Research graph
References from Human herpesvirus 6B glycoprotein B postfusion structure, vulnerability mapping, and receptor recognition. Local targets link to admitted publications; unresolved targets remain external evidence.
Classification of HHV-6A and HHV-6B as distinct viruses
10.1007/s00705-013-1902-5 · 2014 · External reference
Human Herpes Virus-6 (HHV-6) Reactivation after Hematopoietic Cell Transplant and Chimeric Antigen Receptor (CAR)- T Cell Therapy: A Shifting Landscape
10.3390/v16040498 · 2024 · External reference
A population-based study of primary human herpesvirus 6 infection
10.1056/nejmoa042207 · 2005 · External reference
HHV-6-Associated Neurological Disease in Children: Epidemiologic, Clinical, Diagnostic, and Treatment Considerations
10.1016/j.pediatrneurol.2019.10.004 · 2020 · External reference
A systematic review and meta-analysis of HHV-6 and mortality after hematopoietic cell transplant
10.1038/s41409-024-02398-w · 2024 · External reference
Viral encephalitis after hematopoietic cell transplantation: a systematic review
2023 · External reference
HHV-6B detection and host gene expression implicate HHV-6B as pulmonary pathogen after hematopoietic cell transplant
10.1038/s41467-024-44828-9 · 2024 · External reference
Human herpesvirus-6B reactivation is a risk factor for grades II to IV acute graft-versus-host disease after hematopoietic stem cell transplantation: a systematic review and meta-analysis
10.1016/j.bbmt.2018.04.021 · 2018 · External reference
Latent human herpesvirus 6 is reactivated in CAR T cells
10.1038/s41586-023-06704-2 · 2023 · External reference
Targeting herpesvirus entry complex and fusogen glycoproteins with prophylactic and therapeutic agents
10.1016/j.tim.2023.03.001 · 2023 · External reference
Anti-EBV antibodies: Roles in diagnosis, pathogenesis, and antiviral therapy
2023 · External reference
CD134 is a cellular receptor specific for human herpesvirus-6B entry
10.1073/pnas.1305187110 · 2013 · External reference
gp96 Is Critical for both Human Herpesvirus 6A (HHV-6A) and HHV-6B Infections
2020 · External reference
The structural basis of herpesvirus entry
10.1038/s41579-020-00448-w · 2021 · External reference
Nectin-2 Acts as a Viral Entry Mediated Molecule That Binds to Human Herpesvirus 6B Glycoprotein B
10.3390/v14010160 · 2022 · External reference
Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins
10.1016/j.virol.2007.06.031 · 2007 · External reference
Structure of a trimeric variant of the Epstein–Barr virus glycoprotein B
10.1073/pnas.0810530106 · 2009 · External reference
HCMV gB shares structural and functional properties with gB proteins from other herpesviruses
10.1016/j.virol.2012.09.024 · 2013 · External reference
Crystal structure of the human cytomegalovirus glycoprotein B
2015 · External reference
Crystal structure of glycoprotein B from herpes simplex virus 1
10.1126/science.1126548 · 2006 · External reference
The N-terminus of varicella-zoster virus glycoprotein B has a functional role in fusion
10.1371/journal.ppat.1008961 · 2021 · External reference
Structure and Antigenicity of Kaposi’s Sarcoma‐Associated Herpesvirus Glycoprotein B
10.1002/advs.202502231 · 2025 · External reference
Mutagenesis of varicella-zoster virus glycoprotein B: putative fusion loop residues are essential for viral replication, and the furin cleavage motif contributes to pathogenesis in skin tissue in vivo
10.1128/jvi.00400-09 · 2009 · External reference
Cleavage of Epstein-Barr virus glycoprotein B is required for full function in cell-cell fusion with both epithelial and B cells
10.1099/vir.0.007237-0 · 2009 · External reference
Glycoprotein B cleavage is important for murid herpesvirus 4 to infect myeloid cells
10.1128/jvi.00709-13 · 2013 · External reference
Novel trimeric human cytomegalovirus glycoprotein B elicits a high-titer neutralizing antibody response
10.1016/j.vaccine.2018.07.056 · 2018 · External reference
Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops
10.1128/jvi.01203-17 · 2018 · External reference
Structure of the Kaposi’s sarcoma-associated herpesvirus gB in post-fusion conformation
2025 · External reference
Characterization of a panel of insertion mutants in human cytomegalovirus glycoprotein B
10.1128/jvi.74.3.1383-1392.2000 · 2000 · External reference
Prediction of proprotein convertase cleavage sites
10.1093/protein/gzh013 · 2004 · External reference
Identification of a variant A-specific neutralizing epitope on glycoprotein B (gB) of human herpesvirus-6 (HHV-6)
10.1006/viro.1996.0408 · 1996 · External reference
The Neutralizing Linear Epitope of Human Herpesvirus 6A Glycoprotein B Does Not Affect Virus Infectivity
10.1128/jvi.02074-17 · 2018 · External reference
Development of a highly effective combination monoclonal antibody therapy against Herpes simplex virus
10.1186/s12929-024-01045-2 · 2024 · External reference
A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
10.1038/s41467-020-17911-0 · 2020 · External reference
Structural basis for the recognition of human cytomegalovirus glycoprotein B by a neutralizing human antibody
10.1371/journal.ppat.1004377 · 2014 · External reference
Structure of HCMV glycoprotein B in the postfusion conformation bound to a neutralizing human antibody
10.1038/ncomms9176 · 2015 · External reference
Protective anti-gB neutralizing antibodies targeting two vulnerable sites for EBV-cell membrane fusion
2022 · External reference
Non-muscle myosin IIA is a functional entry receptor for herpes simplex virus-1
