Research graph
References from Inactivation of branched-chain amino acid uptake halts Staphylococcus aureus growth and induces bacterial quiescence within macrophages. Local targets link to admitted publications; unresolved targets remain external evidence.
Have we outlived the concept of commensalism for staphylococcus aureus?
10.1093/cid/ciaa1431 · 2021 · External reference
Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management
10.1128/cmr.00134-14 · 2015 · External reference
Staphylococcus aureus colonization: modulation of host immune response and impact on human vaccine design
10.3389/fimmu.2013.00507 · 2014 · External reference
The role of nasal carriage in Staphylococcus aureus infections
10.1016/s1473-3099(05)70295-4 · 2005 · External reference
Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks
10.1128/cmr.10.3.505 · 1997 · External reference
Inside job: Staphylococcus aureus host-pathogen interactions
10.1016/j.ijmm.2017.11.009 · 2018 · External reference
In or out: Phagosomal escape of Staphylococcus aureus
10.1111/cmi.12997 · 2019 · External reference
Microscopy-based phenotypic profiling of infection by Staphylococcus aureus clinical isolates reveals intracellular lifestyle as a prevalent feature
10.1038/s41467-022-34790-9 · 2022 · External reference
Antimicrobial mechanisms of macrophages and the immune evasion strategies of staphylococcus aureus
10.3390/pathogens4040826 · 2015 · External reference
Nutritional immunity: the battle for nutrient metals at the host-pathogen interface
10.1038/s41579-022-00745-6 · 2022 · External reference
Lysosomal solute and water transport
2022 · External reference
Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination
10.1111/cmi.12527 · 2016 · External reference
A potential new pathway for Staphylococcus aureus dissemination: the silent survival of S. aureus phagocytosed by human monocyte-derived macrophages
10.1371/journal.pone.0001409 · 2008 · External reference
Novel antibody-antibiotic conjugate eliminates intracellular S. aureus
10.1038/nature16057 · 2015 · External reference
Clonal population expansion of Staphylococcus aureus occurs due to escape from a finite number of intraphagocyte niches
10.1038/s41598-023-27928-2 · 2023 · External reference
Antimicrobial mechanisms of phagocytes and bacterial evasion strategies
10.1038/nrmicro2128 · 2009 · External reference
Identification and treatment of the Staphylococcus aureus reservoir in vivo
10.1084/jem.20160334 · 2016 · External reference
Staphylococcus aureus Uses the GraXRS Regulatory System To Sense and Adapt to the Acidified Phagolysosome in Macrophages
10.1128/mbio.01143-18 · 2018 · External reference
Insertional inactivation of branched-chain alpha-keto acid dehydrogenase in Staphylococcus aureus leads to decreased branched-chain membrane fatty acid content and increased susceptibility to certain stresses
10.1128/aem.00882-08 · 2008 · External reference
The structure of the pleiotropic transcription regulator CodY provides insight into its GTP-sensing mechanism
2016 · External reference
Repression of branched-chain amino acid synthesis in Staphylococcus aureus is mediated by isoleucine via CodY, and by a leucine-rich attenuator peptide
10.1371/journal.pgen.1007159 · 2018 · External reference
CodY, a master integrator of metabolism and virulence in Gram-positive bacteria
10.1007/s00294-016-0656-5 · 2017 · External reference
Branching out: alterations in bacterial physiology and virulence due to branched-chain amino acid deprivation
10.1128/mbio.01188-18 · 2018 · External reference
Role of BrnQ1 and BrnQ2 in branched-chain amino acid transport and virulence in Staphylococcus aureus
10.1128/iai.02542-14 · 2015 · External reference
Direct targets of CodY in Staphylococcus aureus
10.1128/jb.00220-10 · 2010 · External reference
CodY in Staphylococcus aureus: a regulatory link between metabolism and virulence gene expression
10.1128/jb.01492-08 · 2009 · External reference
The stringent response of Staphylococcus aureus and its impact on survival after phagocytosis through the induction of intracellular PSMs expression
10.1371/journal.ppat.1003016 · 2012 · External reference
A spectrum of CodY activities drives metabolic reorganization and virulence gene expression in Staphylococcus aureus
10.1111/mmi.13404 · 2016 · External reference
The role of two branched-chain amino acid transporters in Staphylococcus aureus growth, membrane fatty acid composition and virulence
10.1111/mmi.13495 · 2016 · External reference
AureoWiki ̵ The repository of the Staphylococcus aureus research and annotation community
