Research graph
References from Mechanisms of AAV neutralization by human alpha-defensins. Local targets link to admitted publications; unresolved targets remain external evidence.
Adeno-associated virus (AAV) cell entry: structural insights
10.1016/j.tim.2021.09.005 · 2022 · External reference
Adeno-associated virus capsid assembly is divergent and stochastic
10.1038/s41467-021-21935-5 · 2021 · External reference
Clades of Adeno-associated viruses are widely disseminated in human tissues
10.1128/jvi.78.12.6381-6388.2004 · 2004 · External reference
Identification and characterization of novel adeno-associated virus isolates in ATCC virus stocks
10.1128/jvi.80.10.5082-5085.2006 · 2006 · External reference
Cloning of an avian adeno-associated virus (AAAV) and generation of recombinant AAAV particles
10.1128/jvi.77.12.6799-6810.2003 · 2003 · External reference
Adeno-Associated Virus (AAV) Gene Delivery: Dissecting Molecular Interactions upon Cell Entry
10.3390/v13071336 · 2021 · External reference
Host determinants of adeno-associated viral vector entry
10.1016/j.coviro.2017.06.003 · 2017 · External reference
Natural Adeno-Associated Virus Serotypes and Engineered Adeno-Associated Virus Capsid Variants: Tropism Differences and Mechanistic Insights
10.3390/v16030442 · 2024 · External reference
Overcoming innate immune barriers that impede AAV gene therapy vectors
10.1172/jci143780 · 2021 · External reference
Adeno-associated Virus (AAV) versus Immune Response
10.3390/v11020102 · 2019 · External reference
Human immunoglobulin inhibits liver transduction by AAV vectors at low AAV2 neutralizing titers in SCID mice
10.1182/blood-2005-08-3229 · 2006 · External reference
Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors
10.1089/hum.2009.182 · 2010 · External reference
Complement is an essential component of the immune response to adeno-associated virus vectors
10.1128/jvi.01990-07 · 2008 · External reference
Modulating immune responses to AAV by expanded polyclonal T-regs and capsid specific chimeric antigen receptor T-regulatory cells
10.1016/j.omtm.2021.10.010 · 2021 · External reference
Cell-Mediated Immunity to AAV Vectors, Evolving Concepts and Potential Solutions
10.3389/fimmu.2014.00350 · 2014 · External reference
α-Defensins in human innate immunity
10.1111/j.1600-065x.2011.01082.x · 2012 · External reference
Mammalian defensins in the antimicrobial immune response
10.1038/ni1206 · 2005 · External reference
Antiviral mechanisms of human defensins
10.1016/j.jmb.2013.09.038 · 2013 · External reference
Defensins in Viral Infection and Pathogenesis
10.1146/annurev-virology-101416-041734 · 2017 · External reference
Functional determinants of human enteric α-defensin HD5: crucial role for hydrophobicity at dimer interface
10.1074/jbc.m112.367995 · 2012 · External reference
Critical determinants of human α-defensin 5 activity against non-enveloped viruses
10.1074/jbc.m112.354068 · 2012 · External reference
A Single Surface-Exposed Amino Acid Determines Differential Neutralization of AAV1 and AAV6 by Human Alpha-Defensins
10.1128/jvi.00060-23 · 2023 · External reference
Human Defensins Inhibit SARS-CoV-2 Infection by Blocking Viral Entry
10.3390/v13071246 · 2021 · External reference
Paneth Cells during Viral Infection and Pathogenesis
10.3390/v10050225 · 2018 · External reference
Human alpha defensin 5 expression in the human kidney and urinary tract
10.1371/journal.pone.0031712 · 2012 · External reference
Paneth cell antimicrobial peptides: topographical distribution and quantification in human gastrointestinal tissues
10.1016/j.febslet.2006.08.083 · 2006 · External reference
Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria
10.1038/77783 · 2000 · External reference
Neutrophil extracellular traps kill bacteria
10.1126/science.1092385 · 2004 · External reference
Discovery and identification of alpha-defensins as low abundant, tumor-derived serum markers in colorectal cancer
10.1053/j.gastro.2005.05.014 · 2005 · External reference
Human α-defensins HNPs-1, -2, and -3 in renal cell carcinoma: influences on tumor cell proliferation
10.1016/s0002-9440(10)62558-8 · 2002 · External reference
Plasma human neutrophil peptides as biomarkers of disease severity and mortality in patients with decompensated cirrhosis
10.1111/liv.15520 · 2023 · External reference
Human Neutrophil Alpha-Defensins Promote NETosis and Liver Injury in Alcohol-Related Liver Cirrhosis: Potential Therapeutic Agents
10.3390/jcm13051237 · 2024 · External reference
Defensins: A Double-Edged Sword in Host Immunity
10.3389/fimmu.2020.00764 · 2020 · External reference
Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis
1993 · External reference