10.1038/nature09420 · 2010 · External reference
Nonmuscle myosin heavy chain IIb mediates herpes simplex virus 1 entry
10.1128/jvi.03079-14 · 2015 · External reference
PILRalpha is a herpes simplex virus-1 entry coreceptor that associates with glycoprotein B
10.1016/j.cell.2008.01.043 · 2008 · External reference
Myelin-associated glycoprotein mediates membrane fusion and entry of neurotropic herpesviruses
10.1073/pnas.0913351107 · 2010 · External reference
Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells
10.1038/ncomms7240 · 2015 · External reference
Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis
2023 · External reference
Discovering broader antiviral strategies: Role of interferon-induced transmembrane proteins in virus infection
10.1016/j.hlife.2024.07.002 · 2024 · External reference
Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion
10.1073/pnas.1212912109 · 2012 · External reference
Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion
2021 · External reference
Clinical characteristics and outcome of human herpesvirus-6 encephalitis after allogeneic hematopoietic stem cell transplantation
10.1038/bmt.2017.175 · 2017 · External reference
A gB nanoparticle vaccine elicits a protective neutralizing antibody response against EBV
2023 · External reference
The structure of HSV-1 gB bound to a potent neutralizing antibody reveals a conservative antigenic domain across herpesviruses
10.1016/j.hlife.2023.12.004 · 2024 · External reference
Current landscape in antiviral drug development against herpes simplex virus infections
10.1002/smmd.20220004 · 2022 · External reference
Structure-based design of a soluble human cytomegalovirus glycoprotein B antigen stabilized in a prefusion-like conformation
10.1073/pnas.2404250121 · 2024 · External reference
Antigenic and mutational analyses of herpes simplex virus glycoprotein B reveal four functional regions
10.1128/jvi.02710-06 · 2007 · External reference
B cell repertoire analysis identifies new antigenic domains on glycoprotein B of human cytomegalovirus which are target of neutralizing antibodies
10.1371/journal.ppat.1002172 · 2011 · External reference
Recognition of a highly conserved glycoprotein B epitope by a bivalent antibody neutralizing HCMV at a post-attachment step
2020 · External reference
Computational design of prefusion-stabilized herpesvirus gB trimers
2024 · External reference
Furin-mediated protein processing in infectious diseases and cancer
10.1002/cti2.1073 · 2019 · External reference
The Proteolytic Regulation of Virus Cell Entry by Furin and Other Proprotein Convertases
10.3390/v11090837 · 2019 · External reference
Cleavage of Epstein-Barr virus glycoprotein B is required for full function in cell-cell fusion with both epithelial and B cells
10.1099/vir.0.007237-0 · 2009 · External reference
Positively Selected Sites at HCMV gB Furin Processing Region and Their Effects in Cleavage Efficiency
10.3389/fmicb.2017.00934 · 2017 · External reference
Proteolytic cleavage of glycoprotein B is dispensable for in vitro replication, but required for syncytium formation of pseudorabies virus
10.1099/vir.0.82610-0 · 2007 · External reference
Neuropilin-1 Facilitates Pseudorabies Virus Replication and Viral Glycoprotein B Promotes Its Degradation in a Furin-Dependent Manner
10.1128/jvi.01318-22 · 2022 · External reference
Epistatic models predict mutable sites in SARS-CoV-2 proteins and epitopes
10.1073/pnas.2113118119 · 2022 · External reference
HSV-1 Infection: Role of Viral Proteins and Cellular Receptors
10.1615/critreveukaryotgeneexpr.2019025561 · 2019 · External reference
cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination
10.1038/nmeth.4169 · 2017 · External reference
Non-uniform refinement: adaptive regularization improves single-particle cryo-EM reconstruction
10.1038/s41592-020-00990-8 · 2020 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
UCSF ChimeraX: Structure visualization for researchers, educators, and developers
10.1002/pro.3943 · 2021 · External reference
Structural basis of Epstein-Barr virus gp350 receptor recognition and neutralization
10.1016/j.celrep.2024.115168 · 2025 · External reference
Coot: model-building tools for molecular graphics
10.1107/s0907444904019158 · 2004 · External reference
PHENIX: a comprehensive Python-based system for macromolecular structure solution
10.1107/s0907444909052925 · 2010 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference
Deciphering key features in protein structures with the new ENDscript server
10.1093/nar/gku316 · 2014 · External reference
AL2CO: calculation of positional conservation in a protein sequence alignment
10.1093/bioinformatics/17.8.700 · 2001 · External reference
ColabFold: making protein folding accessible to all
10.1038/s41592-022-01488-1 · 2022 · External reference
SWISS-MODEL: homology modelling of protein structures and complexes
10.1093/nar/gky427 · 2018 · External reference
The SWISS-MODEL Repository-new features and functionality
10.1093/nar/gkw1132 · 2017 · External reference
Automated comparative protein structure modeling with SWISS-MODEL and Swiss-PdbViewer: A historical perspective
10.1002/elps.200900140 · 2009 · External reference
QMEANDisCo-distance constraints applied on model quality estimation
10.1093/bioinformatics/btz828 · 2020 · External reference
Modeling protein quaternary structure of homo- and hetero-oligomers beyond binary interactions by homology
10.1038/s41598-017-09654-8 · 2017 · External reference