10.1016/j.ijmm.2017.11.011 · 2018 · External reference
Alternative Enzyme Protection Assay To Overcome the Drawbacks of the Gentamicin Protection Assay for Measuring Entry and Intracellular Survival of Staphylococci
2019 · External reference
Impact of Gentamicin Concentration and Exposure Time on Intracellular Yersinia pestis
10.3389/fcimb.2017.00505 · 2017 · External reference
Macrophage-driven nutrient delivery to phagosomal Staphylococcus aureus supports bacterial growth
10.15252/embr.202050348 · 2020 · External reference
A genetic resource for rapid and comprehensive phenotype screening of nonessential Staphylococcus aureus genes
2013 · External reference
CodY deletion enhances in vivo virulence of community-associated methicillin-resistant Staphylococcus aureus clone USA300
10.1128/iai.06172-11 · 2012 · External reference
Intracellular Staphylococcus aureus employs the cysteine protease staphopain A to induce host cell death in epithelial cells
10.1371/journal.ppat.1009874 · 2021 · External reference
Intracellular Habitation of Staphylococcus aureus: Molecular Mechanisms and Prospects for Antimicrobial Therapy
10.3390/biomedicines10081804 · 2022 · External reference
A Photoconvertible Reporter System for Bacterial Metabolic Activity Reveals That Staphylococcus aureus Enters a Dormant-Like State to Persist within Macrophages
2022 · External reference
Rapid removal of phagosomal ferroportin in macrophages contributes to nutritional immunity
10.1182/bloodadvances.2020002833 · 2021 · External reference
In Staphylococcus aureus, fur is an interactive regulator with PerR, contributes to virulence, and Is necessary for oxidative stress resistance through positive regulation of catalase and iron homeostasis
10.1128/jb.183.2.468-475.2001 · 2001 · External reference
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon
10.1046/j.1365-2958.2002.03113.x · 2002 · External reference
RegPrecise 3.0--a resource for genome-scale exploration of transcriptional regulation in bacteria
10.1186/1471-2164-14-745 · 2013 · External reference
Intracellular Staphylococcus aureus persisters upon antibiotic exposure
10.1038/s41467-020-15966-7 · 2020 · External reference
Elucidating the CodY regulon in Staphylococcus aureus USA300 substrains TCH1516 and LAC
2023 · External reference
Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection
10.1002/emmm.201000115 · 2011 · External reference
Metabolic cross-talk between human bronchial epithelial cells and internalized staphylococcus aureus as a driver for infection
10.1074/mcp.ra118.001138 · 2019 · External reference
ClpC affects the intracellular survival capacity of Staphylococcus aureus in non-professional phagocytic cells
10.1038/s41598-019-52731-3 · 2019 · External reference
Intracellular survival of Staphylococcus aureus in endothelial cells: A matter of growth or persistence
10.3389/fmicb.2017.01354 · 2017 · External reference
Inability to sustain intraphagolysosomal killing of Staphylococcus aureus predisposes to bacterial persistence in macrophages
10.1111/cmi.12485 · 2016 · External reference
Bacterial persistence as a phenotypic switch
10.1126/science.1099390 · 2004 · External reference
Definitions and guidelines for research on antibiotic persistence
10.1038/s41579-019-0196-3 · 2019 · External reference
The classification of bacterial survival strategies in the presence of antimicrobials
10.1016/j.micpath.2021.104901 · 2021 · External reference
Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics
10.1016/j.chom.2024.04.019 · 2024 · External reference
Host Cell Oxidative Stress Induces Dormant Staphylococcus aureus Persisters
10.1128/spectrum.02313-21 · 2022 · External reference
Reactive oxygen species induce antibiotic tolerance during systemic Staphylococcus aureus infection
10.1038/s41564-019-0627-y · 2020 · External reference
Two small (p)ppGpp synthases in Staphylococcus aureus mediate tolerance against cell envelope stress conditions
2013 · External reference
Staphylococcus aureus small-colony variants are adapted phenotypes for intracellular persistence
10.1086/656047 · 2010 · External reference
Unstable chromosome rearrangements in Staphylococcus aureus cause phenotype switching associated with persistent infections
10.1073/pnas.1904861116 · 2019 · External reference
Staphylococcus aureus persistence in non-professional phagocytes
10.1016/j.ijmm.2013.11.011 · 2014 · External reference
Persistence of Staphylococcus aureus: Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs)
10.3389/fmicb.2020.01028 · 2020 · External reference
