Research graph
References from Host environment shapes filarial parasite fitness and Wolbachia endosymbionts dynamics. Local targets link to admitted publications; unresolved targets remain external evidence.
Shaking the Tree: Multi-locus Sequence Typing Usurps Current Onchocercid (Filarial Nematode) Phylogeny
10.1371/journal.pntd.0004233 · 2015 · External reference
Biology of the Human Filariases
10.5772/intechopen.102926 · 2022 · External reference
The long and winding road towards new treatments against lymphatic filariasis and onchocerciasis
10.1016/j.pt.2024.07.005 · 2024 · External reference
Of mice, cattle, and humans: the immunology and treatment of river blindness
10.1371/journal.pntd.0000217 · 2008 · External reference
The global status of Dirofilaria immitis in dogs: a systematic review and meta-analysis based on published articles
10.1016/j.rvsc.2020.04.002 · 2020 · External reference
Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With Onchocerca ochengi
10.3389/fcimb.2022.869039 · 2022 · External reference
New paradigms in research on Dirofilaria immitis
10.1186/s13071-023-05762-9 · 2023 · External reference
Unresolved reference
1992 · External reference
Breakdown of coevolution between symbiotic bacteria Wolbachia and their filarial hosts
10.7717/peerj.1840 · 2016 · External reference
Diminutive, degraded but dissimilar: Wolbachia genomes from filarial nematodes do not conform to a single paradigm
2020 · External reference
Wolbachia springs eternal: symbiosis in Collembola is associated with host ecology
10.1098/rsos.230288 · 2023 · External reference
The Wolbachia Endosymbionts
10.1128/microbiolspec.bai-0018-2019 · 2019 · External reference
Wolbachia Control Stem Cell Behavior and Stimulate Germline Proliferation in Filarial Nematodes
10.1016/j.devcel.2018.03.017 · 2018 · External reference
The symbiotic role of Wolbachia in Onchocercidae and its impact on filariasis
10.1111/1469-0691.12069 · 2013 · External reference
Eosinophils contribute to killing of adult Onchocerca ochengi within onchocercomata following elimination of Wolbachia
10.1016/j.micinf.2006.07.017 · 2006 · External reference
A worm’s best friend: recruitment of neutrophils by Wolbachia confounds eosinophil degranulation against the filarial nematode Onchocerca ochengi
2010 · External reference
Wolbachia endosymbionts induce neutrophil extracellular trap formation in human onchocerciasis
10.1038/srep35559 · 2016 · External reference
Antibiotics and Wolbachia in filarial nematodes: antifilarial activity of rifampicin, oxytetracycline and chloramphenicol against Onchocerca gutturosa, Onchocerca lienalis and Brugia pahangi
10.1080/00034983.2000.11813605 · 2000 · External reference
Lymphatic filariasis and onchocerciasis
10.1016/s0140-6736(10)60586-7 · 2010 · External reference
Anti-filarial activity of antibiotic therapy is due to extensive apoptosis after Wolbachia depletion from filarial nematodes
10.1371/journal.ppat.1002351 · 2011 · External reference
Filarial lymphedema is characterized by antigen-specific Th1 and th17 proinflammatory responses and a lack of regulatory T cells
10.1371/journal.pntd.0000420 · 2009 · External reference
Immunopathogenesis of lymphatic filarial disease
10.1007/s00281-012-0346-4 · 2012 · External reference
Regulatory T cell subsets in filarial infection and their function
10.3389/fimmu.2013.00305 · 2013 · External reference
Unraveling the Dynamics of Human Filarial Infections: Immunological Responses, Host Manifestations, and Pathogen Biology
10.3390/pathogens14030223 · 2025 · External reference
Maturation of the filaria Litomosoides sigmodontis in BALB/c mice; comparative susceptibility of nine other inbred strains
10.1051/parasite/1992675144 · 1992 · External reference
The fate of the filaria Litomosoides sigmodontis in susceptible and naturally resistant mice
10.1051/parasite/1996031025 · 1996 · External reference
Human filariasis-contributions of the Litomosoides sigmodontis and Acanthocheilonema viteae animal model
10.1007/s00436-020-07026-2 · 2021 · External reference
The immune response of inbred laboratory mice to Litomosoides sigmodontis: A route to discovery in myeloid cell biology
10.1111/pim.12708 · 2020 · External reference
