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References from Biochemical and structural characterization of the human gut microbiome metallopeptidase IgAse provides insight into its unique specificity for the Fab’ region of IgA1 and IgA2. Local targets link to admitted publications; unresolved targets remain external evidence.
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IgA nephropathy
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Urticarial erythema associated with IgA myeloma
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Linear IgA and IgG bullous dermatosis
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IgA subclasses have different effector functions associated with distinct glycosylation profiles
10.1038/s41467-019-13992-8 · 2020 · External reference
The site of cleavage in human alpha chains of IgA1 and IgA2:A2m(1) allotype paraproteins by the clostridial IGA protease
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Cysteine residues required for the attachment of the light chain in human IgA2
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Isolation of an enzyme from Streptococcus sanguis which specifically cleaves IgA
10.4049/jimmunol.113.1.289 · 1974 · External reference
Biological significance of IgA1 proteases in bacterial colonization and pathogenesis: critical evaluation of experimental evidence
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Chapter 274 - The IgA protease of Clostridium ramosum.
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Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease
10.1038/s41467-020-19887-3 · 2020 · External reference
How to use the MEROPS database and website to help understand peptidase specificity
10.1002/pro.3948 · 2021 · External reference
A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases
10.1038/s42003-022-04173-3 · 2022 · External reference
Architecture and function of metallopeptidase catalytic domains
10.1002/pro.2400 · 2014 · External reference
Multiple Architectures and Mechanisms of Latency in Metallopeptidase Zymogens
10.1021/acs.chemrev.8b00030 · 2018 · External reference
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A standard orientation for metallopeptidases
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AlphaFold predictions are valuable hypotheses and accelerate but do not replace experimental structure determination
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10.1002/pro.4519 · 2023 · External reference
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10.1038/365277a0 · 1993 · External reference
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An unfolded CH1 domain controls the assembly and secretion of IgG antibodies
10.1016/j.molcel.2009.04.028 · 2009 · External reference
A tool kit for rapid cloning and expression of recombinant antibodies
10.1038/srep05885 · 2014 · External reference
Weak protein complexes: challenging to study but essential for life
10.1111/febs.12744 · 2014 · External reference
Solvent content of protein crystals
10.1016/0022-2836(68)90205-2 · 1968 · External reference
Ten years of probabilistic estimates of biocrystal solvent content: new insights via nonparametric kernel density estimate
10.1107/s1399004714005550 · 2014 · External reference
Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the “metzincins”
10.1016/0014-5793(93)80312-i · 1993 · External reference
Structural aspects of the metzincin clan of metalloendopeptidases
10.1385/mb:24:2:157 · 2003 · External reference
Catalytic domain architecture of metzincin metalloproteases
10.1074/jbc.r800069200 · 2009 · External reference
Structure of the proteolytic enzyme PAPP-A with the endogenous inhibitor stanniocalcin-2 reveals its inhibitory mechanism
10.1038/s41467-022-33698-8 · 2022 · External reference
Structural insights into latency of the metallopeptidase ulilysin (lysargiNase) and its unexpected inhibition by a sulfonyl-fluoride inhibitor of serine peptidases
10.1039/d3dt00458a · 2023 · External reference
On the relevance of the Met-turn methionine in metzincins
10.1074/jbc.m109.083378 · 2010 · External reference
Structural features of a superfamily of zinc-endopeptidases: the metzincins
10.1016/0959-440x(95)80101-4 · 1995 · External reference
The roles of Glu93 and Tyr149 in astacin-like zinc peptidases
10.1016/s0014-5793(00)02163-3 · 2000 · External reference
Crystal structure of archaemetzincin AmzA from Methanopyrus kandleri at 1.5 A resolution
10.1002/prot.22777 · 2010 · External reference
The JCSG high-throughput structural biology pipeline
10.1107/s1744309110038212 · 2010 · External reference
Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2
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10.1016/s0021-9258(17)46181-3 · 1990 · External reference
Structural Basis for Latency and Function of Immune Inhibitor A Metallopeptidase, a Modulator of the Bacillus anthracis Secretome
10.1016/j.str.2015.10.015 · 2016 · External reference
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2021 · External reference
A review of the approaches used to solve sub-100 kDa membrane proteins by cryo-electron microscopy
10.1016/j.jsb.2023.107959 · 2023 · External reference
Prospects and Limitations of High-Resolution Single-Particle Cryo-Electron Microscopy
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The C-type lectin-like domain superfamily
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2023 · External reference
Structural insights into SraP-mediated Staphylococcus aureus adhesion to host cells
2014 · External reference
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
10.1038/s41592-020-00990-8 · 2020 · External reference
Chimeric Fusion between Clostridium Ramosum IgA Protease and IgG Fc Provides Long-Lasting Clearance of IgA Deposits in Mouse Models of IgA Nephropathy
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Highly accurate protein structure prediction for the human proteome
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Recombinant production, purification, crystallization, and structure analysis of human transforming growth factor β2 in a new conformation
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An IgA-binding peptide derived from a streptococcal surface protein
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NIH Image to ImageJ: 25 years of image analysis
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Integration, scaling, space-group assignment and post-refinement
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