Metabolic immunity against microbes
10.1016/j.tcb.2023.10.013 · 2024 · External reference
Feast or famine: the host-pathogen battle over amino acids
10.1111/cmi.12140 · 2013 · External reference
Hierarchical expression of genes controlled by the Bacillus subtilis global regulatory protein CodY
10.1073/pnas.1321308111 · 2014 · External reference
mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient
10.1016/j.cell.2017.09.046 · 2017 · External reference
Controlled branched-chain amino acids auxotrophy in Listeria monocytogenes allows isoleucine to serve as a host signal and virulence effector
10.1371/journal.pgen.1007283 · 2018 · External reference
The amino acid requirements of Staphylococcus aureus isolated from cases of bovine mastitis
10.1016/0378-1135(95)00041-8 · 1995 · External reference
The Ins and Outs of Cathepsins: Physiological Function and Role in Disease Management
10.3390/cells9071679 · 2020 · External reference
Protease-mediated growth of Staphylococcus aureus on host proteins is opp3 dependent
10.1128/mbio.02553-18 · 2019 · External reference
Only one of four oligopeptide transport systems mediates nitrogen nutrition in Staphylococcus aureus
10.1128/jb.00274-07 · 2007 · External reference
Mapping the Global Network of Extracellular Protease Regulation in Staphylococcus aureus
10.1128/msphere.00676-19 · 2019 · External reference
Bacterial persisters: formation, eradication, and experimental systems
10.1016/j.tim.2014.03.008 · 2014 · External reference
Staphylococcus aureus chronic and relapsing infections: Evidence of a role for persister cells: An investigation of persister cells, their formation and their role in S. aureus disease
10.1002/bies.201400080 · 2014 · External reference
Prolonged bacterial lag time results in small colony variants that represent a sub-population of persisters
10.1038/s41467-018-06527-0 · 2018 · External reference
Staphylococcus aureus Small Colony Variants (SCVs): News From a Chronic Prosthetic Joint Infection
2019 · External reference
Clinical Significance and Pathogenesis of Staphylococcal Small Colony Variants in Persistent Infections
10.1128/cmr.00069-15 · 2016 · External reference
Iron restriction induces the small-colony variant phenotype in Staphylococcus aureus
10.3389/fmicb.2022.978859 · 2022 · External reference
Antibiotic activity against small-colony variants of Staphylococcus aureus: review of in vitro, animal and clinical data
10.1093/jac/dkt072 · 2013 · External reference
Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections
10.1038/nrmicro1384 · 2006 · External reference
Exploring amino acid and peptide transporters as therapeutic targets to attenuate virulence and antibiotic resistance in Staphylococcus aureus
10.1371/journal.ppat.1009093 · 2021 · External reference
FastCloning: a highly simplified, purification-free, sequence- and ligation-independent PCR cloning method
10.1186/1472-6750-11-92 · 2011 · External reference
Staphylococcal alpha-toxin is not sufficient to mediate escape from phagolysosomes in upper-airway epithelial cells
10.1128/iai.01478-08 · 2009 · External reference
Genetic tools to enhance the study of gene function and regulation in Staphylococcus aureus
10.1128/aem.00136-13 · 2013 · External reference
Leukoreduction System Chambers as a Source of Viable Human Peripheral Blood Mononuclear Cells.
10.1182/blood.v110.11.4912.4912 · 2007 · External reference
Fiji: an open-source platform for biological-image analysis
10.1038/nmeth.2019 · 2012 · External reference
Nondenaturing agarose gel electrophoresis of RNA
2010 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
READemption-a tool for the computational analysis of deep-sequencing-based transcriptome data
10.1093/bioinformatics/btu533 · 2014 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
10.1006/meth.2001.1262 · 2001 · External reference
progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement
10.1371/journal.pone.0011147 · 2010 · External reference
Prokka: rapid prokaryotic genome annotation
10.1093/bioinformatics/btu153 · 2014 · External reference
A fluorescence based-proliferation assay for the identification of replicating bacteria within host cells
10.3389/fmicb.2018.03084 · 2018 · External reference
Methionine biosynthesis in Staphylococcus aureus is tightly controlled by a hierarchical network involving an initiator tRNA-specific T-box riboswitch
2013 · External reference
Staphylococcus aureus Exploits a Non-ribosomal Cyclic Dipeptide to Modulate Survival within Epithelial Cells and Phagocytes
10.1371/journal.ppat.1005857 · 2016 · External reference