Elevated levels of human alpha -defensin in tears of patients with allergic conjunctival disease complicated by corneal lesions: detection by SELDI ProteinChip system and quantification
2005 · External reference
Elevated Tear Human Neutrophil Peptides 1-3, Human Beta Defensin-2 Levels and Conjunctival Cathelicidin LL-37 Gene Expression in Ocular Rosacea
10.1080/09273948.2018.1504971 · 2019 · External reference
Inhibition of recombinant adeno-associated virus (rAAV) transduction by bronchial secretions from cystic fibrosis patients
10.1038/sj.gt.3301268 · 2000 · External reference
Mechanism of adenovirus neutralization by Human alpha-defensins
10.1016/j.chom.2007.12.001 · 2008 · External reference
Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization
10.1371/journal.ppat.1000959 · 2010 · External reference
Alpha-defensin HD5 inhibits furin cleavage of human papillomavirus 16 L2 to block infection
10.1128/jvi.02901-14 · 2015 · External reference
α-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome
10.1128/mbio.02304-16 · 2017 · External reference
Human alpha-defensins block papillomavirus infection
10.1073/pnas.0508033103 · 2006 · External reference
Human alpha-defensins inhibit BK virus infection by aggregating virions and blocking binding to host cells
10.1074/jbc.m805902200 · 2008 · External reference
The human alpha defensin HD5 neutralizes JC polyomavirus infection by reducing endoplasmic reticulum traffic and stabilizing the viral capsid
10.1128/jvi.02766-13 · 2014 · External reference
Corrected and republished from: “VP4 Is a Determinant of Alpha-Defensin Modulation of Rotaviral Infection”
2023 · External reference
Defensin-driven viral evolution
10.1371/journal.ppat.1009018 · 2020 · External reference
Direct evidence from single-cell analysis that human {alpha}-defensins block adenovirus uncoating to neutralize infection
10.1128/jvi.02471-09 · 2010 · External reference
Delineation of interfaces on human alpha-defensins critical for human adenovirus and human papillomavirus inhibition
10.1371/journal.ppat.1004360 · 2014 · External reference
Infectious entry pathway of adeno-associated virus and adeno-associated virus vectors
10.1128/jvi.74.6.2777-2785.2000 · 2000 · External reference
The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity
10.1099/0022-1317-83-5-973 · 2002 · External reference
A conformational change in the adeno-associated virus type 2 capsid leads to the exposure of hidden VP1 N termini
10.1128/jvi.79.9.5296-5303.2005 · 2005 · External reference
Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus
10.1128/jvi.01056-06 · 2006 · External reference
Intrinsic phospholipase A2 activity of adeno-associated virus is involved in endosomal escape of incoming particles
10.1016/j.virol.2010.09.025 · 2011 · External reference
Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection
10.1128/jvi.74.19.9281-9293.2000 · 2000 · External reference
Subcellular compartmentalization of adeno-associated virus type 2 assembly
10.1128/jvi.71.2.1341-1352.1997 · 1997 · External reference
Characterization of the Adeno-Associated Virus 1 and 6 Sialic Acid Binding Site
10.1128/jvi.00161-16 · 2016 · External reference
Development of AAV serotype-specific ELISAs using novel monoclonal antibodies
10.1016/j.jviromet.2006.10.005 · 2007 · External reference
AAV-6 mediated efficient transduction of mouse lower airways
10.1016/j.virol.2011.06.009 · 2011 · External reference
Evidence for pH-dependent protease activity in the adeno-associated virus capsid
10.1128/jvi.01717-12 · 2012 · External reference
Comparative analysis of adeno-associated virus capsid stability and dynamics
10.1128/jvi.01415-13 · 2013 · External reference
Adeno-Associated Virus (AAV) Capsid Stability and Liposome Remodeling During Endo/Lysosomal pH Trafficking
10.3390/v12060668 · 2020 · External reference
Separate basic region motifs within the adeno-associated virus capsid proteins are essential for infectivity and assembly
10.1128/jvi.02723-05 · 2006 · External reference
Membrane-associated heparan sulfate proteoglycan is a receptor for adeno-associated virus type 2 virions
10.1128/jvi.72.2.1438-1445.1998 · 1998 · External reference
Single amino acid changes can influence titer, heparin binding, and tissue tropism in different adeno-associated virus serotypes
10.1128/jvi.01288-06 · 2006 · External reference
Alpha2,3 and alpha2,6 N-linked sialic acids facilitate efficient binding and transduction by adeno-associated virus types 1 and 6
10.1128/jvi.00895-06 · 2006 · External reference
Structural and cellular biology of adeno-associated virus attachment and entry
10.1016/bs.aivir.2020.01.002 · 2020 · External reference
