Research graph
References from Viral hijacking of host DDX60 promotes Crimean-Congo haemorrhagic fever virus replication via G-quadruplex unwinding. Local targets link to admitted publications; unresolved targets remain external evidence.
Crimean-Congo haemorrhagic fever virus
10.1038/s41579-023-00871-9 · 2023 · External reference
The global distribution of Crimean-Congo hemorrhagic fever
10.1093/trstmh/trv050 · 2015 · External reference
Current status of Crimean-Congo haemorrhagic fever in the World Health Organization Eastern Mediterranean Region: issues, challenges, and future directions
10.1016/j.ijid.2017.02.018 · 2017 · External reference
Crimean-Congo Hemorrhagic Fever Virus for Clinicians-Epidemiology, Clinical Manifestations, and Prevention
2024 · External reference
Severity scoring index for Crimean-Congo hemorrhagic fever and the impact of ribavirin and corticosteroids on fatality
10.1093/cid/cit527 · 2013 · External reference
The epidemiology of tick-borne Crimean-Congo hemorrhagic fever in Asia, Europe, and Africa
10.1093/jmedent/15.4.307 · 1979 · External reference
Crimean-Congo haemorrhagic fever in India
10.1016/s0140-6736(11)60680-6 · 2011 · External reference
Early use of ribavirin is beneficial in Crimean-Congo hemorrhagic fever
10.1089/vbz.2013.1421 · 2014 · External reference
The role of ribavirin in the therapy of Crimean-Congo hemorrhagic fever: early use is promising
10.1007/s10096-009-0728-2 · 2009 · External reference
Ribavirin for patients with Crimean-Congo haemorrhagic fever: a systematic review and meta-analysis
10.1093/jac/dkr136 · 2011 · External reference
The efficacy of ribavirin in the treatment of Crimean-Congo hemorrhagic fever in Eastern Black Sea region in Turkey
10.1016/j.jcv.2009.11.007 · 2010 · External reference
Crimean-Congo hemorrhagic fever in Turkey: Current status and future challenges
10.1016/j.antiviral.2015.12.003 · 2016 · External reference
Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever
10.1371/journal.pntd.0002804 · 2014 · External reference
Identification of 2’-deoxy-2’-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus
10.1016/j.antiviral.2017.10.008 · 2017 · External reference
In vitro and in vivo efficacy of a novel nucleoside analog H44 against Crimean-Congo hemorrhagic fever virus
10.1016/j.antiviral.2022.105273 · 2022 · External reference
Novel Broad-Spectrum Antiviral Inhibitors Targeting Host Factors Essential for Replication of Pathogenic RNA Viruses
10.3390/v12121423 · 2020 · External reference
LDLR is an entry receptor for Crimean-Congo hemorrhagic fever virus
10.1038/s41422-023-00917-w · 2024 · External reference
Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells
2024 · External reference
The regulation and functions of DNA and RNA G-quadruplexes
10.1038/s41580-020-0236-x · 2020 · External reference
DNA G-Quadruplex in Human Telomeres and Oncogene Promoters: Structures, Functions, and Small Molecule Targeting
10.1021/acs.accounts.2c00337 · 2022 · External reference
Unlocking G-Quadruplexes as Antiviral Targets
10.1124/pharmrev.120.000230 · 2021 · External reference
G-quadruplexes: a promising target for cancer therapy
10.1186/s12943-021-01328-4 · 2021 · External reference
Deciphering RNA G-quadruplex function during the early steps of HIV-1 infection
10.1093/nar/gkac1030 · 2022 · External reference
RNA G-quadruplex formed in SARS-CoV-2 used for COVID-19 treatment in animal models
10.1038/s41421-022-00450-x · 2022 · External reference
RNA G-quadruplex in TMPRSS2 reduces SARS-CoV-2 infection
10.1038/s41467-022-29135-5 · 2022 · External reference
Targeting RNA G-Quadruplex in SARS-CoV-2: A Promising Therapeutic Target for COVID-19?