Development of patent Litomosoides sigmodontis infections in semi-susceptible C57BL/6 mice in the absence of adaptive immune responses
10.1186/s13071-015-1011-2 · 2015 · External reference
Murine filariasis: interleukin 4 and interleukin 5 lead to containment of different worm developmental stages
10.1007/s00430-002-0155-9 · 2003 · External reference
Interleukin-4 is essential for the control of microfilariae in murine infection with the filaria Litomosoides sigmodontis
10.1128/iai.69.5.2950-2956.2001 · 2001 · External reference
A new mechanism for IL-5-dependent helminth control: neutrophil accumulation and neutrophil-mediated worm encapsulation in murine filariasis are abolished in the absence of IL-5
10.1093/intimm/12.6.899 · 2000 · External reference
IL-4 receptor dependent expansion of lung CD169+ macrophages in microfilaria-driven inflammation
10.1371/journal.pntd.0007691 · 2019 · External reference
Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils
10.1186/s13071-019-3502-z · 2019 · External reference
IL-4/5 signalling plays an important role during Litomosoides sigmodontis infection, influencing both immune system regulation and tissue pathology in the thoracic cavity
10.1016/j.ijpara.2017.06.009 · 2017 · External reference
Unbalanced Arginine pathway and altered maturation of pleural macrophages in Th2-deficient mice during Litomosoides sigmodontis filarial infection
10.3389/fimmu.2022.866373 · 2022 · External reference
Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection
10.7554/elife.30947 · 2018 · External reference
T helper 2 cells control monocyte to tissue-resident macrophage differentiation during nematode infection of the pleural cavity
10.1016/j.immuni.2023.02.016 · 2023 · External reference
Unresolved reference
2002 · External reference
Nematodes ultrastructure: complex systems and processes
10.1007/s12639-015-0707-8 · 2016 · External reference
Both asymmetric mitotic segregation and cell-to-cell invasion are required for stable germline transmission of Wolbachia in filarial nematodes
10.1242/bio.2012737 · 2012 · External reference
Oogenesis in Caenorhabditis elegans
10.1159/000531019 · 2023 · External reference
Dual RNAseq analyses at soma and germline levels reveal evolutionary innovations in the elephantiasis-agent Brugia malayi, and adaptation of its Wolbachia endosymbionts
10.1371/journal.pntd.0008935 · 2021 · External reference
Co-evolution between an endosymbiont and its nematode host: Wolbachia asymmetric posterior localization and AP polarity establishment
10.1371/journal.pntd.0003096 · 2014 · External reference
Asymmetric Wolbachia segregation during early Brugia malayi embryogenesis determines its distribution in adult host tissues
10.1371/journal.pntd.0000758 · 2010 · External reference
Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model
10.1371/journal.pntd.0006116 · 2018 · External reference
Antibiotic therapy in murine filariasis (Litomosoides sigmodontis): comparative effects of doxycycline and rifampicin on Wolbachia and filarial viability
10.1046/j.1365-3156.2003.01040.x · 2003 · External reference
Litomosoides, parasites of rodents; taxonomic consequences
10.1051/parasite/1989644268 · 1989 · External reference
Wolbachia depletion blocks transmission of lymphatic filariasis by preventing chitinase-dependent parasite exsheathment
10.1073/pnas.2120003119 · 2022 · External reference
Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host
10.1186/1756-3305-5-12 · 2012 · External reference
Infection of the intermediate mite host with Wolbachia-depleted Litomosoides sigmodontis microfilariae: impaired L1 to L3 development and subsequent sex-ratio distortion in adult worms
10.1016/j.ijpara.2007.12.006 · 2008 · External reference
Dual protonophore-chitinase inhibitors dramatically affect O. volvulus molting
10.1021/jm5006435 · 2014 · External reference
A qPCR to quantify Wolbachia from few Onchocerca volvulus microfilariae as a surrogate for adult worm histology in clinical trials of antiwolbachial drugs
10.1007/s00436-021-07411-5 · 2022 · External reference
Signaling in Parasitic Nematodes: Physicochemical Communication Between Host and Parasite and Endogenous Molecular Transduction Pathways Governing Worm Development and Survival
