Research graph
References from Kaposi sarcoma-associated herpesvirus cooperates with Epstein-Barr virus to co-transform a small set of human B cells oncogenically. Local targets link to admitted publications; unresolved targets remain external evidence.
Epstein-Barr virus: Biology and clinical disease
10.1016/j.cell.2022.08.026 · 2022 · External reference
Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas
10.1056/nejm199505043321802 · 1995 · External reference
HIV-Associated Cancers and Related Diseases
10.1056/nejmra1615896 · 2018 · External reference
Clonal transformation of adult human leukocytes by Epstein-Barr virus
10.1128/jvi.23.3.503-508.1977 · 1977 · External reference
Efficiency of transformation of lymphocytes by Epstein-Barr virus
10.1016/0042-6822(77)90292-6 · 1977 · External reference
Covalently closed circular duplex DNA of Epstein-Barr virus in a human lymphoid cell line
10.1016/0022-2836(76)90331-4 · 1976 · External reference
KSHV infects a subset of human tonsillar B cells, driving proliferation and plasmablast differentiation
10.1172/jci44185 · 2011 · External reference
Primary B Lymphocytes Infected with Kaposi’s Sarcoma-Associated Herpesvirus Can Be Expanded In Vitro and Are Recognized by LANA-Specific CD4+ T Cells
10.1128/jvi.02377-15 · 2016 · External reference
How Kaposi’s sarcoma-associated herpesvirus stably transforms peripheral B cells towards lymphomagenesis
10.1073/pnas.1905025116 · 2019 · External reference
Persistent KSHV Infection Increases EBV-Associated Tumor Formation In Vivo via Enhanced EBV Lytic Gene Expression
10.1016/j.chom.2017.06.009 · 2017 · External reference
The coupling of synthesis and partitioning of EBV’s plasmid replicon is revealed in live cells
10.1038/sj.emboj.7601853 · 2007 · External reference
Kaposi’s sarcoma-associated herpesvirus stably clusters its genomes across generations to maintain itself extrachromosomally
10.1083/jcb.201702013 · 2017 · External reference
Contribution of viral and cellular cytokines to Kaposi’s sarcoma-associated herpesvirus pathogenesis
10.1189/jlb.1107777 · 2008 · External reference
Involvement of interleukin-10 (IL-10) and viral IL-6 in the spontaneous growth of Kaposi’s sarcoma herpesvirus-associated infected primary effusion lymphoma cells
10.1182/blood.v94.8.2871.420k25_2871_2879 · 1999 · External reference
Runaway Kaposi Sarcoma-associated herpesvirus replication correlates with systemic IL-10 levels
10.1016/j.virol.2019.10.002 · 2020 · External reference
Kaposi’s sarcoma herpesvirus microRNAs target caspase 3 and regulate apoptosis
10.1371/journal.ppat.1002405 · 2011 · External reference
Epstein-Barr virus maintains lymphomas via its miRNAs
10.1038/onc.2013.71 · 2014 · External reference
Kaposi’s Sarcoma-Associated Herpesvirus MicroRNAs Target GADD45B To Protect Infected Cells from Cell Cycle Arrest and Apoptosis
2017 · External reference
Gene expression profile analysis of AIDS-related primary effusion lymphoma (PEL) suggests a plasmablastic derivation and identifies PEL-specific transcripts
10.1182/blood-2002-10-3090 · 2003 · External reference
KSHV induces immunoglobulin rearrangements in mature B lymphocytes
10.1371/journal.ppat.1006967 · 2018 · External reference
EBV is necessary for proliferation of dually infected primary effusion lymphoma cells
10.1158/0008-5472.can-08-0627 · 2008 · External reference
Epstein-Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus
10.1073/pnas.1810128115 · 2018 · External reference
Epstein-Barr virus.