10.1002/anie.202011419 · 2021 · External reference
G-quadruplex binder pyridostatin as an effective multi-target ZIKV inhibitor
10.1016/j.ijbiomac.2021.08.121 · 2021 · External reference
Inhibition of Zika virus replication by G-quadruplex-binding ligands
10.1016/j.omtn.2020.12.030 · 2021 · External reference
G-quadruplexes in the evolution of hepatitis B virus
10.1093/nar/gkad556 · 2023 · External reference
A G-quadruplex motif in an envelope gene promoter regulates transcription and virion secretion in HBV genotype B
10.1093/nar/gkx823 · 2017 · External reference
G-quadruplex, Friend or Foe: The Role of the G-quartet in Anticancer Strategies
10.1016/j.molmed.2020.05.002 · 2020 · External reference
G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy
10.1093/nar/gky187 · 2018 · External reference
G-Quadruplexes in hemorrhagic fever viruses of Bunyavirales
10.1080/17460794.2024.2351737 · 2024 · External reference
Presence, location and conservation of putative g-quadruplex forming sequences in arboviruses infecting humans
10.3390/ijms24119523 · 2023 · External reference
G-quadruplex forming sequences in the genome of all known human viruses: A comprehensive guide
10.1371/journal.pcbi.1006675 · 2018 · External reference
Promotion of order Bunyavirales to class Bunyaviricetes to accommodate a rapidly increasing number of related polyploviricotine viruses
2024 · External reference
G-quadruplex ligands as therapeutic agents against cancer, neurological disorders and viral infections
10.4155/fmc-2023-0202 · 2023 · External reference
RNA G-quadruplexes and stress: emerging mechanisms and functions
10.1016/j.tcb.2024.01.005 · 2024 · External reference
Research in Emergency and Critical Care Settings: Debates, Obstacles and Solutions
10.1007/s11948-015-9730-5 · 2016 · External reference
Development of a reverse genetics system to generate a recombinant Ebola virus Makona expressing a green fluorescent protein
10.1016/j.virol.2015.06.013 · 2015 · External reference
Action and function of helicases on RNA G-quadruplexes
10.1016/j.ymeth.2021.09.003 · 2022 · External reference
Dual RNA-Seq characterization of host and pathogen gene expression in liver cells infected with Crimean-Congo Hemorrhagic Fever Virus
10.1371/journal.pntd.0008105 · 2020 · External reference
Genome-wide computational and expression analyses reveal G-quadruplex DNA motifs as conserved cis-regulatory elements in human and related species
10.1021/jm800448a · 2008 · External reference
Structure and possible function of a G-quadruplex in the long terminal repeat of the proviral HIV-1 genome
10.1093/nar/gkw432 · 2016 · External reference
A dynamic G-quadruplex region regulates the HIV-1 long terminal repeat promoter
10.1021/jm400914r · 2013 · External reference
Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription
10.1093/nar/gkv897 · 2015 · External reference
G-quadruplexes regulate Epstein-Barr virus-encoded nuclear antigen 1 mRNA translation
10.1038/nchembio.1479 · 2014 · External reference
Viral hijacking of hnRNPH1 unveils a G-quadruplex-driven mechanism of stress control
10.1016/j.chom.2024.07.006 · 2024 · External reference
Unfolding of an RNA G-quadruplex motif in the negative strand genome of porcine reproductive and respiratory syndrome virus by host and viral helicases to promote viral replication
10.1093/nar/gkad759 · 2023 · External reference
DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling
10.1128/mcb.01368-10 · 2011 · External reference
DDX60 Is Involved in RIG-I-Dependent and Independent Antiviral Responses, and Its Function Is Attenuated by Virus-Induced EGFR Activation
10.1016/j.celrep.2015.04.047 · 2015 · External reference
Mouse superkiller-2-like helicase DDX60 is dispensable for type I IFN induction and immunity to multiple viruses
10.1002/eji.201545794 · 2015 · External reference
Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders
10.1039/d2cc03135c · 2022 · External reference
Pharmacological Activity of Cepharanthine
10.3390/molecules28135019 · 2023 · External reference
Molecular mechanisms and therapeutic implications of tetrandrine and cepharanthine in T cell acute lymphoblastic leukemia and autoimmune diseases
10.1016/j.pharmthera.2020.107659 · 2021 · External reference
Cepharanthine: An update of its mode of action, pharmacological properties and medical applications
10.1016/j.phymed.2019.152956 · 2019 · External reference
Pharmacological Effects and Clinical Prospects of Cepharanthine
10.3390/molecules27248933 · 2022 · External reference
Cepharanthine, an alkaloid from Stephania cepharantha Hayata, inhibits the inflammatory response in the RAW264.7 cell and mouse models
10.1007/s10753-013-9734-8 · 2014 · External reference
Using rhodamine 123 accumulation in CD8 cells as a surrogate indicator to study the P-glycoprotein modulating effect of cepharanthine hydrochloride in vivo
2011 · External reference
Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products
10.1038/s41392-021-00531-5 · 2021 · External reference
The brief overview, antivirus and anti-SARS-CoV-2 activity, quantitative methods, and pharmacokinetics of cepharanthine: a potential small-molecule drug against COVID-19
10.3389/fphar.2023.1098972 · 2023 · External reference
Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean-Congo hemorrhagic fever virus
2024 · External reference
Discovery of baloxavir sodium as a novel anti-CCHFV inhibitor: Biological evaluation of in vitro and in vivo
10.1016/j.antiviral.2024.105890 · 2024 · External reference
pqsfinder: an exhaustive and imperfection-tolerant search tool for potential quadruplex-forming sequences in R
10.1093/bioinformatics/btx413 · 2017 · External reference
pqsfinder web: G-quadruplex prediction using optimized pqsfinder algorithm
10.1093/bioinformatics/btz928 · 2020 · External reference
QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences
10.1093/nar/gkl253 · 2006 · External reference
G4Hunter web application: a web server for G-quadruplex prediction
10.1093/bioinformatics/btz087 · 2019 · External reference
Re-evaluation of G-quadruplex propensity with G4Hunter
10.1093/nar/gkw006 · 2016 · External reference
WebLogo: a sequence logo generator
10.1101/gr.849004 · 2004 · External reference
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
10.1038/nature14136 · 2015 · External reference
Recovery of Recombinant Crimean Congo Hemorrhagic Fever Virus Reveals a Function for Non-structural Glycoproteins Cleavage by Furin
10.1371/journal.ppat.1004879 · 2015 · External reference
CRISPRdirect: software for designing CRISPR/Cas guide RNA with reduced off-target sites
10.1093/bioinformatics/btu743 · 2015 · External reference