An Alternate Route for Adeno-associated Virus (AAV) Entry Independent of AAV Receptor
10.1128/jvi.02213-17 · 2018 · External reference
An essential receptor for adeno-associated virus infection
10.1038/nature16465 · 2016 · External reference
GPR108 Is a Highly Conserved AAV Entry Factor
10.1016/j.ymthe.2019.11.005 · 2020 · External reference
Pooled Screens Identify GPR108 and TM9SF2 as Host Cell Factors Critical for AAV Transduction
10.1016/j.omtm.2020.03.012 · 2020 · External reference
Protoparvovirus Knocking at the Nuclear Door
10.3390/v9100286 · 2017 · External reference
Endocytosis and nuclear trafficking of adeno-associated virus type 2 are controlled by rac1 and phosphatidylinositol-3 kinase activation
10.1128/jvi.74.19.9184-9196.2000 · 2000 · External reference
Cytoplasmic trafficking, endosomal escape, and perinuclear accumulation of adeno-associated virus type 2 particles are facilitated by microtubule network
10.1128/jvi.00935-12 · 2012 · External reference
Adeno-associated virus type 2 (AAV2) uncoating is a stepwise process and is linked to structural reorganization of the nucleolus
10.1371/journal.ppat.1010187 · 2022 · External reference
Enhancement of adeno-associated virus infection by mobilizing capsids into and out of the nucleolus
10.1128/jvi.02309-08 · 2009 · External reference
Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking
10.1128/jvi.02524-12 · 2013 · External reference
Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activity
10.1128/jvi.79.4.2528-2540.2005 · 2005 · External reference
Tyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infection
10.1021/cb3000265 · 2012 · External reference
Structurally Mapping Antigenic Epitopes of Adeno-associated Virus 9: Development of Antibody Escape Variants
10.1128/jvi.01251-21 · 2022 · External reference
Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach
10.1128/jvi.00976-20 · 2020 · External reference
Characterization of AAV-Specific Affinity Ligands: Consequences for Vector Purification and Development Strategies
10.1016/j.omtm.2020.10.001 · 2020 · External reference
Adeno-Associated Virus VP1u Exhibits Protease Activity
10.3390/v11050399 · 2019 · External reference
VP2 cleavage and the leucine ring at the base of the fivefold cylinder control pH-dependent externalization of both the VP1 N terminus and the genome of minute virus of mice
10.1128/jvi.80.1.161-171.2006 · 2006 · External reference
Parvovirus Capsid Structures Required for Infection: Mutations Controlling Receptor Recognition and Protease Cleavages
10.1128/jvi.01871-16 · 2017 · External reference
Low pH-dependent endosomal processing of the incoming parvovirus minute virus of mice virion leads to externalization of the VP1 N-terminal sequence (N-VP1), N-VP2 cleavage, and uncoating of the full-length genome
10.1128/jvi.80.2.1015-1024.2006 · 2006 · External reference
Alpha-defensin binding expands human adenovirus tropism
10.1371/journal.ppat.1012317 · 2024 · External reference
Alpha-defensin-dependent enhancement of enteric viral infection
10.1371/journal.ppat.1006446 · 2017 · External reference
Human defensins 5 and 6 enhance HIV-1 infectivity through promoting HIV attachment
10.1186/1742-4690-8-45 · 2011 · External reference
Defensins in innate immunity
10.1007/s00441-010-1022-4 · 2011 · External reference
Distinct classes of proteasome-modulating agents cooperatively augment recombinant adeno-associated virus type 2 and type 5-mediated transduction from the apical surfaces of human airway epithelia
10.1128/jvi.78.6.2863-2874.2004 · 2004 · External reference
Cross-packaging of a single adeno-associated virus (AAV) type 2 vector genome into multiple AAV serotypes enables transduction with broad specificity
10.1128/jvi.76.2.791-801.2002 · 2002 · External reference
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system
10.1016/j.ymthe.2004.05.024 · 2004 · External reference
Production of high-titer recombinant adeno-associated virus vectors in the absence of helper adenovirus
10.1128/jvi.72.3.2224-2232.1998 · 1998 · External reference
Thermal Stability as a Determinant of AAV Serotype Identity
10.1016/j.omtm.2017.07.003 · 2017 · External reference
Adeno-associated virus serotype 1 (AAV1)- and AAV5-antibody complex structures reveal evolutionary commonalities in parvovirus antigenic reactivity
10.1128/jvi.02710-14 · 2015 · External reference
Mechanisms of AAV neutralization by human alpha-defensins.
2025 · External reference
Cellpose 2.0: how to train your own model
10.1038/s41592-022-01663-4 · 2022 · External reference
CellProfiler 4: improvements in speed, utility and usability
10.1186/s12859-021-04344-9 · 2021 · External reference