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References from Tibetan PHD2D4E;C127S variant protects from viral diseases in hypoxia, but predispose to infections in normoxia via HIFα:IFN axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Infections at high altitude
10.1086/324163 · 2001 · External reference
Effect of altitude on hospitalizations for respiratory syncytial virus infection
10.1542/peds.2004-2795 · 2006 · External reference
Infectious diseases at high altitude
10.1128/microbiolspec.iol5-0006-2015 · 2015 · External reference
Undifferentiated febrile illness in Kathmandu, Nepal
10.4269/ajtmh.14-0709 · 2015 · External reference
The role of HIF in immunity and inflammation
10.1016/j.cmet.2020.08.002 · 2020 · External reference
HIF transcription factors, inflammation, and immunity
10.1016/j.immuni.2014.09.008 · 2014 · External reference
SARS-CoV-2 infection: physiological and environmental gift factors at high altitude
10.1007/s13337-020-00626-7 · 2020 · External reference
SARS-CoV-2 Viral Load Analysis at Low and High Altitude: A Case Study from Ecuador
10.3390/ijerph19137945 · 2022 · External reference
Natural selection on EPAS1 (HIF2α) associated with low hemoglobin concentration in Tibetan highlanders
10.1073/pnas.1002443107 · 2010 · External reference
Identifying signatures of natural selection in Tibetan and Andean populations using dense genome scan data
10.1371/journal.pgen.1001116 · 2010 · External reference
A genetic mechanism for Tibetan high-altitude adaptation
10.1038/ng.3067 · 2014 · External reference
Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas
10.1093/molbev/msq290 · 2011 · External reference
Genetic evidence for high-altitude adaptation in Tibet
10.1126/science.1189406 · 2010 · External reference
The overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean natives
10.1073/pnas.1909002116 · 2019 · External reference
Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders.
10.1007/s00109-017-1519-3 · 2017 · External reference
Sequencing of 50 human exomes reveals adaptation to high altitude
10.1126/science.1190371 · 2010 · External reference
Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation
10.1093/molbev/mst090 · 2013 · External reference
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing
10.1074/jbc.m001914200 · 2000 · External reference
Reactive oxygen species regulate hypoxia-inducible factor 1α differentially in cancer and ischemia
10.1128/mcb.00060-08 · 2008 · External reference
Gain-of-function Tibetan PHD2D4E;C127S variant suppresses monocyte function: a lesson in inflammatory response to inspired hypoxia
10.1016/j.ebiom.2021.103418 · 2021 · External reference
High altitude illness
2016 · External reference
pVHL suppresses kinase activity of Akt in a proline-hydroxylation–dependent manner
10.1126/science.aad5755 · 2016 · External reference
α-Ketoglutarate inhibits thrombosis and inflammation by Prolyl Hydroxylase-2 mediated inactivation of Phospho-Akt
10.1016/j.ebiom.2021.103672 · 2021 · External reference
Targeting hypoxia in the tumor microenvironment: a potential strategy to improve cancer immunotherapy
10.1186/s13046-020-01820-7 · 2021 · External reference
Regulated oxygen sensing by protein hydroxylation in renal erythropoietin-producing cells
10.1152/ajprenal.00736.2009 · 2010 · External reference
Elevated glucose levels favor SARS-CoV-2 infection and monocyte response through a HIF-1α/Glycolysis-dependent axis
10.1016/j.cmet.2020.07.015 · 2020 · External reference
Improving cancer immunotherapy by targeting the hypoxic tumor microenvironment: new opportunities and challenges
10.3390/cells8091083 · 2019 · External reference