10.1007/s40588-016-0046-2 · 2016 · External reference
On the role of dauer in the adaptation of nematodes to a parasitic lifestyle
10.1186/s13071-021-04953-6 · 2021 · External reference
Filarial DAF-12 sense the host serum to resume iL3 development during infection
10.1371/journal.ppat.1011462 · 2023 · External reference
Larval biology of six filariae of the sub-family Onchocercinae in a vertebrate host
10.1051/parasite/1994013241 · 1994 · External reference
Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung
10.1371/journal.pntd.0005596 · 2017 · External reference
Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels
10.1038/s41467-019-10675-2 · 2019 · External reference
CCL17 controls mast cells for the defense against filarial larval entry
10.4049/jimmunol.1000612 · 2011 · External reference
The Role of Dafachronic Acid Signaling in Development and Longevity in Caenorhabditis elegans: Digging Deeper Using Cutting-Edge Analytical Chemistry
10.3389/fendo.2016.00012 · 2016 · External reference
Identification of ligands for DAF-12 that govern dauer formation and reproduction in C. elegans
10.1016/j.cell.2006.01.037 · 2006 · External reference
The NHR-8 nuclear receptor regulates cholesterol and bile acid homeostasis in C. elegans
10.1016/j.cmet.2013.07.007 · 2013 · External reference
Dafachronic acid promotes larval development in Haemonchus contortus by modulating dauer signalling and lipid metabolism
2019 · External reference
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
10.1126/science.277.5328.942 · 1997 · External reference
Growth factor receptors in helminth parasites: signalling and host-parasite relationships
10.1016/j.febslet.2006.03.046 · 2006 · External reference
IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity
10.1073/pnas.1009152108 · 2010 · External reference
Tetracycline treatment and sex-ratio distortion: a role for Wolbachia in the moulting of filarial nematodes?
10.1016/s0020-7519(02)00158-3 · 2002 · External reference
Granulocytes in Helminth Infection - Who is Calling the Shots?
10.2174/092986712799828337 · 2012 · External reference
The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system
10.3389/fmicb.2023.1213143 · 2023 · External reference
Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents
10.1186/s13071-020-04428-0 · 2020 · External reference
Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis
10.1073/pnas.1710845114 · 2017 · External reference
Combinations of the azaquinazoline anti-Wolbachia agent, AWZ1066S, with benzimidazole anthelmintics synergise to mediate sub-seven-day sterilising and curative efficacies in experimental models of filariasis
10.3389/fmicb.2024.1346068 · 2024 · External reference
The transcription factor NHR-8: A new target to increase ivermectin efficacy in nematodes
10.1371/journal.ppat.1007598 · 2019 · External reference
Identification of the nuclear receptor DAF-12 as a therapeutic target in parasitic nematodes
10.1073/pnas.0904064106 · 2009 · External reference
Antigen-specific production of interleukin (IL)-13 and IL-5 cooperate to mediate IL-4Ralpha-independent airway hyperreactivity
10.1002/eji.200324178 · 2003 · External reference
Fitness Cost ofLitomosoides sigmodontisFilarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions
10.1155/2013/584105 · 2013 · External reference
Quantitative appraisal of murine filariasis confirms host strain differences but reveals that BALB/c females are more susceptible than males to Litomosoides sigmodontis
10.1016/j.micinf.2004.12.019 · 2005 · External reference
B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection
10.1128/iai.69.11.7067-7073.2001 · 2001 · External reference
QuPath: Open source software for digital pathology image analysis
10.1038/s41598-017-17204-5 · 2017 · External reference
Corallopyronin A specifically targets and depletes essential obligate Wolbachia endobacteria from filarial nematodes in vivo
10.1093/infdis/jis341 · 2012 · External reference
Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections
10.1126/scitranslmed.aav3523 · 2019 · External reference
The transcription factor EGR2 is indispensable for tissue-specific imprinting of alveolar macrophages in health and tissue repair
10.1126/sciimmunol.abj2132 · 2021 · External reference
