467-022-31351-y
10.1038/s41467-022-31351-y · 2022 · External reference
Lysine methylation shields an intracellular pathogen from ubiquitylation and autophagy
10.1126/sciadv.abg2517 · 2021 · External reference
Rocky mountain spotted fever: vaccination of monkeys and man
10.2307/4577679 · 1924 · External reference
Immunization of man against epidemic typhus by infection with avirulent Rickettsia prowazeki strain E. IV. Persistence of immunity and a note as to differing complement-fixation antigen requirements in post-infection and post-vaccination sera
10.4049/jimmunol.79.4.348 · 1957 · External reference
Cell-mediated immune responses of adults to vaccination, challenge with Rickettsia rickettsii, or both
10.4269/ajtmh.1992.46.105 · 1992 · External reference
Rickettsia rickettsii Whole-Cell Antigens Offer Protection against Rocky Mountain Spotted Fever in the Canine Host
10.1128/iai.00628-18 · 2019 · External reference
Rocky Mountain spotted fever: a comparative study of the active immunity induced by inactivated and viable pathogenic Rickettsia rickettsii
10.1093/infdis/128.3.340 · 1973 · External reference
Reactogenicity, immunogenicity, and efficacy of a chick embryo cell-derived vaccine for Rocky Mountain spotted fever
10.1093/infdis/148.5.922 · 1983 · External reference
A mutation inactivating the methyltransferase gene in avirulent Madrid E strain of Rickettsia prowazekii reverted to wild type in the virulent revertant strain Evir
10.1016/j.vaccine.2005.11.044 · 2006 · External reference
Emerging and re-emerging rickettsioses: endothelial cell infection and early disease events
10.1038/nrmicro1866 · 2008 · External reference
Pathogenesis of Rickettsial Diseases: Pathogenic and Immune Mechanisms of an Endotheliotropic Infection
10.1146/annurev-pathmechdis-012418-012800 · 2019 · External reference
Evolving functions of endothelial cells in inflammation
10.1038/nri2171 · 2007 · External reference
IL-6 and IL-8 production from cultured human endothelial cells stimulated by infection with Rickettsia conorii via a cell-associated IL-1 alpha-dependent pathway
10.1172/jci118354 · 1995 · External reference
Interleukin-1 alpha production during Rickettsia rickettsii infection of cultured endothelial cells: potential role in autocrine cell stimulation
10.1128/iai.64.5.1609-1613.1996 · 1996 · External reference
Rickettsia rickettsii infection of human macrovascular and microvascular endothelial cells reveals activation of both common and cell type-specific host response mechanisms
10.1128/iai.01335-09 · 2010 · External reference
Expression and secretion of chemotactic cytokines IL-8 and MCP-1 by human endothelial cells after Rickettsia rickettsii infection: regulation by nuclear transcription factor NF-kappaB
10.1016/j.ijmm.2005.05.006 · 2005 · External reference
Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever
10.1016/j.jinf.2008.11.008 · 2009 · External reference
Rickettsia conorii infection enhances vascular cell adhesion molecule-1- and intercellular adhesion molecule-1-dependent mononuclear cell adherence to endothelial cells
10.1086/520353 · 1997 · External reference
Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
10.1074/jbc.274.12.7611 · 1999 · External reference
The structural basis of lipopolysaccharide recognition by the TLR4-MD-2 complex
10.1038/nature07830 · 2009 · External reference
Recognition of lipopolysaccharide pattern by TLR4 complexes
2013 · External reference
Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock
10.1126/science.1240988 · 2013 · External reference
Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury
10.1172/jci94495 · 2017 · External reference
Distinct Compartmentalization of the Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 Determine Discrete Stages of Neutrophil Diapedesis
10.1016/j.immuni.2018.09.018 · 2018 · External reference
Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line
10.1084/jem.169.4.1485 · 1989 · External reference
Monocyte chemotactic protein-1 regulates voltage-gated K+ channels and macrophage transmigration
10.1007/s11481-008-9135-1 · 2009 · External reference
Chronic inflammation upregulates chemokine receptors and induces neutrophil migration to monocyte chemoattractant protein-1
10.1172/jci5208 · 1999 · External reference
Lymphocyte migration through monolayers of endothelial cell lines involves VCAM-1 signaling via endothelial cell NADPH oxidase
10.4049/jimmunol.164.12.6550 · 2000 · External reference
Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling
10.1152/ajpheart.00400.2008 · 2008 · External reference
Endothelial cell cortactin coordinates intercellular adhesion molecule-1 clustering and actin cytoskeleton remodeling during polymorphonuclear leukocyte adhesion and transmigration
10.4049/jimmunol.177.9.6440 · 2006 · External reference
Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity
10.1016/j.immuni.2019.03.012 · 2019 · External reference
The role of IL-6 in host defence against infections: immunobiology and clinical implications
10.1038/nrrheum.2017.83 · 2017 · External reference
Interferon-Induced Protein 44 Interacts with Cellular FK506-Binding Protein 5, Negatively Regulates Host Antiviral Responses, and Supports Virus Replication
10.1128/mbio.01839-19 · 2019 · External reference
Interferon-Induced Protein 44 and Interferon-Induced Protein 44-Like Restrict Replication of Respiratory Syncytial Virus
10.1128/jvi.00297-20 · 2020 · External reference
Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs
10.1038/s41564-020-0778-x · 2020 · External reference
The interferon-induced protein, IFIT2, requires RNA-binding activity and neuronal expression to protect mice from intranasal vesicular stomatitis virus infection
10.1128/mbio.00568-24 · 2024 · External reference
IFIT2 is an effector protein of type I IFN-mediated amplification of lipopolysaccharide (LPS)-induced TNF-α secretion and LPS-induced endotoxin shock
10.4049/jimmunol.1203305 · 2013 · External reference
The interferon stimulated gene 54 promotes apoptosis
10.1074/jbc.m110.207068 · 2011 · External reference
NF-kappa B-dependent inhibition of apoptosis is essential for host cellsurvival during Rickettsia rickettsii infection
10.1073/pnas.95.8.4646 · 1998 · External reference
Rickettsia rickettsii infection protects human microvascular endothelial cells against staurosporine-induced apoptosis by a cIAP(2)-independent mechanism
10.1086/597805 · 2009 · External reference
Differences in Intracellular Fate of Two Spotted Fever Group Rickettsia in Macrophage-Like Cells
10.3389/fcimb.2016.00080 · 2016 · External reference
Characteristics of in vitro infection of human monocytes, by Rickettsia helvetica
10.1016/j.micinf.2020.11.003 · 2021 · External reference