2013 · External reference
KSHV/HHV8-mediated hematologic diseases
10.1182/blood.2020005470 · 2022 · External reference
Comprehensive profiling of functional Epstein-Barr virus miRNA expression in human cell lines
10.1186/s12864-016-2978-6 · 2016 · External reference
Importance of the RNA secondary structure for the relative accumulation of clustered viral microRNAs
10.1093/nar/gku424 · 2014 · External reference
Genetic analysis of immortalizing functions of Epstein-Barr virus in human B lymphocytes
10.1038/340393a0 · 1989 · External reference
Epstein-Barr virus nuclear protein 2 is a key determinant of lymphocyte transformation
10.1073/pnas.86.23.9558 · 1989 · External reference
The apoptotic v-cyclin-CDK6 complex phosphorylates and inactivates Bcl-2
10.1038/35041064 · 2000 · External reference
Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling
10.1182/blood-2006-06-028092 · 2007 · External reference
Targeting mTOR with MLN0128 Overcomes Rapamycin and Chemoresistant Primary Effusion Lymphoma
10.1128/mbio.02871-18 · 2019 · External reference
Pacritinib inhibits proliferation of primary effusion lymphoma cells and production of viral interleukin-6 induced cytokines
10.1038/s41598-024-54453-7 · 2024 · External reference
Primary effusion lymphoma: a liquid phase lymphoma of fluid-filled body cavities
10.1016/s0065-230x(01)80014-2 · 2001 · External reference
Low expression of CD20 and CD23 in Epstein-Barr virus-induced B cell tumors in SCID/hu mice
1993 · External reference
KSHV 2.0: a comprehensive annotation of the Kaposi’s sarcoma-associated herpesvirus genome using next-generation sequencing reveals novel genomic and functional features
10.1371/journal.ppat.1003847 · 2014 · External reference
Coupled transcriptome and proteome analysis of human lymphotropic tumor viruses: insights on the detection and discovery of viral genes
10.1186/1471-2164-12-625 · 2011 · External reference
Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes
10.1073/pnas.88.15.6550 · 1991 · External reference
Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells
10.1126/science.aaz7548 · 2020 · External reference
Latent membrane protein 1 of Epstein-Barr virus coordinately regulates proliferation with control of apoptosis
10.1038/sj.onc.1208367 · 2005 · External reference
Characterization of target gene regulation by the two Epstein-Barr virus oncogene LMP1 domains essential for B-cell transformation
10.1128/mbio.02338-23 · 2023 · External reference
Lack of glucocorticoid-induced leucine zipper (GILZ) deregulates B-cell survival and results in B-cell lymphocytosis in mice
10.1182/blood-2015-03-631580 · 2015 · External reference
Quantitative Analysis of the KSHV Transcriptome Following Primary Infection of Blood and Lymphatic Endothelial Cells
10.3390/pathogens6010011 · 2017 · External reference
Human herpesvirus 8 viral FLICE-inhibitory protein inhibits Fas-mediated apoptosis through binding and prevention of procaspase-8 maturation
2001 · External reference
Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection
10.7554/elife.22509 · 2017 · External reference
Classic and extracavitary primary effusion lymphoma in 51 HIV-infected patients from a single institution
10.1002/ajh.24251 · 2016 · External reference
A Comprehensive Clinicopathologic and Molecular Study of 19 Primary Effusion Lymphomas in HIV-infected Patients
10.1097/pas.0000000000001813 · 2022 · External reference
Body Cavity-Based Lymphoma in a Country with Low Human Immunodeficiency Virus Prevalence: A Series of 17 Cases from the Consortium for Improving Survival of Lymphoma
10.4143/crt.2018.555 · 2019 · External reference
Optimal LentiCRISPR-Based System for Sequential CRISPR/Cas9 Screens
10.1021/acssynbio.2c00152 · 2022 · External reference
Massively parallel Cas13 screens reveal principles for guide RNA design
10.1038/s41587-020-0456-9 · 2020 · External reference
An EBNA3A-Mutated Epstein-Barr Virus Retains the Capacity for Lymphomagenesis in a Cord Blood-Humanized Mouse Model
2020 · External reference
TPMCalculator: one-step software to quantify mRNA abundance of genomic features
10.1093/bioinformatics/bty896 · 2019 · External reference
miRge3.0: a comprehensive microRNA and tRF sequencing analysis pipeline
2021 · External reference
Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed
2006 · External reference
A mammalian microRNA expression atlas based on small RNA library sequencing
10.1016/j.cell.2007.04.040 · 2007 · External reference
Identification of virus-encoded microRNAs
10.1126/science.1096781 · 2004 · External reference
miRBase: from microRNA sequences to function
10.1093/nar/gky1141 · 2019 · External reference
miRBase: microRNA sequences, targets and gene nomenclature
10.1093/nar/gkj112 · 2006 · External reference
A simple reverse transcriptase PCR assay to distinguish EBNA1 gene transcripts associated with type I and II latency from those arising during induction of the viral lytic cycle
10.1128/jvi.70.11.8204-8208.1996 · 1996 · External reference
Transcription of the Epstein-Barr virus nuclear antigen 1 (EBNA1) gene occurs before induction of the BCR2 (Cp) EBNA gene promoter during the initial stages of infection in B cells
10.1128/jvi.70.6.3561-3570.1996 · 1996 · External reference
